CA2107466A1 - Low density microspheres and their use as contrast agents for computed tomography - Google Patents

Low density microspheres and their use as contrast agents for computed tomography

Info

Publication number
CA2107466A1
CA2107466A1 CA002107466A CA2107466A CA2107466A1 CA 2107466 A1 CA2107466 A1 CA 2107466A1 CA 002107466 A CA002107466 A CA 002107466A CA 2107466 A CA2107466 A CA 2107466A CA 2107466 A1 CA2107466 A1 CA 2107466A1
Authority
CA
Canada
Prior art keywords
low density
computed tomography
density microspheres
contrast agents
microspheres
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002107466A
Other languages
French (fr)
Other versions
CA2107466C (en
Inventor
Evan C. Unger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lantheus Medical Imaging Inc
Original Assignee
Evan C. Unger
Imarx Pharmaceutical Corp.
Dupont Contrast Imaging Inc.
Bristol-Myers Squibb Medical Imaging, Inc.
Lantheus Medical Imaging, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24733297&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2107466(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Evan C. Unger, Imarx Pharmaceutical Corp., Dupont Contrast Imaging Inc., Bristol-Myers Squibb Medical Imaging, Inc., Lantheus Medical Imaging, Inc. filed Critical Evan C. Unger
Publication of CA2107466A1 publication Critical patent/CA2107466A1/en
Application granted granted Critical
Publication of CA2107466C publication Critical patent/CA2107466C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A61K49/0414—Particles, beads, capsules or spheres
    • A61K49/0419—Microparticles, microbeads, microcapsules, microspheres, i.e. having a size or diameter higher or equal to 1 micrometer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31855—Of addition polymer from unsaturated monomers
    • Y10T428/31859—Next to an aldehyde or ketone condensation product
    • Y10T428/31862—Melamine-aldehyde

Abstract

Substantially homogeneous aqueous suspensions of low density microspheres are presented as contrast media for imaging the gastrointestinal tract and other body cavities using computed tomography.
In one embodiment, the low density microspheres are gas-filled. With computed tomography, the contrast media serve to change the relative density of certain areas within the gas-trointestinal tract and other body cavities, and improve the overall diagnostic efficacy of this imaging method.
CA 2107466 1991-04-05 1992-03-18 Low density microspheres and their use as contrast agents for computed tomography Expired - Lifetime CA2107466C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/680,984 US5205290A (en) 1991-04-05 1991-04-05 Low density microspheres and their use as contrast agents for computed tomography
US680,984 1991-04-05
PCT/US1992/002150 WO1992017514A1 (en) 1991-04-05 1992-03-18 Low density microspheres and their use as contrast agents for computed tomography

Publications (2)

Publication Number Publication Date
CA2107466A1 true CA2107466A1 (en) 1992-10-06
CA2107466C CA2107466C (en) 2001-07-03

Family

ID=24733297

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2107466 Expired - Lifetime CA2107466C (en) 1991-04-05 1992-03-18 Low density microspheres and their use as contrast agents for computed tomography

Country Status (12)

Country Link
US (10) US5205290A (en)
EP (3) EP1064953A3 (en)
JP (2) JP3518548B2 (en)
AT (2) ATE180794T1 (en)
AU (2) AU660676B2 (en)
BR (1) BR1100619A (en)
CA (1) CA2107466C (en)
DE (2) DE69229342T2 (en)
DK (2) DK0804932T3 (en)
ES (2) ES2134214T5 (en)
GR (2) GR3030411T3 (en)
WO (1) WO1992017514A1 (en)

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* Cited by examiner, † Cited by third party
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