CA2085255A1 - Polyurethane-biopolymer composite - Google Patents

Polyurethane-biopolymer composite

Info

Publication number
CA2085255A1
CA2085255A1 CA002085255A CA2085255A CA2085255A1 CA 2085255 A1 CA2085255 A1 CA 2085255A1 CA 002085255 A CA002085255 A CA 002085255A CA 2085255 A CA2085255 A CA 2085255A CA 2085255 A1 CA2085255 A1 CA 2085255A1
Authority
CA
Canada
Prior art keywords
cross
drug delivery
polyurethane
wound dressing
biopolymer composite
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002085255A
Other languages
French (fr)
Other versions
CA2085255C (en
Inventor
Matthew Bootman
Ronald Yamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Integra Lifesciences Corp
Original Assignee
Matthew Bootman
Ronald Yamamoto
Vitaphore Corporation
Integra Lifesciences Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matthew Bootman, Ronald Yamamoto, Vitaphore Corporation, Integra Lifesciences Corporation filed Critical Matthew Bootman
Publication of CA2085255A1 publication Critical patent/CA2085255A1/en
Application granted granted Critical
Publication of CA2085255C publication Critical patent/CA2085255C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • A61L15/325—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/60—Liquid-swellable gel-forming materials, e.g. super-absorbents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/08—Processes
    • C08G18/10—Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/64—Macromolecular compounds not provided for by groups C08G18/42 - C08G18/63
    • C08G18/6415—Macromolecular compounds not provided for by groups C08G18/42 - C08G18/63 having nitrogen
    • C08G18/6446—Proteins and derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/64—Macromolecular compounds not provided for by groups C08G18/42 - C08G18/63
    • C08G18/6484—Polysaccharides and derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00902—Plasters containing means
    • A61F2013/00906—Plasters containing means for transcutaneous or transdermal drugs application
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00902—Plasters containing means
    • A61F2013/0091—Plasters containing means with disinfecting or anaesthetics means, e.g. anti-mycrobic

Abstract

A method is provided for preparing a drug delivery material and device comprising cross-linking a biological polymer with a cross-linking agent and loading the cross-linked biopolymer with a bioactive went. Preferred embodiments are disclosed wher-ein the drug delivery material is used in a catheter securing, drug delivery device, in a wound dressing, and in a wound dressing for percutaneous catheters.
CA002085255A 1990-06-14 1991-06-14 Polyurethane-biopolymer composite Expired - Lifetime CA2085255C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53999090A 1990-06-14 1990-06-14
US539,990 1990-06-14
PCT/US1991/004095 WO1991019470A1 (en) 1990-06-14 1991-06-14 Polyurethane-biopolymer composite

Publications (2)

Publication Number Publication Date
CA2085255A1 true CA2085255A1 (en) 1991-12-15
CA2085255C CA2085255C (en) 2001-10-09

Family

ID=24153514

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002085255A Expired - Lifetime CA2085255C (en) 1990-06-14 1991-06-14 Polyurethane-biopolymer composite

Country Status (8)

Country Link
EP (3) EP0797965B1 (en)
JP (1) JP3046623B2 (en)
AT (2) ATE204151T1 (en)
CA (1) CA2085255C (en)
DE (2) DE69132692T2 (en)
DK (1) DK0533809T3 (en)
ES (1) ES2160207T3 (en)
WO (1) WO1991019470A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8529939B2 (en) 2003-12-08 2013-09-10 Gel-Del Technologies, Inc. Mucoadhesive drug delivery devices and methods of making and using thereof
US11890371B2 (en) 2007-12-26 2024-02-06 Petvivo Holdings, Inc. Biocompatible protein-based particles and methods thereof

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5833665A (en) * 1990-06-14 1998-11-10 Integra Lifesciences I, Ltd. Polyurethane-biopolymer composite
GB9213773D0 (en) * 1992-06-29 1992-08-12 Cv Lab Ltd Dual release alginate fibre
US5503844A (en) * 1993-05-18 1996-04-02 Mli Acquisition Corp. Ii Foam laminate transdermal patch
US7662409B2 (en) 1998-09-25 2010-02-16 Gel-Del Technologies, Inc. Protein matrix materials, devices and methods of making and using thereof
JP3557356B2 (en) * 1998-11-04 2004-08-25 株式会社大塚製薬工場 Patch for sanitary management of vascular catheter insertion site
US6309454B1 (en) 2000-05-12 2001-10-30 Johnson & Johnson Medical Limited Freeze-dried composite materials and processes for the production thereof
CA2349989A1 (en) * 2001-06-07 2002-12-07 Paul J. Santerre Bioactive surface modifiers for polymers and articles made therefrom
GB0215023D0 (en) * 2002-06-28 2002-08-07 Bristol Myers Squibb Co Wound dressing
JP2006521445A (en) * 2003-03-14 2006-09-21 サートーマー・テクノロジー・カンパニー・インコーポレイテッド Controlled release polymer gel
US8465537B2 (en) 2003-06-17 2013-06-18 Gel-Del Technologies, Inc. Encapsulated or coated stent systems
DE102004031955A1 (en) * 2004-06-24 2006-01-12 Paul Hartmann Ag wound dressing
CA2574933C (en) * 2004-07-26 2015-05-19 Synthes (U.S.A.) Biocompatible, biodegradable polyurethane materials with controlled hydrophobic to hydrophilic ratio
JP4786189B2 (en) * 2005-02-01 2011-10-05 リンテック株式会社 Adhesive composition for skin application and adhesive sheet for skin application
EP2403886A2 (en) 2009-03-06 2012-01-11 Biopolymer Technologies, Ltd. Protein-containing foams, manufacture and use thereof
CN102439056B (en) 2009-03-06 2016-01-13 生物高聚物技术有限公司 Emulsion containing albumen and tackiness agent and their manufacture and purposes
ES2619849T3 (en) 2010-06-07 2017-06-27 Evertree Adhesives containing protein, and manufacture and use thereof
JP5631783B2 (en) * 2011-03-11 2014-11-26 株式会社イノアック技術研究所 Antibacterial polyurethane
SI2753633T1 (en) 2011-09-09 2017-05-31 Evertree Protein-containing adhesives, and manufacture and use thereof
EP2760879B1 (en) 2011-09-09 2023-06-14 Evertree Protein-containing adhesives, and manufacture and use thereof
WO2014020447A2 (en) 2012-07-30 2014-02-06 Biopolymer Tecnologies, Ltd. Protein adhesives containing an anhydride, carboxylic acid, and/or carboxylate salt compound and their use
US8969649B2 (en) * 2012-08-10 2015-03-03 Ethicon, Inc. Integrated dressing device
US10422158B2 (en) 2012-12-20 2019-09-24 SafeHandles, LLC Replaceable antimicrobial system
EP2907502A1 (en) * 2014-02-17 2015-08-19 Ferrari S.r.l. Interface membrane for the contact with the skin
EP2944565B1 (en) 2014-05-13 2017-09-27 Entrotech, Inc. Erosion protective sleeve
EP3600441A1 (en) 2017-03-22 2020-02-05 Genentech, Inc. Hydrogel cross-linked hyaluronic acid prodrug compositions and methods
US20200261276A1 (en) * 2017-11-08 2020-08-20 University Of Massachusetts Post-Operative Hybrid Dressing To Optimize Skin-Grafting Procedures In Reconstructive Surgery
CN113425501A (en) * 2021-05-31 2021-09-24 振德医疗用品股份有限公司 Negative pressure drainage wound-protecting dressing and negative pressure drainage wound-protecting device
WO2023053884A1 (en) * 2021-09-29 2023-04-06 テルモ株式会社 Adhesion device and adhesion method

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2748882A1 (en) * 1977-11-02 1979-05-03 Arnis Dr Med Rava Plaster protecting wound against infection - esp. during application of intravenous catheter, permitting continuous use for ten days
CA1190855A (en) * 1980-09-03 1985-07-23 Rolf W. Pfirrmann Treatment of osteitis
EP0119248B1 (en) * 1982-09-13 1989-04-12 Hydromer, Inc. Anti-bacterial medical material and device
GB8319766D0 (en) * 1983-07-22 1983-08-24 Graham N B Controlled release device
DK96985A (en) * 1984-03-02 1985-09-03 Dow Chemical Co PROCEDURE FOR THE PREPARATION OF CROSS-BOND POLYAMINES
EP0224987B1 (en) * 1985-11-29 1992-04-15 Biomatrix, Inc. Drug delivery systems based on hyaluronan, derivatives thereof and their salts and method of producing same
US4847049A (en) * 1985-12-18 1989-07-11 Vitaphore Corporation Method of forming chelated collagen having bactericidal properties
US4915694A (en) * 1987-10-02 1990-04-10 Vitaphore Corporation Antimicrobial wound dressing and skin fixator for percutaneous conduits
US4861652A (en) * 1987-10-13 1989-08-29 Kimberly-Clark Corporation Diaper article with elasticized waist panel
IT1219587B (en) * 1988-05-13 1990-05-18 Fidia Farmaceutici SELF-CROSS-LINKED CARBOXYLY POLYSACCHARIDES
DE3836828A1 (en) * 1988-10-28 1990-05-03 Pfrimmer Kabi Gmbh & Co Kg LIABILITY FOR INTRAVENOESE PERIPHERE CANUELEN
US5162430A (en) * 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8529939B2 (en) 2003-12-08 2013-09-10 Gel-Del Technologies, Inc. Mucoadhesive drug delivery devices and methods of making and using thereof
US11890371B2 (en) 2007-12-26 2024-02-06 Petvivo Holdings, Inc. Biocompatible protein-based particles and methods thereof

Also Published As

Publication number Publication date
EP0533809A1 (en) 1993-03-31
EP0533809B1 (en) 1997-07-30
ATE204151T1 (en) 2001-09-15
DE69132692T2 (en) 2002-07-04
JP3046623B2 (en) 2000-05-29
EP0797965B1 (en) 2001-08-16
JPH05507925A (en) 1993-11-11
DE69127081T2 (en) 1998-02-05
EP1120112A3 (en) 2001-11-14
DE69132692D1 (en) 2001-09-20
ES2160207T3 (en) 2001-11-01
ATE155996T1 (en) 1997-08-15
EP0533809A4 (en) 1994-09-07
DE69127081D1 (en) 1997-09-04
DK0533809T3 (en) 1997-08-25
EP1120112A2 (en) 2001-08-01
CA2085255C (en) 2001-10-09
EP0797965A1 (en) 1997-10-01
WO1991019470A1 (en) 1991-12-26

Similar Documents

Publication Publication Date Title
CA2085255A1 (en) Polyurethane-biopolymer composite
US5833665A (en) Polyurethane-biopolymer composite
EP0674528A4 (en) Cyclodextrin and polymer based drug delivery system.
HK199696A (en) Swelling modulated polymeric drug delivery device
WO1997029778A3 (en) Bioresponsive pharmacologically-active polymers and articles made therefrom
IL82834A0 (en) Biodegradable polymeric materials based on polyether glycols,processes for the preparation thereof and surgical articles made therefrom
CA2103306A1 (en) Extrudable compositions for topical or transdermal drug delivery
EP0514913A3 (en) A polymeric article, such as a medical catheter, and method for making the same
JPS6247372A (en) Drug release member, its production and medical plaster material using said member
EP0402031A3 (en) Injectable polymeric bodies
EP0683207A3 (en) L-lactic acid polymer composition, molded product and film.
PL289322A1 (en) Method of obtaining a composition of controllable release of medicine contained therein
CA2063521A1 (en) Tacky, hydrophilic gel dressings and products therefrom
AU1498892A (en) Process for preparing polymer polyols, and polymer polyol so made
NZ220016A (en) Transdermal drug delivery system with drug reservoir(s), adhesive layer(s) and flexible backing layer
AU559597B2 (en) Storage bag
AU3321293A (en) Polymer matrix drug delivery apparatus and method
AU3127697A (en) Intravenous catheter and delivery system
CA2060242A1 (en) Net wound dressings
EP0417572A3 (en) Extended drug delivery of small, water-soluble molecules
DE3750639T2 (en) Polymeric drug with controlled physical properties and process for its manufacture.
CA2106312A1 (en) Percutaneous anaesthesia
EP0423628A3 (en) Core-shell polymer, resin composition and molded article thereof
RU93035980A (en) MEANS FOR TREATMENT OF THE RAS AND FIRST AID MEASURES
CA2135439A1 (en) Water-curable supporting bandage

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry