CA2101189A1 - Agglomerated hydrophilic complexes with multi-phasic release characteristics - Google Patents

Agglomerated hydrophilic complexes with multi-phasic release characteristics

Info

Publication number
CA2101189A1
CA2101189A1 CA2101189A CA2101189A CA2101189A1 CA 2101189 A1 CA2101189 A1 CA 2101189A1 CA 2101189 A CA2101189 A CA 2101189A CA 2101189 A CA2101189 A CA 2101189A CA 2101189 A1 CA2101189 A1 CA 2101189A1
Authority
CA
Canada
Prior art keywords
release characteristics
phasic release
agglomerated
hydrophilic complexes
phasic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2101189A
Other languages
French (fr)
Other versions
CA2101189C (en
Inventor
Anand R. Baichwal
John N. Staniforth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Penwest Pharmaceuticals Co
Original Assignee
Mendell Edward Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mendell Edward Co Inc filed Critical Mendell Edward Co Inc
Publication of CA2101189A1 publication Critical patent/CA2101189A1/en
Application granted granted Critical
Publication of CA2101189C publication Critical patent/CA2101189C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin

Abstract

The present invention relates to a controlled release formulation which includes a therapeutically active medicament, a heterodisperse gum matrix, a pharmaceutically acceptable diluent, and an effective amount of a pharmaceutically acceptable surfactant and/or wetting agent to provide a multi-phasic controlled release of a therapeutically active medicament. The invention also relates to a method of preparing the same.
CA002101189A 1992-07-30 1993-07-23 Agglomerated hydrophilic complexes with multi-phasic release characteristics Expired - Lifetime CA2101189C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/922,312 US5472711A (en) 1992-07-30 1992-07-30 Agglomerated hydrophilic complexes with multi-phasic release characteristics
US07/922,312 1992-07-30

Publications (2)

Publication Number Publication Date
CA2101189A1 true CA2101189A1 (en) 1994-01-31
CA2101189C CA2101189C (en) 1999-09-21

Family

ID=25446878

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002101189A Expired - Lifetime CA2101189C (en) 1992-07-30 1993-07-23 Agglomerated hydrophilic complexes with multi-phasic release characteristics

Country Status (13)

Country Link
US (3) US5472711A (en)
EP (2) EP1582205A3 (en)
JP (1) JP3967389B2 (en)
KR (1) KR100342299B1 (en)
AT (1) ATE311861T1 (en)
AU (1) AU669531B2 (en)
CA (1) CA2101189C (en)
DE (1) DE69333927T2 (en)
ES (1) ES2252731T3 (en)
FI (1) FI117962B (en)
HU (1) HUT67622A (en)
IL (1) IL106253A (en)
MX (1) MX9304485A (en)

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Also Published As

Publication number Publication date
HU9302104D0 (en) 1993-10-28
CA2101189C (en) 1999-09-21
JP3967389B2 (en) 2007-08-29
EP0581676A2 (en) 1994-02-02
AU669531B2 (en) 1996-06-13
FI933393A (en) 1994-01-31
AU4185593A (en) 1994-02-03
HUT67622A (en) 1995-04-28
KR100342299B1 (en) 2002-11-18
ATE311861T1 (en) 2005-12-15
DE69333927D1 (en) 2006-01-12
KR940005291A (en) 1994-03-21
US5472711A (en) 1995-12-05
JPH06172221A (en) 1994-06-21
EP0581676B1 (en) 2005-12-07
FI933393A0 (en) 1993-07-29
EP0581676A3 (en) 1995-06-07
US5670168A (en) 1997-09-23
FI117962B (en) 2007-05-15
MX9304485A (en) 1994-04-29
EP1582205A2 (en) 2005-10-05
DE69333927T2 (en) 2006-06-29
ES2252731T3 (en) 2006-05-16
EP1582205A3 (en) 2008-07-30
IL106253A0 (en) 1993-11-15
IL106253A (en) 1998-03-10
US5478574A (en) 1995-12-26

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