CA2061824A1 - Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer - Google Patents

Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer

Info

Publication number
CA2061824A1
CA2061824A1 CA2061824A CA2061824A CA2061824A1 CA 2061824 A1 CA2061824 A1 CA 2061824A1 CA 2061824 A CA2061824 A CA 2061824A CA 2061824 A CA2061824 A CA 2061824A CA 2061824 A1 CA2061824 A1 CA 2061824A1
Authority
CA
Canada
Prior art keywords
aqueous dispersion
controlled release
coating derived
hydrophobic polymer
release substrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2061824A
Other languages
French (fr)
Other versions
CA2061824C (en
Inventor
Benjamin Oshlack
Mark Chasin
Frank Pedi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euro Celtique SA
Original Assignee
Euro Celtique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25214195&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2061824(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Euro Celtique SA filed Critical Euro Celtique SA
Publication of CA2061824A1 publication Critical patent/CA2061824A1/en
Application granted granted Critical
Publication of CA2061824C publication Critical patent/CA2061824C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core

Abstract

A stabilized solid controlled release dosage form having a coating derived from an aqueous dispersion of ethylcellulose is obtained by overcoating a substrate including a therapeutically active agent with an aqueous dispersion of ethylcellulose and then curing the coated substrate at a temperature and relative humidity elevated to a suitable level above ambient conditions until the coated dosage form attains a stabilized dissolution profile substantially unaffected by exposure to storage conditions of elevated temperature and/or elevated relative humidity.
CA002061824A 1991-12-24 1992-02-25 Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer Expired - Lifetime CA2061824C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/814,111 US5273760A (en) 1991-12-24 1991-12-24 Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer
US814,111 1991-12-24

Publications (2)

Publication Number Publication Date
CA2061824A1 true CA2061824A1 (en) 1993-06-25
CA2061824C CA2061824C (en) 1999-04-06

Family

ID=25214195

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002061824A Expired - Lifetime CA2061824C (en) 1991-12-24 1992-02-25 Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer

Country Status (24)

Country Link
US (1) US5273760A (en)
EP (1) EP0548448B1 (en)
JP (1) JP3061474B2 (en)
KR (1) KR100252188B1 (en)
AT (1) ATE196079T1 (en)
AU (1) AU652871B2 (en)
BR (1) BR9202982A (en)
CA (1) CA2061824C (en)
DE (1) DE69231415T2 (en)
DK (1) DK0548448T3 (en)
EG (1) EG20083A (en)
ES (1) ES2152221T3 (en)
FI (1) FI921548A (en)
GR (1) GR3034951T3 (en)
HK (1) HK1005686A1 (en)
IE (1) IE920795A1 (en)
IL (1) IL101080A (en)
MX (1) MX9200932A (en)
NO (1) NO312577B1 (en)
NZ (1) NZ241660A (en)
PT (1) PT548448E (en)
SG (1) SG44703A1 (en)
YU (1) YU48345B (en)
ZA (1) ZA921366B (en)

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