CA2028830C - Device in connection with an inhaler - Google Patents
Device in connection with an inhaler Download PDFInfo
- Publication number
- CA2028830C CA2028830C CA 2028830 CA2028830A CA2028830C CA 2028830 C CA2028830 C CA 2028830C CA 2028830 CA2028830 CA 2028830 CA 2028830 A CA2028830 A CA 2028830A CA 2028830 C CA2028830 C CA 2028830C
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- CA
- Canada
- Prior art keywords
- inhaler
- inhalation
- detector
- sound
- dosage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
- A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
- A61J7/0409—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers
- A61J7/0418—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers with electronic history memory
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
- A61M2016/0018—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
- A61M2016/0021—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical with a proportional output signal, e.g. from a thermistor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3375—Acoustical, e.g. ultrasonic, measuring means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/43—General characteristics of the apparatus making noise when used correctly
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2206/00—Characteristics of a physical parameter; associated device therefor
- A61M2206/10—Flow characteristics
- A61M2206/14—Static flow deviators in tubes disturbing laminar flow in tubes, e.g. archimedes screws
Abstract
The present invention refers to a device in connection with an in-haler intended for measuring and recording the course of inhalation of a patient. The device is intended for use in medication, e.g. in clinical tests, where there is a need of afterwards being able to control if the patient has taken medicine in a prescribed way. The device comprises an electronical unit provided in the inhaler for recording of the time for each dosage of the medicine of the inhaler. A detector (16, 32, 36) is provided in the inhaler in connection with a passage for the airflow of the inhalation, whereby the detector detects the airflow of the inhalation through the inhaler as well as the availability of the medecine at the inhalation, so that a combination of these two detected values decides if and how the performed inhalation should be recorded in the electronical unit (11, 33, 35).
Description
':, i'd 1~ 1 '! ~~
w0 90~1oa7o 1 ~-~~ '.:'. :; :.; ~.~ ~~ p~>SE90/oo137 Field of the invention .. . .. ..
The present invention relates to a,;devi~e in connection wixh an inhaler intended for measuring and recording of the inhalation course of a patient. The device is intended,:for use in;.medical treatment, e.g. in clinical tests, where them is a need fp; ;.
recording a course of events afterwards in order to be able to verify if the patient has taken medicine in the prescribe~t,way.
The device can also be used to detect the level of trouble. of the patient between the patient's visits. to a doctor.
. _:. -.: _.:.
Background of the invention ... z The omission of a patient to keep up to a medication_presc~~.bed by a doctor might be the reason for: an unsuccessful treatment e.g. _for Ironical deseases. with a desease as e.g. asthma, where a continous . .medication program is: necessary,-, it_ i s especially important that the medication is performed in a prescribed way.
Investigations have proven that between 30 and 50 %. of the patients take medicines irregularly. and incorrect when they take the medicines themselves, which fact-,often is nat discovered bye the doctor in charge. The difficulty off, recording how well. the patient follows the prescriptions for the medication results in an unsatisfactory security in the evaluation of clinical tests.
One type of control systems for the medication of patients,. used today, the so called MEMS~ system, comprises different types of ordinary standard medicines containers, which are Provided with microprocessors, which record date and moment for each opening and closing of the containers. _...
. . _ .
Another known control system, called Nebulizer ~hxo~zolog~, con-sists of a .small portable device, in which is contained a stan-dard aerosol container. At each release of an aerosol dose, a contact device is actuated, whereby an electronical memory unit stores date and moment for each dosage fed out.
For a patient inhaling his medicine to receive an acceptable dosage to the lungs, however, it is necessary that the release of an aerosol dosage is coordinated with the inhalation of the patient. When using a powder inhaler device, the inhalation flow must reach a "critical flow" to make the powder dose follow the airflow and for the formation of a favourable particle picture, which can reach far enough down into the lungs.
The above disclosed known systems used today record the moment for each event when a medicine package is opened or each time a medicine dose is released, but these known systems lack the possibility of detecting if and when a satisfactory medication has been performed of the patient. With these systems one has not been able to receive a confirmation of that the patient really takes his does and that the patient takes his dose in the prescribed way in order to get a medical effect.
Summary of the Invention According to the present invention there is provided a device in connection with an inhaler, comprising an electronical unit arranged in the inhaler for recording of the moment for each dosage of the medicine in the inhaler characterized in that a detector is provided in the inhaler in connection with a passage for the inhalation air-flow whereby the detector detects the airflow of the inhalation as well as the availability of the medicine at the inhalation, so that a combination of these two detected values determine if and how the performed inhalation shall be recorded in the electronical 2a unit.
According to the present invention there is further provided a method of recording medication with an inhaler using a device in the inhaler, whereby the availability of a medicine dose is detected and the time for detection is recorded in an electronical unit, characterized in that a detector detects the inhalation flow through the inhaler and that the signal arising hereby is combined with the signal from the detection of the dosage availability in a processor in the electronical unit so that the combination of the signals determines if and how the performed medication shall be recorded in the electronical unit.
Also according to the present invention there is provided an inhaler comprising an electronical unit for recording of the time for each dosage of the medicine of the inhaler, characterized in that a detector is provided in the inhaler in connection with a passage for the inhalation airflow, whereby the detector detects partly the airflow of the inhalation through the inhaler and partly the accessibility of the medicine at the inhalation, so that a combination of these two detected values decide if and how the inhalation performed should be recorded in the electronical unit.
One embodiment of the invention can measure and record if and when a satisfactory medication has been performed in a patient.
Further advantageous features of the invention will be evident from the following description of embodiments and the sub-i ''~' ~' ~~ j 'OVA 90/10470 3 . . .. p~,~E,~/00137 claims.
A change of sound or gressure occuring at the feeding of a pow-der dose, at the release of a pressure aerosol or at the punc-tuation of a powder capsule can be detected.by a deteotor and-the generated signal can subsequently be treated and.recorded by the components in an electronical unit. A characteristic back voice or a pressure drop, which occurs in the inhaler at inhala-tion can be detected by the detector and can thereafter be trea-ted and recorded by the electronical unit. v-In order to obtain a satisfactory picture of how a patient has .-performed a planned medication with the aid.of an inhaler, it is_-thus important to be able to detect the patient's own inhalation in combination with a detection of the availability of the:mec~i~-cine dose for the patient. In certain cases it is also important to be able to read how the course of the inhalation looks, that is how strong and how~long it is, in order to=be. able.ahereby: a determine if the inhalation of the patient has enough strength and duration for the obtaining of a correct deposition of active substance in the lungs.
The device according to the invention is also suitable for use in measuring and recording the level o~ severity of a patient!s_ sickness state in periods between the patient'.s visits to a doctor. By the recording ef different inralation parameters, which correlates to the severity of the asthma decease, with. the aid of the device according to the invention, the doctor can get a good picture of the development of the patient's decease du-ring the time between the medical eraminations.
The detector can be comprised of a sound detector, e.g. a micro-phone of the type electret microphone, bat also other types of detectors, such as for example a prewsure transmitter, are :.
feasible within the scope of the i.nventien.
short deRrriRtion ef as"gy~~~~,;.,~3 s .: p ~ a i WO 90/10470 4 ~,;; i, , '; ~ .~,~ ~; .;, ~ P~/SE90/00137 One embodiment of the device according to the present invention and modifications thereof are described more in detail below with reference to the accompanying drawings, wherein Fig. 1 shows an exploded view of a powder inhaler wherein the airflow through the inhaler is marked with arrows, Fig. 2 shows a cross-sectional view through a powder inhaler according to Fig. 1 with a device for measuring and recording sound according to the invention, Fig. 3a show two alternative block diagrams of comprised and 3b electronical components in Fig. 2, Fig. 4 shows a diagram of how the microphone in Fig. 2 cat-ches outside, disturbing noise, Fig. 5 shows a diagram of how the microphone in Fig. 2 cat ches inhalation noise through the inhaler, Fig. 6 shows a diagram of the measuring signal of the inhala-tion after passage through filter and amplifier, Fig. 7 shows a cross sectional view through a dose aerosol with a device according to the invention, and Fig. 8 shows a cross sectional view through a powder inhaler fox gelatine capsules with a device according to the invention.
Detailed description of preferred embodiments of the invention In Fig. 1 an exploded view of a powder inhaler is shown, which is driven by the patient's own breath. The airflow through the inhaler at the inhalation is marked by arrows A.
Figs. 1 and 2 show the different parts of the powder inhaler. A
pivotable control unit 1 with double grip rings 2 cooperates i ~.1 : 7 : i 1.1 W090/10470 5 , ',' . . ' ~.~,/SE90/00~37 with a dosage unit 3, which, when the operating unit l is tur-ned, feeds a powder dose to an inhalation channel 4.:The active substance is kept in a substance container S:~A. mouthpiece 6-is provided with an insert xith narrow helical..defl,~ction devices 7 for decomposition of the substance powder into an inhalatable powder f ruction . The dosage unit 3 is shaped as _a ~_ flat r ~ rot,at-able disc with groups of dosage holes 8 and;rthe.-.disc-i~~ar~ranged at the bottom of the substance containerb5.~'Th~dosage holes_,8-are filled with substance in the position belottx.~the,substance.
container 5. When the grip rings 2 are turned~:al8d_fed~ome step ' forward the dosage dis;. 3 is brought therewith: in the-. rotation.
A number of scrapers 9 are arranged.to abut the dosage..disc 3r whereby the scrapers remove excess powder substa~ace;abQve the dosage holes 8 at the turning of the dosage disc, 3.. ~:. . _. . _ _ .
- _.. ~. ~; ,.. _ :=_ When the patient inhales from-the mouthpiece~opening, air-flows through two opposite air inlets 10 iw the operating.unit -l and through the group of dosage holes 8, which at~, the.: momeat a~eM ex-posed at the inhalation channel 4 situated-aboye._the dQS.age_disc 3, further through the channel 9 and out.thraugh thet.:~alouthpiece -_ 6. When the airflow passes the dosage holes 8 thev,dase_:~f active substance loaded in the holes will be releassd.and_:hrill by -.
brought further an together with the air flaw and::will4be decom-posed in the helical passage in the mouthpiece 6.
a,~ 6;:i, . .. .. . ... .... ..._ Inside the twa' separable grip rings 2 of: the.: operating unit -aft.
electronical .unit 11 with a battery 12 as the:-source of: voltage is arranged. Two contact surfaces 13 are arranged on.the::uPPer and outer side of the upper grip ring 2. When the:inhalgr~is not used, a protective cover 19 is put over the mouthpiece :~ of the inhaler and down over the air intakes 10, whereby the protective cover 19 with its lower edge abuts the upper side of the upper grip ring 2. The lower edge of the protective.oover-l4~is.~~provi-ded with a metal contact ring 15. The contact ring-15 abuts the two contact surfaces i3 on the grip ring 2 when the protective cover 14 is put on, whereby the two contact surfaces~l3 get electrical contact. A microphone 16 is arranged_in direct connection with an air Channel 17 between the air intakes l0.and r,o ,~s. r: ~ f1 .') ' ) i'i the dosage disc 3 and the microphone is connected to the elec-tronical unit 11 inside the operating unit 1. The microphone 16 can alternatively be placed in connection with the air channel, but separated from this through a thin diaphragm.
S
The electronical unit is explained more in detail with reference to the block diagram in Fig. 3a. The microphone 16 detects the sound of the "click", which occurs upon turning forward of a new dose and the sound of the airflow at an inhalation, and trans-fers these signals. A band pass filter 18 separates one for the inhalation typical and suitable working frequency (se Fig. 5).
An amplifier 19 lifts up the signal level from the microphone 16, which leaves signals of the order of a few millivolts and the signals will here be amplified to about 1 V. The signal is rectified and is low pass filtered in a detector 20 so that the envelope of the signal is obtained. The envelope signal is a measure of the momentary air flow. A Schmitt trigger 21 quanti-tizes the signal and leaves the values "approved" and "not approved", respectively. The signal of the microphone is here transformed to a binary signal which states if the strength of the inhalation is sufficient. The hysteres of the Schmitt trig-ger makes that small variations in flow will not make the signal flutter between "approved" and "not approved".
With the need of more than two quantitizing leves (approved/not approved) the Schmitt trigger 21 might be replaced by an ana-logue-digital-converter (A/D converter) 22, which is shown in Fi.g. 3b, the function of Which is to measure the airflow one or several times during the inhalation. These results are stored together with a time notation in a memory 23 for further treat-ment.
The microphone signal, which is generated by the sound of the forward turning, is rectified in a detector 24 so that the abso-lute value of the signal is obtained. An amplifier 25 lifts the level of the signal from the microphone 16 to an order of about 1 V. This signal passes a puls stretcher 26, which stretches the short, transient "click" sound to a signal with logical levels i VO 90/10470 ~ PGT/SE90/00937 and a sufficient duration for a processor to record it.
The processor 27 shall-keep track of acual time., i..e.-be a ..
clock, collect the treated signals from the micorphone and through t:~ese signals eheck that the patient: takes-his dosage in the prescribed way. The prescribed way means that the patient shall turn forward a dose and breath with a.suf:ficient flow and sufficient duration in order to obtain an~effe.ctive deposition in the lungs. The processor 27 performs the measurement of-the ZO length of the inhalation and transfers the time for an approved inhalation to thd memory unit 23. The processor 27 also detects if the contact surfaces are short circuited, that iS if_the pro-tective cover 14 is put on, and takes care of,the communicata.on with a reading unit, which reads the gathered.:~.nformation in-the memory unit 23. The . -processor 22 supplies the band;pass filter 18, the amplifier. 19, the detector 20- and the $chmitt trigger 21 with power only when the protective cover 19 is not put-on in order to save the batteryl2 in this way... ~N~c~
. .., .. _ ,. ,r, - ~ -: - -c c . .. . _ The memory unit -23' isr suitably comprised ~of an _EPRO$i.:(Electri-cally .Eraseably Programmable Read Only Memary)~,c ,wh~.~-as an -electri;..ally . .eraseable, fixed memory..; An EPROM i9. preferablg used here since the information must not be 7:ost if the battery sY~ould be finished: In this memory the times --of _ ~.nhalation;_is f 25 saved for approved inhalations and optional_inhalation_.measure-ment test results. . - -- .- .
Fig. 4 shows a diagram of how disturbingwoise from the outside, in this case music from the radio at an extremely.,high sound le-vel, is captured by the microphone 26 inside the powder inhaler according to Fig.2. .. '..-.-Fig. 5 shows the corresponding diagram of how the microphone 16 reacts tG the airflow through the inhaler at the inhalation. The lower graph shows a sound spectrum for an airflow of 10 1/min, and the other 'graphs, in the upward direction,. show. the :corre-sponding pound spectra for 20~1/min, 30 1/min and 60 1/min, res-pectively~. The measuring range which is of interest for the air-fVO 90/10470 8 ;~ r~, ~:; s~ :-~ s'~ ; PCT/SE90/00137 r 1J
'~..% ~"...
~ u.y~d flow lies in the range of between 20 1/min and 100 1/min. Since the measurements should be insensitive for outside noise distur-banr_es it is evident from the graphs in Figs. 9 and 5 that a signal at the frequency of 9 kHz is a suitable measuring signal in this embodiment.
Fig. 6 shows the size of the measuring signal in Volts after filter and amplifier at inhalation flows from 20 1/min to 80 1/min.
When the patient shall medicate with the aid of the described powder inhaler, first he takes off the protective cover 19, whereby the contact ring 15 at the lower edge of the cover breaks the contact with the two contact surfaces 13 in the upper side of the upper grip ring 2, whereby the voltage to the band pass filter 18, the amplifier 19, the detector 20 and the Schmitt trigger 21 are connected. A dosage of active substance is fed forward to the inhalation channel 4 by turning the grip ring 2 forward one step. This turning forward creates a "clicking" sound which is detected by the microphone 16. When the turning forward is recorded by the processor 27 in the elec-tronical unit the microphone 16 "listens" for the noise arising when the patient inhales through the inhaler and thereby inhales the dosage fed forward. Since the noise has a characteristic segment, only noise at this frequency is amplified by the ampli-fier 19. The signal after the amplifier is quantitized in two steps, insufficient flow~or sufficient flow. Alternatively the signal can be measured at several levels with optional grading.
When an approved inhalation is detected, the time for the inha-lation is stored in the memory 23 and in the alternative case also the "value" of the inhalation is stored.
At the next coming visit to the doctor, the doctor can, by sepa-rating the two grip rings 2, get access to the electronical unit and read the memory 23 using a special reading equipment, which is connected to the electronical unit. This reading equipment reads the approved inhalation times and transfers the informa-tion to a computer, which can process and present the material ,, pCCT/SE90/00137 ~~ ~/~11Y7V 9 ~ J ~t.'~ tAJ .j Ll ':.o ~.~
in a way suitable for the doctor. In the alternative, with quan-titizing in more than two levels the "value" ofr~-the,.-in~halaxion is a7.so read, which can be presented as a flo~rltime diagram-or.
as an inhalation measure, e.g. peak inspiratory flowr..plF of to-tal volume tVC) . . _ - _. : s: s.. ,.. _ _ _ His, In Fig. 7 is shown a dose aerosol with pressure filled. canister., The pressure canister 28 is provided with a nozzle 29 and is placed in a bracket 30 with'a nozzle 31. The bracket~c:~~p is_sha-ped with a separable unit, which-comprises a detecfior 32~-.:ln connection with the air channel for the inhalation:~:flow.and an electronical unit 33. When the patient inhales from the mouth-piece opening air flows past the gap around the pressure C~nis-ter 28 and out through the mouthpiece 31.
1~ ~. _ _W:- . ._ _ . .. <: ~.~.
In order to ~tibtain perfect medication effect with a~dose aerosol.
the patient shall, during the introductory -phas~w~of~~ba inha,la-,_ tion, press the canister 28 down so- that a doseUi~ ~released_:~
through the nozzle 29.~The air flow'aorund the canister 2:8-.and.-the bracket 30 give rise to a noise. which.can be.detectedrhy a:~.
noise detector 32. When a dosage is released through the nozzle a sound arises. ~ which can be distinguished from: the~,t~oise .and can be detected by the detector. Since these sounds..::are dif~e-rent from each other, a microphone can be used as slet~ector. also-i5 in this embodiment.
At inhalation through the inhaler according to Fig. 7 a pressure drop is created between the ambient pressure and the pressure at the mouthpiece opening, i.e. a sub-pressure arises inside the 3G bracket 30 when the patient inhales, which sub-pressure can be detected by a pressure transmitter. At the release of a dose a strong pressure change with short duration arises, which is also detectable by a pressure transmitter. In the embodiment accor-ding to Fig. 7 thus also a pressure transmitter can be used for .5 detection of both the inhalation and the release of a dose, i.e.
the information necessary for controlling that the patient uses the dose aerosol in the prescribed way.
WO 90/10470 1 o s~ :-. « r. w, -;
:~ PC'f/SE90/00137 ..;
Fig. 8 shows a powder inhales, which is loaded with a gelatine capsule 39 with powder substance. An electronical unit 35 with detector 36, preferably a microphone, works in a similar way as the powder inhaler shown in Fig. 2. When a capsule is placed in the inhaler it is punctuated/broken by needles 37 brought through. the wall of the capsule. When the capsule has been punc-tuated/'broken the substance will be available for the inhalation flow. The punctuation/braking of the capsule causes a short and intensive sound which is detected by the microphone 36. At inha-lation here also arises a characteristic sound which is detec ted/measured in the same way as in the other embodiments.
Possible modifications of the invention The device according to the invention is also suitable for use in an inhalator with rotating parts, e.g. of the type Rotacaps~
in that instead of measuring the level of the sound one measures the dominating frequency of the rotation sound. The recorded frequency images and can be transformed into a measure of the airflow through the inhaler.
In order to simplify the reading of the memory, any type of external computer contact might be arranged in the cover of the inhaler, thereby being accessible for reading without any need of demounting the inhaler.
w0 90~1oa7o 1 ~-~~ '.:'. :; :.; ~.~ ~~ p~>SE90/oo137 Field of the invention .. . .. ..
The present invention relates to a,;devi~e in connection wixh an inhaler intended for measuring and recording of the inhalation course of a patient. The device is intended,:for use in;.medical treatment, e.g. in clinical tests, where them is a need fp; ;.
recording a course of events afterwards in order to be able to verify if the patient has taken medicine in the prescribe~t,way.
The device can also be used to detect the level of trouble. of the patient between the patient's visits. to a doctor.
. _:. -.: _.:.
Background of the invention ... z The omission of a patient to keep up to a medication_presc~~.bed by a doctor might be the reason for: an unsuccessful treatment e.g. _for Ironical deseases. with a desease as e.g. asthma, where a continous . .medication program is: necessary,-, it_ i s especially important that the medication is performed in a prescribed way.
Investigations have proven that between 30 and 50 %. of the patients take medicines irregularly. and incorrect when they take the medicines themselves, which fact-,often is nat discovered bye the doctor in charge. The difficulty off, recording how well. the patient follows the prescriptions for the medication results in an unsatisfactory security in the evaluation of clinical tests.
One type of control systems for the medication of patients,. used today, the so called MEMS~ system, comprises different types of ordinary standard medicines containers, which are Provided with microprocessors, which record date and moment for each opening and closing of the containers. _...
. . _ .
Another known control system, called Nebulizer ~hxo~zolog~, con-sists of a .small portable device, in which is contained a stan-dard aerosol container. At each release of an aerosol dose, a contact device is actuated, whereby an electronical memory unit stores date and moment for each dosage fed out.
For a patient inhaling his medicine to receive an acceptable dosage to the lungs, however, it is necessary that the release of an aerosol dosage is coordinated with the inhalation of the patient. When using a powder inhaler device, the inhalation flow must reach a "critical flow" to make the powder dose follow the airflow and for the formation of a favourable particle picture, which can reach far enough down into the lungs.
The above disclosed known systems used today record the moment for each event when a medicine package is opened or each time a medicine dose is released, but these known systems lack the possibility of detecting if and when a satisfactory medication has been performed of the patient. With these systems one has not been able to receive a confirmation of that the patient really takes his does and that the patient takes his dose in the prescribed way in order to get a medical effect.
Summary of the Invention According to the present invention there is provided a device in connection with an inhaler, comprising an electronical unit arranged in the inhaler for recording of the moment for each dosage of the medicine in the inhaler characterized in that a detector is provided in the inhaler in connection with a passage for the inhalation air-flow whereby the detector detects the airflow of the inhalation as well as the availability of the medicine at the inhalation, so that a combination of these two detected values determine if and how the performed inhalation shall be recorded in the electronical 2a unit.
According to the present invention there is further provided a method of recording medication with an inhaler using a device in the inhaler, whereby the availability of a medicine dose is detected and the time for detection is recorded in an electronical unit, characterized in that a detector detects the inhalation flow through the inhaler and that the signal arising hereby is combined with the signal from the detection of the dosage availability in a processor in the electronical unit so that the combination of the signals determines if and how the performed medication shall be recorded in the electronical unit.
Also according to the present invention there is provided an inhaler comprising an electronical unit for recording of the time for each dosage of the medicine of the inhaler, characterized in that a detector is provided in the inhaler in connection with a passage for the inhalation airflow, whereby the detector detects partly the airflow of the inhalation through the inhaler and partly the accessibility of the medicine at the inhalation, so that a combination of these two detected values decide if and how the inhalation performed should be recorded in the electronical unit.
One embodiment of the invention can measure and record if and when a satisfactory medication has been performed in a patient.
Further advantageous features of the invention will be evident from the following description of embodiments and the sub-i ''~' ~' ~~ j 'OVA 90/10470 3 . . .. p~,~E,~/00137 claims.
A change of sound or gressure occuring at the feeding of a pow-der dose, at the release of a pressure aerosol or at the punc-tuation of a powder capsule can be detected.by a deteotor and-the generated signal can subsequently be treated and.recorded by the components in an electronical unit. A characteristic back voice or a pressure drop, which occurs in the inhaler at inhala-tion can be detected by the detector and can thereafter be trea-ted and recorded by the electronical unit. v-In order to obtain a satisfactory picture of how a patient has .-performed a planned medication with the aid.of an inhaler, it is_-thus important to be able to detect the patient's own inhalation in combination with a detection of the availability of the:mec~i~-cine dose for the patient. In certain cases it is also important to be able to read how the course of the inhalation looks, that is how strong and how~long it is, in order to=be. able.ahereby: a determine if the inhalation of the patient has enough strength and duration for the obtaining of a correct deposition of active substance in the lungs.
The device according to the invention is also suitable for use in measuring and recording the level o~ severity of a patient!s_ sickness state in periods between the patient'.s visits to a doctor. By the recording ef different inralation parameters, which correlates to the severity of the asthma decease, with. the aid of the device according to the invention, the doctor can get a good picture of the development of the patient's decease du-ring the time between the medical eraminations.
The detector can be comprised of a sound detector, e.g. a micro-phone of the type electret microphone, bat also other types of detectors, such as for example a prewsure transmitter, are :.
feasible within the scope of the i.nventien.
short deRrriRtion ef as"gy~~~~,;.,~3 s .: p ~ a i WO 90/10470 4 ~,;; i, , '; ~ .~,~ ~; .;, ~ P~/SE90/00137 One embodiment of the device according to the present invention and modifications thereof are described more in detail below with reference to the accompanying drawings, wherein Fig. 1 shows an exploded view of a powder inhaler wherein the airflow through the inhaler is marked with arrows, Fig. 2 shows a cross-sectional view through a powder inhaler according to Fig. 1 with a device for measuring and recording sound according to the invention, Fig. 3a show two alternative block diagrams of comprised and 3b electronical components in Fig. 2, Fig. 4 shows a diagram of how the microphone in Fig. 2 cat-ches outside, disturbing noise, Fig. 5 shows a diagram of how the microphone in Fig. 2 cat ches inhalation noise through the inhaler, Fig. 6 shows a diagram of the measuring signal of the inhala-tion after passage through filter and amplifier, Fig. 7 shows a cross sectional view through a dose aerosol with a device according to the invention, and Fig. 8 shows a cross sectional view through a powder inhaler fox gelatine capsules with a device according to the invention.
Detailed description of preferred embodiments of the invention In Fig. 1 an exploded view of a powder inhaler is shown, which is driven by the patient's own breath. The airflow through the inhaler at the inhalation is marked by arrows A.
Figs. 1 and 2 show the different parts of the powder inhaler. A
pivotable control unit 1 with double grip rings 2 cooperates i ~.1 : 7 : i 1.1 W090/10470 5 , ',' . . ' ~.~,/SE90/00~37 with a dosage unit 3, which, when the operating unit l is tur-ned, feeds a powder dose to an inhalation channel 4.:The active substance is kept in a substance container S:~A. mouthpiece 6-is provided with an insert xith narrow helical..defl,~ction devices 7 for decomposition of the substance powder into an inhalatable powder f ruction . The dosage unit 3 is shaped as _a ~_ flat r ~ rot,at-able disc with groups of dosage holes 8 and;rthe.-.disc-i~~ar~ranged at the bottom of the substance containerb5.~'Th~dosage holes_,8-are filled with substance in the position belottx.~the,substance.
container 5. When the grip rings 2 are turned~:al8d_fed~ome step ' forward the dosage dis;. 3 is brought therewith: in the-. rotation.
A number of scrapers 9 are arranged.to abut the dosage..disc 3r whereby the scrapers remove excess powder substa~ace;abQve the dosage holes 8 at the turning of the dosage disc, 3.. ~:. . _. . _ _ .
- _.. ~. ~; ,.. _ :=_ When the patient inhales from-the mouthpiece~opening, air-flows through two opposite air inlets 10 iw the operating.unit -l and through the group of dosage holes 8, which at~, the.: momeat a~eM ex-posed at the inhalation channel 4 situated-aboye._the dQS.age_disc 3, further through the channel 9 and out.thraugh thet.:~alouthpiece -_ 6. When the airflow passes the dosage holes 8 thev,dase_:~f active substance loaded in the holes will be releassd.and_:hrill by -.
brought further an together with the air flaw and::will4be decom-posed in the helical passage in the mouthpiece 6.
a,~ 6;:i, . .. .. . ... .... ..._ Inside the twa' separable grip rings 2 of: the.: operating unit -aft.
electronical .unit 11 with a battery 12 as the:-source of: voltage is arranged. Two contact surfaces 13 are arranged on.the::uPPer and outer side of the upper grip ring 2. When the:inhalgr~is not used, a protective cover 19 is put over the mouthpiece :~ of the inhaler and down over the air intakes 10, whereby the protective cover 19 with its lower edge abuts the upper side of the upper grip ring 2. The lower edge of the protective.oover-l4~is.~~provi-ded with a metal contact ring 15. The contact ring-15 abuts the two contact surfaces i3 on the grip ring 2 when the protective cover 14 is put on, whereby the two contact surfaces~l3 get electrical contact. A microphone 16 is arranged_in direct connection with an air Channel 17 between the air intakes l0.and r,o ,~s. r: ~ f1 .') ' ) i'i the dosage disc 3 and the microphone is connected to the elec-tronical unit 11 inside the operating unit 1. The microphone 16 can alternatively be placed in connection with the air channel, but separated from this through a thin diaphragm.
S
The electronical unit is explained more in detail with reference to the block diagram in Fig. 3a. The microphone 16 detects the sound of the "click", which occurs upon turning forward of a new dose and the sound of the airflow at an inhalation, and trans-fers these signals. A band pass filter 18 separates one for the inhalation typical and suitable working frequency (se Fig. 5).
An amplifier 19 lifts up the signal level from the microphone 16, which leaves signals of the order of a few millivolts and the signals will here be amplified to about 1 V. The signal is rectified and is low pass filtered in a detector 20 so that the envelope of the signal is obtained. The envelope signal is a measure of the momentary air flow. A Schmitt trigger 21 quanti-tizes the signal and leaves the values "approved" and "not approved", respectively. The signal of the microphone is here transformed to a binary signal which states if the strength of the inhalation is sufficient. The hysteres of the Schmitt trig-ger makes that small variations in flow will not make the signal flutter between "approved" and "not approved".
With the need of more than two quantitizing leves (approved/not approved) the Schmitt trigger 21 might be replaced by an ana-logue-digital-converter (A/D converter) 22, which is shown in Fi.g. 3b, the function of Which is to measure the airflow one or several times during the inhalation. These results are stored together with a time notation in a memory 23 for further treat-ment.
The microphone signal, which is generated by the sound of the forward turning, is rectified in a detector 24 so that the abso-lute value of the signal is obtained. An amplifier 25 lifts the level of the signal from the microphone 16 to an order of about 1 V. This signal passes a puls stretcher 26, which stretches the short, transient "click" sound to a signal with logical levels i VO 90/10470 ~ PGT/SE90/00937 and a sufficient duration for a processor to record it.
The processor 27 shall-keep track of acual time., i..e.-be a ..
clock, collect the treated signals from the micorphone and through t:~ese signals eheck that the patient: takes-his dosage in the prescribed way. The prescribed way means that the patient shall turn forward a dose and breath with a.suf:ficient flow and sufficient duration in order to obtain an~effe.ctive deposition in the lungs. The processor 27 performs the measurement of-the ZO length of the inhalation and transfers the time for an approved inhalation to thd memory unit 23. The processor 27 also detects if the contact surfaces are short circuited, that iS if_the pro-tective cover 14 is put on, and takes care of,the communicata.on with a reading unit, which reads the gathered.:~.nformation in-the memory unit 23. The . -processor 22 supplies the band;pass filter 18, the amplifier. 19, the detector 20- and the $chmitt trigger 21 with power only when the protective cover 19 is not put-on in order to save the batteryl2 in this way... ~N~c~
. .., .. _ ,. ,r, - ~ -: - -c c . .. . _ The memory unit -23' isr suitably comprised ~of an _EPRO$i.:(Electri-cally .Eraseably Programmable Read Only Memary)~,c ,wh~.~-as an -electri;..ally . .eraseable, fixed memory..; An EPROM i9. preferablg used here since the information must not be 7:ost if the battery sY~ould be finished: In this memory the times --of _ ~.nhalation;_is f 25 saved for approved inhalations and optional_inhalation_.measure-ment test results. . - -- .- .
Fig. 4 shows a diagram of how disturbingwoise from the outside, in this case music from the radio at an extremely.,high sound le-vel, is captured by the microphone 26 inside the powder inhaler according to Fig.2. .. '..-.-Fig. 5 shows the corresponding diagram of how the microphone 16 reacts tG the airflow through the inhaler at the inhalation. The lower graph shows a sound spectrum for an airflow of 10 1/min, and the other 'graphs, in the upward direction,. show. the :corre-sponding pound spectra for 20~1/min, 30 1/min and 60 1/min, res-pectively~. The measuring range which is of interest for the air-fVO 90/10470 8 ;~ r~, ~:; s~ :-~ s'~ ; PCT/SE90/00137 r 1J
'~..% ~"...
~ u.y~d flow lies in the range of between 20 1/min and 100 1/min. Since the measurements should be insensitive for outside noise distur-banr_es it is evident from the graphs in Figs. 9 and 5 that a signal at the frequency of 9 kHz is a suitable measuring signal in this embodiment.
Fig. 6 shows the size of the measuring signal in Volts after filter and amplifier at inhalation flows from 20 1/min to 80 1/min.
When the patient shall medicate with the aid of the described powder inhaler, first he takes off the protective cover 19, whereby the contact ring 15 at the lower edge of the cover breaks the contact with the two contact surfaces 13 in the upper side of the upper grip ring 2, whereby the voltage to the band pass filter 18, the amplifier 19, the detector 20 and the Schmitt trigger 21 are connected. A dosage of active substance is fed forward to the inhalation channel 4 by turning the grip ring 2 forward one step. This turning forward creates a "clicking" sound which is detected by the microphone 16. When the turning forward is recorded by the processor 27 in the elec-tronical unit the microphone 16 "listens" for the noise arising when the patient inhales through the inhaler and thereby inhales the dosage fed forward. Since the noise has a characteristic segment, only noise at this frequency is amplified by the ampli-fier 19. The signal after the amplifier is quantitized in two steps, insufficient flow~or sufficient flow. Alternatively the signal can be measured at several levels with optional grading.
When an approved inhalation is detected, the time for the inha-lation is stored in the memory 23 and in the alternative case also the "value" of the inhalation is stored.
At the next coming visit to the doctor, the doctor can, by sepa-rating the two grip rings 2, get access to the electronical unit and read the memory 23 using a special reading equipment, which is connected to the electronical unit. This reading equipment reads the approved inhalation times and transfers the informa-tion to a computer, which can process and present the material ,, pCCT/SE90/00137 ~~ ~/~11Y7V 9 ~ J ~t.'~ tAJ .j Ll ':.o ~.~
in a way suitable for the doctor. In the alternative, with quan-titizing in more than two levels the "value" ofr~-the,.-in~halaxion is a7.so read, which can be presented as a flo~rltime diagram-or.
as an inhalation measure, e.g. peak inspiratory flowr..plF of to-tal volume tVC) . . _ - _. : s: s.. ,.. _ _ _ His, In Fig. 7 is shown a dose aerosol with pressure filled. canister., The pressure canister 28 is provided with a nozzle 29 and is placed in a bracket 30 with'a nozzle 31. The bracket~c:~~p is_sha-ped with a separable unit, which-comprises a detecfior 32~-.:ln connection with the air channel for the inhalation:~:flow.and an electronical unit 33. When the patient inhales from the mouth-piece opening air flows past the gap around the pressure C~nis-ter 28 and out through the mouthpiece 31.
1~ ~. _ _W:- . ._ _ . .. <: ~.~.
In order to ~tibtain perfect medication effect with a~dose aerosol.
the patient shall, during the introductory -phas~w~of~~ba inha,la-,_ tion, press the canister 28 down so- that a doseUi~ ~released_:~
through the nozzle 29.~The air flow'aorund the canister 2:8-.and.-the bracket 30 give rise to a noise. which.can be.detectedrhy a:~.
noise detector 32. When a dosage is released through the nozzle a sound arises. ~ which can be distinguished from: the~,t~oise .and can be detected by the detector. Since these sounds..::are dif~e-rent from each other, a microphone can be used as slet~ector. also-i5 in this embodiment.
At inhalation through the inhaler according to Fig. 7 a pressure drop is created between the ambient pressure and the pressure at the mouthpiece opening, i.e. a sub-pressure arises inside the 3G bracket 30 when the patient inhales, which sub-pressure can be detected by a pressure transmitter. At the release of a dose a strong pressure change with short duration arises, which is also detectable by a pressure transmitter. In the embodiment accor-ding to Fig. 7 thus also a pressure transmitter can be used for .5 detection of both the inhalation and the release of a dose, i.e.
the information necessary for controlling that the patient uses the dose aerosol in the prescribed way.
WO 90/10470 1 o s~ :-. « r. w, -;
:~ PC'f/SE90/00137 ..;
Fig. 8 shows a powder inhales, which is loaded with a gelatine capsule 39 with powder substance. An electronical unit 35 with detector 36, preferably a microphone, works in a similar way as the powder inhaler shown in Fig. 2. When a capsule is placed in the inhaler it is punctuated/broken by needles 37 brought through. the wall of the capsule. When the capsule has been punc-tuated/'broken the substance will be available for the inhalation flow. The punctuation/braking of the capsule causes a short and intensive sound which is detected by the microphone 36. At inha-lation here also arises a characteristic sound which is detec ted/measured in the same way as in the other embodiments.
Possible modifications of the invention The device according to the invention is also suitable for use in an inhalator with rotating parts, e.g. of the type Rotacaps~
in that instead of measuring the level of the sound one measures the dominating frequency of the rotation sound. The recorded frequency images and can be transformed into a measure of the airflow through the inhaler.
In order to simplify the reading of the memory, any type of external computer contact might be arranged in the cover of the inhaler, thereby being accessible for reading without any need of demounting the inhaler.
Claims (16)
1. A device in connection with an inhaler, comprising an electronical unit arranged in the inhaler for recording of the moment for each dosage of the medicine in the inhaler characterized in that a detector (16, 32, 36) is provided in the inhaler in connection with a passage for the inhalation air-flow whereby the detector detects the airflow of the inhalation as well as the availability of the medicine at the inhalation, so that a combination of these two detected values determine if and how the performed inhalation shall be recorded in the electronical unit (11, 33, 35).
2. A device according to to claim 1, characterized in that the detector (16, 32, 36) is comprised of a sound detector, which detects the sound of an out-or forward feeding of a medicine dose as well as a sound arising at inhalation through the inhaler.
3. A device according to claim 2, characterized in that the sound detector (16, 32, 36) is comprised of a microphone.
4. A device according to claim 1, characterized in that the inhaler is a dose aerosol and that the detector is comprised of a pressure transmitter (32), which detects a sub-pressure in the inhaler at an inhalation as well as detects a momentaneous pressure change arising at the release of an aerosol dose.
5. A device according to claim 1, characterized in that the detector (16, 32, 36) is connected to a microprocessor (27) in the electronical unit (11, 33, 35) for working of the signals of the detector (16, 32, 36), whereby the treated signals are stored in a readable memory unit (23).
6. A device according to claim 2, characterized in that the inhaler is a powder inhaler with a turnable dosage disc (3) with dosage holes (8), which step by step are fed to an inhalation channel (4), whereby the sound detector (16) is arranged to detect a forward turning sound, which arises when the dosage disc (3) is fed froward one step.
7. A device according to claim 6, characterized in that the sound detector (16) is arranged close to an air channel (17) between the air intake (10) of the inhaler and the dosage disc (3), whereby the sound detector (16) detects the noise arising in the air channel at the inhalation.
8. A device according to claim 2, characterized in that the signal of the sound detector (16, 32, 36) from the inhalation sound is quantitized to a binary signal, approved and not approved inhalation, respectively, in a Schmitt trigger (21).
9. A device according to claim 5, characterized in that a battery (12) is arranged to provide the electronical unit (11, 33, 35) with power, whereby the power supply is arranged to be broken when a protective cover (14) with a metal ring (15) is put on the inhaler to a position such that the metal ring (15) abuts two contact surfaces (13) on the inhaler, which are short-circuited by the metal ring (15).
10. A method of recording medication with an inhaler using a device in the inhaler, whereby the availability of a medicine dose is detected and the time for detection is recorded in an electronical unit, characterized in that a detector (16, 32, 36) detects the inhalation flow through the inhaler and that the signal arising hereby is combined with the signal from the detection of the dosage availability in a processor (27) in the electronical unit (11, 33, 35) so that the combination of the signals determines if and how the performed medication shall be recorded in the electronical unit.
11. A method according to claim 10, characterized in that the processor (27) checks if the medication takes place in an approved way by combination of the detected signals and, if that is the case, the time of an approved medication is recorded and stored in a memory unit (23).
12. An inhaler comprising an electronical unit for recording of the time for each dosage of the medicine of the inhaler, characterized in that a detector (16, 32, 26) is provided in the inhaler in connection with a passage for the inhalation airflow, whereby the detector detects partly the airflow of the inhalation through the inhaler and partly the accessibility of the medicine at the inhalation, so that a combination of these two detected values decide if and how the inhalation performed should be recorded in the electronical unit (11, 33, 35).
13. An inhaler according to claim 12, characterized in that the detector (16, 32, 36) is comprised of a sound detector.
14. An inhaler according to claim 13, characterized in that the inhaler is a powder inhaler with a turnable dosage disc (3) with dosage holes (8), which step by step are fed forward to an inhalation channel (4), whereby the sound detector (16) is arranged to detect a forward turning sound, which arises when the dosage disc (3) is fed forward one step.
15. An inhaler according to claim 14, characterized in that the sound detector (16) is arranged close to an air channel (17) between the air intake (10) of the inhaler and the dosage disc (3), whereby the sound detector (16) detects the sound arising in the air channel at the inhalation.
16. An inhaler as claimed in any one of claims 13 to 15, wherein said sound detector comprises a microphone.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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SE8900793A SE466684B (en) | 1989-03-07 | 1989-03-07 | DEVICE INHALATOR AND PROCEDURE TO REGISTER WITH THE DEVICE INHALATOR MEDICATION |
SE8900793-4 | 1989-03-07 | ||
PCT/SE1990/000137 WO1990010470A1 (en) | 1989-03-07 | 1990-03-02 | Device in connection with an inhaler |
Publications (2)
Publication Number | Publication Date |
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CA2028830A1 CA2028830A1 (en) | 1990-09-08 |
CA2028830C true CA2028830C (en) | 2000-02-08 |
Family
ID=20375263
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA 2028830 Expired - Lifetime CA2028830C (en) | 1989-03-07 | 1990-03-02 | Device in connection with an inhaler |
Country Status (16)
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US (1) | US5331953A (en) |
EP (1) | EP0387222B1 (en) |
JP (1) | JP2927541B2 (en) |
KR (1) | KR0135309B1 (en) |
AT (1) | ATE91911T1 (en) |
AU (1) | AU613264B2 (en) |
CA (1) | CA2028830C (en) |
DE (1) | DE69002353T2 (en) |
DK (1) | DK0387222T3 (en) |
ES (1) | ES2042267T3 (en) |
FI (1) | FI102948B (en) |
IE (1) | IE64129B1 (en) |
NO (1) | NO175289C (en) |
PT (1) | PT93347B (en) |
SE (1) | SE466684B (en) |
WO (1) | WO1990010470A1 (en) |
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- 1990-03-02 DE DE1990602353 patent/DE69002353T2/en not_active Expired - Lifetime
- 1990-03-02 AU AU52710/90A patent/AU613264B2/en not_active Expired
- 1990-03-02 JP JP50469490A patent/JP2927541B2/en not_active Expired - Fee Related
- 1990-03-02 AT AT90850086T patent/ATE91911T1/en not_active IP Right Cessation
- 1990-03-02 CA CA 2028830 patent/CA2028830C/en not_active Expired - Lifetime
- 1990-03-02 KR KR1019900702391A patent/KR0135309B1/en not_active IP Right Cessation
- 1990-03-05 IE IE76590A patent/IE64129B1/en not_active IP Right Cessation
- 1990-03-06 PT PT93347A patent/PT93347B/en not_active IP Right Cessation
- 1990-11-05 NO NO904809A patent/NO175289C/en not_active IP Right Cessation
- 1990-11-07 FI FI905521A patent/FI102948B/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
NO904809D0 (en) | 1990-11-05 |
CA2028830A1 (en) | 1990-09-08 |
FI905521A0 (en) | 1990-11-07 |
SE8900793D0 (en) | 1989-03-07 |
JPH03504457A (en) | 1991-10-03 |
SE466684B (en) | 1992-03-23 |
WO1990010470A1 (en) | 1990-09-20 |
DE69002353T2 (en) | 1993-12-02 |
PT93347B (en) | 1998-05-29 |
IE900765L (en) | 1990-09-07 |
NO904809L (en) | 1990-11-05 |
NO175289C (en) | 1994-09-28 |
AU5271090A (en) | 1990-10-09 |
KR0135309B1 (en) | 1998-04-23 |
FI102948B1 (en) | 1999-03-31 |
SE8900793L (en) | 1990-09-08 |
EP0387222A1 (en) | 1990-09-12 |
ATE91911T1 (en) | 1993-08-15 |
FI102948B (en) | 1999-03-31 |
KR920700050A (en) | 1992-02-19 |
AU613264B2 (en) | 1991-07-25 |
PT93347A (en) | 1990-11-07 |
DK0387222T3 (en) | 1993-08-30 |
US5331953A (en) | 1994-07-26 |
ES2042267T3 (en) | 1993-12-01 |
EP0387222B1 (en) | 1993-07-28 |
DE69002353D1 (en) | 1993-09-02 |
NO175289B (en) | 1994-06-20 |
IE64129B1 (en) | 1995-07-12 |
JP2927541B2 (en) | 1999-07-28 |
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MKEX | Expiry |