CA2031164A1 - Recombinant herpesvirus of turkeys and live vector vaccines derived thereof - Google Patents

Recombinant herpesvirus of turkeys and live vector vaccines derived thereof

Info

Publication number
CA2031164A1
CA2031164A1 CA002031164A CA2031164A CA2031164A1 CA 2031164 A1 CA2031164 A1 CA 2031164A1 CA 002031164 A CA002031164 A CA 002031164A CA 2031164 A CA2031164 A CA 2031164A CA 2031164 A1 CA2031164 A1 CA 2031164A1
Authority
CA
Canada
Prior art keywords
turkeys
recombinant herpesvirus
live vector
vector vaccines
hvt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002031164A
Other languages
French (fr)
Other versions
CA2031164C (en
Inventor
Paulus J. A. Sondermeijer
Johannes A. J. Claessens
Albert P. A. Mockett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intervet International BV
Original Assignee
Akzo NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8202517&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2031164(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Akzo NV filed Critical Akzo NV
Publication of CA2031164A1 publication Critical patent/CA2031164A1/en
Application granted granted Critical
Publication of CA2031164C publication Critical patent/CA2031164C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16311—Mardivirus, e.g. Gallid herpesvirus 2, Marek-like viruses, turkey HV
    • C12N2710/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16311—Mardivirus, e.g. Gallid herpesvirus 2, Marek-like viruses, turkey HV
    • C12N2710/16341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/16343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/816—Viral vaccine for avian species, e.g. poultry or other birds

Abstract

The present invention is concerned with a recombinant Herpesvirus of Turkeys (HVT), containing a heterologous gene incorporated into an insertion-region of the genome of HVT.
The invention also relates to a vector vaccine comprising such a recombinant HVT which expresses a heterologous antigenic polypeptide and induces an adequate immune response on infection of an appropriate host animal.
CA002031164A 1989-12-04 1990-11-29 Recombinant herpesvirus of turkeys and live vector vaccines derived thereof Expired - Lifetime CA2031164C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP89203071 1989-12-04
EP89.203071.9 1989-12-04

Publications (2)

Publication Number Publication Date
CA2031164A1 true CA2031164A1 (en) 1991-06-05
CA2031164C CA2031164C (en) 2001-10-16

Family

ID=8202517

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002031164A Expired - Lifetime CA2031164C (en) 1989-12-04 1990-11-29 Recombinant herpesvirus of turkeys and live vector vaccines derived thereof

Country Status (13)

Country Link
US (2) US5187087A (en)
EP (1) EP0431668B1 (en)
JP (1) JP3194751B2 (en)
KR (1) KR0179994B1 (en)
CN (1) CN1056878C (en)
AU (1) AU633663B2 (en)
BR (1) BR1100637A (en)
CA (1) CA2031164C (en)
DE (1) DE69016956T2 (en)
ES (1) ES2070997T3 (en)
HU (1) HU214904B (en)
NZ (1) NZ236294A (en)
ZA (1) ZA909570B (en)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5928648A (en) * 1985-09-06 1999-07-27 Syntro Corporation Recombinant herpesvirus of turkeys and uses thereof
US5961982A (en) * 1985-09-06 1999-10-05 Syntro Corporation Recombinant herpesvirus of turkeys and uses thereof
US5965138A (en) * 1985-09-06 1999-10-12 Syntro Corporation Recombinant chimeric virus and uses thereof
WO1990002802A2 (en) * 1988-09-13 1990-03-22 Institute For Animal Health Limited Viral nucleotide sequences
FR2693472B1 (en) * 1992-06-26 1994-12-23 Rhone Merieux Mutants of the infectious bovine rhinotracheitis virus, deleted in one of the genes of minor glycoproteins, vaccines prepared from these strains, production methods and methods of use.
FR2659349B1 (en) * 1990-03-12 1993-12-24 Rhone Merieux RECOMBINANT HERPIC VIRUSES ESPECIALLY FOR THE PRODUCTION OF VACCINES, THEIR PREPARATION PROCESS, THE PLASMIDS MADE DURING THIS PROCESS AND THE VACCINES OBTAINED.
EP0473210B1 (en) * 1990-07-30 1994-04-13 Akzo Nobel N.V. Recombinant Marek's disease virus
FR2666589B1 (en) * 1990-09-07 1994-08-05 Rhone Merieux NOVEL RECOMBINANT HERPIC VIRUSES, VACCINE BASED ON SUCH RECOMBINANTS, PREPARATION METHOD THEREOF, GENES, VECTORS AND PLASMIDS USED IN THIS PROCESS.
ZA918426B (en) * 1990-10-31 1992-12-30 Akzo Nv Chicken anemia virus vaccine and diagnostic
DE4110962A1 (en) * 1991-04-05 1992-10-08 Bayer Ag EQUINE HERPESVIREN (EHV) CONTAINING FOREIGN DNA, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN Vaccines
AU657144B2 (en) * 1991-07-09 1995-03-02 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Recombinant Marek's disease virus, process for preparing the same and vaccine containing the same
US5853733A (en) * 1993-02-26 1998-12-29 Syntro Corporation Recombinant herpesvirus of turkeys and uses thereof
US6913751B2 (en) 1992-06-12 2005-07-05 Schering-Plough Veterinary Corporation Recombinant avian herpesvirus useful in vaccine production
ES2187508T3 (en) 1992-07-30 2003-06-16 Akzo Nobel Nv VACCINES VECTORS OF HERPES VIRUS FELINO RECOMBINED.
US5403582A (en) * 1993-01-21 1995-04-04 Nippon Zeon Co., Ltd. Vaccine comprising fowlpox virus recombinants expressing the envelope glycoprotein of an avian reticuloendotheliosis retrovirus
EP0609739A1 (en) * 1993-02-02 1994-08-10 American Cyanamid Company Method of reversing immunosuppression in vaccines
US6984728B2 (en) 1993-09-24 2006-01-10 Schering Corporation Recombinant infectious laryngotracheitis virus and uses thereof
EP0745127A4 (en) * 1994-01-11 1999-10-20 Cornell Res Foundation Inc Control of marek's disease by the inhibition of latency and tumor cell development
EP0750670A1 (en) * 1994-02-07 1997-01-02 Cornell Research Foundation, Inc. Compositions useful in controlling marek's disease
FR2719056B1 (en) * 1994-04-20 1996-09-06 Rhone Merieux Herpesvirus transformed to express gD in vitro.
US5833980A (en) * 1995-10-27 1998-11-10 Board Of Trustess Operating Michigan State University Sustainable cell line for the production of the Marek's disease vaccines
US6048535A (en) * 1997-06-12 2000-04-11 Regents Of The University Of Minnesota Multivalent in ovo avian vaccine
US6632664B1 (en) * 1997-10-03 2003-10-14 Nippon Zeon Co., Ltd. Avian infectious herpesvirus recombinants and recombinant vaccines prepared with the use of the same
US8119395B1 (en) 1998-02-27 2012-02-21 The Trustees Of The University Of Pennsylvania Vaccines, immunotherapeutics and methods for using the same
CN1120238C (en) * 1998-05-04 2003-09-03 本元正阳基因技术股份有限公司 Recombined pure herpes virus built by using adhesive particles as basis and use thereof
EP1038952A3 (en) 1998-12-09 2001-06-27 Pfizer Products Inc. Processes for preparation of Marek's Disease Virus using continuous avian cell lines
MXPA01008883A (en) 1999-03-03 2003-07-21 Univ Pennsylvania Vaccines and gene therapy compositions and methods of making and using the same.
CA2369747A1 (en) 1999-04-30 2000-11-09 The Trustees Of The University Of Pennsylvania Mutant human cd80 and compositions for and methods of making and using the same
WO2001005988A1 (en) * 1999-07-16 2001-01-25 Merial Select, Inc Live recombinant vaccine against avian leukosis virus using a marek's disease virus (mdv) virus as vector
KR100815888B1 (en) * 2000-07-14 2008-03-21 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 DNA Vaccines Encoding HIV Accessory Proteins
AU2002211524B2 (en) * 2000-10-04 2007-03-22 The Trustees Of The University Of Pennsylvania Highly expressible genes
AR031405A1 (en) * 2000-11-21 2003-09-24 Wyeth Corp METHODS AND VACCINES TO CONFERENCE PROTECTION IN OVO AGAINST TURKEY'S RHINOTRACHISIS
US7314715B2 (en) 2001-06-14 2008-01-01 Schering-Plough Animal Health Corporation Recombinant avian herpesvirus useful in vaccine production
US8008265B2 (en) 2003-06-13 2011-08-30 The Trustees Of The University Of Pennsylvania Vaccines, immunotherapeutics and methods for using the same
NZ570709A (en) 2003-06-13 2010-04-30 Univ Pennsylvania Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same
US20080274140A1 (en) * 2004-11-19 2008-11-06 David B Weiner Vaccines and Methods for Using the Same
KR101421745B1 (en) * 2006-01-13 2014-07-22 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 Vaccines and immunotherapeutics using codon optimized il-15 and methods for using the same
EP1981905B1 (en) 2006-01-16 2016-08-31 THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Chlamydia vaccine
CA2949851C (en) 2006-07-28 2019-11-12 The Trustees Of The University Of Pennsylvania Htert sequences and methods for using the same
CN107083391A (en) * 2008-04-04 2017-08-22 宾夕法尼亚大学托管会 Chikungunya virus albumen consensus sequence, the nucleic acid molecules and composition and its application method for encoding the chikungunya virus albumen consensus sequence
CN102016023A (en) 2008-04-04 2011-04-13 宾夕法尼亚州立大学托管会 Vaccines and immunotherapeutics using IL-28 and compositions and methods of using the same
CN102056941A (en) * 2008-06-23 2011-05-11 英特威国际有限公司 Recombinant herpesvirus of turkeys encoding for interleukin-12
US8829174B2 (en) 2008-10-29 2014-09-09 The Trustees Of The University Of Pennsylvania HCV vaccines and methods for using the same
US8921536B2 (en) 2008-10-29 2014-12-30 The Trustees Of The University Of Pennsylvania HCV vaccines and methods for using the same
US9050287B2 (en) 2009-01-23 2015-06-09 The Trustees Of The University Of Pennsylvania Vaccines for human papilloma virus and methods for using the same
CA2653478A1 (en) * 2009-01-23 2010-07-23 Gregg Martin Automated wash system for industrial vehicles
AU2010291900A1 (en) 2009-09-14 2012-03-22 The Trustees Of The University Of Pennsylvania Vaccines and immunotherapeutics comprising IL-15 receptor alpha and/or nucleic acid molecules encoding the same, and methods for using the same
CN102712931A (en) 2009-11-02 2012-10-03 宾夕法尼亚大学托管会 Foot and mouth disease virus (FMDV) consensus proteins, coding sequences therefor and vaccines made therefrom
US8298820B2 (en) 2010-01-26 2012-10-30 The Trustees Of The University Of Pennsylvania Influenza nucleic acid molecules and vaccines made therefrom
CN102781952B (en) 2010-02-08 2015-09-02 宾夕法尼亚大学托管会 The nucleic acid molecule of coding RANTES, the composition comprising it and its using method
EP2629794B1 (en) 2010-10-18 2017-06-07 Intervet International B.V. Herpesvirus of turkeys vectored vaccine against avian influenza in poultry
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US9238679B2 (en) 2011-02-11 2016-01-19 The Trustees Of The University Of Pennslyvania Nucleic acid molecule encoding hepatitis B virus core protein and surface antigen protein and vaccine comprising the same
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CN103687625B (en) 2011-07-11 2017-06-13 艾诺奥医药品有限公司 Intersecting protective arenavirus vaccine and its application method
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HUE041723T2 (en) * 2011-10-21 2019-05-28 Intervet Int Bv Recombinant non-pathogenic marek's disease virus constructs encoding infectious laryngotracheitis virus and newcastle disease virus antigens
EP2768529A1 (en) 2011-10-21 2014-08-27 Intervet International B.V. Recombinant nonpathogenic mdv vector providing multivalent immunity
EP2771035B1 (en) 2011-10-24 2018-04-11 The Trustees Of The University Of Pennsylvania Improved hcv vaccines and methods for using the same
US9114108B2 (en) 2011-11-30 2015-08-25 Merial, Inc. Recombinant HVT vectors expressing antigens of avian pathogens and uses thereof
US9101598B2 (en) 2011-11-30 2015-08-11 Merial, Inc. Recombinant Gallid herpesvirus 3 (MDV serotype 2) vectors expressing antigens of avian pathogens and uses thereof
ES2719409T5 (en) 2011-11-30 2022-12-07 Boehringer Ingelheim Animal Health Usa Inc Recombinant Gallid herpesvirus 3 (mdv serotype 2) vectors expressing avian pathogen antigens and uses thereof
US9750795B2 (en) 2011-12-12 2017-09-05 The Trustees Of The University Of Pennsylvania Proteins comprising MRSA PBP2a and fragments thereof, nucleic acids encoding the same, and compositions and their use to prevent and treat MRSA infections
JP6333730B2 (en) 2011-12-12 2018-05-30 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア Composition comprising improved IL-12 gene construct and vaccine, immunotherapeutic agent and method using the same
EP2644702A1 (en) 2012-03-30 2013-10-02 Ceva Sante Animale Multivalent recombinant avian herpes virus and vaccine for immunizing avian species
US10040828B2 (en) 2012-04-10 2018-08-07 The Trustees Of The University Of Pennsylvania Human respiratory syncytial virus consensus antigens, nucleic acid constructs and vaccines made therefrom, and methods of using same
CN114181961A (en) 2013-03-12 2022-03-15 宾夕法尼亚大学理事会 Improved vaccines for human papilloma virus and methods of use thereof
US9993545B2 (en) 2013-03-15 2018-06-12 The Trustees Of The University Of Pennsylvania Foot and mouth disease virus (FMDV) consensus proteins, coding sequences therefor and vaccines made therefrom
EA034110B1 (en) 2013-03-15 2019-12-27 Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания Cancer vaccines and methods of treatment using the same
CN104046597A (en) * 2014-06-05 2014-09-17 北京市农林科学院 HVT (Herpesvirus of turkey) recombinant for expressing chlamydia psittaci pmpD-N gene and construction thereof
AR103245A1 (en) 2014-12-24 2017-04-26 Intervet Int Bv HVT-BASED VECTOR VACCINE (HERPES VIRUS DE LOS PAVOS) AGAINST ND (NEWCASTLE DISEASE) - IMPROVED IBD (GUMBOR DISEASE)
JP7046014B2 (en) 2016-06-17 2022-04-01 インターベット インターナショナル ベー． フェー． Recombinant non-pathogenic Marek's disease virus construct encoding antigens for infectious laryngeal tracheitis virus and infectious bursal disease virus
CA3047101A1 (en) 2016-12-14 2018-06-21 Boehringer Ingelheim Animal Health USA Inc. Recombinant hvt vectors expressing multiple antigens of avian pathogens, and vaccines comprising them
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US11235044B2 (en) 2017-12-13 2022-02-01 Inovio Pharmaceuticals, Inc. Cancer vaccines targeting MUC16 and uses thereof
CN114616325A (en) * 2019-09-11 2022-06-10 硕腾服务有限责任公司 Recombinant herpesvirus of turkeys vector expressing avian pathogen antigen and uses thereof
US20230031097A1 (en) 2019-12-20 2023-02-02 Intervet Inc. Multivalent hvt vector vaccine
EP4168043A1 (en) 2020-06-17 2023-04-26 Boehringer Ingelheim Vetmedica GmbH Recombinant hvt vectors expressing influenza hemagglutinin and immunogenic compositions, and production and uses thereof
KR102432779B1 (en) 2020-10-07 2022-08-16 서울과학기술대학교 산학협력단 One-step synthesized method of black oxide particle
CN116648259A (en) 2020-12-24 2023-08-25 英特维特国际股份有限公司 Multivalent HVT Vector Vaccine
WO2023213946A1 (en) 2022-05-05 2023-11-09 Intervet International B.V. New multivalent hvt vector vaccine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4859587A (en) * 1984-06-04 1989-08-22 Institut Merieux Recombinant herpes simplex viruses, vaccines and methods
AU619181B2 (en) * 1987-03-19 1992-01-23 Synergen, Inc. Viral vector system for the introduction of foreign dna expression products into gallinaceous birds
AU628294B2 (en) * 1987-07-27 1992-09-17 Syntro Corporation Attenuated herpes viruses, herpes viruses which include foreign dna encoding an amino acid sequence and vaccines containing same
JP2779447B2 (en) * 1988-03-20 1998-07-23 財団法人阪大微生物病研究会 Method for producing recombinant gene using attenuated Marek's disease virus vector and recombinant of the virus

Also Published As

Publication number Publication date
JP3194751B2 (en) 2001-08-06
AU6769890A (en) 1991-06-06
EP0431668B1 (en) 1995-02-15
CN1052896A (en) 1991-07-10
HU908031D0 (en) 1991-06-28
KR910012233A (en) 1991-08-07
DE69016956D1 (en) 1995-03-23
CA2031164C (en) 2001-10-16
KR0179994B1 (en) 1999-04-01
JPH05103667A (en) 1993-04-27
ZA909570B (en) 1991-10-30
AU633663B2 (en) 1993-02-04
US5187087A (en) 1993-02-16
CN1056878C (en) 2000-09-27
HUT57264A (en) 1991-11-28
HU214904B (en) 1998-07-28
EP0431668A1 (en) 1991-06-12
BR1100637A (en) 2000-03-21
US5470734A (en) 1995-11-28
DE69016956T2 (en) 1995-07-20
ES2070997T3 (en) 1995-06-16
NZ236294A (en) 1992-05-26

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