CA2074309A1 - Stabilized controlled release formulations having acrylic polymer coating - Google Patents

Stabilized controlled release formulations having acrylic polymer coating

Info

Publication number
CA2074309A1
CA2074309A1 CA2074309A CA2074309A CA2074309A1 CA 2074309 A1 CA2074309 A1 CA 2074309A1 CA 2074309 A CA2074309 A CA 2074309A CA 2074309 A CA2074309 A CA 2074309A CA 2074309 A1 CA2074309 A1 CA 2074309A1
Authority
CA
Canada
Prior art keywords
acrylic polymer
controlled release
polymer coating
release formulations
stabilized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2074309A
Other languages
French (fr)
Other versions
CA2074309C (en
Inventor
Benjamin Oshlack
Mark Chasin
Frank Pedi, Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euro Celtique SA
Original Assignee
Benjamin Oshlack
Mark Chasin
Pedi, Frand, Jr.
Frank Pedi, Jr.
Euroceltique, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25245664&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2074309(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Benjamin Oshlack, Mark Chasin, Pedi, Frand, Jr., Frank Pedi, Jr., Euroceltique, S.A. filed Critical Benjamin Oshlack
Publication of CA2074309A1 publication Critical patent/CA2074309A1/en
Application granted granted Critical
Publication of CA2074309C publication Critical patent/CA2074309C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core

Abstract

A stabilized solid controlled release dosage form having a coating derived from an aqueous dispersion of an acrylic polymer is obtained by overcoating a substrate including a therapeutically active with an aqueous dispersion of the plasticized acrylic polymer and then curing the coated substrate at a temperature above the glass transition temperature of the plasticized acrylic polymer, until the coated dosage form attains a stabilized dissolution profile substantially unaffected by exposure to storage conditions of elevated temperature and/or elevated relative humidity.
CA002074309A 1992-01-27 1992-07-21 Stabilized controlled release formulations having acrylic polymer coating Expired - Lifetime CA2074309C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/826,084 US5286493A (en) 1992-01-27 1992-01-27 Stabilized controlled release formulations having acrylic polymer coating
US826,084 1992-01-27

Publications (2)

Publication Number Publication Date
CA2074309A1 true CA2074309A1 (en) 1993-07-28
CA2074309C CA2074309C (en) 1999-11-23

Family

ID=25245664

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002074309A Expired - Lifetime CA2074309C (en) 1992-01-27 1992-07-21 Stabilized controlled release formulations having acrylic polymer coating

Country Status (22)

Country Link
US (1) US5286493A (en)
EP (1) EP0553392B2 (en)
JP (1) JP3957329B2 (en)
AT (1) ATE184786T1 (en)
AU (1) AU660512B2 (en)
BR (1) BR9204577A (en)
CA (1) CA2074309C (en)
DE (1) DE69230028T3 (en)
DK (1) DK0553392T4 (en)
EG (1) EG20307A (en)
ES (1) ES2141713T5 (en)
GR (1) GR3032106T3 (en)
HK (1) HK1005687A1 (en)
HU (1) HU219350B (en)
IL (1) IL102851A (en)
MX (1) MX9205823A (en)
NO (1) NO309360B1 (en)
NZ (1) NZ245298A (en)
PL (1) PL171376B1 (en)
RU (1) RU2127587C1 (en)
SG (1) SG44698A1 (en)
ZA (1) ZA925687B (en)

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