CA2067188A1 - Multi-color laser scanning confocal imaging system - Google Patents

Multi-color laser scanning confocal imaging system

Info

Publication number
CA2067188A1
CA2067188A1 CA002067188A CA2067188A CA2067188A1 CA 2067188 A1 CA2067188 A1 CA 2067188A1 CA 002067188 A CA002067188 A CA 002067188A CA 2067188 A CA2067188 A CA 2067188A CA 2067188 A1 CA2067188 A1 CA 2067188A1
Authority
CA
Canada
Prior art keywords
imaging system
laser scanning
scanning confocal
confocal imaging
color laser
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002067188A
Other languages
French (fr)
Other versions
CA2067188C (en
Inventor
Todd Clark Brelje
Robert L. Sorenson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Minnesota
Original Assignee
Todd Clark Brelje
Robert L. Sorenson
The Regents Of The University Of Minnesota
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24259447&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2067188(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Todd Clark Brelje, Robert L. Sorenson, The Regents Of The University Of Minnesota filed Critical Todd Clark Brelje
Publication of CA2067188A1 publication Critical patent/CA2067188A1/en
Application granted granted Critical
Publication of CA2067188C publication Critical patent/CA2067188C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0064—Optical details of the image generation multi-spectral or wavelength-selective arrangements, e.g. wavelength fan-out, chromatic profiling

Abstract

A true multi-color laser scanning confocal imaging system for use with a microscope is described in which a single laser having a multi-line output is used to simultaneously or individually excite a plurality of dyes. The images may be simultaneously viewed by a plurality of photomultiplier tubes to reconstruct an image showing distinct features of a specimen stained with different dyes. The images may also be constructed using a single detector is a time-multiplex fashion and using a computer to construct the image.
CA002067188A 1990-08-10 1991-01-28 Multi-color laser scanning confocal imaging system Expired - Lifetime CA2067188C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/565,625 US5127730A (en) 1990-08-10 1990-08-10 Multi-color laser scanning confocal imaging system
US07/565,625 1990-08-10
PCT/US1991/000607 WO1992002839A1 (en) 1990-08-10 1991-01-28 Laser for confocal microscope

Publications (2)

Publication Number Publication Date
CA2067188A1 true CA2067188A1 (en) 1992-02-11
CA2067188C CA2067188C (en) 2001-05-15

Family

ID=24259447

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002067188A Expired - Lifetime CA2067188C (en) 1990-08-10 1991-01-28 Multi-color laser scanning confocal imaging system

Country Status (9)

Country Link
US (1) US5127730A (en)
EP (1) EP0495930B1 (en)
JP (1) JP2824462B2 (en)
AT (1) ATE179527T1 (en)
CA (1) CA2067188C (en)
DE (2) DE495930T1 (en)
DK (1) DK0495930T3 (en)
ES (1) ES2133283T3 (en)
WO (1) WO1992002839A1 (en)

Families Citing this family (236)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9015793D0 (en) * 1990-07-18 1990-09-05 Medical Res Council Confocal scanning optical microscope
US5214658A (en) * 1990-07-27 1993-05-25 Ion Laser Technology Mixed gas ion laser
US5296703A (en) * 1992-04-01 1994-03-22 The Regents Of The University Of California Scanning confocal microscope using fluorescence detection
DE4323129C2 (en) * 1992-07-24 2002-10-02 Zeiss Carl Inverted microscope
GB9302799D0 (en) * 1993-02-12 1993-03-31 Medical Res Council Detecting means for a scanning optical microscope
US5547849A (en) * 1993-02-17 1996-08-20 Biometric Imaging, Inc. Apparatus and method for volumetric capillary cytometry
US5280548A (en) * 1993-03-11 1994-01-18 Boc Health Care, Inc. Emission based fiber optic sensors for pH and carbon dioxide analysis
US5479252A (en) * 1993-06-17 1995-12-26 Ultrapointe Corporation Laser imaging system for inspection and analysis of sub-micron particles
US5923430A (en) 1993-06-17 1999-07-13 Ultrapointe Corporation Method for characterizing defects on semiconductor wafers
USH1530H (en) * 1993-06-17 1996-05-07 Ultrapointe Corporation Surface extraction from a three-dimensional data set
US5463897A (en) * 1993-08-17 1995-11-07 Digital Instruments, Inc. Scanning stylus atomic force microscope with cantilever tracking and optical access
US5381224A (en) * 1993-08-30 1995-01-10 A. E. Dixon Scanning laser imaging system
US5528426A (en) * 1994-07-14 1996-06-18 Tti Medical Laser block beam splitter for microscopes
US5591981A (en) * 1995-03-16 1997-01-07 Bio-Rad Laboratories, Inc. Tunable excitation and/or tunable emission fluorescence imaging
US5784152A (en) * 1995-03-16 1998-07-21 Bio-Rad Laboratories Tunable excitation and/or tunable detection microplate reader
US5863504A (en) * 1995-03-16 1999-01-26 Bio-Rad Laboratories, Inc. Fluorescence imaging instrument utilizing fish
JP3526489B2 (en) * 1995-05-25 2004-05-17 オリンパス株式会社 Epi-fluorescence microscope
US20050100946A1 (en) * 1995-06-29 2005-05-12 Affymetrix, Inc. Integrated nucleic acid diagnostic device and method for in-situ confocal microscopy
AU7398996A (en) 1995-10-11 1997-04-30 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
US5981180A (en) * 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
US5736330A (en) * 1995-10-11 1998-04-07 Luminex Corporation Method and compositions for flow cytometric determination of DNA sequences
FR2754341B1 (en) * 1996-10-04 1998-12-24 Dilor SPECTRAL ANALYSIS APPARATUS CAPABLE OF WORKING IN MULTIPLE SPECTRAL AREAS OF DIFFERENT WAVELENGTHS
US6449562B1 (en) 1996-10-10 2002-09-10 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
AU4920297A (en) 1996-10-25 1998-05-15 Applied Imaging, Inc. Multifluor-fluorescence in situ hybridization (m-fish) imaging techniques using multiple multiband filters with image registration
US5880473A (en) * 1997-07-28 1999-03-09 Applied Imaging, Inc. Multifluor-fluorescence in-situ hybridization (M-FISH) imaging techniques using multiple multiband filters with image registration
US6148114A (en) * 1996-11-27 2000-11-14 Ultrapointe Corporation Ring dilation and erosion techniques for digital image processing
US6008264A (en) 1997-04-30 1999-12-28 Laser Med, Inc. Method for curing polymeric materials, such as those used in dentistry, and for tailoring the post-cure properties of polymeric materials through the use of light source power modulation
US6282013B1 (en) 1997-04-30 2001-08-28 Lasermed, Inc. System for curing polymeric materials, such as those used in dentistry, and for tailoring the post-cure properties of polymeric materials through the use of light source power modulation
EP1027010A1 (en) 1997-10-29 2000-08-16 Bisco, Inc. Dental composite light curing system
US6116900A (en) * 1997-11-17 2000-09-12 Lumachem, Inc. Binary energizer and peroxide delivery system for dental bleaching
US6051835A (en) * 1998-01-07 2000-04-18 Bio-Rad Laboratories, Inc. Spectral imaging apparatus and methodology
WO1999036564A1 (en) * 1998-01-16 1999-07-22 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
US6200134B1 (en) 1998-01-20 2001-03-13 Kerr Corporation Apparatus and method for curing materials with radiation
EP2267507A3 (en) 1998-02-26 2011-08-17 The General Hospital Corporation Confocal microscopy with multi-spectral encoding
US6831781B2 (en) 1998-02-26 2004-12-14 The General Hospital Corporation Confocal microscopy with multi-spectral encoding and system and apparatus for spectroscopically encoded confocal microscopy
US7498164B2 (en) 1998-05-16 2009-03-03 Applied Biosystems, Llc Instrument for monitoring nucleic acid sequence amplification reaction
CA2328609A1 (en) * 1998-05-16 1999-11-25 Pe Corporation (Ny) Instrument for monitoring polymerase chain reaction of dna
US6818437B1 (en) * 1998-05-16 2004-11-16 Applera Corporation Instrument for monitoring polymerase chain reaction of DNA
DE19829944C2 (en) * 1998-07-04 2002-03-28 Zeiss Carl Jena Gmbh Method and arrangement for device configuration of a fluorescence laser scanning microscope
DE19829981C2 (en) † 1998-07-04 2002-10-17 Zeiss Carl Jena Gmbh Method and arrangement for confocal microscopy
DE19835070B4 (en) * 1998-08-04 2006-03-16 Carl Zeiss Jena Gmbh Arrangement for adjustable wavelength-dependent detection in a fluorescence microscope
KR20010090718A (en) 1998-08-21 2001-10-19 써로메드, 인크. Novel optical architectures for microvolume laser-scanning cytometers
DE19842153C2 (en) * 1998-09-15 2003-07-31 Leica Microsystems fluorescence microscope
JP4270610B2 (en) * 1998-09-24 2009-06-03 オリンパス株式会社 Scanning optical microscope
US6628385B1 (en) * 1999-02-05 2003-09-30 Axon Instruments, Inc. High efficiency, large field scanning microscope
US6937330B2 (en) 1999-04-23 2005-08-30 Ppd Biomarker Discovery Sciences, Llc Disposable optical cuvette cartridge with low fluorescence material
US6541778B1 (en) * 1999-04-23 2003-04-01 Iowa State University Research Foundation, Inc. Method and apparatus for ceramic analysis
US6157661A (en) * 1999-05-12 2000-12-05 Laserphysics, Inc. System for producing a pulsed, varied and modulated laser output
WO2000071991A1 (en) * 1999-05-25 2000-11-30 Biometric Imaging, Inc. Apparatus and method for optical detection in a limited depth of field
US6548796B1 (en) 1999-06-23 2003-04-15 Regents Of The University Of Minnesota Confocal macroscope
US6687395B1 (en) 1999-07-21 2004-02-03 Surromed, Inc. System for microvolume laser scanning cytometry
JP2003505707A (en) * 1999-07-21 2003-02-12 サーロメッド・インコーポレーテッド System for small volume laser scanning cytometry
EP1102101A1 (en) * 1999-11-22 2001-05-23 Leica Microsystems Heidelberg GmbH Laser scanning microscope
DE10024135B4 (en) * 2000-01-28 2004-07-08 Leica Microsystems Heidelberg Gmbh microscope
DE10004233B4 (en) * 2000-02-01 2005-02-17 Leica Microsystems Heidelberg Gmbh The microscope assemblage
US6313433B1 (en) 2000-04-03 2001-11-06 Universal Laser Systems, Inc Laser material processing system with multiple laser sources apparatus and method
IL135522A (en) 2000-04-06 2005-11-20 Orbotech Ltd Optical inspection of laser vias
JP2002090628A (en) * 2000-09-18 2002-03-27 Olympus Optical Co Ltd Confocal microscope
US20040224421A1 (en) * 2000-06-15 2004-11-11 Deweerd Herman Bi-directional scanning method
DE20122791U1 (en) 2000-06-17 2007-11-29 Leica Microsystems Cms Gmbh scanning microscope
DE20122782U1 (en) 2000-06-17 2007-11-15 Leica Microsystems Cms Gmbh lighting device
DE20122783U1 (en) 2000-06-17 2007-11-15 Leica Microsystems Cms Gmbh Arrangement for examining microscopic specimens with a scanning microscope and illumination device for a scanning microscope
EP1164402B1 (en) * 2000-06-17 2010-04-28 Leica Microsystems CMS GmbH Scanning microscope with multiband illumination and optical element for a scanning microsscope with multiband illumination
US6898367B2 (en) 2000-06-17 2005-05-24 Leica Microsystems Heidelberg Gmbh Method and instrument for microscopy
DE10115488A1 (en) * 2000-06-17 2001-12-20 Leica Microsystems Arrangement for investigating microscopic preparations, has optical component between scanning laser and imaging optical arrangement to spectrally expand laser light during single pass
EP1164406B1 (en) 2000-06-17 2019-04-17 Leica Microsystems CMS GmbH Method and device for illuminating an object
GB2363857A (en) * 2000-06-23 2002-01-09 Yokogawa Electric Corp Nipkow disk confocal scanner with optical image separation system
DE10044636A1 (en) 2000-09-08 2002-03-21 Leica Microsystems Optical arrangement for illuminating objects for confocal scanning microscopes
EP1434522B1 (en) * 2000-10-30 2010-01-13 The General Hospital Corporation Optical systems for tissue analysis
US9295391B1 (en) 2000-11-10 2016-03-29 The General Hospital Corporation Spectrally encoded miniature endoscopic imaging probe
US6787761B2 (en) * 2000-11-27 2004-09-07 Surromed, Inc. Median filter for liquid chromatography-mass spectrometry data
WO2002044715A1 (en) * 2000-11-28 2002-06-06 Surromed, Inc. Methods for efficiently minig broad data sets for biological markers
DE10065784C2 (en) * 2000-12-30 2003-12-04 Leica Microsystems Method for finding contact points between cells in a stimulable microscopic sample during calcium migration and scanning microscope for carrying out the method
DE10120425C2 (en) * 2001-04-26 2003-12-18 Leica Microsystems scanning microscope
WO2002088684A1 (en) * 2001-04-30 2002-11-07 The General Hospital Corporation Method and apparatus for improving image clarity and sensitivity in optical coherence tomography using dynamic feedback to control focal properties and coherence gating
AT503309B1 (en) 2001-05-01 2011-08-15 Gen Hospital Corp DEVICE FOR DETERMINING ATHEROSCLEROTIC BEARING BY MEASURING OPTICAL TISSUE PROPERTIES
JP2003028797A (en) * 2001-07-11 2003-01-29 Hitachi Software Eng Co Ltd Fluorescence reader
US6873915B2 (en) * 2001-08-24 2005-03-29 Surromed, Inc. Peak selection in multidimensional data
US20030078739A1 (en) * 2001-10-05 2003-04-24 Surromed, Inc. Feature list extraction from data sets such as spectra
DE10150542B4 (en) * 2001-10-12 2007-03-29 Leica Microsystems Cms Gmbh Method for fluorescence microscopy
US6980299B1 (en) * 2001-10-16 2005-12-27 General Hospital Corporation Systems and methods for imaging a sample
WO2003038503A1 (en) * 2001-11-02 2003-05-08 Olympus Corporation Scanning con-focal microscope
DE10156506C1 (en) 2001-11-16 2003-05-22 Leica Microsystems Multi-color image forming method and microscope
EP1316794A1 (en) * 2001-11-28 2003-06-04 Cambridge University Technical Services Limited A dual wavelength optical fluorescence analyser
US7158294B2 (en) * 2001-12-18 2007-01-02 Olympus Optical Co., Ltd. Laser scanning confocal microscope apparatus, image recording method, and recording medium
JP2005530128A (en) 2002-01-11 2005-10-06 ザ・ジェネラル・ホスピタル・コーポレイション Apparatus for OCT imaging using axial line focus to improve resolution and depth regions
US7355716B2 (en) * 2002-01-24 2008-04-08 The General Hospital Corporation Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
DE10212554A1 (en) * 2002-03-16 2003-10-30 Zeiss Carl Jena Gmbh Arrangement and method for an imaging spectrometer
KR100483706B1 (en) * 2002-04-04 2005-04-18 바디텍메드 주식회사 A Apparatus for the Detection of Laser-induced Epifluoresecne
DE10217545A1 (en) * 2002-04-17 2003-11-06 Zeiss Carl Jena Gmbh Microscope with position detection of changers of optical elements
JP2005524833A (en) * 2002-05-03 2005-08-18 イムニベスト・コーポレイション Devices and methods for analytical cell imaging
CA2484625A1 (en) * 2002-05-09 2003-11-20 Surromed, Inc. Methods for time-alignment of liquid chromatography-mass spectrometry data
DE10225838B4 (en) 2002-06-11 2021-10-21 Leica Microsystems Cms Gmbh Method for scanning microscopy, scanning microscope and device for coding an illuminating light beam
DE10231475A1 (en) 2002-07-12 2004-01-22 Leica Microsystems Heidelberg Gmbh Scanning microscope with optical component and optical component
DE10231776B4 (en) * 2002-07-13 2021-07-22 Leica Microsystems Cms Gmbh Procedure for scanning microscopy and scanning microscope
DE10362402B3 (en) 2002-08-28 2022-03-03 Carl Zeiss Meditec Ag Microscopy system and microscopy method
US7038848B2 (en) * 2002-12-27 2006-05-02 Olympus Corporation Confocal microscope
DE10302259B3 (en) * 2003-01-22 2004-06-03 Leica Microsystems Heidelberg Gmbh Confocal scanning microscope has acousto-optical component for directing partial beam obtained from illumination beam onto monitoring detector for illumination intensity regulation
US7567349B2 (en) 2003-03-31 2009-07-28 The General Hospital Corporation Speckle reduction in optical coherence tomography by path length encoded angular compounding
CA2514189A1 (en) 2003-01-24 2004-08-12 The General Hospital Corporation System and method for identifying tissue using low-coherence interferometry
US7643153B2 (en) 2003-01-24 2010-01-05 The General Hospital Corporation Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
DE10309911B4 (en) 2003-03-07 2021-10-14 Leica Microsystems Cms Gmbh Method for determining a longitudinal color defect of a scanning microscope and scanning microscope
DE10324478B3 (en) * 2003-05-30 2004-12-09 Leica Microsystems Heidelberg Gmbh Device for determining the light output of a light beam and scanning microscope
KR20130138867A (en) 2003-06-06 2013-12-19 더 제너럴 하스피탈 코포레이션 Process and apparatus for a wavelength tunning source
DE10331906B4 (en) * 2003-07-15 2005-06-16 Leica Microsystems Heidelberg Gmbh Light source with a microstructured optical element and microscope with light source
DE10333388B4 (en) 2003-07-23 2021-09-16 Leica Microsystems Cms Gmbh Scanning microscopy and scanning microscope procedures
DE10334145A1 (en) * 2003-07-26 2005-02-24 Leica Microsystems Heidelberg Gmbh scanning microscope
DE10340964A1 (en) 2003-09-05 2005-03-31 Leica Microsystems Heidelberg Gmbh Light source with a microstructured optical element
JP4756819B2 (en) 2003-10-21 2011-08-24 オリンパス株式会社 Scanning microscope system
CN103181754A (en) 2003-10-27 2013-07-03 通用医疗公司 Method and apparatus for performing optical imaging using frequency-domain interferometry
WO2005054780A1 (en) * 2003-11-28 2005-06-16 The General Hospital Corporation Method and apparatus for three-dimensional spectrally encoded imaging
US7248360B2 (en) 2004-04-02 2007-07-24 Ppd Biomarker Discovery Sciences, Llc Polychronic laser scanning system and method of use
JP4323369B2 (en) * 2004-04-09 2009-09-02 オリンパス株式会社 Scanning fluorescence microscope
WO2005117534A2 (en) 2004-05-29 2005-12-15 The General Hospital Corporation Process, system and software arrangement for a chromatic dispersion compensation using reflective layers in optical coherence tomography (oct) imaging
FR2871358B1 (en) * 2004-06-14 2007-02-09 Mauna Kea Technologies Soc Par METHOD AND SYSTEM FOR MICROSCOPIC MULTI-MARKING FIBER FLUORESCENCE IMAGING
DE102004030669A1 (en) 2004-06-24 2006-01-19 Leica Microsystems Cms Gmbh microscope
US7447408B2 (en) * 2004-07-02 2008-11-04 The General Hospital Corproation Imaging system and related techniques
US8081316B2 (en) 2004-08-06 2011-12-20 The General Hospital Corporation Process, system and software arrangement for determining at least one location in a sample using an optical coherence tomography
EP1793730B1 (en) 2004-08-24 2011-12-28 The General Hospital Corporation Process, system and software arrangement for determining elastic modulus
KR20120062944A (en) 2004-08-24 2012-06-14 더 제너럴 하스피탈 코포레이션 Method and apparatus for imaging of vessel segments
KR101269455B1 (en) 2004-09-10 2013-05-30 더 제너럴 하스피탈 코포레이션 System and method for optical coherence imaging
JP4997112B2 (en) 2004-09-29 2012-08-08 ザ ジェネラル ホスピタル コーポレイション Apparatus for transmitting at least one electromagnetic radiation and method of manufacturing the same
DE102004047820A1 (en) 2004-09-29 2006-03-30 Leica Microsystems Cms Gmbh Scanning microscope and scanning microscopy method
EP2272424A1 (en) * 2004-10-29 2011-01-12 The General Hospital Corporation Polarisation-sensitive optical coherence tomography
JP5623692B2 (en) * 2004-11-02 2014-11-12 ザ ジェネラル ホスピタル コーポレイション Optical fiber rotator, optical system and method for sample imaging
US7995210B2 (en) 2004-11-24 2011-08-09 The General Hospital Corporation Devices and arrangements for performing coherence range imaging using a common path interferometer
EP1816949A1 (en) 2004-11-29 2007-08-15 The General Hospital Corporation Arrangements, devices, endoscopes, catheters and methods for performing optical imaging by simultaneously illuminating and detecting multiple points on a sample
US7491502B2 (en) * 2004-12-17 2009-02-17 The General Hospital Corporation In vivo flow cytometry system and method
US7264794B2 (en) * 2004-12-17 2007-09-04 The General Hospital Methods of in vivo cytometry
JP2006208681A (en) * 2005-01-27 2006-08-10 Olympus Corp Connection unit and optical scanning type fluorescent observation device
EP1856509B1 (en) * 2005-03-03 2011-12-28 QIAGEN Lake Constance GmbH Fluorescence meter
US7297149B2 (en) 2005-04-14 2007-11-20 Ethicon Endo-Surgery, Inc. Surgical clip applier methods
US7686820B2 (en) 2005-04-14 2010-03-30 Ethicon Endo-Surgery, Inc. Surgical clip applier ratchet mechanism
US8523882B2 (en) 2005-04-14 2013-09-03 Ethicon Endo-Surgery, Inc. Clip advancer mechanism with alignment features
US7288098B2 (en) * 2005-04-14 2007-10-30 Ethicon Endo-Surgery, Inc. Force limiting mechanism for medical instrument
US7261724B2 (en) * 2005-04-14 2007-08-28 Ethicon Endo-Surgery, Inc. Surgical clip advancement mechanism
US8038686B2 (en) * 2005-04-14 2011-10-18 Ethicon Endo-Surgery, Inc. Clip applier configured to prevent clip fallout
US7740641B2 (en) 2005-04-14 2010-06-22 Ethicon Endo-Surgery, Inc. Clip applier with migrational resistance features
EP1875436B1 (en) 2005-04-28 2009-12-09 The General Hospital Corporation Evaluation of image features of an anatomical structure in optical coherence tomography images
WO2006130797A2 (en) * 2005-05-31 2006-12-07 The General Hospital Corporation Spectral encoding heterodyne interferometry techniques for imaging
JP5702049B2 (en) 2005-06-01 2015-04-15 ザ ジェネラル ホスピタル コーポレイション Apparatus, method and system for performing phase resolved optical frequency domain imaging
ES2354287T3 (en) 2005-08-09 2011-03-11 The General Hospital Corporation APPARATUS AND METHOD FOR PERFORMING A DEMODULATION IN QUADRATURE BY POLARIZATION IN OPTICAL COHERENCE TOMOGRAPHY.
JP6046325B2 (en) 2005-09-29 2016-12-14 ザ ジェネラル ホスピタル コーポレイション Method and apparatus for the observation and analysis of one or more biological samples with progressively increased resolution
US7889348B2 (en) 2005-10-14 2011-02-15 The General Hospital Corporation Arrangements and methods for facilitating photoluminescence imaging
US8290239B2 (en) * 2005-10-21 2012-10-16 Orbotech Ltd. Automatic repair of electric circuits
US20080311585A1 (en) * 2005-11-02 2008-12-18 Affymetrix, Inc. System and method for multiplex liquid handling
US8075852B2 (en) * 2005-11-02 2011-12-13 Affymetrix, Inc. System and method for bubble removal
US20080038714A1 (en) * 2005-11-02 2008-02-14 Affymetrix, Inc. Instrument to Pneumatically Control Lab Cards and Method Thereof
US20070099288A1 (en) * 2005-11-02 2007-05-03 Affymetrix, Inc. Microfluidic Methods, Devices, and Systems for Fluid Handling
US8007267B2 (en) * 2005-11-02 2011-08-30 Affymetrix, Inc. System and method for making lab card by embossing
WO2007082228A1 (en) 2006-01-10 2007-07-19 The General Hospital Corporation Systems and methods for generating data based on one or more spectrally-encoded endoscopy techniques
WO2007084903A2 (en) 2006-01-19 2007-07-26 The General Hospital Corporation Apparatus for obtaining information for a structure using spectrally-encoded endoscopy techniques and method for producing one or more optical arrangements
WO2007084945A1 (en) * 2006-01-19 2007-07-26 The General Hospital Corporation Systems and methods for performing rapid fluorescense lifetime, excitation and emission spectral measurements
CN104257348A (en) 2006-01-19 2015-01-07 通用医疗公司 Methods And Systems For Optical Imaging Of Epithelial Luminal Organs By Beam Scanning Thereof
US20070171430A1 (en) * 2006-01-20 2007-07-26 The General Hospital Corporation Systems and methods for providing mirror tunnel micropscopy
EP1986545A2 (en) 2006-02-01 2008-11-05 The General Hospital Corporation Apparatus for applying a plurality of electro-magnetic radiations to a sample
WO2007149601A2 (en) 2006-02-01 2007-12-27 The General Hospital Corporation Apparatus for controlling at least one of at least two sections of at least one fiber
JP5524487B2 (en) 2006-02-01 2014-06-18 ザ ジェネラル ホスピタル コーポレイション A method and system for emitting electromagnetic radiation to at least a portion of a sample using a conformal laser treatment procedure.
EP1988825B1 (en) 2006-02-08 2016-12-21 The General Hospital Corporation Arrangements and systems for obtaining information associated with an anatomical sample using optical microscopy
WO2007101026A2 (en) 2006-02-24 2007-09-07 The General Hospital Corporation Methods and systems for performing angle-resolved fourier-domain optical coherence tomography
WO2007109540A2 (en) * 2006-03-17 2007-09-27 The General Hospital Corporation Arrangement, method and computer-accessible medium for identifying characteristics of at least a portion of a blood vessel contained within a tissue using spectral domain low coherence interferometry
CN101466298B (en) 2006-04-05 2011-08-31 通用医疗公司 Methods arrangements and systems for polarization-sensitive optical frequency domain imaging of a sample
EP3150110B1 (en) 2006-05-10 2020-09-02 The General Hospital Corporation Processes, arrangements and systems for providing frequency domain imaging of a sample
WO2007133964A2 (en) * 2006-05-12 2007-11-22 The General Hospital Corporation Processes, arrangements and systems for providing a fiber layer thickness map based on optical coherence tomography images
JP2010501877A (en) 2006-08-25 2010-01-21 ザ ジェネラル ホスピタル コーポレイション Apparatus and method for improving optical coherence tomography imaging capabilities using volumetric filtering techniques
DE102006047816A1 (en) * 2006-10-07 2008-04-17 Leica Microsystems Cms Gmbh Method and apparatus for high resolution optical scanning of a sample
WO2008049118A2 (en) 2006-10-19 2008-04-24 The General Hospital Corporation Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample and effecting such portion(s)
US8155730B2 (en) * 2006-10-24 2012-04-10 The Research Foundation Of State University Of New York Composition, method, system, and kit for optical electrophysiology
US7911621B2 (en) 2007-01-19 2011-03-22 The General Hospital Corporation Apparatus and method for controlling ranging depth in optical frequency domain imaging
EP2104968A1 (en) 2007-01-19 2009-09-30 The General Hospital Corporation Rotating disk reflection for fast wavelength scanning of dispersed broadband light
WO2008118781A2 (en) 2007-03-23 2008-10-02 The General Hospital Corporation Methods, arrangements and apparatus for utilizing a wavelength-swept laser using angular scanning and dispersion procedures
US10534129B2 (en) 2007-03-30 2020-01-14 The General Hospital Corporation System and method providing intracoronary laser speckle imaging for the detection of vulnerable plaque
WO2008131082A1 (en) 2007-04-17 2008-10-30 The General Hospital Corporation Apparatus and methods for measuring vibrations using spectrally-encoded endoscopy techniques
WO2008137693A2 (en) * 2007-05-04 2008-11-13 The General Hospital Corporation D/B/A Massachusetts General Hospital Retinal flow cytometry
WO2008137637A2 (en) 2007-05-04 2008-11-13 The General Hospital Corporation Methods, arrangements and systems for obtaining information associated with a sample using brillouin microscopy
WO2009016548A2 (en) * 2007-07-27 2009-02-05 Koninklijke Philips Electronics N.V. Method and system for imaging samples
WO2009018456A2 (en) 2007-07-31 2009-02-05 The General Hospital Corporation Systems and methods for providing beam scan patterns for high speed doppler optical frequency domain imaging
JP5536650B2 (en) 2007-08-31 2014-07-02 ザ ジェネラル ホスピタル コーポレイション System and method for self-interfering fluorescence microscopy and associated computer-accessible media
HU229592B1 (en) 2007-09-03 2014-02-28 Univ Szegedi Tomographic optical microscope system and method for reconstructing the image of an object
JP2011500173A (en) * 2007-10-12 2011-01-06 ザ ジェネラル ホスピタル コーポレイション System and process for optical imaging of luminal anatomical structures
US7933021B2 (en) 2007-10-30 2011-04-26 The General Hospital Corporation System and method for cladding mode detection
US9332942B2 (en) * 2008-01-28 2016-05-10 The General Hospital Corporation Systems, processes and computer-accessible medium for providing hybrid flourescence and optical coherence tomography imaging
US11123047B2 (en) 2008-01-28 2021-09-21 The General Hospital Corporation Hybrid systems and methods for multi-modal acquisition of intravascular imaging data and counteracting the effects of signal absorption in blood
US8574859B2 (en) * 2008-03-27 2013-11-05 The General Hospital Corporation In vivo flow cytometry based on cellular autofluorescence
EP2274572A4 (en) 2008-05-07 2013-08-28 Gen Hospital Corp System, method and computer-accessible medium for tracking vessel motion during three-dimensional coronary artery microscopy
JP5795531B2 (en) 2008-06-20 2015-10-14 ザ ジェネラル ホスピタル コーポレイション Fused fiber optic coupler structure and method of using the same
JP5667051B2 (en) 2008-07-14 2015-02-12 ザ ジェネラル ホスピタル コーポレイション Equipment for color endoscopy
DE102008034008B4 (en) * 2008-07-21 2010-07-01 Carl Zeiss Surgical Gmbh Filter kit for the observation of fluorescence radiation in biological tissue
EP3330696B1 (en) 2008-12-10 2023-07-12 The General Hospital Corporation Systems, apparatus and methods for extending imaging depth range of optical coherence tomography through optical sub-sampling
JP2012515930A (en) 2009-01-26 2012-07-12 ザ ジェネラル ホスピタル コーポレーション System, method and computer-accessible medium for providing a wide-field super-resolution microscope
WO2010091190A2 (en) 2009-02-04 2010-08-12 The General Hospital Corporation Apparatus and method for utilization of a high-speed optical wavelength tuning source
US9351642B2 (en) 2009-03-12 2016-05-31 The General Hospital Corporation Non-contact optical system, computer-accessible medium and method for measurement at least one mechanical property of tissue using coherent speckle technique(s)
US9072572B2 (en) 2009-04-02 2015-07-07 Kerr Corporation Dental light device
US9066777B2 (en) 2009-04-02 2015-06-30 Kerr Corporation Curing light device
US11490826B2 (en) 2009-07-14 2022-11-08 The General Hospital Corporation Apparatus, systems and methods for measuring flow and pressure within a vessel
US8262679B2 (en) 2009-10-09 2012-09-11 Ethicon Endo-Surgery, Inc. Clip advancer
US8267945B2 (en) 2009-10-09 2012-09-18 Ethicon Endo-Surgery, Inc. Clip advancer with lockout mechanism
US8804126B2 (en) 2010-03-05 2014-08-12 The General Hospital Corporation Systems, methods and computer-accessible medium which provide microscopic images of at least one anatomical structure at a particular resolution
US9069130B2 (en) 2010-05-03 2015-06-30 The General Hospital Corporation Apparatus, method and system for generating optical radiation from biological gain media
EP2575598A2 (en) 2010-05-25 2013-04-10 The General Hospital Corporation Apparatus, systems, methods and computer-accessible medium for spectral analysis of optical coherence tomography images
EP2575597B1 (en) 2010-05-25 2022-05-04 The General Hospital Corporation Apparatus for providing optical imaging of structures and compositions
US10285568B2 (en) 2010-06-03 2019-05-14 The General Hospital Corporation Apparatus and method for devices for imaging structures in or at one or more luminal organs
US9510758B2 (en) 2010-10-27 2016-12-06 The General Hospital Corporation Apparatus, systems and methods for measuring blood pressure within at least one vessel
US20130324846A1 (en) 2011-02-17 2013-12-05 University Of Massachusetts Devices and methods for optical pathology
DE102011016138A1 (en) * 2011-03-30 2012-10-04 Karl Storz Gmbh & Co. Kg Device for fluorescence diagnosis
WO2012149175A1 (en) 2011-04-29 2012-11-01 The General Hospital Corporation Means for determining depth-resolved physical and/or optical properties of scattering media
US9330092B2 (en) 2011-07-19 2016-05-03 The General Hospital Corporation Systems, methods, apparatus and computer-accessible-medium for providing polarization-mode dispersion compensation in optical coherence tomography
WO2013029047A1 (en) 2011-08-25 2013-02-28 The General Hospital Corporation Methods, systems, arrangements and computer-accessible medium for providing micro-optical coherence tomography procedures
EP2769491A4 (en) 2011-10-18 2015-07-22 Gen Hospital Corp Apparatus and methods for producing and/or providing recirculating optical delay(s)
WO2013059432A1 (en) 2011-10-19 2013-04-25 Ethicon Endo-Surgery, Inc. Clip applier adapted for use with a surgical robot
US9629528B2 (en) 2012-03-30 2017-04-25 The General Hospital Corporation Imaging system, method and distal attachment for multidirectional field of view endoscopy
WO2013177154A1 (en) 2012-05-21 2013-11-28 The General Hospital Corporation Apparatus, device and method for capsule microscopy
US8964183B2 (en) * 2012-05-31 2015-02-24 General Electric Company Systems and methods for screening of biological samples
JP6227652B2 (en) 2012-08-22 2017-11-08 ザ ジェネラル ホスピタル コーポレイション System, method, and computer-accessible medium for fabricating a miniature endoscope using soft lithography
WO2014120791A1 (en) 2013-01-29 2014-08-07 The General Hospital Corporation Apparatus, systems and methods for providing information regarding the aortic valve
WO2014121082A1 (en) 2013-02-01 2014-08-07 The General Hospital Corporation Objective lens arrangement for confocal endomicroscopy
EP2967491B1 (en) 2013-03-15 2022-05-11 The General Hospital Corporation A transesophageal endoscopic system for determining a mixed venous oxygen saturation of a pulmonary artery
US9347852B1 (en) 2013-05-08 2016-05-24 Thomas DiMatteo Microscope illumination diagnostic cube
WO2014186353A1 (en) 2013-05-13 2014-11-20 The General Hospital Corporation Detecting self-interefering fluorescence phase and amplitude
WO2015009932A1 (en) 2013-07-19 2015-01-22 The General Hospital Corporation Imaging apparatus and method which utilizes multidirectional field of view endoscopy
EP3021735A4 (en) 2013-07-19 2017-04-19 The General Hospital Corporation Determining eye motion by imaging retina. with feedback
ES2893237T3 (en) 2013-07-26 2022-02-08 Massachusetts Gen Hospital Apparatus with a laser arrangement using optical scattering for applications in optical coherence tomography in the Fourier domain
WO2015087824A1 (en) * 2013-12-09 2015-06-18 株式会社ニコン Optical apparatus, measuring apparatus, measuring method, screening apparatus, and screening method
US9733460B2 (en) 2014-01-08 2017-08-15 The General Hospital Corporation Method and apparatus for microscopic imaging
WO2015116986A2 (en) 2014-01-31 2015-08-06 The General Hospital Corporation System and method for facilitating manual and/or automatic volumetric imaging with real-time tension or force feedback using a tethered imaging device
WO2015153982A1 (en) 2014-04-04 2015-10-08 The General Hospital Corporation Apparatus and method for controlling propagation and/or transmission of electromagnetic radiation in flexible waveguide(s)
DE102014008243A1 (en) 2014-05-27 2015-12-03 Carl Zeiss Meditec Ag Fluorescence observation system and optical filter system therefor
EP3171766B1 (en) 2014-07-25 2021-12-29 The General Hospital Corporation Apparatus for in vivo imaging and diagnosis
DE102014016850B9 (en) 2014-11-13 2017-07-27 Carl Zeiss Meditec Ag Optical system for fluorescence observation
DE102015011429B9 (en) * 2015-09-01 2020-01-09 Carl Zeiss Meditec Ag Optical filter system and fluorescence observation system
EP3350578B1 (en) * 2015-09-02 2022-03-09 Inscopix, Inc. Systems and methods for color imaging
CN108474736B (en) 2015-11-05 2022-01-25 英思克斯公司 System and method for optogenetic imaging
DE102018114695B9 (en) * 2018-06-19 2020-05-28 Carl Zeiss Meditec Ag Filter set, system and method for the simultaneous excitation and observation of protoporphyrin IX and fluorescein
DE102019101773B9 (en) * 2019-01-24 2021-11-25 Carl Zeiss Meditec Ag Microscopy system and method for operating a microscopy system
EP3907497B1 (en) * 2020-05-08 2023-08-02 Leica Microsystems CMS GmbH Apparatus and method for displaying and/or printing images of a specimen including a fluorophore
CN112859315A (en) * 2021-01-11 2021-05-28 北京大学 Multicolor dual-mode structured light illumination microscopic imaging system and imaging method thereof

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE455646B (en) * 1984-10-22 1988-07-25 Radians Innova Ab FLUORESCENT DEVICE
US4689491A (en) * 1985-04-19 1987-08-25 Datasonics Corp. Semiconductor wafer scanning system
JPS62138819A (en) * 1985-12-13 1987-06-22 Hitachi Ltd Scanning type laser microscope
GB8531011D0 (en) * 1985-12-17 1986-01-29 Medical Res Council Confocal scanning microscope
US4710635A (en) * 1986-04-14 1987-12-01 Becton, Dickinson And Company Dual laser excitation from single laser source
EP0267278A4 (en) * 1986-05-13 1989-12-19 Richard Kennedy Mixing device.
US4684602A (en) * 1986-06-30 1987-08-04 Eastman Kodak Company Multicolor laser recording method and element
US4745285A (en) * 1986-08-21 1988-05-17 Becton Dickinson And Company Multi-color fluorescence analysis with single wavelength excitation
US4791310A (en) * 1986-10-02 1988-12-13 Syracuse University Fluorescence microscopy
GB8626576D0 (en) * 1986-11-06 1986-12-10 Amersham Int Plc Imaging method
JP2836829B2 (en) * 1987-03-27 1998-12-14 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ Scanning confocal optical microscope
US4847823A (en) * 1987-06-19 1989-07-11 Siscan Systems, Inc. Method and apparatus for reading or measuring magneto-optical storage media using pinhole aperture
CS263329B1 (en) * 1987-07-24 1989-04-14 Petran Mojmir Light disjoining system
US4884880A (en) * 1987-11-16 1989-12-05 Washington University Kit for converting a standard microscope into a single aperture confocal scanning epi-illumination microscope
US4884881A (en) * 1987-11-16 1989-12-05 Washington University Single aperture confocal scanning epi-illumination microscope
US4802748A (en) * 1987-12-14 1989-02-07 Tracor Northern, Inc. Confocal tandem scanning reflected light microscope
FR2626383B1 (en) * 1988-01-27 1991-10-25 Commissariat Energie Atomique EXTENDED FIELD SCAN AND DEPTH CONFOCAL OPTICAL MICROSCOPY AND DEVICES FOR CARRYING OUT THE METHOD
EP0393165B2 (en) * 1988-07-13 2007-07-25 Optiscan Pty Ltd Scanning confocal endoscope
US4972258A (en) * 1989-07-31 1990-11-20 E. I. Du Pont De Nemours And Company Scanning laser microscope system and methods of use
DE68924460T2 (en) * 1988-10-11 1996-06-13 Du Pont Laser scanning microscope and application method.

Also Published As

Publication number Publication date
DE69131176D1 (en) 1999-06-02
DK0495930T3 (en) 1999-11-08
JPH05501458A (en) 1993-03-18
DE69131176T2 (en) 1999-12-30
ES2133283T3 (en) 1999-09-16
EP0495930B1 (en) 1999-04-28
JP2824462B2 (en) 1998-11-11
EP0495930A1 (en) 1992-07-29
CA2067188C (en) 2001-05-15
DE495930T1 (en) 1993-02-25
WO1992002839A1 (en) 1992-02-20
ATE179527T1 (en) 1999-05-15
US5127730A (en) 1992-07-07

Similar Documents

Publication Publication Date Title
CA2067188A1 (en) Multi-color laser scanning confocal imaging system
Bertani et al. A scanning device for infrared reflectography
CA2289930A1 (en) Identification of objects by means of multiple imaging
DE69508248D1 (en) AUTOFOCUS SYSTEM FOR SCAN MICROSCOPY
WO1998059314B1 (en) Bacteria colony counter and classifier
GB9015793D0 (en) Confocal scanning optical microscope
DE69831933T2 (en) DEVICE AND METHOD FOR MONITORING A BIOLOGICAL SAMPLE
Hook et al. Confocal scanning fluorescence microscopy: a new method for phagocytosis research
GB9014570D0 (en) Method for transmitted-light and reflected-light imaging
CA2087888A1 (en) Optical information processor
FR2630833B1 (en) APPARATUS FOR STORING PHOTONS AND APPARATUS FOR DETERMINING THE SHAPE OF A SHORT-LIGHT PULSE USING THE SAME
ATE130151T1 (en) COLOR FILTER WHEEL FOR ENDOSCOPES AND PROCESSING THE COLOR SIGNALS GENERATED.
JPS56101119A (en) Observing device
Passarelli et al. A simple device for ultramicroscopic studies of motile microorganisms
Foy The photon counting camera CP40
Yatchmenoff et al. Ceramic surface analysis using optical sections
JPS6224581U (en)
梅二文 et al. Technique of Hadamard transform microscope fluorescence image analysis
JPS5294768A (en) Electronic microscope
EP0270251A3 (en) Imaging method and apparatus
Inoue et al. Through-focal and time-lapse stereoscopic imaging of dividing cells and developing embryos in DIC and polarization microscopy
SU1179990A1 (en) Method of investigating color vision
JPS55166617A (en) Color dark viewing device
DE69217435T2 (en) Dye ribbon and an imaging process using the same
Hess Transition from scanned photo to digital photo for graphic arts: Who makes it when- and why

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry