CA2098294A1 - Directly compressible xylitol and method - Google Patents
Directly compressible xylitol and methodInfo
- Publication number
- CA2098294A1 CA2098294A1 CA2098294A CA2098294A CA2098294A1 CA 2098294 A1 CA2098294 A1 CA 2098294A1 CA 2098294 A CA2098294 A CA 2098294A CA 2098294 A CA2098294 A CA 2098294A CA 2098294 A1 CA2098294 A1 CA 2098294A1
- Authority
- CA
- Canada
- Prior art keywords
- xylitol
- directly compressible
- granulate
- compressible xylitol
- metabolic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Abstract
A directly compressible xylitol granulate comprising xylitol and a physiologically acceptable, non-cariogenic binder taken from the group consisting of polymerized reducing sugars, an alkali carboxymethylcellulose and hydrogenated starch hydrolysate. The granulate is directly compressible and exhibits the taste profile, metabolic and cariostatic properties of xylitol.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/626,495 US5204115A (en) | 1990-12-12 | 1990-12-12 | Directly compressible xylitol and method |
US07/626,495 | 1990-12-12 | ||
PCT/FI1991/000362 WO1992010168A1 (en) | 1990-12-12 | 1991-11-29 | Directly compressible xylitol and method |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2098294A1 true CA2098294A1 (en) | 1992-06-13 |
CA2098294C CA2098294C (en) | 2000-11-21 |
Family
ID=24510603
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002098294A Expired - Lifetime CA2098294C (en) | 1990-12-12 | 1991-11-29 | Directly compressible xylitol and method |
Country Status (13)
Country | Link |
---|---|
US (1) | US5204115A (en) |
EP (1) | EP0561815B1 (en) |
JP (2) | JP2753657B2 (en) |
AT (1) | ATE127337T1 (en) |
CA (1) | CA2098294C (en) |
DE (1) | DE69112841T2 (en) |
DK (1) | DK0561815T3 (en) |
EE (1) | EE02969B1 (en) |
ES (1) | ES2079686T3 (en) |
FI (1) | FI109648B (en) |
GR (1) | GR3018052T3 (en) |
NO (1) | NO305424B1 (en) |
WO (1) | WO1992010168A1 (en) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2670398B1 (en) * | 1990-12-14 | 1995-02-17 | Roquette Freres | DIRECTLY COMPRESSIBLE POWDER COMPOSITION AND PROCESS FOR OBTAINING SAME. |
US5525360A (en) * | 1992-12-18 | 1996-06-11 | Wm. Wrigley Jr. Company | Chewing gum products using polydextrose |
CA2128820A1 (en) * | 1993-07-27 | 1995-01-28 | Walter G. Gowan, Jr. | Rapidly disintegrating pharmaceutical dosage form and process for preparation thereof |
PL187160B1 (en) * | 1994-01-31 | 2004-05-31 | Yamanouchi Pharma Co Ltd | Compaction-moulded mouldings dissoluble in mouth fluids and method of making them |
US5804165A (en) * | 1996-07-24 | 1998-09-08 | Arnold; Michael J. | Antiplaque oral composition |
US5846568A (en) * | 1996-09-19 | 1998-12-08 | Xyrofin Oy | Directly compressible lactitol and method |
WO1999018935A1 (en) * | 1997-10-15 | 1999-04-22 | Merck Patent Gmbh | Preparation of a directly mouldable tabletting auxiliary |
FI974385A0 (en) | 1997-12-01 | 1997-12-01 | Xyrofin Oy | Preparation of xylitol For the purpose of pharmaceutical treatment and xylitol preparations For the manufacture of xylitol |
FI110095B (en) | 1998-05-18 | 2002-11-29 | Xyrofin Oy | Crystallization of Xylitol, Crystalline Xylitol Product and Its Use |
NL1009350C2 (en) * | 1998-06-09 | 1999-12-10 | Sara Lee De Nv | Sweetener tablet. |
CA2348452A1 (en) * | 1998-10-27 | 2000-05-04 | Biovail Technologies Ltd. | Microparticles containing peg and/or peg glyceryl esters |
US7815937B2 (en) * | 1998-10-27 | 2010-10-19 | Biovail Laboratories International Srl | Quick dissolve compositions and tablets based thereon |
EP1177728A4 (en) | 1999-04-16 | 2003-03-19 | San Ei Gen Ffi Inc | Sucralose-containing composition and eatable product comprising the same |
ES2157160B2 (en) * | 1999-05-27 | 2002-12-16 | Ind Rodriguez S A | MANUFACTURING PROCEDURE OF A REFRESHING CANDY. |
DE19943491B4 (en) * | 1999-09-10 | 2010-04-01 | Südzucker AG Mannheim/Ochsenfurt | Improved compressed |
FR2802551B1 (en) * | 1999-12-17 | 2006-08-04 | Roquette Freres | DEXTROSE HYDRATE PULVERULENT AND PROCESS FOR PREPARING THE SAME |
FI117465B (en) | 2000-02-03 | 2006-10-31 | Danisco Sweeteners Oy | Procedure for hard coating of chewable cores |
JP4886107B2 (en) * | 2000-10-13 | 2012-02-29 | サンスター株式会社 | Oral dissolving tablets for periodontal disease prevention |
RU2203042C2 (en) * | 2000-11-28 | 2003-04-27 | Комиссарова Ирина Алексеевна | Pharmaceutical composition and method for its preparing |
SE0200539D0 (en) * | 2002-02-25 | 2002-02-25 | Metcon Medicin Ab | Granulation process and starch granulate |
ATE299131T1 (en) * | 2002-10-22 | 2005-07-15 | Dhw Deutsche Hydrierwerke Gmbh | SPRAY DRIED XYLITOL AND METHOD FOR THE PRODUCTION THEREOF |
FR2846520B1 (en) * | 2002-11-06 | 2006-09-29 | Roquette Freres | USE OF MALTODEXTRINS BRANCHED AS BLEACHES OF GRANULATION |
US20040109889A1 (en) * | 2002-12-04 | 2004-06-10 | Bunick Frank J. | Surface treatment composition for soft substrates |
DE10260738A1 (en) * | 2002-12-23 | 2004-07-15 | Outokumpu Oyj | Process and plant for conveying fine-grained solids |
DE10260731B4 (en) * | 2002-12-23 | 2005-04-14 | Outokumpu Oyj | Process and plant for the heat treatment of iron oxide-containing solids |
US6984732B2 (en) * | 2003-03-31 | 2006-01-10 | Mcneil-Ppc, Inc. | High-intensity sweetener composition and delivery of same |
EP1633209B1 (en) * | 2003-06-04 | 2009-08-26 | Nestec S.A. | Weight management beverage |
US20040258822A1 (en) * | 2003-06-16 | 2004-12-23 | Shyhyuan Liao | Chilsonated sucralose product |
US7282217B1 (en) | 2003-08-29 | 2007-10-16 | Kv Pharmaceutical Company | Rapidly disintegrable tablets |
ES2242523B1 (en) * | 2004-02-17 | 2006-12-01 | Enrique Bernat F., S.A. | DIRECTLY COMPRESSIBLE XYLITOL POWDER. |
CA2581703C (en) | 2004-05-24 | 2015-06-30 | Nycomed Pharma As | Agglomeration of a calcium-containing compound by roller compaction |
BRPI0511710B8 (en) | 2004-06-01 | 2021-05-25 | Nycomed Pharma As | chewable, suckable and swallowable calcium-containing tablet |
WO2006072920A2 (en) * | 2005-01-07 | 2006-07-13 | Ranbaxy Laboratories Limited | Tablets of stevia extract and process for their preparation |
EP1845950A2 (en) | 2005-02-03 | 2007-10-24 | Nycomed Pharma AS | Fast wet-massing method for the preparation of calcium-containing compositions |
EA010751B1 (en) | 2005-02-03 | 2008-10-30 | Никомед Фарма Ас | Melt granulation of a composition containing a calcium-containing compound |
US7750146B2 (en) | 2005-03-18 | 2010-07-06 | Tate & Lyle Plc | Granular sucralose |
AU2012201676B2 (en) * | 2005-03-30 | 2012-12-06 | Mylan Pharmaceuticals Ulc | Combined-step process for pharmaceutical compositions |
EP1871363A4 (en) * | 2005-03-30 | 2009-01-21 | Genpharm Inc | Combined-step process for pharmaceutical compositions |
CN1686089B (en) * | 2005-05-08 | 2010-08-18 | 北京健健康康生物技术有限公司 | Xylitol granule capable of directly being pressed into tablet and its preparation method |
US9101160B2 (en) | 2005-11-23 | 2015-08-11 | The Coca-Cola Company | Condiments with high-potency sweetener |
UA95093C2 (en) | 2005-12-07 | 2011-07-11 | Нікомед Фарма Ас | Method for the preparation of calcium-containing compound |
US8906411B2 (en) | 2005-12-07 | 2014-12-09 | Takeda Nycomed As | Pre-compacted calcium-containing compositions |
US7807715B2 (en) * | 2006-06-09 | 2010-10-05 | Ucb Pharma Gmbh | Pharmaceutical compositions comprising fesoterodine |
JP4777847B2 (en) * | 2006-08-30 | 2011-09-21 | 物産フードサイエンス株式会社 | An agent that weakens the taste and astringency and brings a strong cooling sensation |
US8017168B2 (en) | 2006-11-02 | 2011-09-13 | The Coca-Cola Company | High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith |
CN101283776A (en) * | 2007-04-11 | 2008-10-15 | 欧劳福林精细化工(昆山)有限公司 | Granular sweetener |
JP2008263864A (en) * | 2007-04-20 | 2008-11-06 | Hamada Shokuhin Kogyo Kk | Readily-soluble sweetening granule |
EP2183262A1 (en) * | 2007-07-27 | 2010-05-12 | Cargill, Incorporated | Micronization of polyols |
EP2358374B1 (en) | 2008-11-17 | 2013-09-18 | Takeda Nycomed AS | Improved dissolution stability of calcium carbonate tablets |
JP5195623B2 (en) * | 2009-04-30 | 2013-05-08 | ユーハ味覚糖株式会社 | Tablet confectionery |
US20110027446A1 (en) * | 2009-07-28 | 2011-02-03 | Heartland Sweeteners, LLC | No-calorie sweetener compositions |
US20110027445A1 (en) * | 2009-07-28 | 2011-02-03 | Heartland Sweeteners, LLC | No-calorie sweetener compositions |
US20110027444A1 (en) * | 2009-07-28 | 2011-02-03 | Heartland Sweeteners, LLC | No-calorie sweetener compositions |
WO2012068457A1 (en) | 2010-11-19 | 2012-05-24 | Cargill, Incorporated | Method for the enrichment of rebaudioside b and/or rebaudioside d in stevia-derived glycoside compositions using adsorb-desorb chromatography with a macroporous neutral adsorbent resin |
CN102429885B (en) * | 2011-12-30 | 2013-05-08 | 山东力诺科峰制药有限公司 | DC (Directly compressible)-xylitol and preparation method thereof |
FR3011466A1 (en) * | 2013-10-09 | 2015-04-10 | Roquette Freres | USE OF A POLYOL IN THE REMINERALIZATION OF EMAIL |
US11058633B2 (en) * | 2018-05-17 | 2021-07-13 | Fertin Pharma A/S | Disintegrating oral tablet suitable for active pharmaceutical ingredients |
CN109172533A (en) * | 2018-11-16 | 2019-01-11 | 山东福田药业有限公司 | A kind of xylitol grains of directly compressible and preparation method thereof |
CN109512789B (en) * | 2018-11-22 | 2020-11-20 | 浙江华康药业股份有限公司 | High-purity granular xylitol capable of being directly tabletted and preparation method thereof |
AU2021268062A1 (en) * | 2020-05-08 | 2022-11-17 | Fertin Pharma A/S | Flowpack for oral delivery of active ingredients |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3042531A (en) * | 1959-12-09 | 1962-07-03 | Leslie Salt Company | Method of making a compressed tablet |
US4013775A (en) * | 1968-10-14 | 1977-03-22 | Cpc International Inc. | Process for preparing a sugar tablet |
DE2912411B2 (en) * | 1979-03-29 | 1981-02-05 | August Storck Kg, 4802 Halle | Viscous, sugar-free confectionery mass based on sorbitol and a bulking agent and process for its production |
DE3062775D1 (en) * | 1979-11-07 | 1983-05-19 | Tate & Lyle Plc | Tablets containing isomaltulose, their use and a method of producing them |
US4405647A (en) * | 1981-06-15 | 1983-09-20 | Wm. Wrigley Jr. Company | Method of compacting chewing gum base |
US4569852A (en) * | 1983-08-23 | 1986-02-11 | Warner-Lambert Company | Maintenance of flavor intensity in pressed tablets |
US4753805A (en) * | 1984-01-31 | 1988-06-28 | Warner-Lambert Company | Tabletted chewing gum composition and method of preparation |
US4882154A (en) * | 1985-12-20 | 1989-11-21 | Warner Lambert Co. | Confectionery delivery system for mineral supplements |
US4680189A (en) * | 1986-07-07 | 1987-07-14 | Warner-Lambert Company | Ingestible, high density, compressed-tablet fiber-composition |
SE463541B (en) * | 1987-08-31 | 1990-12-10 | Lejus Medical Ab | GRANULATED PRODUCT TRANSFER OF A MELT OF ITSELF AND THE PROCEDURE FOR ITS PREPARATION |
FI81004C (en) * | 1988-02-25 | 1990-09-10 | Suomen Sokeri Oy | BINDE- OCH UTSPAEDNINGSMEDEL PAO BASIS AV XYLITOL OCH FOERFARANDE FOER DESS FRAMSTAELLNING. |
JPH0669948B2 (en) * | 1989-07-21 | 1994-09-07 | エスエス製薬株式会社 | Lozenges |
US4980169A (en) * | 1990-05-03 | 1990-12-25 | Warner-Lambert Company | Flavor enhancing and increasing efficacy of cough drops |
-
1990
- 1990-12-12 US US07/626,495 patent/US5204115A/en not_active Expired - Lifetime
-
1991
- 1991-11-29 CA CA002098294A patent/CA2098294C/en not_active Expired - Lifetime
- 1991-11-29 AT AT91920167T patent/ATE127337T1/en not_active IP Right Cessation
- 1991-11-29 ES ES91920167T patent/ES2079686T3/en not_active Expired - Lifetime
- 1991-11-29 JP JP4500395A patent/JP2753657B2/en not_active Expired - Lifetime
- 1991-11-29 DK DK91920167.3T patent/DK0561815T3/en active
- 1991-11-29 EP EP91920167A patent/EP0561815B1/en not_active Expired - Lifetime
- 1991-11-29 DE DE69112841T patent/DE69112841T2/en not_active Expired - Lifetime
- 1991-11-29 WO PCT/FI1991/000362 patent/WO1992010168A1/en active IP Right Grant
-
1993
- 1993-06-10 NO NO932118A patent/NO305424B1/en not_active IP Right Cessation
- 1993-06-11 FI FI932698A patent/FI109648B/en not_active IP Right Cessation
-
1994
- 1994-11-22 EE EE9400244A patent/EE02969B1/en not_active IP Right Cessation
-
1995
- 1995-11-09 GR GR950403150T patent/GR3018052T3/en unknown
-
1997
- 1997-10-07 JP JP9290392A patent/JPH1149666A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
DK0561815T3 (en) | 1995-10-16 |
FI932698A (en) | 1993-06-11 |
DE69112841T2 (en) | 1996-04-04 |
EP0561815A1 (en) | 1993-09-29 |
GR3018052T3 (en) | 1996-02-29 |
WO1992010168A1 (en) | 1992-06-25 |
EP0561815B1 (en) | 1995-09-06 |
EE02969B1 (en) | 1997-04-15 |
NO305424B1 (en) | 1999-05-31 |
FI932698A0 (en) | 1993-06-11 |
JP2753657B2 (en) | 1998-05-20 |
JPH06503080A (en) | 1994-04-07 |
NO932118L (en) | 1993-08-11 |
ATE127337T1 (en) | 1995-09-15 |
NO932118D0 (en) | 1993-06-10 |
FI109648B (en) | 2002-09-30 |
DE69112841D1 (en) | 1995-10-12 |
US5204115A (en) | 1993-04-20 |
ES2079686T3 (en) | 1996-01-16 |
CA2098294C (en) | 2000-11-21 |
JPH1149666A (en) | 1999-02-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed | ||
MKEC | Expiry (correction) |
Effective date: 20121202 |