CA2110858A1 - Radiation Responsive Surgical Instrument - Google Patents

Radiation Responsive Surgical Instrument

Info

Publication number
CA2110858A1
CA2110858A1 CA2110858A CA2110858A CA2110858A1 CA 2110858 A1 CA2110858 A1 CA 2110858A1 CA 2110858 A CA2110858 A CA 2110858A CA 2110858 A CA2110858 A CA 2110858A CA 2110858 A1 CA2110858 A1 CA 2110858A1
Authority
CA
Canada
Prior art keywords
finger
detector
crystal
housing
surgeon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2110858A
Other languages
French (fr)
Other versions
CA2110858C (en
Inventor
Marlin O. Thurston
Karl W. Olson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Navidea Biopharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2110858A1 publication Critical patent/CA2110858A1/en
Application granted granted Critical
Publication of CA2110858C publication Critical patent/CA2110858C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01T—MEASUREMENT OF NUCLEAR OR X-RADIATION
    • G01T1/00—Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
    • G01T1/16—Measuring radiation intensity
    • G01T1/161—Applications in the field of nuclear medicine, e.g. in vivo counting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/42—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis
    • A61B6/4208—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector
    • A61B6/4258—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector for detecting non x-ray radiation, e.g. gamma radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00022—Sensing or detecting at the treatment site
    • A61B2017/00079—Radioactivity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/0042—Surgical instruments, devices or methods, e.g. tourniquets with special provisions for gripping
    • A61B2017/00438—Surgical instruments, devices or methods, e.g. tourniquets with special provisions for gripping connectable to a finger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/361—Image-producing devices, e.g. surgical cameras
    • A61B2090/3614—Image-producing devices, e.g. surgical cameras using optical fibre

Abstract

A crystal containing detector (56) particularly suited for use in immunoguided surgery capable of detecting gamma emissions present at tumor sites. The instrument utilizes a cadmium-zinc-telluride detector crystal which may be retained within a finger mount (50) positioned over the surgeon's finger. Within this mount there also is incorporated a first preamplification stage (58) designed to accumulate charge signals from the detector as well as to drive a relatively short length of cable (22) to a second preamplification stage located, for example, within a housing (30) at the surgeon's upper arm. The small finger mounted probe (50) may be moved between operative orientations at the underside of the tip of the finger to stand-by orientations at the top of the finger adjacent the knuckles. In an additional embodiment, the finger probe incorporates a sodium iodide crystal, the scintillations from which are transmitted via a short length of fiber optic cable to an upper arm mounted housing which contains a photomultiplier tube. Signals from the remote, arm-mounted housing (30) then are transmitted via longer cabling (34) or the like to a control console. <IMAGE> <IMAGE>
CA002110858A 1992-12-18 1993-12-07 Radiation responsive surgical instrument Expired - Fee Related CA2110858C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/992,622 US5441050A (en) 1992-12-18 1992-12-18 Radiation responsive surgical instrument
US07/992,622 1992-12-18

Publications (2)

Publication Number Publication Date
CA2110858A1 true CA2110858A1 (en) 1994-06-19
CA2110858C CA2110858C (en) 1999-02-16

Family

ID=25538549

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002110858A Expired - Fee Related CA2110858C (en) 1992-12-18 1993-12-07 Radiation responsive surgical instrument

Country Status (11)

Country Link
US (1) US5441050A (en)
EP (1) EP0603111B1 (en)
JP (1) JP2816643B2 (en)
KR (1) KR0181304B1 (en)
AT (1) ATE180955T1 (en)
AU (2) AU671318B2 (en)
CA (1) CA2110858C (en)
DE (1) DE69325248T2 (en)
ES (1) ES2133374T3 (en)
IL (1) IL107921A (en)
MX (1) MX9400055A (en)

Families Citing this family (141)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7820798B2 (en) * 1994-11-07 2010-10-26 Human Genome Sciences, Inc. Tumor necrosis factor-gamma
US7597886B2 (en) * 1994-11-07 2009-10-06 Human Genome Sciences, Inc. Tumor necrosis factor-gamma
US5732704A (en) * 1995-10-13 1998-03-31 Neoprobe Corporation Radiation based method locating and differentiating sentinel nodes
US5857463A (en) * 1995-10-13 1999-01-12 Neoprobe Corporation Remotely controlled apparatus and system for tracking and locating a source of photoemissions
US5967983A (en) * 1995-10-31 1999-10-19 Digirad Corporation Apparatus for securing a medical imaging device to a body
US7888466B2 (en) 1996-01-11 2011-02-15 Human Genome Sciences, Inc. Human G-protein chemokine receptor HSATU68
US5682888A (en) * 1996-06-13 1997-11-04 Neoprobe Corporation Apparatus and system for detecting and locating photon emissions with remote switch control
EP0822405A3 (en) * 1996-07-30 2004-07-07 Bayer Corporation Electronics system for a hematology analytical instrument
US5810806A (en) * 1996-08-29 1998-09-22 Ethicon Endo-Surgery Methods and devices for collection of soft tissue
US6487439B1 (en) * 1997-03-17 2002-11-26 Victor N. Skladnev Glove-mounted hybrid probe for tissue type recognition
US5928150A (en) * 1997-10-04 1999-07-27 Neoprobe Corporation System for locating and detecting a source of photon emissions
US6077508A (en) * 1998-03-23 2000-06-20 American Diagnostica Inc. Urokinase plasminogen activator receptor as a target for diagnosis of metastases
US6264949B1 (en) 1998-09-29 2001-07-24 Mount Sinai School Of Medicine Of New York University Noninvasive agents for diagnosis and prognosis of the progression of fibrosis
US6191422B1 (en) 1998-10-06 2001-02-20 Neoprobe Corporation Radiation probe with compound semiconductor crystal performing in a trapping-dependent operational mode
US6496717B2 (en) 1998-10-06 2002-12-17 University Of South Florida Radio guided seed localization of imaged lesions
US6222193B1 (en) 1998-10-06 2001-04-24 Neoprobe Corporation Radiation responsive surgical probe apparatus
US6204505B1 (en) * 1998-10-06 2001-03-20 Neoprobe Corporation Surgical probe apparatus and system
US6218669B1 (en) 1998-10-06 2001-04-17 Neoprobe Corporation Surgical probe apparatus
US8114006B2 (en) * 1998-10-06 2012-02-14 University Of South Florida Radio guided seed localization of imaged lesions
US6242741B1 (en) 1998-10-23 2001-06-05 United States Surgical Corporation Radiation detection apparatus
WO2000050620A2 (en) 1999-02-26 2000-08-31 Human Genome Sciences, Inc. Human endokine alpha and methods of use
US6331703B1 (en) 1999-03-12 2001-12-18 Ethicon Endo-Surgery, Inc. Guidance method for radiation detection
US6236880B1 (en) 1999-05-21 2001-05-22 Raymond R. Raylman Radiation-sensitive surgical probe with interchangeable tips
US6280398B1 (en) * 1999-10-18 2001-08-28 Ethicon Endo-Surgery Methods and devices for collection of soft tissue
WO2002043660A2 (en) 2000-11-28 2002-06-06 Mediummune, Inc Methods of administering/dosing anti-rsv antibodies for prophylaxis and treatment
US6602488B1 (en) 2000-03-03 2003-08-05 Intramedical Imaging, Llc Use of radiopharmaceuticals and intraoperative radiation probe for delivery of medicinal treatments
US6510336B1 (en) 2000-03-03 2003-01-21 Intra Medical Imaging, Llc Methods and devices to expand applications of intraoperative radiation probes
US7373197B2 (en) * 2000-03-03 2008-05-13 Intramedical Imaging, Llc Methods and devices to expand applications of intraoperative radiation probes
AU2001264563A1 (en) 2000-04-12 2001-10-30 Human Genome Sciences, Inc. Albumin fusion proteins
WO2001096528A2 (en) 2000-06-15 2001-12-20 Human Genome Sciences, Inc. Human tumor necrosis factor delta and epsilon
KR101287395B1 (en) 2000-06-16 2014-11-04 휴먼 게놈 사이언시즈, 인코포레이티드 Antibodies that immunospecifically bind to BLyS
US8909325B2 (en) 2000-08-21 2014-12-09 Biosensors International Group, Ltd. Radioactive emission detector equipped with a position tracking system and utilization thereof with medical systems and in medical procedures
US8036731B2 (en) 2001-01-22 2011-10-11 Spectrum Dynamics Llc Ingestible pill for diagnosing a gastrointestinal tract
US8565860B2 (en) 2000-08-21 2013-10-22 Biosensors International Group, Ltd. Radioactive emission detector equipped with a position tracking system
US8489176B1 (en) 2000-08-21 2013-07-16 Spectrum Dynamics Llc Radioactive emission detector equipped with a position tracking system and utilization thereof with medical systems and in medical procedures
EP2341060B1 (en) 2000-12-12 2019-02-20 MedImmune, LLC Molecules with extended half-lives, compositions and uses thereof
CN1310617C (en) 2001-01-22 2007-04-18 V-目标技术有限公司 Ingestible pill
KR20030093316A (en) 2001-04-13 2003-12-06 휴먼 게놈 사이언시즈, 인코포레이티드 Vascular endothelial growth factor 2
CN100594935C (en) 2001-05-25 2010-03-24 人体基因组科学有限公司 Antibodies that immunospecifically bind to trail receptors
GB0120086D0 (en) * 2001-08-17 2001-10-10 Secr Defence A non-slip extremity dosimeter
US7795213B2 (en) * 2001-12-13 2010-09-14 Posco Methods of contacting β amyloid protein with VEGF
EP1997829A1 (en) 2001-12-21 2008-12-03 Human Genome Sciences, Inc. Albumin fusion proteins
EP1497445A2 (en) * 2002-04-01 2005-01-19 Human Genome Sciences, Inc. Antibodies that specifically bind to gmad
JP2005535572A (en) 2002-04-12 2005-11-24 メディミューン，インコーポレーテッド Recombinant anti-interleukin-9 antibody
CN100418981C (en) 2002-06-10 2008-09-17 瓦西尼斯公司 Gene differentially expressed in breast and bladder cancer and encoded polypeptides
AU2003262650B2 (en) 2002-08-14 2009-10-29 Macrogenics, Inc. FcgammaRIIB-specific antibodies and methods of use thereof
US7429382B2 (en) 2002-10-16 2008-09-30 Corixa Corporation Antibodies that bind cell-associated CA 125/O772P and methods of use thereof
US20040116807A1 (en) * 2002-10-17 2004-06-17 Roni Amrami Blood vessels wall imaging catheter
AU2003276658A1 (en) 2002-11-04 2004-06-07 V-Target Technologies Ltd. Apparatus and methods for imaging and attenuation correction
WO2004065551A2 (en) * 2003-01-21 2004-08-05 Bristol-Myers Squibb Company Polynucleotide encoding a novel acyl coenzyme a, monoacylglycerol acyltransferase-3 (mgat3), and uses thereof
ES2391087T3 (en) 2003-04-11 2012-11-21 Medimmune, Llc Recombinant IL-9 antibodies and uses thereof
US20050239700A1 (en) * 2003-10-14 2005-10-27 Biogen Idec Inc. Treatment of cancer using antibodies to LRRC15
CA2548180C (en) * 2003-12-04 2014-02-04 Vaccinex, Inc. Methods of killing tumor cells by targeting internal antigens exposed on apoptotic tumor cells
WO2005058961A2 (en) * 2003-12-12 2005-06-30 Amgen Inc. Antibodies specific for human galanin, and uses thereof
PL2805728T3 (en) 2003-12-23 2020-07-13 Genentech, Inc. Novel anti-IL 13 antibodies and uses thereof
WO2005067383A2 (en) 2004-01-13 2005-07-28 Spectrum Dynamics Llc Multi-dimensional image reconstruction
US8586932B2 (en) 2004-11-09 2013-11-19 Spectrum Dynamics Llc System and method for radioactive emission measurement
WO2008010227A2 (en) 2006-07-19 2008-01-24 Spectrum Dynamics Llc Imaging protocols
US9470801B2 (en) 2004-01-13 2016-10-18 Spectrum Dynamics Llc Gating with anatomically varying durations
WO2007010537A2 (en) 2005-07-19 2007-01-25 Spectrum Dynamics Llc Reconstruction stabilizer and active vision
US7968851B2 (en) 2004-01-13 2011-06-28 Spectrum Dynamics Llc Dynamic spect camera
US8571881B2 (en) 2004-11-09 2013-10-29 Spectrum Dynamics, Llc Radiopharmaceutical dispensing, administration, and imaging
PL1729795T3 (en) 2004-02-09 2016-08-31 Human Genome Sciences Inc Albumin fusion proteins
US20050203331A1 (en) * 2004-03-09 2005-09-15 Szapucki Matthew P. Neurosurgical instrument with gamma ray detector
US7247855B2 (en) * 2004-03-09 2007-07-24 United States Of America As Represented By The Secretary Of The Army Portable nuclear detector
WO2005112895A2 (en) * 2004-05-20 2005-12-01 Spectrum Dynamics Llc Ingestible device platform for the colon
EP1778957A4 (en) 2004-06-01 2015-12-23 Biosensors Int Group Ltd Radioactive-emission-measurement optimization to specific body structures
US8280124B2 (en) 2004-06-01 2012-10-02 Spectrum Dynamics Llc Methods of view selection for radioactive emission measurements
US8423125B2 (en) 2004-11-09 2013-04-16 Spectrum Dynamics Llc Radioimaging
US8615405B2 (en) 2004-11-09 2013-12-24 Biosensors International Group, Ltd. Imaging system customization using data from radiopharmaceutical-associated data carrier
EP1827505A4 (en) 2004-11-09 2017-07-12 Biosensors International Group, Ltd. Radioimaging
US9316743B2 (en) 2004-11-09 2016-04-19 Biosensors International Group, Ltd. System and method for radioactive emission measurement
US9943274B2 (en) 2004-11-09 2018-04-17 Spectrum Dynamics Medical Limited Radioimaging using low dose isotope
US7872235B2 (en) 2005-01-13 2011-01-18 Spectrum Dynamics Llc Multi-dimensional image reconstruction and analysis for expert-system diagnosis
EP1893647A2 (en) 2005-06-23 2008-03-05 MedImmune, Inc. Antibody formulations having optimized aggregation and fragmentation profiles
EP1904652A2 (en) * 2005-07-08 2008-04-02 Brystol-Myers Squibb Company Single nucleotide polymorphisms associated with dose-dependent edema and methods of use thereof
US8644910B2 (en) 2005-07-19 2014-02-04 Biosensors International Group, Ltd. Imaging protocols
US8837793B2 (en) 2005-07-19 2014-09-16 Biosensors International Group, Ltd. Reconstruction stabilizer and active vision
US20070202512A1 (en) * 2005-08-19 2007-08-30 Bristol-Myers Squibb Company Human single nucleotide polymorphisms associated with dose-dependent weight gain and methods of use thereof
US7705316B2 (en) 2005-11-09 2010-04-27 Spectrum Dynamics Llc Dynamic SPECT camera
JP2007139435A (en) * 2005-11-15 2007-06-07 Mitsubishi Electric Corp Radiation monitor
US8204500B2 (en) 2005-12-28 2012-06-19 Starhome Gmbh Optimal voicemail deposit for roaming cellular telephony
US8894974B2 (en) 2006-05-11 2014-11-25 Spectrum Dynamics Llc Radiopharmaceuticals for diagnosis and therapy
AU2007281876B2 (en) 2006-06-26 2013-09-05 Macrogenics, Inc. FcgammaRIIB-specific antibodies and methods of use thereof
US7572618B2 (en) 2006-06-30 2009-08-11 Bristol-Myers Squibb Company Polynucleotides encoding novel PCSK9 variants
DK2484696T3 (en) 2006-08-28 2017-10-02 Kyowa Hakko Kirin Co Ltd Antagonistic hLIGHT-specific human monoclonal antibodies
EP2783700A1 (en) 2006-09-07 2014-10-01 Stemline Therapeutics, Inc. Cancer stem cell-targeted cancer therapy
EP2526970A1 (en) 2006-09-07 2012-11-28 Stemline Therapeutics, Inc. Monitoring cancer stem cells
DK3207941T6 (en) 2006-09-07 2020-11-09 Scott & White Memorial Hospital PROCEDURES AND COMPOSITIONS BASED ON DIPHTHERITOXIN-INTERLEUKIN-3 CONJUGATES
EP2407548A1 (en) 2006-10-16 2012-01-18 MedImmune, LLC Molecules with reduced half-lives, compositions and uses thereof
US8610075B2 (en) 2006-11-13 2013-12-17 Biosensors International Group Ltd. Radioimaging applications of and novel formulations of teboroxime
WO2008075362A2 (en) 2006-12-20 2008-06-26 Spectrum Dynamics Llc A method, a system, and an apparatus for using and processing multidimensional data
US8521253B2 (en) 2007-10-29 2013-08-27 Spectrum Dynamics Llc Prostate imaging
US8637026B2 (en) 2007-12-26 2014-01-28 Vaccinex, Inc. Anti-C35 antibody combination therapies and methods
WO2009158490A1 (en) * 2008-06-25 2009-12-30 Neoprobe Corporation Surgical probe apparatus and system
US8344331B1 (en) 2009-03-20 2013-01-01 Devicor Medical Products, Inc. K-alpha probe for detection of photon emissions
CN102439482A (en) * 2009-03-24 2012-05-02 阿克蒂斯有限公司 Universal intraoperative radiation detection probe
WO2010137547A1 (en) 2009-05-25 2010-12-02 国立大学法人東京工業大学 Pharmaceutical composition containing nuclear factor involved in proliferation and differentiation of central neuronal cells
US8338788B2 (en) 2009-07-29 2012-12-25 Spectrum Dynamics Llc Method and system of optimized volumetric imaging
WO2011031890A2 (en) 2009-09-10 2011-03-17 Kominox Usa, Inc. Cancer stem cell-targeted and drug resistant cancer therapy
US20110233421A1 (en) * 2010-03-24 2011-09-29 Actis, Ltd Universal Intraoperative Radiation Detection Probe
KR101021028B1 (en) 2010-10-20 2011-03-09 고희창 Alarm apparatus wearable the body
WO2012103165A2 (en) 2011-01-26 2012-08-02 Kolltan Pharmaceuticals, Inc. Anti-kit antibodies and uses thereof
JP6072771B2 (en) 2011-04-20 2017-02-01 メディミューン，エルエルシー Antibodies and other molecules that bind to B7-H1 and PD-1
CA2834535A1 (en) 2011-04-29 2012-11-01 Celgene Corporation Methods for the treatment of cancer and inflammatory diseases using cereblon as a predictor
WO2013025779A1 (en) 2011-08-15 2013-02-21 Amplimmune, Inc. Anti-b7-h4 antibodies and their uses
WO2013028786A2 (en) * 2011-08-22 2013-02-28 Fuller Bradbury Hand-mounted, video-guided system for treating peritonitis and other medical conditions
EP3855184B1 (en) 2012-03-19 2023-12-27 Stemline Therapeutics Inc. Methods for treating and monitoring the status of cancer
ES2699810T3 (en) 2012-06-29 2019-02-12 Celgene Corp Methods to determine the efficacy of drugs using cereblon-associated proteins
DK3381943T3 (en) 2012-07-25 2022-05-16 Celldex Therapeutics Inc ANTI-KIT ANTIBODIES AND USES THEREOF
US9587281B2 (en) 2012-08-14 2017-03-07 Celgene Corporation Cereblon isoforms and their use as biomarkers for therapeutic treatment
AU2013361275B2 (en) 2012-12-19 2016-11-24 Amplimmune, Inc. Anti-human B7-H4 antibodies and their uses
EP2935332B1 (en) 2012-12-21 2021-11-10 MedImmune, LLC Anti-h7cr antibodies
BR112015029395A2 (en) 2013-05-24 2017-09-19 Medimmune Llc ANTI-B7-H5 ANTIBODIES AND THEIR USES
WO2014194293A1 (en) 2013-05-30 2014-12-04 Amplimmune, Inc. Improved methods for the selection of patients for pd-1 or b7-h4 targeted therapies, and combination therapies thereof
ES2891755T3 (en) 2013-06-06 2022-01-31 Pf Medicament Anti-C10orf54 antibodies and uses thereof
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
US10098664B2 (en) 2014-05-07 2018-10-16 Pop Medical Solutions Ltd. System and method for pelvic floor procedures
EP3888690A3 (en) 2014-05-16 2021-10-20 MedImmune, LLC Molecules with altered neonate fc receptor binding having enhanced therapeutic and diagnostic properties
CA2951506C (en) * 2014-06-10 2023-04-04 Pop Medical Solutions Ltd. Tissue repair device and method
ES2843973T3 (en) 2014-06-27 2021-07-21 Celgene Corp Compositions and methods to induce conformational changes in cereblon and other E3 ubiquitin ligases
GB201418713D0 (en) 2014-10-21 2014-12-03 Kymab Ltd Bindings Proteins
PT3800202T (en) 2014-12-11 2023-01-05 Pf Medicament Anti-c10orf54 antibodies and uses thereof
BR112017015880A2 (en) 2015-03-03 2018-07-31 Kymab Ltd antibodies, uses and methods
US9771040B2 (en) 2015-08-18 2017-09-26 Sti Holdings, Inc. Trailer with rear impact guard
US11191498B2 (en) 2015-10-27 2021-12-07 Devicor Medical Products, Inc. Surgical probe and apparatus with improved graphical display
EP3871605B1 (en) 2015-10-27 2024-03-20 Devicor Medical Products, Inc. Surgical probe apparatus and system
US10830762B2 (en) 2015-12-28 2020-11-10 Celgene Corporation Compositions and methods for inducing conformational changes in cereblon and other E3 ubiquitin ligases
CN105572947A (en) * 2016-03-18 2016-05-11 京东方科技集团股份有限公司 Array base plate and manufacturing method thereof as well as display device
EP3515478B1 (en) 2016-09-21 2024-02-28 Nextcure, Inc. Antibodies for siglec-15 and methods of use thereof
US11779604B2 (en) 2016-11-03 2023-10-10 Kymab Limited Antibodies, combinations comprising antibodies, biomarkers, uses and methods
US10369949B2 (en) 2017-02-27 2019-08-06 Sti Holdings, Inc. Rear impact guard
US20210002373A1 (en) 2018-03-01 2021-01-07 Nextcure, Inc. KLRG1 Binding Compositions and Methods of Use Thereof
MA53160A (en) 2018-07-20 2021-05-26 Pf Medicament RECEIVER FOR VISTA
EP3877783A1 (en) 2019-02-18 2021-09-15 Devicor Medical Products, Inc. Surgical probe and apparatus with improved graphical display
US11467295B2 (en) 2019-06-18 2022-10-11 Ohio State Innovation Foundation Gamma detection system incorporating electronic probe collimation
US20230227545A1 (en) 2022-01-07 2023-07-20 Johnson & Johnson Enterprise Innovation Inc. Materials and methods of il-1beta binding proteins
WO2024013727A1 (en) 2022-07-15 2024-01-18 Janssen Biotech, Inc. Material and methods for improved bioengineered pairing of antigen-binding variable regions
WO2024028731A1 (en) 2022-08-05 2024-02-08 Janssen Biotech, Inc. Transferrin receptor binding proteins for treating brain tumors
WO2024028732A1 (en) 2022-08-05 2024-02-08 Janssen Biotech, Inc. Cd98 binding constructs for treating brain tumors
WO2024050524A1 (en) 2022-09-01 2024-03-07 University Of Georgia Research Foundation, Inc. Compositions and methods for directing apolipoprotein l1 to induce mammalian cell death

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3110161C2 (en) * 1980-03-17 1986-07-24 Matsushita Electric Industrial Co., Ltd., Kadoma, Osaka Thermoluminescence Dosimeter
DE3100868C2 (en) * 1981-01-14 1986-07-24 Kernforschungsanlage Jülich GmbH, 5170 Jülich Thermoluminescence dosimeter to determine the dose depending on the tissue depth
US4782840A (en) * 1984-03-02 1988-11-08 Neoprobe Corporation Method for locating, differentiating, and removing neoplasms
JPS6188175A (en) * 1984-09-17 1986-05-06 Power Reactor & Nuclear Fuel Dev Corp Partial exposure alarm device for radiant ray
US4999504A (en) * 1984-09-20 1991-03-12 International Sensor Technology, Inc. Remote radiation dosimetry
EP0182249A3 (en) * 1984-11-19 1988-11-17 Michio Arai Time indicating apparatus
US4932412A (en) * 1986-12-18 1990-06-12 Immunomedics, Inc. Intraoperative and endoscopic tumor detection and therapy
US5070878A (en) * 1988-11-14 1991-12-10 Neoprobe Corporation Detector and localizer for low energy radiation emissions
US5151598A (en) * 1987-03-17 1992-09-29 Neoprobe Corporation Detector and localizer for low energy radiation emissions
US4801803A (en) * 1987-03-17 1989-01-31 Neoprobe Corporation Detector and localizer for low energy radiation emissions
US4889991A (en) * 1988-09-23 1989-12-26 Neoprobe Corporation Gamma radiation detector with enhanced signal treatment
FR2660761B1 (en) * 1990-04-06 1995-10-06 Thomson Csf DEVICE FOR DETECTING DANGEROUS RADIATION FOR LIVING BEINGS.
US5152293A (en) * 1991-07-01 1992-10-06 Northwestern University Finger-mounted intraoperative imaging device

Also Published As

Publication number Publication date
EP0603111A3 (en) 1995-02-01
AU694322B2 (en) 1998-07-16
IL107921A0 (en) 1994-04-12
US5441050A (en) 1995-08-15
AU671318B2 (en) 1996-08-22
AU5246593A (en) 1994-06-30
KR940013465A (en) 1994-07-15
ES2133374T3 (en) 1999-09-16
IL107921A (en) 1997-02-18
DE69325248D1 (en) 1999-07-15
EP0603111A2 (en) 1994-06-22
AU4821596A (en) 1996-07-04
CA2110858C (en) 1999-02-16
EP0603111B1 (en) 1999-06-09
DE69325248T2 (en) 2000-01-27
JPH06235767A (en) 1994-08-23
ATE180955T1 (en) 1999-06-15
JP2816643B2 (en) 1998-10-27
MX9400055A (en) 1994-07-29
KR0181304B1 (en) 1999-04-01

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