CA2098082A1 - Bone cement composition and method of manufacture - Google Patents
Bone cement composition and method of manufactureInfo
- Publication number
- CA2098082A1 CA2098082A1 CA002098082A CA2098082A CA2098082A1 CA 2098082 A1 CA2098082 A1 CA 2098082A1 CA 002098082 A CA002098082 A CA 002098082A CA 2098082 A CA2098082 A CA 2098082A CA 2098082 A1 CA2098082 A1 CA 2098082A1
- Authority
- CA
- Canada
- Prior art keywords
- beads
- cement composition
- bone cement
- opacifier
- polymerization initiator
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K9/00—Use of pretreated ingredients
- C08K9/10—Encapsulated ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0015—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
- A61L24/0089—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing inorganic fillers not covered by groups A61L24/0078 or A61L24/0084
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/406—Antibiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/44—Radioisotopes, radionuclides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
- A61L2300/622—Microcapsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Abstract
A bone cement composition has adjustable rheological properties, high strength, and produces a uniform radiological image. The cement comprises beads containing a polymerization initiator in controllable concentrations from 0% to 5% or more by weight. These same beads or others may also contain an opacifier. The polymerization initiator and the opacifier may be selectively distributed throughout the beads or at specific radial locations in the beads or within the beads in specific strata. They may also be selectively placed in beads of a particular advantageous size range. Furthermore, in other embodiments of the invention, other advantageous additives can be incorporated in the beads such as dyes, antibiotics, bone growth factors, and other pharmacological or therapeutic agents.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/921,030 | 1992-07-28 | ||
US07/921,030 US5334626A (en) | 1992-07-28 | 1992-07-28 | Bone cement composition and method of manufacture |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2098082A1 true CA2098082A1 (en) | 1994-01-29 |
CA2098082C CA2098082C (en) | 2004-11-23 |
Family
ID=25444810
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002098082A Expired - Lifetime CA2098082C (en) | 1992-07-28 | 1993-06-09 | Bone cement composition and method of manufacture |
Country Status (6)
Country | Link |
---|---|
US (2) | US5334626A (en) |
EP (1) | EP0581387B1 (en) |
JP (2) | JPH0678987A (en) |
AU (1) | AU666191B2 (en) |
CA (1) | CA2098082C (en) |
DE (1) | DE69331176T2 (en) |
Families Citing this family (86)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6080801A (en) * | 1990-09-13 | 2000-06-27 | Klaus Draenert | Multi-component material and process for its preparation |
KR0139235B1 (en) * | 1994-01-29 | 1998-04-28 | 조세현 | Cement bead composition for orthopaedic surgery and its manufacturing process |
US20020032298A1 (en) * | 1994-07-22 | 2002-03-14 | Bennett Steven L. | Bioabsorbable branched polymers containing units derived from dioxanone and medical/surgical devices manufactured therefrom |
US5578662A (en) | 1994-07-22 | 1996-11-26 | United States Surgical Corporation | Bioabsorbable branched polymers containing units derived from dioxanone and medical/surgical devices manufactured therefrom |
US6339130B1 (en) * | 1994-07-22 | 2002-01-15 | United States Surgical Corporation | Bioabsorbable branched polymers containing units derived from dioxanone and medical/surgical devices manufactured therefrom |
US5795922A (en) * | 1995-06-06 | 1998-08-18 | Clemson University | Bone cement composistion containing microencapsulated radiopacifier and method of making same |
EP0831756A1 (en) * | 1995-06-06 | 1998-04-01 | Merck & Co., Inc. | Bisphosphonate cement composition to prevent aseptic loosening of orthopedic implant devices |
US5942559A (en) * | 1996-08-26 | 1999-08-24 | Ivoclar Ag | Dental light-curing opaquer |
US5756127A (en) * | 1996-10-29 | 1998-05-26 | Wright Medical Technology, Inc. | Implantable bioresorbable string of calcium sulfate beads |
US5902839A (en) * | 1996-12-02 | 1999-05-11 | Northwestern University | Bone cement and method of preparation |
US6713527B2 (en) | 1997-02-07 | 2004-03-30 | Queen's University At Kingston | Anaesthetic bone cement |
US5847046A (en) * | 1997-03-12 | 1998-12-08 | United States Surgical Corporation | Biodegradable bone cement |
US6309420B1 (en) * | 1997-10-14 | 2001-10-30 | Parallax Medical, Inc. | Enhanced visibility materials for implantation in hard tissue |
US6020396A (en) * | 1998-03-13 | 2000-02-01 | The Penn State Research Foundation | Bone cement compositions |
EP1163016A2 (en) * | 1999-03-31 | 2001-12-19 | The Brigham And Women's Hospital, Inc. | Nanocomposite surgical materials and method of producing them |
US7371408B1 (en) * | 1999-06-07 | 2008-05-13 | Wright Medical Technology, Inc. | Bone graft substitute composition |
CA2287112C (en) | 1999-09-02 | 2008-02-19 | Kieran Murphy | Method and apparatus for strengthening vertebral bodies |
WO2002058592A2 (en) * | 2001-01-26 | 2002-08-01 | Uab Research Foundation | Bone cement and a system for mixing and delivery thereof |
US7008433B2 (en) * | 2001-02-15 | 2006-03-07 | Depuy Acromed, Inc. | Vertebroplasty injection device |
CA2447683A1 (en) * | 2001-04-16 | 2002-10-24 | James J. Cassidy | Dense/porous structures for use as bone substitutes |
ITVI20010126A1 (en) * | 2001-05-30 | 2002-11-30 | Tecres Spa | RADIOPACO BONE CEMENT FOR ORTHOPEDIC USE AND METHOD OF REALIZATION |
US7371409B2 (en) | 2001-09-06 | 2008-05-13 | Wright Medical Technology, Inc. | Bone graft substitute composition |
US7211266B2 (en) | 2002-03-29 | 2007-05-01 | Wright Medical Technology, Inc. | Bone graft substitute composition |
US7291179B2 (en) * | 2002-06-24 | 2007-11-06 | Wright Medical Technology, Inc. | Bone graft substitute composition |
US6652887B1 (en) | 2002-06-24 | 2003-11-25 | Wright Medical Technology, Inc. | Bone graft substitute composition |
AU2003284924B2 (en) * | 2002-10-28 | 2009-01-08 | Covidien Lp | Bioabsorbable adhesive compounds |
US7507257B2 (en) * | 2003-02-04 | 2009-03-24 | Wright Medical Technology, Inc. | Injectable resorbable bone graft material, powder for forming same and methods relating thereto for treating bone defects |
WO2004080357A1 (en) | 2003-03-14 | 2004-09-23 | Ferreyro Irigoyen Roque Humber | Hydraulic device for the injection of bone cement in percutaneous vertebroplasty |
US8066713B2 (en) | 2003-03-31 | 2011-11-29 | Depuy Spine, Inc. | Remotely-activated vertebroplasty injection device |
IL166017A0 (en) * | 2004-12-28 | 2006-01-15 | Disc O Tech Medical Tech Ltd | Materials devices and methods for treating bones |
US8415407B2 (en) | 2004-03-21 | 2013-04-09 | Depuy Spine, Inc. | Methods, materials, and apparatus for treating bone and other tissue |
US8579908B2 (en) | 2003-09-26 | 2013-11-12 | DePuy Synthes Products, LLC. | Device for delivering viscous material |
WO2005084725A1 (en) | 2004-03-02 | 2005-09-15 | Nanotherapeutics, Inc. | Compositions for repairing bone and methods for preparing and using such compositions |
US7621952B2 (en) * | 2004-06-07 | 2009-11-24 | Dfine, Inc. | Implants and methods for treating bone |
US20060095138A1 (en) * | 2004-06-09 | 2006-05-04 | Csaba Truckai | Composites and methods for treating bone |
CA2575699C (en) | 2004-07-30 | 2014-07-08 | Disc-O-Tech Medical Technologies Ltd. | Methods, materials and apparatus for treating bone and other tissue |
US20060106459A1 (en) * | 2004-08-30 | 2006-05-18 | Csaba Truckai | Bone treatment systems and methods |
DE102004049121B4 (en) * | 2004-10-07 | 2008-01-10 | Heraeus Kulzer Gmbh | Antibiotic / antibiotics containing PMMA bone cement |
US7250550B2 (en) * | 2004-10-22 | 2007-07-31 | Wright Medical Technology, Inc. | Synthetic bone substitute material |
US8048083B2 (en) * | 2004-11-05 | 2011-11-01 | Dfine, Inc. | Bone treatment systems and methods |
US7722620B2 (en) | 2004-12-06 | 2010-05-25 | Dfine, Inc. | Bone treatment systems and methods |
US9381024B2 (en) | 2005-07-31 | 2016-07-05 | DePuy Synthes Products, Inc. | Marked tools |
IL174347A0 (en) * | 2005-07-31 | 2006-08-20 | Disc O Tech Medical Tech Ltd | Bone cement and methods of use thereof |
US9918767B2 (en) | 2005-08-01 | 2018-03-20 | DePuy Synthes Products, Inc. | Temperature control system |
US8540723B2 (en) | 2009-04-14 | 2013-09-24 | Dfine, Inc. | Medical system and method of use |
US8777479B2 (en) | 2008-10-13 | 2014-07-15 | Dfine, Inc. | System for use in bone cement preparation and delivery |
DE102005040429A1 (en) * | 2005-08-25 | 2007-03-01 | Heraeus Kulzer Gmbh | Drug release system and its use |
US8025903B2 (en) | 2005-09-09 | 2011-09-27 | Wright Medical Technology, Inc. | Composite bone graft substitute cement and articles produced therefrom |
CA2619469C (en) | 2005-09-09 | 2015-03-03 | Wright Medical Technology, Inc. | Composite bone graft cement comprising calcium sulfate dihydrate and brushite |
US8360629B2 (en) | 2005-11-22 | 2013-01-29 | Depuy Spine, Inc. | Mixing apparatus having central and planetary mixing elements |
US9301792B2 (en) * | 2006-01-27 | 2016-04-05 | Stryker Corporation | Low pressure delivery system and method for delivering a solid and liquid mixture into a target site for medical treatment |
US20070233250A1 (en) * | 2006-02-07 | 2007-10-04 | Shadduck John H | Systems for treating bone |
US7918889B2 (en) * | 2006-02-27 | 2011-04-05 | Warsaw Orthopedic, Inc. | Expandable spinal prosthetic devices and associated methods |
WO2007106256A2 (en) * | 2006-03-01 | 2007-09-20 | Poly-Med, Inc. | Antimicrobial, radiopaque, microfiber-reinforced, polymeric methacrylate bone cement |
WO2008006083A2 (en) | 2006-07-07 | 2008-01-10 | Surmodics, Inc. | Beaded wound spacer device |
US8383734B2 (en) * | 2006-07-17 | 2013-02-26 | Syracuse University | Multi-solution bone cements and methods of making the same |
US8575274B2 (en) * | 2006-07-17 | 2013-11-05 | Syracuse University | Multi-solution bone cements and methods of making the same |
US9072808B2 (en) * | 2006-07-17 | 2015-07-07 | Syracuse University | Multi-solution bone cements and methods of making the same |
WO2008032322A2 (en) * | 2006-09-14 | 2008-03-20 | Depuy Spine, Inc. | Bone cement and methods of use thereof |
AU2011226788B2 (en) * | 2006-09-14 | 2013-07-25 | Depuy Spine, Inc. | Bone Cement and Methods of Use Thereof |
CA2747850C (en) | 2006-10-19 | 2013-05-14 | Depuy Spine, Inc. | Fluid delivery system |
US20100233225A1 (en) * | 2007-02-09 | 2010-09-16 | Bingyun Li | Method of surface coating devices to incorporate bioactive molecules |
WO2008137428A2 (en) | 2007-04-30 | 2008-11-13 | Dfine, Inc. | Bone treatment systems and methods |
US7883511B2 (en) * | 2007-09-12 | 2011-02-08 | Fernyhough Jeffrey C | Method and composition for use in reinforcing bone |
US8500947B2 (en) | 2007-11-15 | 2013-08-06 | Covidien Lp | Speeding cure rate of bioadhesives |
US20090131886A1 (en) | 2007-11-16 | 2009-05-21 | Liu Y King | Steerable vertebroplasty system |
US9510885B2 (en) | 2007-11-16 | 2016-12-06 | Osseon Llc | Steerable and curvable cavity creation system |
WO2009073209A1 (en) * | 2007-12-06 | 2009-06-11 | Osseon Therapeutics, Inc. | Vertebroplasty implant with enhanced interfacial shear strength |
US20090202609A1 (en) * | 2008-01-06 | 2009-08-13 | Keough Steven J | Medical device with coating composition |
US9445854B2 (en) * | 2008-02-01 | 2016-09-20 | Dfine, Inc. | Bone treatment systems and methods |
EP2252336B1 (en) * | 2008-02-28 | 2014-06-25 | Dfine, Inc. | Bone treatment systems and methods |
US9180416B2 (en) | 2008-04-21 | 2015-11-10 | Dfine, Inc. | System for use in bone cement preparation and delivery |
EP2361077A4 (en) * | 2008-07-11 | 2012-09-05 | Univ Syracuse | Multi-solution bone cements and methods of making the same |
US20100298832A1 (en) | 2009-05-20 | 2010-11-25 | Osseon Therapeutics, Inc. | Steerable curvable vertebroplasty drill |
EP2563233B1 (en) | 2010-04-29 | 2020-04-01 | Dfine, Inc. | System for use in treatment of vertebral fractures |
WO2014062839A1 (en) | 2012-10-16 | 2014-04-24 | Surmodics, Inc. | Wound packing device and methods |
RU2712216C2 (en) * | 2013-09-30 | 2020-01-27 | Лусайт Интернэшнл Спешиэлити Полимерс Энд Резинс Лимитед | Curing multicomponent acrylic composition |
US10201457B2 (en) | 2014-08-01 | 2019-02-12 | Surmodics, Inc. | Wound packing device with nanotextured surface |
CN104906640A (en) * | 2015-06-15 | 2015-09-16 | 东华大学 | Developable biodegradable medical strapping tape and preparation method thereof |
JP2019534130A (en) | 2016-10-27 | 2019-11-28 | ディーファイン,インコーポレイティド | Articulated osteotome with cement delivery channel |
KR20190082300A (en) | 2016-11-28 | 2019-07-09 | 디파인 인코포레이티드 | Tumor ablation device and related method |
US10470781B2 (en) | 2016-12-09 | 2019-11-12 | Dfine, Inc. | Medical devices for treating hard tissues and related methods |
EP3565486B1 (en) | 2017-01-06 | 2021-11-10 | Dfine, Inc. | Osteotome with a distal portion for simultaneous advancement and articulation |
EP3603685A4 (en) * | 2017-03-31 | 2021-01-06 | Mitsui Chemicals, Inc. | Composition for repairing hard tissue and kit for repairing hard tissue |
CN110461377B (en) * | 2017-03-31 | 2022-05-10 | 三井化学株式会社 | Composition for hard tissue repair and kit for hard tissue repair |
WO2020097334A1 (en) | 2018-11-08 | 2020-05-14 | Dfine, Inc. | Ablation systems with parameter-based modulation and related devices and methods |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3715331A (en) * | 1970-05-01 | 1973-02-06 | Coe Labor | Monomer soluble x-ray opaque methacrylate particles |
US4045403A (en) * | 1972-07-19 | 1977-08-30 | General Electric Company | Method of compounding thermo-plastic polymeric materials and fillers |
US4404327A (en) * | 1979-10-31 | 1983-09-13 | Crugnola Aldo M | Orthopaedic cement from acrylate polymers |
US4341691A (en) * | 1980-02-20 | 1982-07-27 | Zimmer, Inc. | Low viscosity bone cement |
DE3128923A1 (en) * | 1981-07-22 | 1983-02-10 | Beiersdorf Ag, 2000 Hamburg | POWDER BLEND FOR SURGICAL PURPOSES |
US4535485A (en) * | 1982-03-12 | 1985-08-20 | Medical Biological Sciences, Inc. | Polymeric acrylic prothesis |
JPS59500453A (en) * | 1982-03-12 | 1984-03-22 | ユナイテイド ステイツ サ−ジカル コ−ポレイシヨン | polymer acrylic prosthesis |
US4547390A (en) * | 1982-03-12 | 1985-10-15 | Medical Biological Sciences, Inc. | Process of making implantable prosthesis material of modified polymeric acrylic (PMMA) beads coated with PHEMA and barium sulfate |
US4500658A (en) * | 1983-06-06 | 1985-02-19 | Austenal International, Inc. | Radiopaque acrylic resin |
DE3341888A1 (en) * | 1983-11-19 | 1985-05-30 | Bayer Ag, 5090 Leverkusen | INORGANIC-ORGANIC FILLERS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN POLYMERIZABLE MEASURES |
US4675140A (en) * | 1984-05-18 | 1987-06-23 | Washington University Technology Associates | Method for coating particles or liquid droplets |
GB8524152D0 (en) * | 1985-10-01 | 1985-11-06 | Cole Polymers Ltd | Bone cement |
WO1988003811A1 (en) * | 1986-11-19 | 1988-06-02 | Laboratorium Für Experimentelle Chirurgie, Forschu | Method and apparatus for preparing a self-curing two-component powder liquid bone cement |
US4837279A (en) * | 1988-02-22 | 1989-06-06 | Pfizer Hospital Products Corp, Inc. | Bone cement |
US5061520A (en) * | 1990-10-05 | 1991-10-29 | Kv Pharmaceutical Company | Particle enrobing process and apparatus |
US5143662A (en) * | 1991-02-12 | 1992-09-01 | United States Surgical Corporation | Process for preparing particles of bioabsorbable polymer |
-
1992
- 1992-07-28 US US07/921,030 patent/US5334626A/en not_active Expired - Lifetime
-
1993
- 1993-05-27 AU AU39840/93A patent/AU666191B2/en not_active Expired
- 1993-06-09 CA CA002098082A patent/CA2098082C/en not_active Expired - Lifetime
- 1993-07-02 JP JP5164504A patent/JPH0678987A/en not_active Withdrawn
- 1993-07-28 DE DE69331176T patent/DE69331176T2/en not_active Expired - Lifetime
- 1993-07-28 EP EP93202227A patent/EP0581387B1/en not_active Expired - Lifetime
-
1994
- 1994-07-27 US US08/281,326 patent/US5512610A/en not_active Expired - Lifetime
-
2002
- 2002-10-24 JP JP2002309650A patent/JP3670637B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2098082C (en) | 2004-11-23 |
JP2003160372A (en) | 2003-06-03 |
AU3984093A (en) | 1994-02-03 |
US5512610A (en) | 1996-04-30 |
AU666191B2 (en) | 1996-02-01 |
JPH0678987A (en) | 1994-03-22 |
DE69331176T2 (en) | 2002-07-11 |
EP0581387B1 (en) | 2001-11-21 |
JP3670637B2 (en) | 2005-07-13 |
EP0581387A1 (en) | 1994-02-02 |
US5334626A (en) | 1994-08-02 |
DE69331176D1 (en) | 2002-01-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2098082A1 (en) | Bone cement composition and method of manufacture | |
PL298845A1 (en) | Arylecetamides, method of obtaining them as well as pharmaceutical preparation and method of obtaining same | |
TW386983B (en) | Air controlling polymeric superplasticizers, cement compositions comprising the same and method for making an air controlling hydraulic cement composition | |
HUT68005A (en) | Method for producing of biologically degradable polymer compositions | |
CA2279200A1 (en) | Anaesthetic bone cement | |
AU2566892A (en) | Composition suitable for forming into shaped articles, process for preparing the composition, process for preparing shaped articles using the composition, and shaped articles so-formed | |
NZ263360A (en) | Aza-cyclohexapeptide compounds and their use as antibiotic compounds | |
AU5681090A (en) | Indolino-spiroquinoxalino oxazine photochromic compounds, method for their preparation, photochromic compositions and articles containing such compounds | |
AU6217490A (en) | Liquid polymer and polyol compositions, and process for preparing phenol-functional polymer | |
DE69620832D1 (en) | Cement dispersant, process for its preparation and cement composition containing this dispersant | |
EP1746160A3 (en) | Hepatocyte growth factor receptor antagonists and uses thereof | |
GR3036586T3 (en) | Novel hydrogels containing triblock copolymers, and preparation and use thereof | |
AU6363390A (en) | Biologically degradable film and method of preparation the same | |
CA2051361A1 (en) | Cementitious compositions and method | |
PL310494A1 (en) | Composition for polymerisation of olefins, method of obtaining such composition and method of polymerising the olefins | |
AU7239794A (en) | Process for preparing 5,8-dihydronaphthoquinone derivatives, novel 5,8-dihydronaphthoquinone derivatives and their use as anticancer agent | |
EP0475023A3 (en) | Curable mixtures for the preparation of epoxy-networks, method for their preparation and their application | |
GB9021634D0 (en) | Stabilizer composition for chlorine-containing polymers and process for preparation thereof | |
HRP930957A2 (en) | Novel biologically active eburnamenine derivatives, maceutical compositions containing them and process for aring the same | |
AU7728891A (en) | Cement based compositions having elastomeric properties, and method of manufacture | |
CA2027305A1 (en) | Process and apparatus for accelerated weathering of textiles and articles produced thereby | |
AU649499B2 (en) | Fluorine compounds | |
HU9503083D0 (en) | Composition containing cholestyramine and method of producing the same | |
AU4341689A (en) | Polymer composition and process for producing the same | |
GB9304521D0 (en) | Improved alumoxane,method for its preparation and polymerisation process using such alumoxane |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request |