CA2078347A1 - Use of copper(ii) containing compounds to accelerate wound healing - Google Patents
Use of copper(ii) containing compounds to accelerate wound healingInfo
- Publication number
- CA2078347A1 CA2078347A1 CA2078347A CA2078347A CA2078347A1 CA 2078347 A1 CA2078347 A1 CA 2078347A1 CA 2078347 A CA2078347 A CA 2078347A CA 2078347 A CA2078347 A CA 2078347A CA 2078347 A1 CA2078347 A1 CA 2078347A1
- Authority
- CA
- Canada
- Prior art keywords
- copper
- containing compounds
- wound healing
- accelerate
- warm
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/34—Copper; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Compositions of copper(II) containing compounds for use as active therapeutic substances, to accelerate healing of wounds in warm-blooded animals, and in the manufacture of medicaments for accelerating wound healing in warm-blooded ani-mals are disclosed. Methods of the present invention include systemic loading of copper(II) to accelerate the rate of wound heal-ing following injury or surgery. The copper(II) containing compounds include copper(II) complexes with amino acids and pep-tides, and copper(II) salts.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/499,606 US5164367A (en) | 1990-03-26 | 1990-03-26 | Method of using copper(ii) containing compounds to accelerate wound healing |
US499,606 | 1990-03-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2078347A1 true CA2078347A1 (en) | 1991-09-27 |
CA2078347C CA2078347C (en) | 1996-07-02 |
Family
ID=23985940
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002078347A Expired - Lifetime CA2078347C (en) | 1990-03-26 | 1991-03-26 | Use of copper(ii) containing compounds to accelerate wound healing |
Country Status (8)
Country | Link |
---|---|
US (1) | US5164367A (en) |
EP (1) | EP0522004B1 (en) |
JP (1) | JPH05505808A (en) |
AT (1) | ATE187646T1 (en) |
AU (1) | AU7565091A (en) |
CA (1) | CA2078347C (en) |
DE (1) | DE69131847T2 (en) |
WO (1) | WO1991014437A2 (en) |
Families Citing this family (79)
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MX172248B (en) * | 1989-12-20 | 1993-12-09 | Univ Mexico | PROCEDURE FOR THE OBTAINING OF NEW MIXED COPPER AMINO ACID COMPLEXES BASED ON FENYLATED PHENANTROLINS AS ANTI-CANCER AGENTS |
US5382431A (en) * | 1992-09-29 | 1995-01-17 | Skin Biology, Inc. | Tissue protective and regenerative compositions |
WO1995026198A1 (en) * | 1994-03-28 | 1995-10-05 | Skin Biology, Inc. | Metal complexes of aloe extracts for skin and hair |
WO1995026194A1 (en) * | 1994-03-28 | 1995-10-05 | Skin Biology, Inc. | Allantoin-metal complexes for skin and hair |
AU2231495A (en) * | 1994-03-28 | 1995-10-17 | Skin Biology, Inc. | Starch-metal complexes for skin and hair |
JPH07316192A (en) * | 1994-05-27 | 1995-12-05 | Hoechst Japan Ltd | L-lysyl-glycyl-l-histidine and therapeutic agent for wound |
US5656588A (en) * | 1994-07-19 | 1997-08-12 | Wake Forest University | Wound healing formula |
ES2081771B1 (en) * | 1994-08-05 | 1996-10-01 | Arredondo Javier Olaechea | COMPOSITION OF A LIQUID PRODUCT FOR TOPICAL USE FOR BURNS AND BLOWS. |
US5888522A (en) * | 1996-08-23 | 1999-03-30 | Skin Biology, Inc. | Tissue protective and regenerative compositions |
US6096861A (en) * | 1997-03-18 | 2000-08-01 | The Regents Of The University Of California | Peptide-peptoid metal complexes |
US7632803B2 (en) | 1999-10-01 | 2009-12-15 | Dmi Life Sciences, Inc. | Metal-binding compounds and uses therefor |
AU770999C (en) | 1999-10-01 | 2005-04-21 | Ampio Pharmaceuticals, Inc. | Metal-binding compounds and uses therefor |
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US20030130185A1 (en) * | 2000-09-29 | 2003-07-10 | David Bar-Or | Metal-binding compounds and uses therefor |
US8512718B2 (en) | 2000-07-03 | 2013-08-20 | Foamix Ltd. | Pharmaceutical composition for topical application |
US20030166510A1 (en) * | 2000-10-11 | 2003-09-04 | Pickart Loren R. | Methods and compositions for increasing skin remodeling |
WO2003030926A1 (en) * | 2001-10-05 | 2003-04-17 | Procyte Corporation | Stable solutions of peptide copper complexes and cosmetic and pharmaceutical formulations produced therefrom |
US20050209131A1 (en) * | 2001-11-16 | 2005-09-22 | Singleton Laura C | Composition containing peptides complexed with a copper ion |
AU2003247816A1 (en) * | 2002-07-02 | 2004-01-23 | Procyte Corporation | Compositions containing peptide copper complexes and soft tissue fillers |
IL152486A0 (en) | 2002-10-25 | 2003-05-29 | Meir Eini | Alcohol-free cosmetic and pharmaceutical foam carrier |
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MXPA05004278A (en) | 2002-10-25 | 2005-10-05 | Foamix Ltd | Cosmetic and pharmaceutical foam. |
US8486376B2 (en) | 2002-10-25 | 2013-07-16 | Foamix Ltd. | Moisturizing foam containing lanolin |
US8900554B2 (en) | 2002-10-25 | 2014-12-02 | Foamix Pharmaceuticals Ltd. | Foamable composition and uses thereof |
US7704518B2 (en) | 2003-08-04 | 2010-04-27 | Foamix, Ltd. | Foamable vehicle and pharmaceutical compositions thereof |
US8119109B2 (en) | 2002-10-25 | 2012-02-21 | Foamix Ltd. | Foamable compositions, kits and methods for hyperhidrosis |
US9211259B2 (en) | 2002-11-29 | 2015-12-15 | Foamix Pharmaceuticals Ltd. | Antibiotic kit and composition and uses thereof |
US7820145B2 (en) | 2003-08-04 | 2010-10-26 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
US9668972B2 (en) | 2002-10-25 | 2017-06-06 | Foamix Pharmaceuticals Ltd. | Nonsteroidal immunomodulating kit and composition and uses thereof |
US20080138296A1 (en) | 2002-10-25 | 2008-06-12 | Foamix Ltd. | Foam prepared from nanoemulsions and uses |
US8119150B2 (en) | 2002-10-25 | 2012-02-21 | Foamix Ltd. | Non-flammable insecticide composition and uses thereof |
US7700076B2 (en) | 2002-10-25 | 2010-04-20 | Foamix, Ltd. | Penetrating pharmaceutical foam |
US20040142853A1 (en) * | 2002-11-07 | 2004-07-22 | Procyte Corporation | Stimulation of hair growth by compositions containing peptide copper complexes and minoxidil |
US20040197319A1 (en) * | 2003-03-24 | 2004-10-07 | Paul Harch | Wound healing composition derived from low platelet concentration plasma |
US7128923B2 (en) * | 2003-03-31 | 2006-10-31 | Procyte Corporation | Preserved and stable compositions containing peptide copper complexes and method related thereto |
US6927205B2 (en) * | 2003-04-28 | 2005-08-09 | Procyte Corporation | Compositions and methods for treatment of psoriasis |
US7575739B2 (en) | 2003-04-28 | 2009-08-18 | Foamix Ltd. | Foamable iodine composition |
CA2526971A1 (en) * | 2003-06-04 | 2005-01-06 | Ebersytes, Llc | Novel dermatological composition |
US6927206B2 (en) | 2003-06-06 | 2005-08-09 | Procyte Corporation | Compositions and methods for treatment of rosacea |
US20060246047A1 (en) * | 2003-06-24 | 2006-11-02 | Masaya Imoto | Peptide wirh apoptosis-inhibiting activity |
US8795693B2 (en) | 2003-08-04 | 2014-08-05 | Foamix Ltd. | Compositions with modulating agents |
US8486374B2 (en) | 2003-08-04 | 2013-07-16 | Foamix Ltd. | Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses |
WO2005097061A1 (en) * | 2004-04-01 | 2005-10-20 | Procyte Corporation | Encapsulated peptide copper complexes and compositions and methods related thereto |
WO2006023465A1 (en) * | 2004-08-18 | 2006-03-02 | Procyte Corporation | Polyethylene glycol-peptide copper complexes and compositions and methods related thereto |
TW200700107A (en) * | 2005-03-16 | 2007-01-01 | Procyte Corp | Methods and compositions for preventing and treating aging or photodamaged skin |
WO2007087738A1 (en) * | 2006-02-03 | 2007-08-09 | Pentapharm Ag | Biologically active tripeptides and copper complexes and salts thereof |
US7687650B2 (en) | 2006-02-03 | 2010-03-30 | Jr Chem, Llc | Chemical compositions and methods of making them |
US7927614B2 (en) | 2006-02-03 | 2011-04-19 | Jr Chem, Llc | Anti-aging treatment using copper and zinc compositions |
US7897800B2 (en) | 2006-02-03 | 2011-03-01 | Jr Chem, Llc | Chemical compositions and methods of making them |
ES2283212B1 (en) * | 2006-03-31 | 2008-08-16 | Lipotec S.A. | USEFUL SYNTHETIC PEPTIDES IN THE TREATMENT OF SKIN AND ITS USE IN COSMETIC OR DERMOPHARMACEUTICAL COMPOSITIONS. |
US7867522B2 (en) | 2006-09-28 | 2011-01-11 | Jr Chem, Llc | Method of wound/burn healing using copper-zinc compositions |
US20080260655A1 (en) | 2006-11-14 | 2008-10-23 | Dov Tamarkin | Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses |
US8636982B2 (en) | 2007-08-07 | 2014-01-28 | Foamix Ltd. | Wax foamable vehicle and pharmaceutical compositions thereof |
WO2009069006A2 (en) | 2007-11-30 | 2009-06-04 | Foamix Ltd. | Foam containing benzoyl peroxide |
WO2010041141A2 (en) | 2008-10-07 | 2010-04-15 | Foamix Ltd. | Oil-based foamable carriers and formulations |
WO2009072007A2 (en) | 2007-12-07 | 2009-06-11 | Foamix Ltd. | Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof |
US8273791B2 (en) | 2008-01-04 | 2012-09-25 | Jr Chem, Llc | Compositions, kits and regimens for the treatment of skin, especially décolletage |
CA2712120A1 (en) | 2008-01-14 | 2009-07-23 | Foamix Ltd. | Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses |
WO2010085753A1 (en) | 2009-01-23 | 2010-07-29 | Jr Chem, Llc | Rosacea treatments and kits for performing them |
WO2010125470A2 (en) | 2009-04-28 | 2010-11-04 | Foamix Ltd. | Foamable vehicle and pharmaceutical compositions comprising aprotic polar solvents and uses thereof |
WO2011013009A2 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses |
CA2769677A1 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses |
CA2776474C (en) | 2009-10-02 | 2021-01-12 | Foamix Ltd. | Topical tetracycline compositions |
US9849142B2 (en) | 2009-10-02 | 2017-12-26 | Foamix Pharmaceuticals Ltd. | Methods for accelerated return of skin integrity and for the treatment of impetigo |
US8952057B2 (en) | 2011-01-11 | 2015-02-10 | Jr Chem, Llc | Compositions for anorectal use and methods for treating anorectal disorders |
US9586989B1 (en) | 2011-04-12 | 2017-03-07 | Skin Biology, Inc. | Non-toxic skin cancer therapy with copper peptides |
US10398733B2 (en) | 2013-03-15 | 2019-09-03 | Cda Research Group, Inc. | Topical copper ion treatments and methods of treatment using topical copper ion treatments in the dermatological areas of the body |
US11083750B2 (en) * | 2013-03-15 | 2021-08-10 | Cda Research Group, Inc. | Methods of treatment using topical copper ion formulations |
US11000545B2 (en) | 2013-03-15 | 2021-05-11 | Cda Research Group, Inc. | Copper ion compositions and methods of treatment for conditions caused by coronavirus and influenza |
US11007143B2 (en) | 2013-03-15 | 2021-05-18 | Cda Research Group, Inc. | Topical copper ion treatments and methods of treatment using topical copper ion treatments in the oral-respiratory-otic areas of the body |
US11318089B2 (en) | 2013-03-15 | 2022-05-03 | Cda Research Group, Inc. | Topical copper ion treatments and methods of making topical copper ion treatments for use in various anatomical areas of the body |
GB201507002D0 (en) * | 2015-04-24 | 2015-06-10 | Medical Res Council | Copper Oxo-hydroxide nanoparticles and their uses as biocidal agents |
WO2017049529A1 (en) | 2015-09-24 | 2017-03-30 | Innolife Co., Ltd. | A pharmaceutical composition comprising a copper chelating tetramine and the use thereof |
MX2020012139A (en) | 2016-09-08 | 2021-01-29 | Vyne Pharmaceuticals Inc | Compositions and methods for treating rosacea and acne. |
US11193184B2 (en) | 2019-02-22 | 2021-12-07 | Cda Research Group, Inc. | System for use in producing a metal ion suspension and process of using same |
US11471497B1 (en) | 2019-03-13 | 2022-10-18 | David Gordon Bermudes | Copper chelation therapeutics |
US10898724B2 (en) | 2019-06-11 | 2021-01-26 | Soletluna Holdings, Inc. | Wearable phototherapy apparatus with anti-viral and other effects |
US10716953B1 (en) * | 2019-06-11 | 2020-07-21 | Soletluna Holdings, Inc. | Wearable phototherapy apparatus |
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---|---|---|---|---|
US3194732A (en) * | 1960-10-03 | 1965-07-13 | Neuhauser Irene | Assisting healing of skin-denuded areas on the body with dried non-fibrous egg-shellmembrane products and compositions therefor |
US3558770A (en) * | 1967-09-01 | 1971-01-26 | Kraftco Corp | Wound treating composition employing an enzyme modified casein |
US3551554A (en) * | 1968-08-16 | 1970-12-29 | Crown Zellerbach Corp | Enhancing tissue penetration of physiologically active agents with dmso |
US3767784A (en) * | 1970-12-01 | 1973-10-23 | S Gluck | Composition for the protection and treatment of injured body tissue and method of utilizing the same |
US3832338A (en) * | 1972-03-23 | 1974-08-27 | Diagnostic Data Inc | Orgotein production using a buffer solution containing divalent metal salts |
US3758682A (en) * | 1972-03-23 | 1973-09-11 | Diagnostics Data Inc | Pharmaceutical compositions comprising orgotein and their use |
US4022888A (en) * | 1975-09-09 | 1977-05-10 | Diagnostic Data, Inc. | Esterified orgotein |
DE2700043C2 (en) * | 1977-01-03 | 1983-12-08 | Thera Gesellschaft für Patentverwertung mbH, 8036 Herrsching | Means to improve blood circulation and wound healing |
US4167945A (en) * | 1977-01-31 | 1979-09-18 | Gottlieb Sheldon K | Method for enhancing the healing of grafted tissue |
US4287184A (en) * | 1977-11-23 | 1981-09-01 | The Massachusetts General Hospital | Process for healing wounds |
US4263428A (en) * | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
US4440788A (en) * | 1980-05-13 | 1984-04-03 | Mitsubishi Chemical Industries, Limited | Cysteine derivatives |
US4461724A (en) * | 1981-10-28 | 1984-07-24 | Nippon Zoki Pharmaceutical Co., Ltd. | Peptide compounds, a process for manufacturing them, pharmaceutical compositions containing them, and methods for treating ulcer and thrombus with them |
HU193289B (en) * | 1984-06-19 | 1987-09-28 | Universal Vegyipari Szoevetkez | Cosmetical composition for treating hair and nail containing blood plasma concentrate as active agent |
US4937230A (en) * | 1985-01-24 | 1990-06-26 | Procyte Corporation | Method of healing wounds in horses |
US4760051A (en) * | 1985-01-24 | 1988-07-26 | Pickart Loren R | Use of GHL-Cu as a wound-healing and anti-inflammatory agent |
US4810693A (en) * | 1985-02-08 | 1989-03-07 | Procyte Corporation | Method for inducing biological coverings in wounds |
US4767753A (en) * | 1985-02-08 | 1988-08-30 | Procyte Corporation | Methods and compositions for preventing ulcers |
US4665054A (en) * | 1985-02-08 | 1987-05-12 | Bioheal, Inc. | Chemical derivatives of GHL-Cu |
ATE103608T1 (en) * | 1987-04-20 | 1994-04-15 | Procyte Corp | CHEMICAL DERIVATIVES OF GHL-CU. |
AU1799588A (en) * | 1987-05-11 | 1988-12-06 | Procyte Corporation | Method of tumor inhibition in warm-blooded animals |
CA1323839C (en) * | 1987-05-11 | 1993-11-02 | Loren Ralph Pickart | Methods for stimulating hair growth |
-
1990
- 1990-03-26 US US07/499,606 patent/US5164367A/en not_active Expired - Lifetime
-
1991
- 1991-03-26 AT AT91907108T patent/ATE187646T1/en not_active IP Right Cessation
- 1991-03-26 DE DE69131847T patent/DE69131847T2/en not_active Expired - Fee Related
- 1991-03-26 CA CA002078347A patent/CA2078347C/en not_active Expired - Lifetime
- 1991-03-26 EP EP91907108A patent/EP0522004B1/en not_active Expired - Lifetime
- 1991-03-26 JP JP91506664A patent/JPH05505808A/en active Pending
- 1991-03-26 AU AU75650/91A patent/AU7565091A/en not_active Abandoned
- 1991-03-26 WO PCT/US1991/002028 patent/WO1991014437A2/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
EP0522004A1 (en) | 1993-01-13 |
AU7565091A (en) | 1991-10-21 |
EP0522004B1 (en) | 1999-12-15 |
WO1991014437A2 (en) | 1991-10-03 |
WO1991014437A3 (en) | 1991-11-28 |
DE69131847T2 (en) | 2000-04-27 |
JPH05505808A (en) | 1993-08-26 |
DE69131847D1 (en) | 2000-01-20 |
ATE187646T1 (en) | 2000-01-15 |
CA2078347C (en) | 1996-07-02 |
US5164367A (en) | 1992-11-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed | ||
MKEC | Expiry (correction) |
Effective date: 20121202 |