CA2103443A1 - Chewable Drug-Delivery Composition - Google Patents

Chewable Drug-Delivery Composition

Info

Publication number
CA2103443A1
CA2103443A1 CA2103443A CA2103443A CA2103443A1 CA 2103443 A1 CA2103443 A1 CA 2103443A1 CA 2103443 A CA2103443 A CA 2103443A CA 2103443 A CA2103443 A CA 2103443A CA 2103443 A1 CA2103443 A1 CA 2103443A1
Authority
CA
Canada
Prior art keywords
composition
chewable
delivery composition
drug
chewable drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2103443A
Other languages
French (fr)
Other versions
CA2103443C (en
Inventor
Robert P. Geyer
Vinod V. Tuliani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johnson and Johnson Consumer Inc
Original Assignee
Robert P. Geyer
Vinod V. Tuliani
Affinity Biotech, Inc.
Ibah, Inc.
Lds Technologies, Inc.
Mcneil-Ppc, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robert P. Geyer, Vinod V. Tuliani, Affinity Biotech, Inc., Ibah, Inc., Lds Technologies, Inc., Mcneil-Ppc, Inc. filed Critical Robert P. Geyer
Publication of CA2103443A1 publication Critical patent/CA2103443A1/en
Application granted granted Critical
Publication of CA2103443C publication Critical patent/CA2103443C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules

Abstract

A non-aqueous, chewable composition for oral delivery of unpalatable drugs is provided. The composition contains the drug intimately dispersed or dissolved in a pharmaceutically-acceptable lipid that is solid at room temperatures. The composition also has a matrix that contains a granulating agent for the total composition and a rapid dispersal agent and optionally additives such as buffering agents, flavoring agents, surfactants, and the like. Methods for the preparation of the chewable compositions are also provided.
CA002103443A 1991-05-28 1992-05-27 Chewable drug-delivery composition Expired - Lifetime CA2103443C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70634391A 1991-05-28 1991-05-28
US07/706,343 1991-05-28

Publications (2)

Publication Number Publication Date
CA2103443A1 true CA2103443A1 (en) 1992-11-29
CA2103443C CA2103443C (en) 1998-12-22

Family

ID=24837153

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002103443A Expired - Lifetime CA2103443C (en) 1991-05-28 1992-05-27 Chewable drug-delivery composition

Country Status (11)

Country Link
US (1) US5320848A (en)
EP (1) EP0587744B1 (en)
JP (1) JP2948317B2 (en)
AT (1) ATE245023T1 (en)
AU (1) AU653423B2 (en)
CA (1) CA2103443C (en)
DE (1) DE69233130T2 (en)
DK (1) DK0587744T3 (en)
ES (1) ES2202302T3 (en)
IL (1) IL102045A0 (en)
WO (1) WO1992021328A1 (en)

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US20090060983A1 (en) * 2007-08-30 2009-03-05 Bunick Frank J Method And Composition For Making An Orally Disintegrating Dosage Form
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Also Published As

Publication number Publication date
EP0587744A4 (en) 1994-05-25
ES2202302T3 (en) 2004-04-01
US5320848A (en) 1994-06-14
ATE245023T1 (en) 2003-08-15
EP0587744A1 (en) 1994-03-23
DE69233130D1 (en) 2003-08-21
WO1992021328A1 (en) 1992-12-10
JP2948317B2 (en) 1999-09-13
EP0587744B1 (en) 2003-07-16
AU653423B2 (en) 1994-09-29
DK0587744T3 (en) 2003-10-20
CA2103443C (en) 1998-12-22
IL102045A0 (en) 1992-12-30
DE69233130T2 (en) 2005-06-02
JPH06511478A (en) 1994-12-22
AU2146792A (en) 1993-01-08

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Legal Events

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EEER Examination request
MKEX Expiry