CA2056371A1 - Stable microbubbles suspensions injectable into living organisms - Google Patents

Stable microbubbles suspensions injectable into living organisms

Info

Publication number
CA2056371A1
CA2056371A1 CA002056371A CA2056371A CA2056371A1 CA 2056371 A1 CA2056371 A1 CA 2056371A1 CA 002056371 A CA002056371 A CA 002056371A CA 2056371 A CA2056371 A CA 2056371A CA 2056371 A1 CA2056371 A1 CA 2056371A1
Authority
CA
Canada
Prior art keywords
living organisms
surfactants
stable microbubbles
microbubbles suspensions
injectable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002056371A
Other languages
French (fr)
Other versions
CA2056371C (en
Inventor
Michel Schneider
Daniel Bichon
Philippe Bussat
Jerome Puginier
Eva Hybl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco International BV
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8205915&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2056371(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of CA2056371A1 publication Critical patent/CA2056371A1/en
Application granted granted Critical
Publication of CA2056371C publication Critical patent/CA2056371C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acoustics & Sound (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Catching Or Destruction (AREA)
  • Farming Of Fish And Shellfish (AREA)

Abstract

Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the lami-narized surfactants to air or a gas before or after admixing with an aqueous phase.
CA002056371A 1990-04-02 1991-04-02 Stable microbubbles suspensions injectable into living organisms Expired - Lifetime CA2056371C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP90810262.7 1990-04-02
EP90810262 1990-04-02
PCT/EP1991/000620 WO1991015244A2 (en) 1990-04-02 1991-04-02 Stable microbubbles suspensions injectable into living organisms

Publications (2)

Publication Number Publication Date
CA2056371A1 true CA2056371A1 (en) 1991-10-03
CA2056371C CA2056371C (en) 2004-07-27

Family

ID=8205915

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002056371A Expired - Lifetime CA2056371C (en) 1990-04-02 1991-04-02 Stable microbubbles suspensions injectable into living organisms

Country Status (19)

Country Link
US (13) US5271928A (en)
EP (1) EP0474833B2 (en)
JP (3) JP2842453B2 (en)
KR (1) KR960002184B1 (en)
CN (1) CN1055413C (en)
AT (1) ATE125711T1 (en)
AU (1) AU630030B2 (en)
CA (1) CA2056371C (en)
DE (1) DE69111719T3 (en)
DK (1) DK0474833T4 (en)
ES (1) ES2075438T5 (en)
GR (1) GR3017324T3 (en)
IE (1) IE69018B1 (en)
IL (1) IL97730A (en)
IN (1) IN172208B (en)
IS (1) IS3686A7 (en)
NZ (1) NZ237637A (en)
WO (1) WO1991015244A2 (en)
ZA (1) ZA912427B (en)

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US5271928A (en) 1993-12-21
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US5531980A (en) 1996-07-02
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US5380519A (en) 1995-01-10
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