CA2099588A1 - Prevention of synovial adhesions - Google Patents

Prevention of synovial adhesions

Info

Publication number
CA2099588A1
CA2099588A1 CA002099588A CA2099588A CA2099588A1 CA 2099588 A1 CA2099588 A1 CA 2099588A1 CA 002099588 A CA002099588 A CA 002099588A CA 2099588 A CA2099588 A CA 2099588A CA 2099588 A1 CA2099588 A1 CA 2099588A1
Authority
CA
Canada
Prior art keywords
adhesions
synovial
prevention
intercalated
liposome
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002099588A
Other languages
French (fr)
Other versions
CA2099588C (en
Inventor
Larry J. Moore
Jill Adler-Moore
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nexstar Pharmaceuticals Inc
Original Assignee
Larry J. Moore
Jill Adler-Moore
Vestar, Inc.
Nexstar Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Larry J. Moore, Jill Adler-Moore, Vestar, Inc., Nexstar Pharmaceuticals, Inc. filed Critical Larry J. Moore
Publication of CA2099588A1 publication Critical patent/CA2099588A1/en
Application granted granted Critical
Publication of CA2099588C publication Critical patent/CA2099588C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

Adhesions in synovial capsules are prevented through the administration of liposome intercalated nonsteroidal anti-in-flammatory agents.
CA002099588A 1990-12-03 1991-12-03 Prevention of synovial adhesions Expired - Lifetime CA2099588C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62162590A 1990-12-03 1990-12-03
US07/621,625 1990-12-03
PCT/US1991/009017 WO1992009268A1 (en) 1990-12-03 1991-12-03 Prevention of synovial adhesions

Publications (2)

Publication Number Publication Date
CA2099588A1 true CA2099588A1 (en) 1992-06-04
CA2099588C CA2099588C (en) 2003-04-15

Family

ID=24490933

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002099588A Expired - Lifetime CA2099588C (en) 1990-12-03 1991-12-03 Prevention of synovial adhesions

Country Status (11)

Country Link
US (1) US5411743A (en)
EP (1) EP0560900B1 (en)
JP (1) JPH06507882A (en)
AT (1) ATE118168T1 (en)
AU (1) AU664359B2 (en)
CA (1) CA2099588C (en)
DE (1) DE69107309T2 (en)
DK (1) DK0560900T3 (en)
ES (1) ES2071481T3 (en)
GR (1) GR3015663T3 (en)
WO (1) WO1992009268A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7091181B2 (en) 1994-12-12 2006-08-15 Omeros Corporation Method of inhibition of pain and inflammation during surgery comprising administration of soluble TNF receptors
ATE532530T1 (en) * 1994-12-12 2011-11-15 Omeros Corp FLUSHING SOLUTION AND THE USE THEREOF FOR THE PERIOPERATIVE INHIBITION OF PAIN, INFLAMMATION AND/OR SPASMS IN A VESSEL STRUCTURE
US20040127884A1 (en) * 1994-12-12 2004-07-01 Omeros Corporation Vascular irrigation solution and method for inhibition of pain, inflammation, spasm and restenosis
US20020028798A1 (en) * 1995-12-12 2002-03-07 Omeros Medical Systems Irrigation solution and method for inhibition of pain and inflammation
US6492332B1 (en) * 1995-12-12 2002-12-10 Omeros Corporation Irrigation solution and methods for inhibition of tumor cell adhesion, pain and inflammation
BR9509985A (en) 1995-12-12 1998-11-03 Omeros Med Sys Inc Solution for irrigation and method for inhibiting pain, inflammation and sparse
US6413961B1 (en) 1995-12-12 2002-07-02 Omeros Medical Systems, Inc. Irrigation solution and method for inhibition of pain and inflammation
US7067144B2 (en) * 1998-10-20 2006-06-27 Omeros Corporation Compositions and methods for systemic inhibition of cartilage degradation
JP2004135177A (en) 2002-10-11 2004-04-30 Sharp Corp Cellular phone
ES2330295B1 (en) 2008-06-06 2010-09-23 Laboratorios Alcala Farma, Sl TOPIC FORMULATION OF IBUPROFEN.
CN103260702B (en) 2010-10-28 2018-07-27 帕西拉制药有限公司 The sustained release preparation of non-steroid anti-inflammatory drug
EP3541815A4 (en) 2016-11-18 2020-07-15 Pacira Pharmaceuticals, Inc. Zinc meloxicam complex microparticle multivesicular liposome formulations and processes for making the same

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523965A (en) * 1976-03-19 1978-09-06 Ici Ltd Pharmaceutical compositions containing steroids
US4346108A (en) * 1981-06-22 1982-08-24 The Upjohn Manufacturing Company M Method for preventing adhesion formation
DE3217315C2 (en) * 1982-05-08 1986-05-22 Gödecke AG, 1000 Berlin Medicinal preparations containing oxicam derivatives
EP0152379A3 (en) * 1984-02-15 1986-10-29 Ciba-Geigy Ag Process for preparing pharmaceutical compositions containing unilamellar liposomes
CA1260393A (en) * 1984-10-16 1989-09-26 Lajos Tarcsay Liposomes of synthetic lipids
IN166447B (en) * 1985-11-27 1990-05-12 Ethicon Inc
DE3683606D1 (en) * 1985-11-27 1992-03-05 Ethicon Inc INHIBITION OF POST-OPERATIVE ADHAESION FORMATION BY TOPICAL ADMINISTRATION OF AN INFLAMMATORY-RESISTANT NON-STEROID ACTIVE SUBSTANCE.
DE3778972D1 (en) * 1986-06-12 1992-06-17 Liposome Co Inc MEDIUM USING LIPOSOME-ENCLOSED, NON-TEROIDER, ANTI-INFLAMMATORY MEDICINAL PRODUCTS.
US4877619A (en) * 1986-08-25 1989-10-31 Vestar, Inc. Liposomal vesicles for intraperitoneal administration of therapeutic agents
US5403592A (en) * 1987-08-25 1995-04-04 Macnaught Pty Limited Lubricant composition for rheumatism
GB2217596A (en) * 1988-04-26 1989-11-01 American Cyanamid Co Anti-arthritic liposome composition
AU7872491A (en) * 1990-05-07 1991-11-27 Vical, Inc. Lipid prodrugs of salicylate and nonsteroidal anti-inflammatory drugs

Also Published As

Publication number Publication date
GR3015663T3 (en) 1995-07-31
EP0560900A1 (en) 1993-09-22
EP0560900B1 (en) 1995-02-08
ATE118168T1 (en) 1995-02-15
DE69107309D1 (en) 1995-03-23
AU664359B2 (en) 1995-11-16
AU9127991A (en) 1992-06-25
DK0560900T3 (en) 1995-05-08
JPH06507882A (en) 1994-09-08
CA2099588C (en) 2003-04-15
ES2071481T3 (en) 1995-06-16
DE69107309T2 (en) 1995-06-08
US5411743A (en) 1995-05-02
WO1992009268A1 (en) 1992-06-11

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Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry