CA2088831A1 - Photocurable glycosaminoglycan derivatives, crosslinked glycosaminoglycans and method of production thereof - Google Patents

Photocurable glycosaminoglycan derivatives, crosslinked glycosaminoglycans and method of production thereof

Info

Publication number
CA2088831A1
CA2088831A1 CA002088831A CA2088831A CA2088831A1 CA 2088831 A1 CA2088831 A1 CA 2088831A1 CA 002088831 A CA002088831 A CA 002088831A CA 2088831 A CA2088831 A CA 2088831A CA 2088831 A1 CA2088831 A1 CA 2088831A1
Authority
CA
Canada
Prior art keywords
photocurable
derivatives
gag
crosslinked
glycosaminoglycan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002088831A
Other languages
French (fr)
Other versions
CA2088831C (en
Inventor
Takehisa Matsuda
Minoo J. Moghaddam
Katsukiyo Sakurai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Seikagaku Corp
Original Assignee
Takehisa Matsuda
Minoo J. Moghaddam
Katsukiyo Sakurai
Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takehisa Matsuda, Minoo J. Moghaddam, Katsukiyo Sakurai, Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation) filed Critical Takehisa Matsuda
Publication of CA2088831A1 publication Critical patent/CA2088831A1/en
Application granted granted Critical
Publication of CA2088831C publication Critical patent/CA2088831C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/042—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan

Abstract

Photocurable glycosaminoglycan (GAG) derivatives and crosslinked glycosaminoglycans, which are highly safe and biocompatible, a method of preparing such photocurable GAG
derivatives readily moldable by casting using a solvent when desired, by which method unreacted substances causative of adverse effects can be readily eliminated, and a method of producing the crosslinked GAGs and medical materials based on the photocurable GAG derivatives or crosslinked GAGs are provided. The photocurable GAG derivatives comprise a glycosaminoglycan and a photoreactive compound bound thereto and can be produced, for example, by subjecting hydroxyl or carboxyl groups of the glycosaminoglycan to esterification reaction or amidation reaction, respectively, with the photoreactive compound. The crosslinked GAGs are derived from the photocurable GAG derivatives by intermolecular crosslinking of the photoreactive compound bound thereto.
CA002088831A 1992-02-05 1993-02-04 Photocurable glycosaminoglycan derivatives, crosslinked glycosaminoglycans and method of production thereof Expired - Lifetime CA2088831C (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP4774492 1992-02-05
JPHEI.4-47744 1992-02-05
JP20320992 1992-07-08
JPHEI.4-203209 1992-07-08
JP4355441A JP2855307B2 (en) 1992-02-05 1992-12-21 Photoreactive glycosaminoglycans, cross-linked glycosaminoglycans and methods for producing them
JPHEI.4-355441 1992-12-21

Publications (2)

Publication Number Publication Date
CA2088831A1 true CA2088831A1 (en) 1993-08-06
CA2088831C CA2088831C (en) 2004-07-06

Family

ID=27293072

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002088831A Expired - Lifetime CA2088831C (en) 1992-02-05 1993-02-04 Photocurable glycosaminoglycan derivatives, crosslinked glycosaminoglycans and method of production thereof

Country Status (14)

Country Link
US (2) US5462976A (en)
EP (1) EP0554898B1 (en)
JP (1) JP2855307B2 (en)
KR (1) KR100293043B1 (en)
CN (1) CN1083455C (en)
AT (1) ATE152736T1 (en)
AU (1) AU670921B2 (en)
CA (1) CA2088831C (en)
DE (1) DE69310396T2 (en)
DK (1) DK0554898T3 (en)
ES (1) ES2102537T3 (en)
HU (1) HU215503B (en)
RU (1) RU2139886C1 (en)
TW (1) TW222644B (en)

Families Citing this family (123)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824335A (en) * 1991-12-18 1998-10-20 Dorigatti; Franco Non-woven fabric material comprising auto-crosslinked hyaluronic acid derivatives
JPH07250887A (en) * 1994-03-15 1995-10-03 Seikagaku Kogyo Co Ltd Artificial blood vessel and its production
JP3563440B2 (en) * 1994-05-16 2004-09-08 生化学工業株式会社 Method for producing acylated hyaluronic acid
JP3308742B2 (en) * 1994-11-17 2002-07-29 生化学工業株式会社 Photocrosslinkable hyaluronic acid derivative, crosslinked product thereof and methods for producing them
US6025444A (en) * 1994-11-17 2000-02-15 Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation) Cinnamic acid derivative
JP3343181B2 (en) * 1995-09-20 2002-11-11 生化学工業株式会社 Cinnamic acid derivative
CA2162957C (en) * 1994-11-17 2011-08-02 Michinori Waki Cinnamic acid derivative
ES2179930T3 (en) * 1995-02-07 2003-02-01 Fidia Advanced Biopolymers Srl PROCEDURE FOR THE COATING OF OBJECTS WITH Hyaluronic Acid, DERIVATIVES OF THE SAME AND SEMISINTETIC POLYMERS.
AU708454B2 (en) * 1995-03-07 1999-08-05 Novartis Ag Photochemically cross-linked polysaccharide derivatives as supports for the chromatographic separation of enantiomers
JP3955107B2 (en) * 1995-05-01 2007-08-08 生化学工業株式会社 Method for producing crosslinked polysaccharide
TW362100B (en) * 1995-07-21 1999-06-21 Novartis Ag The preparation and use of photochemically cross-linked polysaccharide derivatives having no photopolymerisable functional groups
SI9620106B (en) * 1995-08-29 2005-12-31 Fidia Advanced Biopolymers Srl Bio-materials for preventing post-surgical adhesions comprised of hyaluronic acid derivatives
US5789462A (en) * 1995-09-13 1998-08-04 Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation) Photocured crosslinked-hyaluronic acid contact lens
JP3439481B2 (en) * 1995-11-15 2003-08-25 生化学工業株式会社 Photocrosslinked hyaluronic acid gel and method for producing the same
JP3136352B2 (en) * 1996-01-22 2001-02-19 参天製薬株式会社 Keratoconjunctival disease therapeutic agent
US5922690A (en) * 1996-04-25 1999-07-13 Van Gorp; Cornelius L. Dermatan disulfate, an inhibitor of thrombin generation and activation
JP4317599B2 (en) * 1996-06-26 2009-08-19 武田薬品工業株式会社 Sustained release formulation
WO1998016559A1 (en) * 1996-10-15 1998-04-23 Toray Industries, Inc. Cervical canal maturing agent
ATE229038T1 (en) * 1997-04-04 2002-12-15 Fidia Advanced Biopolymers Srl N-SULFATED HYALURONIC ACID COMPOUNDS, THEIR DERIVATIVES AND METHOD FOR THEIR PRODUCTION
DE19729279A1 (en) 1997-07-09 1999-01-14 Peter Hildebrandt Urological implant, in particular vascular wall support for the urinal tract
US5945457A (en) * 1997-10-01 1999-08-31 A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Science Process for preparing biologically compatible polymers and their use in medical devices
GB9722604D0 (en) * 1997-10-28 1997-12-24 Cancer Res Campaign Tech Heparin-binding growth factor derivatives
ITPD980169A1 (en) 1998-07-06 2000-01-06 Fidia Advanced Biopolymers Srl AMIDES OF HYALURONIC ACID AND ITS DERIVATIVES AND PROCESS FOR THEIR PREPARATION.
US6514534B1 (en) * 1998-08-14 2003-02-04 Incept Llc Methods for forming regional tissue adherent barriers and drug delivery systems
US6632457B1 (en) * 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
US6818018B1 (en) 1998-08-14 2004-11-16 Incept Llc In situ polymerizable hydrogels
US6630457B1 (en) * 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
JP4406943B2 (en) * 1998-10-22 2010-02-03 生化学工業株式会社 Ultraviolet irradiation device and method for producing photocrosslinked glycosaminoglycan
IT1303738B1 (en) * 1998-11-11 2001-02-23 Aquisitio S P A CARBOXYLATE POLYSACCHARIDE CROSS-LINKING PROCESS.
US6409987B1 (en) 1999-04-07 2002-06-25 Intimax Corporation Targeted agents useful for diagnostic and therapeutic applications
CA2377382A1 (en) * 1999-07-01 2001-01-11 Scios, Inc. Prevention and treatment of amyloid-associated disorders
US6518244B2 (en) 2000-03-09 2003-02-11 Intimax Corporation Combinations of heparin cofactor II agonist and platelet IIb/IIIa antagonist, and uses thereof
FR2808271A1 (en) * 2000-04-27 2001-11-02 Oreal NEW AMINO ACID DERIVATIVES, METHOD FOR THEIR PREPARATION, COMPOSITIONS CONTAINING THEM AND THEIR USES AS SUN FILTERS
JP2001329002A (en) * 2000-05-25 2001-11-27 Denki Kagaku Kogyo Kk Modified hyaluronic acid gel, its preparing method and medical material containing same
EP1188773A1 (en) * 2000-08-30 2002-03-20 Nicox S.A. Nitroderivatives of polysaccharides
DE60117502T2 (en) * 2000-12-19 2006-08-24 Seikagaku Corp. Photohardenable derivatives of hyaluronic acid, process for their preparation, cross-linked and photocured derivative of hyaluronic acid and medical material containing them
JP4172176B2 (en) * 2000-12-19 2008-10-29 生化学工業株式会社 Photoreactive hyaluronic acid, process for producing the same, photocrosslinked hyaluronic acid and medical material
US7893225B2 (en) 2001-01-31 2011-02-22 Seikagaku Corporation Crosslinked polysaccharide sponge
US6586493B1 (en) 2001-03-07 2003-07-01 Arizona Board Of Regents Arizona State University Polysaccharide-based hydrogels and pre-gel blends for the same
AU2002258490A1 (en) * 2001-03-12 2003-06-17 Clemson University Polysaccharide-based polmerizable hydrogels
US6610810B2 (en) 2001-03-13 2003-08-26 Glyn Owen Phillips Biopolymers obtained by solid state irradiation in an unsaturated gaseous atmosphere
EP1249247B1 (en) * 2001-03-30 2007-02-28 Chisso Corporation Pharmaceutical preparation for the treatment of gynecological diseases
US6673919B2 (en) * 2001-03-30 2004-01-06 Chisso Cororation Chemically modified hyaluronic acid or salts thereof, and a process for producing thereof
US7157458B2 (en) * 2001-04-17 2007-01-02 Cryolife, Inc. Bifunctional energy-reversible acyl-compositions
US7666462B2 (en) * 2001-05-11 2010-02-23 Exogenesis Corporation Method of controlling a drug release rate
US20100036502A1 (en) * 2008-08-07 2010-02-11 Exogenesis Corporation Medical device for bone implant and method for producing such device
US8889169B2 (en) * 2001-05-11 2014-11-18 Exogenesis Corporation Drug delivery system and method of manufacturing thereof
US7923055B2 (en) 2001-05-11 2011-04-12 Exogenesis Corporation Method of manufacturing a drug delivery system
US6844028B2 (en) * 2001-06-26 2005-01-18 Accelr8 Technology Corporation Functional surface coating
US7501157B2 (en) 2001-06-26 2009-03-10 Accelr8 Technology Corporation Hydroxyl functional surface coating
US8101196B2 (en) 2001-06-26 2012-01-24 Biointeractions, Ltd. Polysaccharide biomaterials and methods of use thereof
JP3947391B2 (en) * 2001-11-28 2007-07-18 独立行政法人 日本原子力研究開発機構 Method for producing chitin derivative and / or chitosan derivative having bridge structure
JP2003190259A (en) * 2001-12-28 2003-07-08 Hisako Ogawara Chamber for artificial organ
ITPD20020064A1 (en) 2002-03-12 2003-09-12 Fidia Advanced Biopolymers Srl FOREIGN DERIVATIVES OF HYALURONIC ACID FOR THE PREPARATION OF HYDROGELD FOR USE IN THE BIOMEDICAL, SANITARY AND SURGICAL FIELD AND AS A SYSTEM
JP4340423B2 (en) * 2002-06-20 2009-10-07 生化学工業株式会社 Photoreactive sugar compound, labeled photoreactive sugar compound, and method for capturing and measuring sugar receptor
US8673333B2 (en) * 2002-09-25 2014-03-18 The Johns Hopkins University Cross-linked polymer matrices, and methods of making and using same
AU2003288911B8 (en) * 2002-09-25 2009-12-24 Johns Hopkins University Cross-linked polymer matrices, and methods of making and using same
JP4813179B2 (en) * 2003-03-11 2011-11-09 生化学工業株式会社 Photocrosslinked polysaccharide composition and method for producing the same
CN101137388A (en) * 2003-05-15 2008-03-05 犹他卅大学研究基金会 Anti-adhesion composites and methods os use thereof
JP2005073606A (en) * 2003-09-01 2005-03-24 Seikagaku Kogyo Co Ltd Cultural base material
EP1666503B1 (en) * 2003-09-12 2010-05-05 Seikagaku Corporation Polysaccharide pseudo-sponge
US7225024B2 (en) 2003-09-30 2007-05-29 Cardiac Pacemakers, Inc. Sensors having protective eluting coating and method therefor
US8313765B2 (en) * 2003-12-04 2012-11-20 Industrial Technology Research Institute Biodegradable hyaluronic acid derivative, biodegradable polymeric micelle composition and pharmaceutical or bioactive composition
GB2408741B (en) * 2003-12-04 2008-06-18 Ind Tech Res Inst Hyaluronic acid derivative with urethane linkage
EP1759719B1 (en) * 2004-05-07 2015-01-07 Seikagaku Corporation Nucleus pulposus filler
US7604830B2 (en) * 2004-06-24 2009-10-20 Cook Incorporated Method and apparatus for coating interior surfaces of medical devices
JP4523812B2 (en) * 2004-07-02 2010-08-11 生化学工業株式会社 Substrate for culturing embryonic stem cells and use thereof
JP2006076968A (en) * 2004-09-10 2006-03-23 Seikagaku Kogyo Co Ltd Physiologically active molecule-containing crosslinked heparin gel composition
EP1794192B1 (en) * 2004-09-15 2016-05-04 Seikagaku Corporation Photoreactive polysaccharide, photocrosslinked polysaccharide products, the method of making them and medical materials made therefrom
US20060069063A1 (en) * 2004-09-27 2006-03-30 Yng-Jiin Wang Crosslinked polygalacturonic acid used for postsurgical tissue adhesion prevention
JP2008516051A (en) * 2004-10-06 2008-05-15 コーナーストーン リサーチ グループ，インコーポレーテッド Photoactivated shape memory copolymer
ITPD20040265A1 (en) * 2004-10-27 2005-01-27 Fidia Advanced Biopolymers Srl VASCULAR COUPLINGS MADE FROM DERIVATIVES OF HYALURONIC ACID IN TUBULAR FORM
WO2006089119A2 (en) * 2005-02-18 2006-08-24 Cartilix, Inc. Biological adhesive
ITPD20050056A1 (en) 2005-03-02 2006-09-03 Fidia Farmaceutici AMIDID DERIVATIVES OF HYALURONIC ACID IN OSTEOARTROSI
EP1905456A4 (en) * 2005-07-06 2010-12-22 Seikagaku Kogyo Co Ltd Drug-containing photocrosslinked hyaluronic acid derivative gel
JP4387445B2 (en) * 2005-10-12 2009-12-16 生化学工業株式会社 Mucosal agent and method for producing the same
AU2012201314B2 (en) * 2005-10-12 2014-04-10 Seikagaku Corporation Agent for applying to mucosa and method for production thereof
EP1973513B1 (en) * 2005-12-28 2010-11-10 DENTSPLY International Inc. Light-curable bone growth material for treating dental bone defects
CN103356694B (en) 2006-12-06 2015-09-02 生化学工业株式会社 The long-acting medicament for the treatment of of arthritis disease
TWI320180B (en) 2007-01-12 2010-02-01 A driving method and a driving system for writing the phase change memory
JP2007146178A (en) * 2007-02-01 2007-06-14 Seikagaku Kogyo Co Ltd Chitosan derivative and crosslinked chitosan
WO2008136536A1 (en) * 2007-05-01 2008-11-13 National University Corporation Tokyo Medical And Dental University Hybrid gel comprising chemically cross-linked hyaluronic acid derivative, and pharmaceutical composition using the same
EP2095832A1 (en) 2008-02-28 2009-09-02 Bayer MaterialScience AG Post-operative adhesion barriers
KR101078302B1 (en) * 2008-05-29 2011-10-31 (주)프로넥스 Drug Delivery System
EP2323708A4 (en) * 2008-08-07 2015-11-18 Exogenesis Corp Drug delivery system and method of munufacturing thereof
EP2396070A4 (en) 2009-02-12 2012-09-19 Incept Llc Drug delivery through hydrogel plugs
JO3008B1 (en) * 2009-08-13 2016-09-05 Seikagaku Kogyo Co Ltd Pharmaceutical Composition For Relieving Pain
US8795727B2 (en) 2009-11-09 2014-08-05 Spotlight Technology Partners Llc Fragmented hydrogels
CN106913902A (en) 2009-11-09 2017-07-04 聚光灯技术合伙有限责任公司 Polysaccharide based aquagel
CZ2009836A3 (en) 2009-12-11 2011-06-22 Contipro C A.S. Hyaluronic acid derivative oxidized in position 6 of saccharide glucosamine portion selectively to aldehyde, process of its preparation and modification method thereof
CZ2009835A3 (en) 2009-12-11 2011-06-22 Contipro C A.S. Process for preparing hyaluronic acid derivative oxidized in position 6 of saccharide glucosamine portion selectively to aldehyde and modification method thereof
CN101831006B (en) * 2010-05-21 2012-01-18 常州大学 Preparation method of new type hyaluronic acid derivative containing coumarin fluorophore
DK2585586T3 (en) * 2010-06-22 2017-07-03 Univ Rouen IMPROVED cross-linked HYALURONIC ACID HYDROGLES FOR 3D CELL CULTURE
ITTO20110428A1 (en) * 2011-05-13 2012-11-14 Rottapharm Spa ESTERS OF HYALURONIC ACID, THEIR PREPARATION AND USE IN DERMATOLOGY
US9567357B2 (en) 2011-06-24 2017-02-14 Biointeractions Ltd. Biocompatible, biomimetic ampholyte materials
JP5263349B2 (en) * 2011-08-08 2013-08-14 生化学工業株式会社 Biologically active molecule-containing crosslinked heparin gel composition
TWI561535B (en) 2011-10-06 2016-12-11 Bvw Holding Ag Copolymers of hydrophobic and hydrophilic segments that reduce protein adsorption
EP2612846A1 (en) 2012-01-09 2013-07-10 Bayer MaterialScience AG Beta amino acid esters and use of same
CZ2012136A3 (en) 2012-02-28 2013-06-05 Contipro Biotech S.R.O. Derivatives based on hyaluronic acid capable of forming hydrogels, process of their preparation, hydrogels based on these derivatives, process of their preparation and use
CZ304512B6 (en) 2012-08-08 2014-06-11 Contipro Biotech S.R.O. Hyaluronic acid derivative, process for its preparation, modification process and use thereof
CZ304654B6 (en) 2012-11-27 2014-08-20 Contipro Biotech S.R.O. C6-C18-acylated hyaluronate-based nanomicellar composition, process for preparing C6-C18-acylated hyaluronate, process for preparing nanomicellar composition and stabilized nanomicellar composition as well as use thereof
CZ2012844A3 (en) * 2012-11-27 2014-02-05 Contipro Biotech S.R.O. Photoreactive derivative of hyaluronic acid, process for its preparation, 3D crosslinked derivative of hyaluronic acid, process for its preparation and use
ITMI20130162A1 (en) 2013-02-06 2014-08-07 Fidia Farmaceutici PHOTORETIC DERIVATIVES OF HYALURONIC ACID, THEIR PROCESS OF PREPARATION AND USE
USRE49528E1 (en) 2013-04-26 2023-05-16 Biointeractions Ltd. Bioactive coatings
CA3105562C (en) 2013-04-26 2023-03-07 Biointeractions Limited Bioactive coatings
GB2518405A (en) * 2013-09-20 2015-03-25 Zeiss Carl Meditec Ag Composition comprising at least one viscoelastic polymer
CZ304977B6 (en) * 2013-11-21 2015-02-25 Contipro Biotech S.R.O. Nanofibers comprising photocurable ester derivative of hyaluronic acid or a salt thereof, photocured nanofibers, method of their synthesis, composition comprising photocured nanofibers and use thereof
EP3101064B1 (en) 2014-01-31 2020-07-15 Seikagaku Corporation Diamine crosslinking agent, acidic polysaccharide crosslinked body, and medical material
CZ305153B6 (en) 2014-03-11 2015-05-20 Contipro Biotech S.R.O. Conjugates of hyaluronic acid oligomer or a salt thereof, process for their preparation and use
CZ2014451A3 (en) 2014-06-30 2016-01-13 Contipro Pharma A.S. Antitumor composition based on hyaluronic acid and inorganic nanoparticles, process of its preparation and use
EP3831394B1 (en) 2015-01-16 2022-12-21 Seikagaku Corporation Cross-linked chondroitin sulfate, composition containing same, and treatment agent for eye disease
CZ309295B6 (en) 2015-03-09 2022-08-10 Contipro A.S. Self-supporting, biodegradable film based on hydrophobized hyaluronic acid, method of its preparation and use
US11253540B2 (en) 2015-05-29 2022-02-22 Seikagaku Corporation Composition including glycosaminoglycan derivative and chemokine receptor activity regulator
CZ306479B6 (en) 2015-06-15 2017-02-08 Contipro A.S. A method of crosslinking polysaccharides by using photolabile protecting groups
CZ306662B6 (en) 2015-06-26 2017-04-26 Contipro A.S. Sulphated polysaccharides derivatives, the method of their preparation, the method of their modification and the use
WO2017030184A1 (en) * 2015-08-20 2017-02-23 生化学工業株式会社 Agent to be applied to ophthalmic device
JP7015784B2 (en) * 2015-12-29 2022-02-15 ガルデルマ エス．エー． Carbohydrate cross-linking agent
CZ308106B6 (en) 2016-06-27 2020-01-08 Contipro A.S. Unsaturated derivatives of polysaccharides, preparing and using them
CZ2016827A3 (en) * 2016-12-23 2018-02-07 Contipro A.S. An ophthalmic preparation
EP3917973A1 (en) * 2019-01-30 2021-12-08 Bausch & Lomb Incorporated Crosslinked polymeric network and use thereof
KR102240726B1 (en) * 2019-01-31 2021-04-16 주식회사 에스엔비아 Radioisotope-labelled photo-crosslinkable hydrogels and fabrication method thereof
CN113230464B (en) * 2021-04-01 2022-04-12 暨南大学 Anti-restenosis 3D printing self-expanding degradable intravascular stent and preparation method thereof
DE102021212812A1 (en) 2021-11-15 2023-05-17 Bauerfeind Ag Anti-inflammatory viscosupplement containing hyaluronic acid

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2349948A1 (en) * 1972-10-06 1974-05-02 Agency Ind Science Techn NEW PHOTOPOLYMERS
US3960685A (en) * 1973-11-12 1976-06-01 Sumitomo Chemical Company, Limited Photosensitive resin composition containing pullulan or esters thereof
US4141973A (en) * 1975-10-17 1979-02-27 Biotrics, Inc. Ultrapure hyaluronic acid and the use thereof
JPS54128482A (en) * 1978-03-29 1979-10-05 Agency Of Ind Science & Technol Microcapsule and its preparation
JPS5647439A (en) * 1979-09-26 1981-04-30 Japan Synthetic Rubber Co Ltd Photosetting material
US4331697A (en) * 1980-09-02 1982-05-25 Teijin Limited Novel heparin derivative, method for production thereof, and method for rendering biomedical materials antithrombotic by use of the novel heparin derivative
JPS5789751A (en) * 1980-11-25 1982-06-04 Japan Synthetic Rubber Co Ltd Photosensitive material
JPS5789752A (en) * 1980-11-25 1982-06-04 Japan Synthetic Rubber Co Ltd Photosensitive material
US4722906A (en) * 1982-09-29 1988-02-02 Bio-Metric Systems, Inc. Binding reagents and methods
US4973493A (en) * 1982-09-29 1990-11-27 Bio-Metric Systems, Inc. Method of improving the biocompatibility of solid surfaces
US5002582A (en) * 1982-09-29 1991-03-26 Bio-Metric Systems, Inc. Preparation of polymeric surfaces via covalently attaching polymers
US5217492A (en) * 1982-09-29 1993-06-08 Bio-Metric Systems, Inc. Biomolecule attachment to hydrophobic surfaces
US4745098A (en) * 1984-02-24 1988-05-17 The Regents Of The University Of California Compositions and method for improving wound healing
JPH0699482B2 (en) * 1984-04-16 1994-12-07 ダイセル化学工業株式会社 Polysaccharide derivative
US4716224A (en) * 1984-05-04 1987-12-29 Seikagaku Kogyo Co. Ltd. Crosslinked hyaluronic acid and its use
SE442820B (en) * 1984-06-08 1986-02-03 Pharmacia Ab GEL OF THE CROSS-BOND HYALURONIC ACID FOR USE AS A GLASS BODY SUBSTITUTE
JPS6016260A (en) * 1984-06-18 1985-01-28 Hitachi Ltd Heat pump type bath heater
US4863907A (en) * 1984-06-29 1989-09-05 Seikagaku Kogyo Co., Ltd. Crosslinked glycosaminoglycans and their use
SE456346B (en) * 1984-07-23 1988-09-26 Pharmacia Ab GEL TO PREVENT ADHESION BETWEEN BODY TISSUE AND SET FOR ITS PREPARATION
US5128326A (en) * 1984-12-06 1992-07-07 Biomatrix, Inc. Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same
US4979959A (en) * 1986-10-17 1990-12-25 Bio-Metric Systems, Inc. Biocompatible coating for solid surfaces
JPS6439569A (en) * 1987-08-05 1989-02-09 Sumitomo Electric Industries Optical magnetic field sensor
JP2606890B2 (en) * 1988-07-26 1997-05-07 富士通株式会社 Semiconductor chip pickup method
SE8900586L (en) * 1989-02-21 1990-08-22 Pharmacia Ab COMPOSITION AND PROCEDURES TO PREVENT ADHESION BETWEEN BODY TISSUE
DE3912122A1 (en) * 1989-04-13 1990-10-25 Wella Ag UV absorbing chitin and chitosan derivs. - for use in hair and skin protection agents
US5356883A (en) * 1989-08-01 1994-10-18 Research Foundation Of State University Of N.Y. Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use
JP2877423B2 (en) * 1990-03-13 1999-03-31 積水化学工業株式会社 Oral bandage
US5143724A (en) * 1990-07-09 1992-09-01 Biomatrix, Inc. Biocompatible viscoelastic gel slurries, their preparation and use
US5246698A (en) * 1990-07-09 1993-09-21 Biomatrix, Inc. Biocompatible viscoelastic gel slurries, their preparation and use

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KR930017921A (en) 1993-09-20
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US5763504A (en) 1998-06-09
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ATE152736T1 (en) 1997-05-15
HU215503B (en) 1999-01-28
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EP0554898A3 (en) 1994-01-26
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CA2088831C (en) 2004-07-06

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