CA2061044A1 - Tip to surface spacing for optimum dispensing - Google Patents

Tip to surface spacing for optimum dispensing

Info

Publication number
CA2061044A1
CA2061044A1 CA2061044A CA2061044A CA2061044A1 CA 2061044 A1 CA2061044 A1 CA 2061044A1 CA 2061044 A CA2061044 A CA 2061044A CA 2061044 A CA2061044 A CA 2061044A CA 2061044 A1 CA2061044 A1 CA 2061044A1
Authority
CA
Canada
Prior art keywords
tip
dispensing
meniscus
depth
contacted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2061044A
Other languages
French (fr)
Other versions
CA2061044C (en
Inventor
James V. Barry
Raymond F. Jakubowicz
J. Eric Hamann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eastman Kodak Co
Original Assignee
Eastman Kodak Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eastman Kodak Co filed Critical Eastman Kodak Co
Publication of CA2061044A1 publication Critical patent/CA2061044A1/en
Application granted granted Critical
Publication of CA2061044C publication Critical patent/CA2061044C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1011—Control of the position or alignment of the transfer device
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00732—Identification of carriers, materials or components in automatic analysers
    • G01N2035/00742—Type of codes
    • G01N2035/00752—Type of codes bar codes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1016—Control of the volume dispensed or introduced
    • G01N2035/102—Preventing or detecting loss of fluid by dripping
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N2035/1025—Fluid level sensing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/115831—Condition or time responsive
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/119163—Automated chemical analysis with aspirator of claimed structure
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Abstract

There is disclosed a method for automatically adjusting a dispensing tip from a surface onto which liquid is to be dispensed, a proper distance that precludes the dispensing stream from puddling up, or from breaking apart. The method features the formation on the tip of a meniscus of a nominal small volume and advancing the tip and meniscus until the surface is contacted. The resulting decrease in pressure in the tip is measured, to trigger the tip to stop its advance and to start dispensing. In circumstances wherein the contacted surface is hydrophobic so as to ideally require a meniscus depth greater than the nominal depth, the tip is retreated from the surface, during dispensing, to the ideal depth.
CA002061044A 1991-03-21 1992-02-11 Tip to surface spacing for optimum dispensing Expired - Lifetime CA2061044C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/672,980 US5143849A (en) 1991-03-21 1991-03-21 Tip to surface spacing for optimum dispensing controlled by a detected pressure change in the tip
US672,980 1991-03-21

Publications (2)

Publication Number Publication Date
CA2061044A1 true CA2061044A1 (en) 1992-09-22
CA2061044C CA2061044C (en) 1995-11-07

Family

ID=24700820

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002061044A Expired - Lifetime CA2061044C (en) 1991-03-21 1992-02-11 Tip to surface spacing for optimum dispensing

Country Status (7)

Country Link
US (1) US5143849A (en)
EP (1) EP0505004B1 (en)
JP (1) JP3688723B2 (en)
KR (1) KR960009754B1 (en)
CA (1) CA2061044C (en)
DE (1) DE69210662T2 (en)
IE (1) IE920902A1 (en)

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US5312757A (en) * 1991-05-02 1994-05-17 Olympus Optical Co., Ltd. Sample distributing method
EP0916396B1 (en) * 1991-11-22 2005-04-13 Affymetrix, Inc. (a Delaware Corporation) Combinatorial strategies for polymer synthesis
US6943034B1 (en) 1991-11-22 2005-09-13 Affymetrix, Inc. Combinatorial strategies for polymer synthesis
US5456880A (en) * 1992-11-20 1995-10-10 Shimadzu Corporation Micropipet apparatus and micromanipulator
US5401467A (en) * 1993-07-21 1995-03-28 Eastman Kodak Company Whole blood metering cup
EP0635712B1 (en) * 1993-07-21 1998-01-14 Johnson & Johnson Clinical Diagnostics, Inc. Method of pretreating diagnostic test elements
US5895761A (en) * 1993-07-21 1999-04-20 Clinical Diagnostic Systems, Inc. Surface area liquid transfer method and related apparatus
DE4331997A1 (en) * 1993-09-21 1995-03-23 Boehringer Mannheim Gmbh Method and system for mixing liquids
DE4341229C2 (en) * 1993-12-03 1995-09-07 Eppendorf Geraetebau Netheler Pipette system
JP3351615B2 (en) * 1994-03-17 2002-12-03 ソニー株式会社 Liquid boundary detection method and liquid separation method
JP3420824B2 (en) * 1994-04-15 2003-06-30 富士写真フイルム株式会社 Method and apparatus for spotting sample liquid on dry analytical film piece
JP3115501B2 (en) * 1994-06-15 2000-12-11 プレシジョン・システム・サイエンス株式会社 Method for controlling desorption of magnetic material using dispenser and various devices processed by this method
US7625697B2 (en) 1994-06-17 2009-12-01 The Board Of Trustees Of The Leland Stanford Junior University Methods for constructing subarrays and subarrays made thereby
US5601980A (en) * 1994-09-23 1997-02-11 Hewlett-Packard Company Manufacturing method and apparatus for biological probe arrays using vision-assisted micropipetting
JP3571092B2 (en) * 1994-12-20 2004-09-29 富士写真フイルム株式会社 Sample solution spotting method on dry analytical film piece
CA2175001A1 (en) * 1995-05-01 1996-11-02 Andrew Shelley Foote Method of avoiding decreased-size first drops when aspirating from immersed rest conditions
US5611996A (en) * 1995-06-06 1997-03-18 Johnson & Johnson Clinical Diagnostics, Inc. Slide test element holder with minimized Z-axis variability
US5750881A (en) * 1995-07-13 1998-05-12 Chiron Diagnostics Corporation Method and apparatus for aspirating and dispensing sample fluids
US6158269A (en) * 1995-07-13 2000-12-12 Bayer Corporation Method and apparatus for aspirating and dispensing sample fluids
US5811306A (en) * 1995-09-04 1998-09-22 Fuji Photo Film Co., Ltd. Liquid spotting method
US5744099A (en) * 1995-09-15 1998-04-28 Cytek Development Inc. Apparatus for transfer of biological fluids
US5665601A (en) * 1996-01-22 1997-09-09 Johnson & Johnson Clinical Diagnostics, Inc. Avoiding bubble formation while sensing air-liquid interface using pressurized air flow
US6689323B2 (en) 1998-10-30 2004-02-10 Agilent Technologies Method and apparatus for liquid transfer
US6270726B1 (en) * 1999-09-30 2001-08-07 Dpc Cirrus, Inc. Tube bottom sensing for small fluid samples
DE10004941A1 (en) * 2000-02-06 2001-08-09 Reimer Offen Tempered liquid sampler
DE10017790A1 (en) * 2000-04-10 2001-10-11 Basf Ag Process for the production of biopolymer fields with real-time control
JP3926546B2 (en) * 2000-09-22 2007-06-06 富士フイルム株式会社 Spotting detection method and spotting detection device
EP1207396A1 (en) * 2000-10-20 2002-05-22 Seyonic SA Fluid dispenser
US6484556B1 (en) * 2000-11-13 2002-11-26 Ortho Clinical Diagnostics, Inc. Thin film detection during fluid aspiration
KR100777362B1 (en) * 2001-05-08 2007-11-19 (주)바이오니아 Spotting Pin for microarraying of biological preparation
WO2002102514A1 (en) * 2001-06-19 2002-12-27 B.C. Cancer Agency Microvolume liquid dispenser suitable for microarrays and methods related thereto
US6579724B2 (en) * 2001-09-13 2003-06-17 First Ten Angstroms Dispensing method and apparatus for dispensing very small quantities of fluid
US6937955B2 (en) 2002-03-29 2005-08-30 Ortho-Clinical Diagnostics, Inc. Method for automatic alignment of metering system for a clinical analyzer
US7955865B2 (en) * 2004-06-09 2011-06-07 The University Of British Columbia Reagent delivery apparatus and methods
JP4373427B2 (en) 2005-11-15 2009-11-25 エフ．ホフマン−ラ ロシュ アーゲー Electrical dripping monitoring
EP1785731A1 (en) * 2005-11-15 2007-05-16 Roche Diagnostics GmbH Electrical drop surveillance
US7457686B2 (en) * 2007-03-14 2008-11-25 Ortho—Clinical Diagnostics, Inc. Robotic arm alignment
US9304141B2 (en) 2007-04-18 2016-04-05 Becton, Dickinson And Company Method and apparatus for determing dispense volume
US20130064737A1 (en) * 2010-01-13 2013-03-14 Hitachi High-Technologies Corporation Automatic analyzer
CA2766735C (en) 2011-02-07 2020-06-02 Ortho-Clinical Diagnostics, Inc. Determining conditions in centrifuged blood using measured pressure
JP2013076674A (en) * 2011-09-30 2013-04-25 Fujifilm Corp Dispenser and suction nozzle position controlling method
WO2014009251A1 (en) 2012-07-13 2014-01-16 Evotec Ag Method for adjusting the dispensing height of pipettes
CN105374253B (en) * 2015-12-08 2018-08-10 辽宁石化职业技术学院 A kind of multifunction instrument calibration equipment and transmitter method of calibration for teaching
JP6807778B2 (en) 2017-03-06 2021-01-06 テラメックス株式会社 Pipette tip tip detection device, pipette tip tip detection program
EP3381560A1 (en) 2017-03-28 2018-10-03 Eppendorf AG Method and a dosing device for contact dosing of liquids
DE102020204670A1 (en) 2020-04-14 2021-10-14 Prime23 GmbH Device and method for wetting biological material with at least one liquid and a holding device

Family Cites Families (11)

* Cited by examiner, † Cited by third party
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US4041995A (en) * 1975-01-30 1977-08-16 Eastman Kodak Company Gas pressure-activated drop dispenser
US4340390A (en) * 1980-06-16 1982-07-20 Eastman Kodak Company Method and apparatus for metering biological fluids
US4347875A (en) * 1980-07-14 1982-09-07 Eastman Kodak Company Self-cleaning nozzle construction for aspirators
JPS60155942A (en) * 1984-01-25 1985-08-16 Fuji Photo Film Co Ltd Spot deposition apparatus of liquid specimen
US4794085A (en) * 1984-07-19 1988-12-27 Eastman Kodak Company Apparatus and method for detecting liquid penetration by a container used for aspirating and dispensing the liquid
US4586546A (en) * 1984-10-23 1986-05-06 Cetus Corporation Liquid handling device and method
US4675301A (en) * 1985-04-01 1987-06-23 Eastman Kodak Company Method for correcting for changes in air pressure above a liquid to be dispensed from a container mounted on a probe
US4615360A (en) * 1985-09-05 1986-10-07 Eastman Kodak Company Means providing separation of exterior sheath of liquid on dispensing tip
JPH076998B2 (en) * 1987-12-04 1995-01-30 富士写真フイルム株式会社 Automatic dispenser and spotting method
US5059393A (en) * 1989-01-05 1991-10-22 Eastman Kodak Company Analysis slide positioning apparatus and method for a chemical analyzer
DE69126690T2 (en) * 1990-04-06 1998-01-02 Perkin Elmer Corp AUTOMATED LABORATORY FOR MOLECULAR BIOLOGY

Also Published As

Publication number Publication date
JP3688723B2 (en) 2005-08-31
EP0505004A3 (en) 1992-12-30
DE69210662D1 (en) 1996-06-20
JPH0599804A (en) 1993-04-23
DE69210662T2 (en) 1996-09-26
IE920902A1 (en) 1992-09-23
EP0505004B1 (en) 1996-05-15
KR960009754B1 (en) 1996-07-24
EP0505004A2 (en) 1992-09-23
US5143849A (en) 1992-09-01
CA2061044C (en) 1995-11-07

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Legal Events

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