CA2099920A1 - Modified Chlorhexidine-Adduct - Google Patents
Modified Chlorhexidine-AdductInfo
- Publication number
- CA2099920A1 CA2099920A1 CA2099920A CA2099920A CA2099920A1 CA 2099920 A1 CA2099920 A1 CA 2099920A1 CA 2099920 A CA2099920 A CA 2099920A CA 2099920 A CA2099920 A CA 2099920A CA 2099920 A1 CA2099920 A1 CA 2099920A1
- Authority
- CA
- Canada
- Prior art keywords
- adduct
- chlorhexidine
- molecule
- modified
- modified chlorhexidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 abstract 2
- 229960003260 chlorhexidine Drugs 0.000 abstract 2
- GEAOJWKXHMGANA-UHFFFAOYSA-N $l^{1}-stannane Chemical compound [SnH] GEAOJWKXHMGANA-UHFFFAOYSA-N 0.000 abstract 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 abstract 1
- 241000194019 Streptococcus mutans Species 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 229910000040 hydrogen fluoride Inorganic materials 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
- C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
- C07C279/265—X and Y being nitrogen atoms, i.e. biguanides containing two or more biguanide groups
Abstract
A chlorhexidine adduct is described, which comprises one molecule of chlorhexidine with three molecules of hydrogen fluoride and one molecule of hydrogen tin trifluoride. The adduct displays a high antibacterial effectiveness against Streptococcus mutans even in very low concentrations.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4222821A DE4222821C2 (en) | 1992-07-08 | 1992-07-08 | Modified chlorhexidine adduct |
DEP4222821.2 | 1992-07-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2099920A1 true CA2099920A1 (en) | 1994-01-09 |
CA2099920C CA2099920C (en) | 1996-12-24 |
Family
ID=6462979
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002099920A Expired - Fee Related CA2099920C (en) | 1992-07-08 | 1993-07-06 | Modified chlorhexidine-adduct |
Country Status (6)
Country | Link |
---|---|
US (1) | US5393516A (en) |
EP (1) | EP0578344B1 (en) |
AT (1) | ATE141912T1 (en) |
AU (1) | AU655547B2 (en) |
CA (1) | CA2099920C (en) |
DE (2) | DE4222821C2 (en) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA965340B (en) * | 1995-06-30 | 1997-01-27 | Interdigital Tech Corp | Code division multiple access (cdma) communication system |
US6293287B1 (en) * | 1996-09-13 | 2001-09-25 | Gillette Canada Inc. | UV-cured resin-coated dental floss |
US5967153A (en) * | 1996-10-15 | 1999-10-19 | Gillette Canada Inc. | Emulsion coated dental floss containing chemotherapeutic active agents |
US6726899B2 (en) | 1998-09-24 | 2004-04-27 | Advantage Dental Products, Inc. | Calcified tissue facing preparation containing antimicrobial agent |
EP1123060B1 (en) * | 1998-09-24 | 2008-04-23 | Advantage Dental Products Inc. | Calcified tissue facing preparation containing an antimicrobial agent |
DE19921727A1 (en) * | 1999-05-12 | 2000-11-16 | Susanne Szep | Fluoriding composition for treating tooth surfaces to prevent caries and reduce sensitivity, containing hydrogen fluoride to form strongly bound fluoride complexes on surface |
DE19921950A1 (en) * | 1999-05-12 | 2000-11-16 | Susanne Szep | Dentine adhesives containing hydrogen fluoride for use in dental restorative work |
ATE548016T1 (en) * | 2000-04-03 | 2012-03-15 | Chx Technologies Inc | USE OF CHLORHEXIDINE TO PREVENT ROOT CARIES |
DE10261241A1 (en) * | 2002-12-20 | 2004-07-15 | 3M Espe Ag | Dental material with bacteriostatic and / or bactericidal substances |
US20060254988A1 (en) * | 2005-05-10 | 2006-11-16 | Confirm Monitoring Systems, Inc. | Methods and compositions for the treatment of water |
EP1787627A1 (en) | 2005-11-17 | 2007-05-23 | 3M Innovative Properties Company | Anti-microbial dental impression material |
EP1973587B1 (en) * | 2005-12-12 | 2019-02-06 | AllAccem, Inc. | Methods and systems for preparing antimicrobial films and coatings |
NZ579785A (en) | 2007-02-21 | 2012-06-29 | Allaccem Inc | Bridged polycyclic compound based compositions for the inhibition and amelioration of disease |
US8153618B2 (en) * | 2007-08-10 | 2012-04-10 | Allaccem, Inc. | Bridged polycyclic compound based compositions for topical applications for pets |
US8153617B2 (en) * | 2007-08-10 | 2012-04-10 | Allaccem, Inc. | Bridged polycyclic compound based compositions for coating oral surfaces in humans |
US8188068B2 (en) * | 2007-08-10 | 2012-05-29 | Allaccem, Inc. | Bridged polycyclic compound based compositions for coating oral surfaces in pets |
US20090074833A1 (en) * | 2007-08-17 | 2009-03-19 | Whiteford Jeffery A | Bridged polycyclic compound based compositions for controlling bone resorption |
US20100016270A1 (en) * | 2008-06-20 | 2010-01-21 | Whiteford Jeffery A | Bridged polycyclic compound based compositions for controlling cholesterol levels |
US20100004218A1 (en) * | 2008-06-20 | 2010-01-07 | Whiteford Jeffery A | Bridged polycyclic compound based compositions for renal therapy |
CN102083404A (en) * | 2008-06-27 | 2011-06-01 | 诺瓦敏科技公司 | Composition and method for enhancing flouride uptake using bioactive glass |
BR112017005431A2 (en) | 2014-09-17 | 2019-05-14 | Garrison Dental Solutions Llc | dental curing light |
RU2696259C2 (en) | 2017-10-23 | 2019-08-01 | Общество С Ограниченной Ответственностью "Сан Системз" | Solubilization of the chlorhexidine base, antiseptic and disinfectant compositions |
DE102019000321A1 (en) | 2019-01-14 | 2020-07-16 | Beuth Hochschule Für Technik Berlin | Oral sustained release polymer composition |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4069310A (en) * | 1970-11-27 | 1978-01-17 | Colgate Palmolive Company | Method for the manufacture of clear dentifrices |
GB1304090A (en) * | 1970-11-27 | 1973-01-24 | ||
US5098711A (en) * | 1988-11-14 | 1992-03-24 | Ira Hill | Method of treating the oral cavity with dental floss containing chemotherapeutic agents |
DE4135397C2 (en) * | 1991-10-26 | 1994-01-20 | Ivoclar Ag Schaan | Chlorhexidine adduct, process for its preparation and its use |
-
1992
- 1992-07-08 DE DE4222821A patent/DE4222821C2/en not_active Expired - Fee Related
-
1993
- 1993-06-15 AT AT93250170T patent/ATE141912T1/en not_active IP Right Cessation
- 1993-06-15 DE DE59303552T patent/DE59303552D1/en not_active Expired - Fee Related
- 1993-06-15 EP EP93250170A patent/EP0578344B1/en not_active Expired - Lifetime
- 1993-06-24 AU AU41508/93A patent/AU655547B2/en not_active Ceased
- 1993-07-06 CA CA002099920A patent/CA2099920C/en not_active Expired - Fee Related
- 1993-07-07 US US08/086,919 patent/US5393516A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU655547B2 (en) | 1994-12-22 |
DE59303552D1 (en) | 1996-10-02 |
EP0578344B1 (en) | 1996-08-28 |
CA2099920C (en) | 1996-12-24 |
DE4222821A1 (en) | 1994-01-13 |
ATE141912T1 (en) | 1996-09-15 |
US5393516A (en) | 1995-02-28 |
AU4150893A (en) | 1994-01-13 |
EP0578344A1 (en) | 1994-01-12 |
DE4222821C2 (en) | 1994-09-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |