CA2066425A1 - Apparatus for administering medicaments to mucosal tissue - Google Patents

Apparatus for administering medicaments to mucosal tissue

Info

Publication number
CA2066425A1
CA2066425A1 CA 2066425 CA2066425A CA2066425A1 CA 2066425 A1 CA2066425 A1 CA 2066425A1 CA 2066425 CA2066425 CA 2066425 CA 2066425 A CA2066425 A CA 2066425A CA 2066425 A1 CA2066425 A1 CA 2066425A1
Authority
CA
Canada
Prior art keywords
control member
mucosal tissue
administering medicaments
medicaments
medicament chamber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2066425
Other languages
French (fr)
Other versions
CA2066425C (en
Inventor
Theodore H. Stanley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Utah Research Foundation UURF
Original Assignee
Theodore H. Stanley
University Of Utah
University Of Utah Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theodore H. Stanley, University Of Utah, University Of Utah Research Foundation filed Critical Theodore H. Stanley
Publication of CA2066425A1 publication Critical patent/CA2066425A1/en
Application granted granted Critical
Publication of CA2066425C publication Critical patent/CA2066425C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
    • A23G3/364—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
    • A23G3/368—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing vitamins, antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches

Abstract

Apparatus and method for the dose-to-effect transmucosal administration of medicaments are disclosed. The invention relates to a disk-shaped control member (22) defining a plurality of openings (24) on one semicircle of the control member (22), positioned adjacent the medicament chamber base (14). An adhesive material (26) located on the control member (22) rotates relative to housing (12) to increase or decrease the effective area of medicament chamber opening (18).
CA002066425A 1989-09-05 1990-08-03 Apparatus for administering medicaments to mucosal tissue Expired - Fee Related CA2066425C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US403,743 1989-09-05
US07/403,743 US5122127A (en) 1985-05-01 1989-09-05 Apparatus and methods for use in administering medicaments by direct medicament contact to mucosal tissues

Publications (2)

Publication Number Publication Date
CA2066425A1 true CA2066425A1 (en) 1991-03-06
CA2066425C CA2066425C (en) 1998-01-20

Family

ID=23596847

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002066425A Expired - Fee Related CA2066425C (en) 1989-09-05 1990-08-03 Apparatus for administering medicaments to mucosal tissue

Country Status (11)

Country Link
US (1) US5122127A (en)
EP (1) EP0491778B1 (en)
JP (1) JP2580076B2 (en)
AT (1) ATE149362T1 (en)
AU (1) AU643233B2 (en)
CA (1) CA2066425C (en)
DE (1) DE69030095T2 (en)
DK (1) DK0491778T3 (en)
ES (1) ES2097760T3 (en)
NO (1) NO920856L (en)
WO (1) WO1991003271A1 (en)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2678514B1 (en) * 1991-07-05 1993-11-05 Fred Cabrera DEVICE FOR THE DERMAL ABSORPTION OF MEDICINAL SOLUTS.
IT1250691B (en) * 1991-07-22 1995-04-21 Giancarlo Santus THERAPEUTIC COMPOSITIONS FOR INTRANASAL ADMINISTRATION INCLUDING KETOROLAC.
CH686816A5 (en) * 1992-02-04 1996-07-15 Asulab Ag Means for delivering a drug.
GB9212511D0 (en) * 1992-06-12 1992-07-22 Cortecs Ltd Pharmaceutical compositions
FI941336A (en) * 1993-03-23 1994-09-24 Diomedes Oy A patch that acts as a dispenser
AU6957594A (en) * 1993-05-26 1994-12-20 Becton Dickinson & Company Patch, with system and apparatus for manufacture
IS1796B (en) * 1993-06-24 2001-12-31 Ab Astra Inhaled polypeptide formulation composition which also contains an enhancer compound
TW402506B (en) 1993-06-24 2000-08-21 Astra Ab Therapeutic preparation for inhalation
US20010003739A1 (en) * 1993-06-24 2001-06-14 Astrazeneca Ab Systemic administration of a therapeutic preparation
US5830853A (en) 1994-06-23 1998-11-03 Astra Aktiebolag Systemic administration of a therapeutic preparation
US6632456B1 (en) 1993-06-24 2003-10-14 Astrazeneca Ab Compositions for inhalation
US6794357B1 (en) * 1993-06-24 2004-09-21 Astrazeneca Ab Compositions for inhalation
US5747445A (en) * 1993-06-24 1998-05-05 Astra Aktiebolag Therapeutic preparation for inhalation
GB9409281D0 (en) 1994-05-10 1994-06-29 Svedman Paul Transdermal device
US6165976A (en) 1994-06-23 2000-12-26 Astra Aktiebolag Therapeutic preparation for inhalation
JP4155594B2 (en) 1994-12-22 2008-09-24 アストラゼネカ・アクチエボラーグ Aerosol formulation
PL321094A1 (en) 1994-12-22 1997-11-24 Astra Ab Parathyroid hormone (pth) containing preparation administered by inhalation
US6524557B1 (en) * 1994-12-22 2003-02-25 Astrazeneca Ab Aerosol formulations of peptides and proteins
US5762494A (en) * 1997-03-24 1998-06-09 Archambault; Gregory A. Applicator device and method
GB9717770D0 (en) * 1997-08-21 1997-10-29 Scherer Ltd R P Pharmaceutical composition
US7153845B2 (en) * 1998-08-25 2006-12-26 Columbia Laboratories, Inc. Bioadhesive progressive hydration tablets
US8765177B2 (en) * 1997-09-12 2014-07-01 Columbia Laboratories, Inc. Bioadhesive progressive hydration tablets
US5981552A (en) * 1998-10-23 1999-11-09 Taylor Pharmaceuticals Sublingual and buccal compositions of droperidol and method for treating migraine
US6103257A (en) * 1998-07-17 2000-08-15 Num-Pop, Inc. System for delivering pharmaceuticals to the buccal mucosa
US6358060B2 (en) * 1998-09-03 2002-03-19 Jsr Llc Two-stage transmucosal medicine delivery system for symptom relief
US6344222B1 (en) 1998-09-03 2002-02-05 Jsr Llc Medicated chewing gum delivery system for nicotine
US6242473B1 (en) 1999-01-08 2001-06-05 Maxim Pharmaceuticals, Inc. Treatment and prevention of reactive oxygen metabolite-mediated cellular damage
US6270781B1 (en) 1999-01-08 2001-08-07 Maxim Pharmaceuticals, Inc. Method and compositions for topical treatment of damaged tissue using reactive oxygen metabolite production or release inhibitors
WO2000074616A1 (en) * 1999-06-02 2000-12-14 Tano Robert S Multipurpose first-aid bandage
WO2001005352A1 (en) * 1999-07-19 2001-01-25 Andrew John Ashworth Apparatus and method for administration of medication
AU7520200A (en) * 1999-09-18 2001-04-24 Heinz-Dieter Unger Container for receiving a pharmaceutical agent which acts upon or via the skin
WO2001089476A1 (en) * 2000-05-19 2001-11-29 Npd Llc Chewing gums, lozenges, candies, tablets, liquids, and sprays for efficient delivery of medications and dietary supplements
NZ524396A (en) 2000-07-31 2003-09-26 Nycomed Danmark As Fentanyl composition for nasal administration comprising water as a solvent
US20020106407A1 (en) * 2000-12-11 2002-08-08 Dennis Coleman Method and apparatus for treating breakthrough pain
WO2002069897A2 (en) * 2001-03-02 2002-09-12 Euro-Celtique, S.A. Method and apparatus for compounding individualized dosage forms
US7438701B2 (en) * 2001-07-26 2008-10-21 Durect Corporation Local concentration management system
US20030153590A1 (en) * 2001-08-14 2003-08-14 Oy Contral Pharma Ltd Method of treating alcoholism or alcohol abuse
DE10141650C1 (en) * 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Safe transdermal therapeutic system for administration of fentanyl or analogous analgesics, having matrix layer of carboxy group-free polyacrylate adhesive providing high permeation rate
BR0205990A (en) * 2001-08-29 2004-01-13 Ricardo Azevedo Ponte Carvalho An implantable one-way delivery system for therapeutic tissue agents
CA2461661A1 (en) * 2001-10-19 2003-05-01 Maxim Pharmaceuticals, Inc. Use of histamine to treat liver disease
JP2005508366A (en) * 2001-11-06 2005-03-31 マキシム ファーマシューティカルス，インコーポレイテッド Composition for the treatment of infectious diseases
WO2004048934A2 (en) * 2002-11-21 2004-06-10 Ada Technologies, Inc. Strobe desorption method for high boiling point materials
US7833802B2 (en) * 2002-11-21 2010-11-16 Ada Technologies, Inc. Stroboscopic liberation and methods of use
GB0300531D0 (en) 2003-01-10 2003-02-12 West Pharm Serv Drug Res Ltd Pharmaceutical compositions
US20040202717A1 (en) 2003-04-08 2004-10-14 Mehta Atul M. Abuse-resistant oral dosage forms and method of use thereof
US7416546B2 (en) 2003-05-05 2008-08-26 Boston Scientific Scimed, Inc. Tissue patches and related delivery systems and methods
US8034048B2 (en) * 2003-05-05 2011-10-11 Boston Scientific Scimed, Inc. Tissue patches and related delivery systems and methods
US7470266B2 (en) * 2003-09-16 2008-12-30 I-Flow Corporation Fluid medication delivery device
FR2863174B1 (en) * 2003-12-08 2006-11-24 Galderma Res & Dev DEVICE FOR DETERMINING A PRODUCT INTENDED TO BE APPLIED ON THE SKIN
US20050171192A1 (en) * 2003-12-11 2005-08-04 Gehlsen Kurt R. Use of histamine to treat bone disease
AT500095B8 (en) * 2004-01-23 2007-02-15 Braun Werner Mag TRANSDERMAL DELIVERY SYSTEM
CA2568201C (en) 2004-05-24 2013-07-30 Universitat Zu Koln Identification of ergothioneine transporter and therapeutic uses thereof
GB2414675B (en) * 2004-06-05 2006-09-06 Dewan Fazlul Hoque Chowdhury Transdermal drug delivery device
US20060002913A1 (en) * 2004-06-22 2006-01-05 Gehlsen Kurt R Use of histamine and related compounds to treat disorders affecting muscle function
US8377711B2 (en) * 2005-04-04 2013-02-19 Ada Technologies, Inc. Stroboscopic liberation and methods of use
EP1931414A4 (en) * 2005-10-05 2016-02-17 Acu Rate Pty Ltd A controlled flow administration set
US8535714B2 (en) 2006-01-06 2013-09-17 Acelrx Pharmaceuticals, Inc. Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US8753308B2 (en) 2006-01-06 2014-06-17 Acelrx Pharmaceuticals, Inc. Methods for administering small volume oral transmucosal dosage forms using a dispensing device
US9066847B2 (en) * 2007-01-05 2015-06-30 Aceirx Pharmaceuticals, Inc. Storage and dispensing devices for administration of oral transmucosal dosage forms
US8252329B2 (en) 2007-01-05 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
US8357114B2 (en) * 2006-01-06 2013-01-22 Acelrx Pharmaceuticals, Inc. Drug dispensing device with flexible push rod
US8252328B2 (en) * 2006-01-06 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
US8202535B2 (en) * 2006-01-06 2012-06-19 Acelrx Pharmaceuticals, Inc. Small-volume oral transmucosal dosage forms
US8865743B2 (en) 2006-01-06 2014-10-21 Acelrx Pharmaceuticals, Inc. Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US9289583B2 (en) * 2006-01-06 2016-03-22 Acelrx Pharmaceuticals, Inc. Methods for administering small volume oral transmucosal dosage forms using a dispensing device
US8642016B2 (en) * 2006-07-21 2014-02-04 Jsrnti, Llc Medicinal delivery system, and related methods
US20080085331A1 (en) * 2006-10-06 2008-04-10 Gluskin Anna E Composition and method for raising blood glucose level
US8363215B2 (en) 2007-01-25 2013-01-29 Ada Technologies, Inc. Methods for employing stroboscopic signal amplification and surface enhanced raman spectroscopy for enhanced trace chemical detection
US7817274B2 (en) * 2007-10-05 2010-10-19 Jingyun Zhang Compact spectrometer
US8345226B2 (en) * 2007-11-30 2013-01-01 Jingyun Zhang Spectrometers miniaturized for working with cellular phones and other portable electronic devices
US8945592B2 (en) 2008-11-21 2015-02-03 Acelrx Pharmaceuticals, Inc. Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same
GB2467377A (en) 2009-02-02 2010-08-04 Nemaura Pharma Ltd Transdermal patch with extensor means actuated to expel drug towards the skin of a patient
US20100291160A1 (en) * 2009-05-13 2010-11-18 Carver David R Pharmaceutical system for trans-membrane delivery
US8690841B2 (en) * 2009-07-09 2014-04-08 R. Gary Diaz Wound care system
BR112012012945A2 (en) 2009-11-25 2020-12-29 Arisgen Sa MUCOSAL RELEASE COMPOSITION, ITS PRODUCTION METHOD, PRE-FORMED PEPTIDE COMPLEX, KIT AND USE OF AN ACTIVE PEPTIDE AGENT
EP2526971A1 (en) 2011-05-25 2012-11-28 ArisGen SA Mucosal delivery of drugs
MY187877A (en) 2014-12-23 2021-10-26 Acelrx Pharmaceuticals Inc Systems, devices and methods for dispensing oral transmucosal dosage forms
CN106546533B (en) 2015-09-20 2019-12-10 大连世佩达光谱智能检测科技有限公司 Equipment for collecting surface enhanced Raman scattering spectrum by using full-aperture angle parabolic mirror
EP4183385A1 (en) * 2021-11-23 2023-05-24 ETH Zurich Mucosal suction patch and uses thereof in drug delivery

Family Cites Families (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US109677A (en) * 1870-11-29 Improvement in confectionery for druggists
US802190A (en) * 1903-03-20 1905-10-17 Solomon E Heineman Emergency-bandage for surgical purposes.
US747525A (en) * 1903-08-22 1903-12-22 Belle Rector Willis Surgical apparatus.
US1430642A (en) * 1921-01-29 1922-10-03 Phillip E Gross Artificial fishing bait
US1593858A (en) * 1923-02-12 1926-07-27 Robert W Venable Confection
US1602344A (en) * 1924-01-09 1926-10-05 Eagle Peter Medicating compress
US1971560A (en) * 1928-10-22 1934-08-28 Parker Meyer Dennis Company Candy and holder therefor
US1847415A (en) * 1929-12-31 1932-03-01 Silver S Snell Holder for candy suckers
US1915614A (en) * 1930-12-22 1933-06-27 Parker Charles Solidified edible and method of making same
DE577563C (en) * 1932-07-31 1933-06-01 Hugo Kratz Dr Device for applying fluids
US2096611A (en) * 1935-02-07 1937-10-19 Parker Meyer Dennis Company Confection
US2208120A (en) * 1938-03-02 1940-07-16 William B Coleman Pharmaceutical preparation and method of making same
US2246778A (en) * 1939-12-21 1941-06-24 Edward E Cahoon Safety handle for confections
US2295042A (en) * 1941-08-25 1942-09-08 Robert L Llewellyn Fish plug
GB550296A (en) * 1941-11-17 1943-01-01 British Oxygen Co Ltd Improvements in or relating to the administration of inhalant gas mixtures
US2323656A (en) * 1942-07-28 1943-07-06 Helfenstein John Fishhook
US2508560A (en) * 1946-10-22 1950-05-23 Mozel A Adams Fishing lure
GB628709A (en) * 1947-10-06 1949-09-02 William Edmondson An appliance for the production and administration of gas-vapour mixtures
US2488272A (en) * 1948-08-06 1949-11-15 Harry E Davis Cellophane stick and method of making it
US2469589A (en) * 1948-09-20 1949-05-10 Toy Pop Corp Confection with support therefor
GB646680A (en) * 1948-10-27 1950-11-29 William Edmondson Apparatus for mixing the vapour of a volatile anaesthetic with air
US2807262A (en) * 1952-12-10 1957-09-24 Robert B Lew Perforated plastic adhesive tape bandage
US2915061A (en) * 1956-12-24 1959-12-01 Cyprane Ltd Volatile anaesthetic vaporising apparatus
US2926121A (en) * 1957-03-20 1960-02-23 American Home Prod Therapeutic candy-like product and its preparation
US2857908A (en) * 1957-04-26 1958-10-28 Leslie S Cornfield Candy coated tongue depressor
US2897624A (en) * 1958-06-27 1959-08-04 Frederick O Yakel Conservation fishhooks
US2963404A (en) * 1958-09-05 1960-12-06 Pfizer & Co C Tannate candy making, and product
US3210247A (en) * 1960-04-16 1965-10-05 Anti-epileptic i-cyclohexyl-z-methyl- aiviino propane salt of phenyl ethyl barbituric acid
CH410963A (en) * 1960-07-28 1966-04-15 Hommel Ag Process for the preparation of 5-allyl-5- (B-oxypropyl) barbituric acid
GB968054A (en) * 1962-02-15 1964-08-26 Cyprane Ltd Improvements in volatile anaesthetic vaporising apparatus
US3264115A (en) * 1962-07-10 1966-08-02 Harry E Davis Safety lollipop
US3493652A (en) * 1962-09-14 1970-02-03 Charles W Hartman Controlled release medicament
US3271256A (en) * 1963-03-21 1966-09-06 Richardson Merrell Inc Chloroform in hard candy
US3172179A (en) * 1963-08-12 1965-03-09 John V Schafer Collar fastener
GB1083896A (en) * 1964-04-30 1967-09-20 Dunster Lab Ltd Vehicles for administering drugs
GB1071659A (en) * 1964-06-09 1967-06-07 Cyprane Ltd Improvements in or relating to volatile anaesthetic vaporising apparatus
US3344030A (en) * 1964-06-15 1967-09-26 American Home Prod Reinforced directly compressed nongranulated pharmaceutical crystalline lactose tables
US3341414A (en) * 1964-08-27 1967-09-12 Merck & Co Inc N-cyclohexylsulfamate solubilized medication
US3367332A (en) * 1965-08-27 1968-02-06 Gen Electric Product and process for establishing a sterile area of skin
GB1171691A (en) * 1967-02-24 1969-11-26 Forest Laboratories Lond-Acting Oral Carrier
US3418743A (en) * 1967-05-02 1968-12-31 Roy H. Halvorsen Fish lure with retractable hooks
US3797494A (en) * 1969-04-01 1974-03-19 Alza Corp Bandage for the administration of drug by controlled metering through microporous materials
US3556811A (en) * 1969-08-11 1971-01-19 Walton J Smith Low-fermentability hard candy
US3996934A (en) * 1971-08-09 1976-12-14 Alza Corporation Medical bandage
BE795384A (en) * 1972-02-14 1973-08-13 Ici Ltd DRESSINGS
FI50578C (en) * 1972-09-05 1976-05-10 Haemeen Anttila Yrjoe Sakari Pull fitted with sliding hooks
US3867927A (en) * 1974-06-13 1975-02-25 Patrick F Hergott Tongue blade sucker
US3943928A (en) * 1974-09-25 1976-03-16 Lariccia Anthony H Eliminating the safety hazard in oral dissolution of a solid
US4093709A (en) * 1975-01-28 1978-06-06 Alza Corporation Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates)
US4131648A (en) * 1975-01-28 1978-12-26 Alza Corporation Structured orthoester and orthocarbonate drug delivery devices
US4168308A (en) * 1976-03-12 1979-09-18 Apoteksvarucentralen Vitrum Ab Composition for enhancing the administration of pharmacologically active agents
US4060084A (en) * 1976-09-07 1977-11-29 Alza Corporation Method and therapeutic system for providing chemotherapy transdermally
US4078568A (en) * 1976-10-12 1978-03-14 Northern Illinois Research, Inc. Plastic composition and method
DE2712161C2 (en) * 1977-03-19 1983-01-05 Blendax-Werke R. Schneider Gmbh & Co, 6500 Mainz Dental and oral care products
DD132404B1 (en) * 1977-08-12 1983-04-27 Roland Schubert METHOD FOR PRODUCING A MEDICAL DEVICE
US4139627A (en) * 1977-10-06 1979-02-13 Beecham Inc. Anesthetic lozenges
DE2860482D1 (en) * 1977-11-07 1981-03-26 Beecham Inc Anaesthetic lozenges and method of preparing them
JPS5562012A (en) * 1978-11-06 1980-05-10 Teijin Ltd Slow-releasing preparation
FR2441341A1 (en) * 1978-11-15 1980-06-13 Batriaud Delautre Marie Sweet or tablet which permits breathing if stuck in throat - has external grooves and/or through holes for passage of air
GB2042888B (en) * 1979-03-05 1983-09-28 Teijin Ltd Preparation for administration to the mucosa of the oral or nasal cavity
US4291015A (en) * 1979-08-14 1981-09-22 Key Pharmaceuticals, Inc. Polymeric diffusion matrix containing a vasodilator
US4307075A (en) * 1979-09-13 1981-12-22 American Home Products Corporation Topical treatment of aphthous stomatitis
JPS56100714A (en) * 1980-01-16 1981-08-12 Teijin Ltd Pharmaceutical adhering to oral mucous membrane or nasal mucous membrane
US4341208A (en) * 1980-07-14 1982-07-27 Whitman Medical Corporation Moisture-retentive covering for ointment application
JPS5758615A (en) * 1980-09-26 1982-04-08 Nippon Soda Co Ltd Film agnent and its preparation
JPS5843368B2 (en) * 1980-10-30 1983-09-27 日東電工株式会社 Anti-inflammatory analgesic patch
US4346709A (en) * 1980-11-10 1982-08-31 Alza Corporation Drug delivery devices comprising erodible polymer and erosion rate modifier
IL61721A (en) * 1980-12-16 1984-03-30 Blank Izhak Nitroglycerin preparations
JPS6059207B2 (en) * 1981-03-13 1985-12-24 日東電工株式会社 Manufacturing method for complex preparations
SU1011126A1 (en) * 1981-07-14 1983-04-15 Всесоюзный научно-исследовательский и испытательный институт медицинской техники Method of treating diabetes mellitus
JPS5924964B2 (en) * 1981-08-11 1984-06-13 帝人株式会社 sustained release formulation
US4372942A (en) * 1981-08-13 1983-02-08 Beecham Inc. Candy base and liquid center hard candy made therefrom
CH653550A5 (en) * 1981-10-20 1986-01-15 Sandoz Ag PHARMACEUTICAL COMPOSITION FOR DELAYED RELEASE OF A MEDICINE IN THE ORAL AREA.
US4460368A (en) * 1981-10-29 1984-07-17 Almedco, Inc. Trans-dermal medication system
CA1208558A (en) * 1982-10-07 1986-07-29 Kazuo Kigasawa Soft buccal
US4573996A (en) * 1984-01-03 1986-03-04 Jonergin, Inc. Device for the administration of an active agent to the skin or mucosa
US4551329A (en) * 1984-01-20 1985-11-05 Joan Harris Oral medicament lollipop
US4588580B2 (en) * 1984-07-23 1999-02-16 Alaz Corp Transdermal administration of fentanyl and device therefor
JPS61101641A (en) * 1984-10-22 1986-05-20 Fuji Heavy Ind Ltd Air-fuel ratio controlling apparatus
US4671953A (en) * 1985-05-01 1987-06-09 University Of Utah Research Foundation Methods and compositions for noninvasive administration of sedatives, analgesics, and anesthetics
DE3527893A1 (en) * 1985-08-03 1987-02-05 Merck Patent Gmbh EPICUTANE TEST PLASTER
US4666441A (en) * 1985-12-17 1987-05-19 Ciba-Geigy Corporation Multicompartmentalized transdermal patches
US4917688A (en) * 1987-01-14 1990-04-17 Nelson Research & Development Co. Bandage for transdermal delivery of systemically-active drug
US4812305A (en) * 1987-11-09 1989-03-14 Vocal Rodolfo S Well medicine strip
US4849224A (en) * 1987-11-12 1989-07-18 Theratech Inc. Device for administering an active agent to the skin or mucosa

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DK0491778T3 (en) 1997-09-08
DE69030095T2 (en) 1997-09-25
DE69030095D1 (en) 1997-04-10
NO920856D0 (en) 1992-03-04
EP0491778A1 (en) 1992-07-01
NO920856L (en) 1992-04-06
JPH05500176A (en) 1993-01-21
AU643233B2 (en) 1993-11-11
US5122127A (en) 1992-06-16
EP0491778B1 (en) 1997-03-05
WO1991003271A1 (en) 1991-03-21
CA2066425C (en) 1998-01-20
EP0491778A4 (en) 1992-08-12
JP2580076B2 (en) 1997-02-12
AU6353990A (en) 1991-04-08
ATE149362T1 (en) 1997-03-15
ES2097760T3 (en) 1997-04-16

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