CA2075201A1 - Use of an .alpha.-tocopherol phosphate or a derivative thereof for preparing cosmetic, dermatological or pharmaceutical compositions, and compositions thereby obtained - Google Patents
Use of an .alpha.-tocopherol phosphate or a derivative thereof for preparing cosmetic, dermatological or pharmaceutical compositions, and compositions thereby obtainedInfo
- Publication number
- CA2075201A1 CA2075201A1 CA002075201A CA2075201A CA2075201A1 CA 2075201 A1 CA2075201 A1 CA 2075201A1 CA 002075201 A CA002075201 A CA 002075201A CA 2075201 A CA2075201 A CA 2075201A CA 2075201 A1 CA2075201 A1 CA 2075201A1
- Authority
- CA
- Canada
- Prior art keywords
- compositions
- dermatological
- hydrogen atom
- methyl
- radical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/02—Preparations containing skin colorants, e.g. pigments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/75—Anti-irritant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/002—Aftershave preparations
Abstract
The present invention relates to the use of an a-tocopherol phosphate, especially in its d1 or d form, or an ester thereof, of the general formula (see formula I) in which: R1 is a hydrogen atom, an alkyl radical having from 1 to 4 carbon atoms, such as the methyl or ethyl radical. in particular, or an a-tocopheryl radi-cal; and R2 is a hydrogen atom, an alkyl radical having from 1 to 4 carbon atoms, such as a methyl or ethyl radical in particular, or an oxyethylene chain of the formula (see formula II) in which R3 and R4 independently are a hydrogen atom or a methyl radical and n is an integer greater than or equal to 1, or a salt thereof, for preparing a pharma-ceutical, dermatological or cosmetic composition for the prevention or treatment of allergic manifestations such as skin allergy or bronchial asthma, or inflamma-tory manifestations, or for the prevention or treatment of the harmful effects of free radicals.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9001143A FR2657526B1 (en) | 1990-01-31 | 1990-01-31 | USE OF AN ALPHA-TOCOPHEROL PHOSPHATE, OR ONE OF ITS DERIVATIVES, FOR THE PREPARATION OF COSMETIC, DERMATOLOGICAL, OR PHARMACEUTICAL COMPOSITIONS; COMPOSITIONS THUS OBTAINED. |
FR9001143 | 1990-01-31 | ||
PCT/FR1991/000055 WO1991011189A1 (en) | 1990-01-31 | 1991-01-30 | USE OF AN α-TOCOPHEROL PHOSPHATE OR A DERIVATIVE THEREOF FOR PREPARING COSMETIC, DERMATOLOGICAL OR PHARMACEUTICAL COMPOSITIONS, AND COMPOSITIONS THEREBY OBTAINED |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2075201A1 true CA2075201A1 (en) | 1991-08-01 |
CA2075201C CA2075201C (en) | 2003-12-02 |
Family
ID=9393284
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002075201A Expired - Lifetime CA2075201C (en) | 1990-01-31 | 1991-01-30 | Use of an .alpha.-tocopherol phosphate or a derivative thereof for preparing cosmetic, dermatological or pharmaceutical compositions, and compositions thereby obtained |
Country Status (11)
Country | Link |
---|---|
US (3) | US5387579A (en) |
EP (2) | EP0652010B1 (en) |
JP (1) | JP3186763B2 (en) |
AT (1) | ATE132370T1 (en) |
CA (1) | CA2075201C (en) |
DE (2) | DE69128653T2 (en) |
DK (1) | DK0513104T3 (en) |
ES (2) | ES2084808T3 (en) |
FR (1) | FR2657526B1 (en) |
GR (1) | GR3019341T3 (en) |
WO (1) | WO1991011189A1 (en) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2657526B1 (en) * | 1990-01-31 | 1994-10-28 | Lvmh Rech | USE OF AN ALPHA-TOCOPHEROL PHOSPHATE, OR ONE OF ITS DERIVATIVES, FOR THE PREPARATION OF COSMETIC, DERMATOLOGICAL, OR PHARMACEUTICAL COMPOSITIONS; COMPOSITIONS THUS OBTAINED. |
FR2679904A1 (en) * | 1991-08-01 | 1993-02-05 | Lvmh Rech | Use of a tocopherol phosphate, or of one of its derivatives, in the preparation of cosmetic or pharmaceutical compositions and compositions thus obtained |
US5643597A (en) * | 1991-08-01 | 1997-07-01 | Lvmh Recherche | Use of a tocopherol phosphate or one of its derivatives for the preparation of cosmetic or pharmaceutical compositions and compositions so obtained |
KR950007045B1 (en) * | 1992-04-14 | 1995-06-30 | 주식회사태평양 | Skin cosmetic material containing polyethoxylate vitamin e. |
US5350775A (en) * | 1992-07-20 | 1994-09-27 | Showa Denko K.K. | Benzopyran derivative, method for producing the same and use thereof |
CA2179940A1 (en) * | 1995-07-18 | 1997-01-19 | Kazumi Ogata | Antiallergic composition comprising a phosphoric diester compound |
FR2747044B1 (en) * | 1996-04-03 | 1998-06-26 | Coletica | USE OF PLANT SEEDS AFTER GERMINATION AS A SOURCE OF SUPEROXIDE DISMUTASE AND COSMETIC, PHARMACEUTICAL OR AGRI-FOOD COMPOSITIONS CONTAINING SUCH A PLANT SUPEROXIDE DISMUTASE, AND EXTRACTION PROCESS |
FR2754713B1 (en) * | 1996-10-22 | 1999-01-08 | Roc Sa | USE OF COMPLEXES FOR THE PREPARATION OF COMPOSITIONS FOR THE TREATMENT OF SENSITIVE SKIN, PREPARATION METHOD AND HYPOALLERGENIC COMPOSITIONS |
US6022867A (en) * | 1996-11-27 | 2000-02-08 | Showa Denko Kabushiki Kaisha | Method of administering vitamin E to animals and compositions containing tocopheryl phosphates and salts thereof for animals |
US6458373B1 (en) | 1997-01-07 | 2002-10-01 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
DE19713368A1 (en) * | 1997-03-29 | 1998-10-01 | Beiersdorf Ag | Preparations with active ingredients sensitive to oxidation |
US7030155B2 (en) * | 1998-06-05 | 2006-04-18 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
US6716451B1 (en) * | 1999-11-30 | 2004-04-06 | Soft Gel Technologies, Inc. | Formulation and delivery method to enhance antioxidant potency of vitamin E |
ATE444756T1 (en) * | 2000-11-14 | 2009-10-15 | Vital Health Sciences Pty Ltd | COMPOSITIONS COMPRISING COMPLEXES OF TOCOPHEROL PHOSPHATE DERIVATIVES |
AUPR549901A0 (en) * | 2001-06-06 | 2001-07-12 | Vital Health Sciences Pty Ltd | Topical formulation containing tocopheryl phosphates |
WO2002040033A1 (en) * | 2000-11-14 | 2002-05-23 | Vital Health Sciences Pty Ltd | Formulation containing phosphate derivatives of electron transfer agents |
WO2002043765A2 (en) * | 2000-11-28 | 2002-06-06 | Transform Pharmaceuticals, Inc. | Pharmaceutical formulations comprising paclitaxel, derivatives, and pharmaceutically acceptable salts thereof |
AU2002317053B2 (en) * | 2001-07-27 | 2004-08-05 | Vital Health Sciences Pty Ltd | Dermal therapy using phosphate derivatives of electron transfer agents |
US20040092428A1 (en) * | 2001-11-27 | 2004-05-13 | Hongming Chen | Oral pharmaceuticals formulation comprising paclitaxel, derivatives and methods of administration thereof |
KR20050044655A (en) * | 2001-12-03 | 2005-05-12 | 노바세아, 인크. | Pharmaceutical compositions comprising active vitamin d compounds |
CN1604772A (en) * | 2001-12-13 | 2005-04-06 | 生命健康科学有限公司 | Transdermal transport of compounds |
US20030236301A1 (en) * | 2001-12-19 | 2003-12-25 | Bob Sanders | Liposomal delivery of vitamin E based compounds |
EP1501474A1 (en) * | 2002-05-09 | 2005-02-02 | Showa Denko K.K. | Skin whitening external preparation |
AU2002950713A0 (en) * | 2002-08-09 | 2002-09-12 | Vital Health Sciences Pty Ltd | Carrier |
US7329688B2 (en) * | 2002-12-17 | 2008-02-12 | Soft Gel Technologies, Inc. | Natural vitamin E compositions with superior antioxidant potency |
US6645514B1 (en) * | 2002-12-19 | 2003-11-11 | Access Business Group International, Llc | Increasing skin cell renewal with water-soluble Vitamin E |
AU2003296454A1 (en) * | 2002-12-19 | 2004-07-29 | Access Business Group International Llc | Increasing skin cell renewal with water-soluble vitamin e |
KR20050086954A (en) * | 2003-01-17 | 2005-08-30 | 바이탈 헬스 사이언시즈 피티와이 리미티드 | Compounds having anti-proliferative properties |
AU2003901815A0 (en) * | 2003-04-15 | 2003-05-01 | Vital Health Sciences Pty Ltd | Phosphate derivatives |
TWI262798B (en) * | 2003-12-31 | 2006-10-01 | Ind Tech Res Inst | Liposome and drug deliver system |
EP1720551B9 (en) | 2004-03-03 | 2011-09-21 | Vital Health Sciences Pty Ltd. | Alkaloid formulations |
US20090004166A1 (en) * | 2004-08-03 | 2009-01-01 | Simon Michael West | Carrier For Enternal Administration |
JP4523388B2 (en) * | 2004-11-19 | 2010-08-11 | 日本メナード化粧品株式会社 | Collagen synthesis promoter and skin external preparation |
US20090239827A1 (en) * | 2005-03-03 | 2009-09-24 | Esra Ogru | Compounds having lipid lowering properties |
EP1858508A4 (en) * | 2005-03-03 | 2009-01-07 | Vital Health Sciences Pty Ltd | Compounds having anti-cancer properties |
CN101247834B (en) * | 2005-06-17 | 2013-10-30 | 生命健康科学公司 | Carrier comprising one or more di and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof |
EP2548581A3 (en) * | 2005-06-17 | 2013-02-20 | Vital Health Sciences Pty Ltd. | A carrier comprising one or more di and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof |
FR2891736B1 (en) * | 2005-10-12 | 2007-11-30 | Gattefosse Sas Soc Par Actions | EXCIPIENT COMPRISING A WAX DERIVATIVE FOR THE MANUFACTURE OF COSMETIC TOPICAL FORMULATIONS |
EP1973547A1 (en) * | 2005-12-23 | 2008-10-01 | Vital Health Sciences Pty Ltd. | Compounds having cytokine modulating properties |
JP4684906B2 (en) * | 2006-02-09 | 2011-05-18 | 日本メナード化粧品株式会社 | Tight junction formation accelerator |
CN101431995B (en) | 2006-02-21 | 2012-02-01 | 玫琳凯有限公司 | stable vitamin C compositions |
JP4675801B2 (en) * | 2006-03-06 | 2011-04-27 | 日本メナード化粧品株式会社 | ROR activator |
JP4781855B2 (en) * | 2006-03-08 | 2011-09-28 | 日本メナード化粧品株式会社 | Composite powder and makeup cosmetic containing the composite powder |
JP4675806B2 (en) * | 2006-03-16 | 2011-04-27 | 日本メナード化粧品株式会社 | Annexin activator |
FR2921259B1 (en) * | 2007-09-26 | 2015-02-13 | Lvmh Rech | COSMETIC USE OF TOCOPHEROL PHOSPHATE AS AN ANTI-AGING SKIN AGENT |
US9445975B2 (en) * | 2008-10-03 | 2016-09-20 | Access Business Group International, Llc | Composition and method for preparing stable unilamellar liposomal suspension |
JP5546809B2 (en) * | 2009-07-09 | 2014-07-09 | 日本メナード化粧品株式会社 | Emulsified cosmetics |
ES2643643T3 (en) * | 2009-12-23 | 2017-11-23 | Phosphagenics Limited | Carrier composition for supply of a biologically active compound |
AU2011213557B2 (en) | 2010-02-05 | 2015-05-07 | Phosphagenics Limited | Carrier comprising non-neutralised tocopheryl phosphate |
US8652511B2 (en) | 2010-03-30 | 2014-02-18 | Phosphagenics Limited | Transdermal delivery patch |
FR2969924B1 (en) | 2010-12-30 | 2013-11-15 | Lvmh Rech | COMPOSITION COMPRISING A TOCOPHEROL PHOSPHATE |
US9561243B2 (en) | 2011-03-15 | 2017-02-07 | Phosphagenics Limited | Composition comprising non-neutralised tocol phosphate and a vitamin A compound |
BR112015003198A2 (en) * | 2012-08-23 | 2017-10-10 | Mylan Laboratories Ltd | improved injectable formulation of daptomycin. |
FR3015247B1 (en) | 2013-12-20 | 2016-12-23 | Lvmh Rech | USE OF TOCOPHEROL PHOSPHATE AS A MOISTURIZING AGENT |
JP6339376B2 (en) * | 2014-02-13 | 2018-06-06 | 株式会社ファンケル | Cosmetics |
JP6882321B2 (en) | 2015-12-09 | 2021-06-02 | フォスファージニクス リミテッド | Pharmaceutical product |
BR112019012946A2 (en) | 2016-12-21 | 2019-11-26 | Avecho Biotechnology Ltd | process |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4144325A (en) * | 1976-11-10 | 1979-03-13 | Voyt Walter F | Method of and composition for preventing sunburn while affording tanning |
JPS5944375A (en) * | 1982-09-06 | 1984-03-12 | Senjiyu Seiyaku Kk | Stable aqueous solution of alpha-tocopherol phosphoric ester |
JPS59219295A (en) * | 1983-05-30 | 1984-12-10 | Senjiyu Seiyaku Kk | Phosphoric diester, its salt, and their preparation |
DE3586859D1 (en) * | 1984-03-07 | 1993-01-07 | Roshdy Ismail | AGENTS FOR TREATING AND PROTECTING THE SKIN. |
RO89761A2 (en) * | 1984-03-19 | 1986-07-30 | Institutul Oncologic,Ro | MEDICINE FOR INCREASING IMMUNITY WITH CELLULAR SUPPORT AND TREATMENT OF MELINE AND VIRAL DISEASES |
US4861580A (en) * | 1985-10-15 | 1989-08-29 | The Liposome Company, Inc. | Composition using salt form of organic acid derivative of alpha-tocopheral |
JPS62265299A (en) * | 1985-12-18 | 1987-11-18 | Senjiyu Seiyaku Kk | Production of alpha-tocopherol, uridinephosphoric acid diester and halogen-substituted compound thereof or their salt |
JPS62145019A (en) * | 1985-12-19 | 1987-06-29 | Senjiyu Seiyaku Kk | Anti-inflammatory agent |
JPS62205091A (en) * | 1986-03-04 | 1987-09-09 | Senjiyu Seiyaku Kk | Novel phosphate diester and its salt, preparation thereof and medicinal preparation containing same |
JP2526059B2 (en) * | 1987-04-28 | 1996-08-21 | 千寿製薬株式会社 | Anti-ulcer agent |
JP2921792B2 (en) * | 1987-10-19 | 1999-07-19 | ザ リポソーム カンパニー,インコーポレイテッド | Drug system based on tocopherol |
US5198432A (en) * | 1988-01-29 | 1993-03-30 | Center For Innovative Technology | Method of preventing chlorohydrocarbon toxicity using sterol derivatives |
FR2628317B1 (en) * | 1988-03-09 | 1991-11-08 | Lvmh Rech | COMPOSITION BASED ON HYDRATED LIPID LAMID PHASES OR LIPOSOMES CONTAINING SCUTELLARIA EXTRACT, OR AT LEAST ONE FLAVONOID SUCH AS BAICALINE OR BAICALINE AND COSMETIC OR PHARMACEUTICAL COMPOSITION, IN PARTICULAR DERMATOLOGICAL, ANTI-ALLERGIC ANTI-ALLERGIC ACTIVITY THE INCORPORANT |
US5100654A (en) * | 1989-04-07 | 1992-03-31 | Yale University | Phosphorylated derivatives of l-dopa and compositions and methods for increasing the melanin content in mammalian skin and hair |
US5516788A (en) * | 1989-06-22 | 1996-05-14 | University Of Bath | Tetrahydroindenoindole compounds useful in the treatment of conditions associated with free radical formation |
FR2657526B1 (en) * | 1990-01-31 | 1994-10-28 | Lvmh Rech | USE OF AN ALPHA-TOCOPHEROL PHOSPHATE, OR ONE OF ITS DERIVATIVES, FOR THE PREPARATION OF COSMETIC, DERMATOLOGICAL, OR PHARMACEUTICAL COMPOSITIONS; COMPOSITIONS THUS OBTAINED. |
US5652274A (en) * | 1991-03-01 | 1997-07-29 | Martin; Alain | Therapeutic-wound healing compositions and methods for preparing and using same |
FR2679904A1 (en) * | 1991-08-01 | 1993-02-05 | Lvmh Rech | Use of a tocopherol phosphate, or of one of its derivatives, in the preparation of cosmetic or pharmaceutical compositions and compositions thus obtained |
US5643597A (en) * | 1991-08-01 | 1997-07-01 | Lvmh Recherche | Use of a tocopherol phosphate or one of its derivatives for the preparation of cosmetic or pharmaceutical compositions and compositions so obtained |
-
1990
- 1990-01-31 FR FR9001143A patent/FR2657526B1/en not_active Expired - Lifetime
-
1991
- 1991-01-30 CA CA002075201A patent/CA2075201C/en not_active Expired - Lifetime
- 1991-01-30 DK DK91903316.7T patent/DK0513104T3/en active
- 1991-01-30 DE DE69128653T patent/DE69128653T2/en not_active Expired - Lifetime
- 1991-01-30 EP EP94116721A patent/EP0652010B1/en not_active Expired - Lifetime
- 1991-01-30 WO PCT/FR1991/000055 patent/WO1991011189A1/en active IP Right Grant
- 1991-01-30 ES ES91903316T patent/ES2084808T3/en not_active Expired - Lifetime
- 1991-01-30 ES ES94116721T patent/ES2114645T3/en not_active Expired - Lifetime
- 1991-01-30 DE DE69116135T patent/DE69116135T2/en not_active Expired - Lifetime
- 1991-01-30 JP JP50377391A patent/JP3186763B2/en not_active Expired - Lifetime
- 1991-01-30 AT AT91903316T patent/ATE132370T1/en not_active IP Right Cessation
- 1991-01-30 EP EP91903316A patent/EP0513104B1/en not_active Expired - Lifetime
- 1991-01-30 US US07/917,142 patent/US5387579A/en not_active Expired - Lifetime
-
1994
- 1994-10-24 US US08/328,041 patent/US5656618A/en not_active Expired - Lifetime
-
1995
- 1995-05-30 US US08/456,665 patent/US5952001A/en not_active Expired - Lifetime
-
1996
- 1996-03-19 GR GR960400736T patent/GR3019341T3/en unknown
Also Published As
Publication number | Publication date |
---|---|
DE69116135D1 (en) | 1996-02-15 |
JPH05505393A (en) | 1993-08-12 |
FR2657526A1 (en) | 1991-08-02 |
ES2084808T3 (en) | 1996-05-16 |
JP3186763B2 (en) | 2001-07-11 |
EP0513104B1 (en) | 1996-01-03 |
ES2114645T3 (en) | 1998-06-01 |
EP0513104A1 (en) | 1992-11-19 |
EP0652010A1 (en) | 1995-05-10 |
GR3019341T3 (en) | 1996-06-30 |
DK0513104T3 (en) | 1996-05-20 |
US5656618A (en) | 1997-08-12 |
US5952001A (en) | 1999-09-14 |
DE69128653D1 (en) | 1998-02-12 |
EP0652010B1 (en) | 1998-01-07 |
ATE132370T1 (en) | 1996-01-15 |
DE69116135T2 (en) | 1996-08-29 |
DE69128653T2 (en) | 1998-07-23 |
CA2075201C (en) | 2003-12-02 |
WO1991011189A1 (en) | 1991-08-08 |
US5387579A (en) | 1995-02-07 |
FR2657526B1 (en) | 1994-10-28 |
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