CA2097602A1 - Non-invasive blood glucose measurement system - Google Patents

Non-invasive blood glucose measurement system

Info

Publication number
CA2097602A1
CA2097602A1 CA2097602A CA2097602A CA2097602A1 CA 2097602 A1 CA2097602 A1 CA 2097602A1 CA 2097602 A CA2097602 A CA 2097602A CA 2097602 A CA2097602 A CA 2097602A CA 2097602 A1 CA2097602 A1 CA 2097602A1
Authority
CA
Canada
Prior art keywords
laser beam
aqueous humor
pump
probe
ocular aqueous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2097602A
Other languages
French (fr)
Other versions
CA2097602C (en
Inventor
Randall V. Tarr
Paul G. Steffes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Georgia Tech Research Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2097602A1 publication Critical patent/CA2097602A1/en
Application granted granted Critical
Publication of CA2097602C publication Critical patent/CA2097602C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement

Abstract

Stimulated Raman spectroscopy is used to non-invasively measure the concentration of an Raman active molecule, preferably D-glucose in the ocular aqueous humor of living being. The apparatus and method make use of two monochromatic laser beams, a pump laser beam and a probe laser beam. The output power of the pump laser beam is amplitude modulated, combined with the probe laser beam and directed into the ocular aqueous humor. The introduction of the laser beams into the ocular aqueous humor induces scattered Raman radiation, which causes a portion of the energy at the pump frequency to shift over to the probe frequency. The pump and probe laser beams are then detected as they exit the ocular aqueous humor. The probe laser beam is filtered, converted into an electrical signal and amplified. It is then compared to the modulation signal to generate an electrical signal representative of the concentration of D-glucose in the ocular aqueous humor.
CA002097602A 1990-12-14 1991-11-12 Non-invasive blood glucose measurement system Expired - Fee Related CA2097602C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/627,631 US5243983A (en) 1990-12-14 1990-12-14 Non-invasive blood glucose measurement system and method using stimulated raman spectroscopy
US627,631 1990-12-14

Publications (2)

Publication Number Publication Date
CA2097602A1 true CA2097602A1 (en) 1992-06-15
CA2097602C CA2097602C (en) 1998-08-11

Family

ID=24515435

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002097602A Expired - Fee Related CA2097602C (en) 1990-12-14 1991-11-12 Non-invasive blood glucose measurement system

Country Status (10)

Country Link
US (1) US5243983A (en)
EP (1) EP0561872B1 (en)
JP (1) JP2677452B2 (en)
AT (1) ATE141478T1 (en)
CA (1) CA2097602C (en)
DE (1) DE69121589T2 (en)
DK (1) DK0561872T3 (en)
ES (1) ES2093243T3 (en)
GR (1) GR3020938T3 (en)
WO (1) WO1992010131A1 (en)

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GR3020938T3 (en) 1996-12-31
JPH06503245A (en) 1994-04-14
US5243983A (en) 1993-09-14
CA2097602C (en) 1998-08-11
ATE141478T1 (en) 1996-09-15
ES2093243T3 (en) 1996-12-16
DE69121589T2 (en) 1997-01-02
DE69121589D1 (en) 1996-09-26
JP2677452B2 (en) 1997-11-17
DK0561872T3 (en) 1996-09-09
EP0561872B1 (en) 1996-08-21
EP0561872A1 (en) 1993-09-29
WO1992010131A1 (en) 1992-06-25

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