CA2092287A1 - Controlled release verapamil tablet - Google Patents

Controlled release verapamil tablet

Info

Publication number
CA2092287A1
CA2092287A1 CA2092287A CA2092287A CA2092287A1 CA 2092287 A1 CA2092287 A1 CA 2092287A1 CA 2092287 A CA2092287 A CA 2092287A CA 2092287 A CA2092287 A CA 2092287A CA 2092287 A1 CA2092287 A1 CA 2092287A1
Authority
CA
Canada
Prior art keywords
controlled release
release verapamil
tablet
verapamil tablet
tablets
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2092287A
Other languages
French (fr)
Other versions
CA2092287C (en
Inventor
Anand R. Baichwal
John N. Staniforth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Penwest Pharmaceuticals Co
Original Assignee
Anand R. Baichwal
John N. Staniforth
Edward Mendell Co., Inc.
Penwest Pharmaceuticals Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anand R. Baichwal, John N. Staniforth, Edward Mendell Co., Inc., Penwest Pharmaceuticals Co. filed Critical Anand R. Baichwal
Publication of CA2092287A1 publication Critical patent/CA2092287A1/en
Application granted granted Critical
Publication of CA2092287C publication Critical patent/CA2092287C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

Controlled release verapamil tablets are disclosed. The tablets include an excipient having a hydrophilic material, prefer-ably containing a mixture of xanthan gum/locust bean gum, and an inert diluent.
CA002092287A 1991-07-25 1992-07-02 Controlled release verapamil tablet Expired - Fee Related CA2092287C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/736,031 US5169639A (en) 1988-09-19 1991-07-25 Controlled release verapamil tablets
US736,031 1991-07-25

Publications (2)

Publication Number Publication Date
CA2092287A1 true CA2092287A1 (en) 1993-01-26
CA2092287C CA2092287C (en) 1997-03-25

Family

ID=24958214

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002092287A Expired - Fee Related CA2092287C (en) 1991-07-25 1992-07-02 Controlled release verapamil tablet

Country Status (17)

Country Link
US (1) US5169639A (en)
EP (1) EP0550737B1 (en)
JP (1) JPH0733339B2 (en)
KR (1) KR0184308B1 (en)
AT (1) ATE147974T1 (en)
AU (1) AU649163B2 (en)
CA (1) CA2092287C (en)
DE (1) DE69217031T2 (en)
DK (1) DK0550737T3 (en)
ES (1) ES2099273T3 (en)
FI (1) FI107231B (en)
GR (1) GR3023086T3 (en)
HU (1) HU218658B (en)
IE (1) IE922411A1 (en)
IL (1) IL102614A (en)
MX (1) MX9204352A (en)
WO (1) WO1993001803A1 (en)

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US6818229B1 (en) 1993-09-20 2004-11-16 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia
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US20040005359A1 (en) * 2002-06-27 2004-01-08 Cheng Xiu Xiu Controlled release oral dosage form
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CN101578096A (en) * 2006-10-10 2009-11-11 潘威斯脱药物公司 Robust sustained release formulations
JP5463537B2 (en) * 2008-02-22 2014-04-09 ＨＯＹＡ Ｔｅｃｈｎｏｓｕｒｇｉｃａｌ株式会社 Separation method
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Also Published As

Publication number Publication date
EP0550737A1 (en) 1993-07-14
KR930701983A (en) 1993-09-08
ES2099273T3 (en) 1997-05-16
IL102614A (en) 1997-02-18
IE922411A1 (en) 1993-01-27
DE69217031D1 (en) 1997-03-06
FI931342A (en) 1993-03-25
FI107231B (en) 2001-06-29
GR3023086T3 (en) 1997-07-30
US5169639A (en) 1992-12-08
AU649163B2 (en) 1994-05-12
MX9204352A (en) 1993-04-01
HU218658B (en) 2000-10-28
HU9300768D0 (en) 1993-06-28
DE69217031T2 (en) 1997-05-07
HUT64221A (en) 1993-12-28
EP0550737A4 (en) 1993-12-15
KR0184308B1 (en) 1999-05-01
FI931342A0 (en) 1993-03-25
CA2092287C (en) 1997-03-25
WO1993001803A1 (en) 1993-02-04
JPH06500576A (en) 1994-01-20
EP0550737B1 (en) 1997-01-22
ATE147974T1 (en) 1997-02-15
DK0550737T3 (en) 1997-02-17
IL102614A0 (en) 1993-01-14
AU2403392A (en) 1993-02-23
JPH0733339B2 (en) 1995-04-12

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