CA2078568A1 - Method of improving assay sensitivity - Google Patents

Method of improving assay sensitivity

Info

Publication number
CA2078568A1
CA2078568A1 CA002078568A CA2078568A CA2078568A1 CA 2078568 A1 CA2078568 A1 CA 2078568A1 CA 002078568 A CA002078568 A CA 002078568A CA 2078568 A CA2078568 A CA 2078568A CA 2078568 A1 CA2078568 A1 CA 2078568A1
Authority
CA
Canada
Prior art keywords
assay sensitivity
optical
improving assay
relates
edge
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002078568A
Other languages
French (fr)
Other versions
CA2078568C (en
Inventor
John Worthington Attridge
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Serono SA
Original Assignee
John Worthington Attridge
Applied Research Systems Ars Holding N.V.
Laboratoires Serono S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by John Worthington Attridge, Applied Research Systems Ars Holding N.V., Laboratoires Serono S.A. filed Critical John Worthington Attridge
Publication of CA2078568A1 publication Critical patent/CA2078568A1/en
Application granted granted Critical
Publication of CA2078568C publication Critical patent/CA2078568C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0346—Capillary cells; Microcells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G01N2021/6465—Angular discrimination
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769—Measurement method of reaction-produced change in sensor
    • G01N2021/7786—Fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/804—Radioisotope, e.g. radioimmunoassay

Abstract

The invention relates to a method of reducing scattering of light emerging from an optical edge of an optical waveguide.
According to the invention, the optical edge is maintained in intimate contact with an index matching substance which itself also forms or intimately contacts a further optical component. The invention also relates to a disposable holder suitable for use in the method.
CA002078568A 1990-04-11 1991-04-10 Method of improving assay sensitivity Expired - Fee Related CA2078568C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB909008261A GB9008261D0 (en) 1990-04-11 1990-04-11 Method of improving assay sensitivity
GB9008261.1 1990-04-11
PCT/GB1991/000567 WO1991015751A1 (en) 1990-04-11 1991-04-10 Method of improving assay sensitivity

Publications (2)

Publication Number Publication Date
CA2078568A1 true CA2078568A1 (en) 1991-10-12
CA2078568C CA2078568C (en) 2002-06-11

Family

ID=10674305

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002078568A Expired - Fee Related CA2078568C (en) 1990-04-11 1991-04-10 Method of improving assay sensitivity

Country Status (12)

Country Link
US (1) US5369717A (en)
EP (1) EP0524224B1 (en)
JP (1) JP3286314B2 (en)
AT (1) ATE135818T1 (en)
AU (1) AU642736B2 (en)
CA (1) CA2078568C (en)
DE (1) DE69118178T2 (en)
DK (1) DK0524224T3 (en)
ES (1) ES2084813T3 (en)
GB (1) GB9008261D0 (en)
GR (1) GR3019483T3 (en)
WO (1) WO1991015751A1 (en)

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US5192510A (en) * 1991-01-30 1993-03-09 E. I. Du Pont De Nemours And Company Apparatus for performing fluorescent assays which separates bulk and evanescent fluorescence
US5677196A (en) * 1993-05-18 1997-10-14 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
US5919712A (en) 1993-05-18 1999-07-06 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
WO1996023220A1 (en) * 1995-01-27 1996-08-01 Northeastern University Polyvinyl alcohol (pva) based covalently bonded stable hydrophilic coating for capillary electrophoresis
US5669997A (en) * 1995-07-13 1997-09-23 Hughes Danbury Optical Systems, Inc. Method of bonding optical members together
US6611634B2 (en) 1996-03-19 2003-08-26 University Of Utah Research Foundation Lens and associatable flow cell
US5568253A (en) * 1996-03-20 1996-10-22 Taiwan Semiconductor Manufacturing Company Ltd. Sample holder for sample testing apparatus
US6180288B1 (en) 1997-03-21 2001-01-30 Kimberly-Clark Worldwide, Inc. Gel sensors and method of use thereof
US6060256A (en) 1997-12-16 2000-05-09 Kimberly-Clark Worldwide, Inc. Optical diffraction biosensor
GB9903283D0 (en) * 1998-06-01 1999-04-07 Farfield Sensors Ltd Device
US6221579B1 (en) 1998-12-11 2001-04-24 Kimberly-Clark Worldwide, Inc. Patterned binding of functionalized microspheres for optical diffraction-based biosensors
US6579673B2 (en) 1998-12-17 2003-06-17 Kimberly-Clark Worldwide, Inc. Patterned deposition of antibody binding protein for optical diffraction-based biosensors
US6701032B1 (en) 1999-05-27 2004-03-02 Farfield Sensors Limited Device for housing a planar optical component
US6370837B1 (en) 1999-08-04 2002-04-16 Anthony B. Mcmahon System for laying masonry blocks
US7167615B1 (en) 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
US6399295B1 (en) 1999-12-17 2002-06-04 Kimberly-Clark Worldwide, Inc. Use of wicking agent to eliminate wash steps for optical diffraction-based biosensors
US7158224B2 (en) * 2000-06-25 2007-01-02 Affymetrix, Inc. Optically active substrates
EP1311892B1 (en) * 2000-08-18 2004-11-03 Koninklijke Philips Electronics N.V. Optical component and method of manufacturing same
US7098041B2 (en) 2001-12-11 2006-08-29 Kimberly-Clark Worldwide, Inc. Methods to view and analyze the results from diffraction-based diagnostics
US7102752B2 (en) 2001-12-11 2006-09-05 Kimberly-Clark Worldwide, Inc. Systems to view and analyze the results from diffraction-based diagnostics
US20030119203A1 (en) 2001-12-24 2003-06-26 Kimberly-Clark Worldwide, Inc. Lateral flow assay devices and methods for conducting assays
US8367013B2 (en) 2001-12-24 2013-02-05 Kimberly-Clark Worldwide, Inc. Reading device, method, and system for conducting lateral flow assays
US20030156819A1 (en) * 2002-02-15 2003-08-21 Mark Pruss Optical waveguide
US7223368B2 (en) 2002-05-03 2007-05-29 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7771922B2 (en) 2002-05-03 2010-08-10 Kimberly-Clark Worldwide, Inc. Biomolecule diagnostic device
US7118855B2 (en) * 2002-05-03 2006-10-10 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7214530B2 (en) * 2002-05-03 2007-05-08 Kimberly-Clark Worldwide, Inc. Biomolecule diagnostic devices and method for producing biomolecule diagnostic devices
US7485453B2 (en) * 2002-05-03 2009-02-03 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7223534B2 (en) 2002-05-03 2007-05-29 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7091049B2 (en) 2002-06-26 2006-08-15 Kimberly-Clark Worldwide, Inc. Enhanced diffraction-based biosensor devices
US7285424B2 (en) 2002-08-27 2007-10-23 Kimberly-Clark Worldwide, Inc. Membrane-based assay devices
US7169550B2 (en) * 2002-09-26 2007-01-30 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7781172B2 (en) 2003-11-21 2010-08-24 Kimberly-Clark Worldwide, Inc. Method for extending the dynamic detection range of assay devices
US7247500B2 (en) 2002-12-19 2007-07-24 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in membrane-based assay devices
US8675276B2 (en) * 2003-02-21 2014-03-18 Kla-Tencor Corporation Catadioptric imaging system for broad band microscopy
US7851209B2 (en) 2003-04-03 2010-12-14 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in assay devices
US20040197819A1 (en) 2003-04-03 2004-10-07 Kimberly-Clark Worldwide, Inc. Assay devices that utilize hollow particles
US20050112703A1 (en) 2003-11-21 2005-05-26 Kimberly-Clark Worldwide, Inc. Membrane-based lateral flow assay devices that utilize phosphorescent detection
US7713748B2 (en) 2003-11-21 2010-05-11 Kimberly-Clark Worldwide, Inc. Method of reducing the sensitivity of assay devices
US7943395B2 (en) 2003-11-21 2011-05-17 Kimberly-Clark Worldwide, Inc. Extension of the dynamic detection range of assay devices
US7943089B2 (en) 2003-12-19 2011-05-17 Kimberly-Clark Worldwide, Inc. Laminated assay devices
US20070196863A1 (en) * 2006-02-17 2007-08-23 Hanson Technologies, Inc. Prion protein detection
US20080026373A1 (en) * 2006-07-26 2008-01-31 Rodionova Natalia A Assays Based On Light Emission From Analyte Complexes Within A Cassette
US9357925B2 (en) * 2013-08-02 2016-06-07 John Adamovics Method and apparatus for scanning 3D dosimeters

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US4124364A (en) * 1976-12-02 1978-11-07 International Standard Electric Corporation Method for making glass sleeve fiber splice
US4469500A (en) * 1981-01-26 1984-09-04 Rca Corporation Method of cleaving a crystal to produce a high optical quality corner
EP0245206A1 (en) * 1986-05-05 1987-11-11 IntraCel Corporation Analytical method for detecting and measuring specifically sequenced nucleic acid
GB8619823D0 (en) * 1986-08-14 1986-09-24 Buckley B M Determining level of analyte
US5152962A (en) * 1988-07-22 1992-10-06 Ord Corp. Immunoassay apparatus
ES2063348T3 (en) * 1989-04-11 1995-01-01 Ars Holding 89 Nv MULTIANALYTICAL TRIAL VEHICLE.
GB8911462D0 (en) * 1989-05-18 1989-07-05 Ares Serono Res & Dev Ltd Devices for use in chemical test procedures
CA2033168C (en) * 1989-06-22 1998-08-18 John Worthington Attridge Method of optical analysis
US5061857A (en) * 1990-11-09 1991-10-29 The United States Of America As Represented By The Secretary Of The Navy Waveguide-binding sensor for use with assays
US5192510A (en) * 1991-01-30 1993-03-09 E. I. Du Pont De Nemours And Company Apparatus for performing fluorescent assays which separates bulk and evanescent fluorescence

Also Published As

Publication number Publication date
US5369717A (en) 1994-11-29
CA2078568C (en) 2002-06-11
EP0524224B1 (en) 1996-03-20
ES2084813T3 (en) 1996-05-16
AU642736B2 (en) 1993-10-28
ATE135818T1 (en) 1996-04-15
AU7668991A (en) 1991-10-30
JP3286314B2 (en) 2002-05-27
GR3019483T3 (en) 1996-07-31
DE69118178D1 (en) 1996-04-25
GB9008261D0 (en) 1990-06-13
JPH05505874A (en) 1993-08-26
WO1991015751A1 (en) 1991-10-17
EP0524224A1 (en) 1993-01-27
DK0524224T3 (en) 1996-04-15
DE69118178T2 (en) 1996-09-12

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