CA2022824A1 - Apparatus for an electrode and method used for iontophoresis - Google Patents
Apparatus for an electrode and method used for iontophoresisInfo
- Publication number
- CA2022824A1 CA2022824A1 CA2022824A CA2022824A CA2022824A1 CA 2022824 A1 CA2022824 A1 CA 2022824A1 CA 2022824 A CA2022824 A CA 2022824A CA 2022824 A CA2022824 A CA 2022824A CA 2022824 A1 CA2022824 A1 CA 2022824A1
- Authority
- CA
- Canada
- Prior art keywords
- conductors
- receivers
- transmitters
- lines
- ions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000004020 conductor Substances 0.000 abstract 6
- 150000002500 ions Chemical class 0.000 abstract 6
- 230000005684 electric field Effects 0.000 abstract 3
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003792 electrolyte Substances 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0432—Anode and cathode
- A61N1/044—Shape of the electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
- A61N1/303—Constructional details
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0448—Drug reservoir
Abstract
An iontophoretic electrode has a plurality of ion transmitters for establishing electric field lines in an area and a plurality of receivers for accepting ions flowing along the field lines. A plurality of shields are located to resist ion flow between adjacent transmitters and receivers. The transmitters, shields and receivers are in at least a sequence of transmitter, shield, receiver, shield.
The electric field lines emanate substantially in one direction and return in substantially the opposite direction. The transmitters and receivers have matrix structures with space to contain ionic medication and electrolyte, respectively. A support for holding a plurality of sequences has current carrying contacts exposed to connect the transmitters and receivers in circuit with a source of electrical power. The preferred method includes establishing an electric field with lines of energy between a plurality of first and second conductors of ions and then passing ions along the energy lines between the conductors. Thereafter the method includes restricting the flow of ions to paths between adjacent first and second conductors and then positioning the first conductors relative to the second conductors so that the energy lines emanate from the first substantially in one direction return to adjacent second conductors in the opposite direction.
The electric field lines emanate substantially in one direction and return in substantially the opposite direction. The transmitters and receivers have matrix structures with space to contain ionic medication and electrolyte, respectively. A support for holding a plurality of sequences has current carrying contacts exposed to connect the transmitters and receivers in circuit with a source of electrical power. The preferred method includes establishing an electric field with lines of energy between a plurality of first and second conductors of ions and then passing ions along the energy lines between the conductors. Thereafter the method includes restricting the flow of ions to paths between adjacent first and second conductors and then positioning the first conductors relative to the second conductors so that the energy lines emanate from the first substantially in one direction return to adjacent second conductors in the opposite direction.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US412,056 | 1989-09-25 | ||
US07/412,056 US4950229A (en) | 1989-09-25 | 1989-09-25 | Apparatus for an electrode used for iontophoresis |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2022824A1 true CA2022824A1 (en) | 1991-03-26 |
CA2022824C CA2022824C (en) | 1995-05-02 |
Family
ID=23631411
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002022824A Expired - Fee Related CA2022824C (en) | 1989-09-25 | 1990-08-07 | Apparatus for an electrode and method used for iontophoresis |
Country Status (9)
Country | Link |
---|---|
US (2) | US4950229A (en) |
EP (1) | EP0419820B1 (en) |
JP (1) | JPH03133464A (en) |
AT (1) | ATE129416T1 (en) |
CA (1) | CA2022824C (en) |
DE (1) | DE69023199T2 (en) |
DK (1) | DK0419820T3 (en) |
ES (1) | ES2081326T3 (en) |
IE (1) | IE902854A1 (en) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6956032B1 (en) | 1986-04-18 | 2005-10-18 | Carnegie Mellon University | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods |
US4950229A (en) * | 1989-09-25 | 1990-08-21 | Becton, Dickinson And Company | Apparatus for an electrode used for iontophoresis |
US5334138A (en) * | 1990-03-15 | 1994-08-02 | North Carolina State University | Method and composition for increased skin concentration of active agents by iontophoresis |
DE4014913C2 (en) * | 1990-05-10 | 1996-05-15 | Lohmann Therapie Syst Lts | Miniaturized transdermal therapeutic system for iontophoresis |
US5160316A (en) * | 1990-09-10 | 1992-11-03 | Henley Julian L | Iontophoretic drug delivery apparatus |
US5169384A (en) * | 1991-08-16 | 1992-12-08 | Bosniak Stephen L | Apparatus for facilitating post-traumatic, post-surgical, and/or post-inflammatory healing of tissue |
US5310403A (en) * | 1992-05-18 | 1994-05-10 | Becton, Dickinson And Company | Iontophoretic drug delivery device and circuit therefor |
US5331979A (en) * | 1992-07-27 | 1994-07-26 | Henley Julian L | Iontophoretic cigarette substitute |
US5427585A (en) * | 1993-03-29 | 1995-06-27 | Bettinger; David S. | On-demand iontophoretic system |
US5667487A (en) * | 1993-04-07 | 1997-09-16 | Henley; Julian L. | Ionosonic drug delivery apparatus |
US5458569A (en) * | 1993-06-08 | 1995-10-17 | Becton Dickinson And Company | Wearable iontophoresis system |
US5415629A (en) * | 1993-09-15 | 1995-05-16 | Henley; Julian L. | Programmable apparatus for the transdermal delivery of drugs and method |
US5540669A (en) * | 1993-09-30 | 1996-07-30 | Becton, Dickinson And Company | Iontophoretic drug delivery system and method for using same |
WO1995009032A1 (en) * | 1993-09-30 | 1995-04-06 | Becton, Dickinson And Company | Iontophoretic drug delivery system and method |
US5556528A (en) * | 1994-05-10 | 1996-09-17 | Biotechnology Research & Development Corporation | Structures with field responsive permeation control |
US5540654A (en) * | 1994-09-02 | 1996-07-30 | North Carolina State University | Iontophoretic electrode |
US5990179A (en) * | 1995-04-28 | 1999-11-23 | Alza Corporation | Composition and method of enhancing electrotransport agent delivery |
AU6260896A (en) * | 1995-06-06 | 1996-12-24 | Board Of Regents, The University Of Texas System | Electrode system in iontophoretic treatment devices |
US5897522A (en) * | 1995-12-20 | 1999-04-27 | Power Paper Ltd. | Flexible thin layer open electrochemical cell and applications of same |
US5676648A (en) | 1996-05-08 | 1997-10-14 | The Aps Organization, Llp | Iontophoretic drug delivery apparatus and method for use |
US6385487B1 (en) | 1996-05-08 | 2002-05-07 | Biophoretic Therapeutic Systems, Llc | Methods for electrokinetic delivery of medicaments |
US5961483A (en) * | 1996-06-19 | 1999-10-05 | Sage; Burton H. | Iontophoretic delivery of cell adhesion inhibitors |
KR20000071103A (en) | 1997-02-17 | 2000-11-25 | 요시히로 미와 | Iontophoretic device |
US5991655A (en) * | 1997-03-03 | 1999-11-23 | Drug Delivery Systems, Inc. | Iontophoretic drug delivery device and method of manufacturing the same |
US6119036A (en) | 1997-03-26 | 2000-09-12 | The Board Of Regents Of The University Of Oklahoma | Iontophoretic transdermal delivery device |
ATE373957T1 (en) | 1997-10-09 | 2007-10-15 | Univ Emory | METHOD AND DEVICE FOR TRANSDERMAL ADMINISTRATION OF LITHIUM |
USRE37796E1 (en) | 1997-12-16 | 2002-07-23 | Biophoretic Therapeutic Systems, Llc | Methods for iontophoretic delivery of antiviral agents |
EP0970719A3 (en) | 1998-07-08 | 2000-08-23 | Nitto Denko Corporation | Electrode structure |
EP2428249B1 (en) * | 1998-07-13 | 2015-10-07 | Inovio Pharmaceuticals, Inc. | Skin and muscle-targeted gene therapy by pulsed electrical field |
US6678556B1 (en) * | 1998-07-13 | 2004-01-13 | Genetronics, Inc. | Electrical field therapy with reduced histopathological change in muscle |
US7922709B2 (en) | 1998-07-13 | 2011-04-12 | Genetronics, Inc. | Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation |
US6192270B1 (en) * | 1998-08-14 | 2001-02-20 | Genetronics, Inc. | Apparatus and method for the delivery of drugs and genes into tissue |
EP1115454B1 (en) * | 1998-08-31 | 2006-10-25 | Travanti Pharma Inc | Controlled dosage drug delivery system |
US6148231A (en) * | 1998-09-15 | 2000-11-14 | Biophoretic Therapeutic Systems, Llc | Iontophoretic drug delivery electrodes and method |
US6424862B1 (en) * | 1999-02-10 | 2002-07-23 | Gmp Drug Delivery, Inc. | Iontophoresis electroporation and combination patches for local drug delivery to body tissues |
US6294063B1 (en) | 1999-02-12 | 2001-09-25 | Board Of Regents, The University Of Texas System | Method and apparatus for programmable fluidic processing |
US6477410B1 (en) * | 2000-05-31 | 2002-11-05 | Biophoretic Therapeutic Systems, Llc | Electrokinetic delivery of medicaments |
US7127285B2 (en) | 1999-03-12 | 2006-10-24 | Transport Pharmaceuticals Inc. | Systems and methods for electrokinetic delivery of a substance |
US6792306B2 (en) | 2000-03-10 | 2004-09-14 | Biophoretic Therapeutic Systems, Llc | Finger-mounted electrokinetic delivery system for self-administration of medicaments and methods therefor |
JP3543097B2 (en) * | 1999-11-24 | 2004-07-14 | 株式会社先端科学技術インキュベーションセンター | Tactile presentation method and device using electrical stimulation |
US6687536B1 (en) * | 1999-12-09 | 2004-02-03 | Iomed, Inc. | Connection system for an iontophoretic drug delivery device |
US6421561B1 (en) * | 1999-12-30 | 2002-07-16 | Birch Point Medical, Inc. | Rate adjustable drug delivery system |
US20040092860A1 (en) * | 2000-07-26 | 2004-05-13 | Dev Nagendu B. | Skin and muscle-targeted gene therapy by pulsed electrical field |
US9084879B2 (en) * | 2002-01-22 | 2015-07-21 | Encore Medical Asset Corporation | Method and device for the iontophoretic delivery of a drug |
US7220778B2 (en) * | 2003-04-15 | 2007-05-22 | The General Hospital Corporation | Methods and devices for epithelial protection during photodynamic therapy |
MXPA06005509A (en) * | 2003-11-13 | 2007-05-23 | Johnson & Johnson | System and method for transdermal delivery. |
US20050234516A1 (en) * | 2004-02-16 | 2005-10-20 | Gueret Jean-Louis H | Treatment kit, composite structure, electric exciter, and cosmetic treatment method |
EP2574370B1 (en) | 2004-02-27 | 2014-12-17 | Empi Corp. | Iontophoretic electrode |
US8974652B2 (en) * | 2004-05-28 | 2015-03-10 | Board Of Regents, The University Of Texas System | Programmable fluidic processors |
RU2008114490A (en) * | 2005-09-15 | 2009-10-20 | ТиТиАй ЭЛЛЕБО, ИНК. (JP) | STEM TYPE IONTOPHORESIS DEVICE |
US20070078445A1 (en) * | 2005-09-30 | 2007-04-05 | Curt Malloy | Synchronization apparatus and method for iontophoresis device to deliver active agents to biological interfaces |
EP1928539A1 (en) * | 2005-09-30 | 2008-06-11 | Tti Ellebeau, Inc. | Functionalized microneedles transdermal drug delivery systems, devices, and methods |
BRPI0616771A2 (en) * | 2005-09-30 | 2011-06-28 | Tti Ellebeau Inc | iontophoresis device to release multiple active agents for biological interfaces |
WO2007079189A2 (en) * | 2005-12-30 | 2007-07-12 | Tti Ellebeau, Inc. | System and method for remote based control of an iontophoresis device |
EP2059298A2 (en) * | 2006-09-05 | 2009-05-20 | Tti Ellebeau, Inc. | Transdermal drug delivery systems, devices, and methods using inductive power supplies |
WO2008062365A2 (en) * | 2006-11-24 | 2008-05-29 | Koninklijke Philips Electronics N.V. | Iontophoretic device |
BRPI0719353A2 (en) * | 2006-12-01 | 2014-01-07 | Titi Ellebeau Inc | SYSTEMS, DEVICES AND METHODS FOR ENERGIZATION AND / OR CONTROL DEVICES, FOR EXAMPLE, TRANSDERMIC DISTRIBUTION DEVICES |
US20080188791A1 (en) * | 2007-02-02 | 2008-08-07 | Difiore Attilio E | Active iontophoresis delivery system |
US8197844B2 (en) | 2007-06-08 | 2012-06-12 | Activatek, Inc. | Active electrode for transdermal medicament administration |
US20080312579A1 (en) * | 2007-06-15 | 2008-12-18 | Transport Pharmaceuticals, Inc. | Method and system for mitigating current concentration in electrokinetic drug delivery |
EP2644228A1 (en) * | 2007-06-27 | 2013-10-02 | The General Hospital Corporation | Method and apparatus for optical inhibition of photodynamic therapy |
US8862223B2 (en) | 2008-01-18 | 2014-10-14 | Activatek, Inc. | Active transdermal medicament patch and circuit board for same |
FR3000897B1 (en) * | 2013-01-14 | 2016-10-28 | Feeligreen | AUTORGANIZED ELECTROSTIMULATION AND / OR IONTOPHORESIS DEVICE |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2047308A (en) * | 1934-05-05 | 1936-07-14 | T M Chapman S Sons Co | Electrical therapeutic pad |
US3848608A (en) * | 1973-07-23 | 1974-11-19 | Gen Electric | Subject integument spatial stimulator |
US4325367A (en) * | 1977-06-13 | 1982-04-20 | Robert Tapper | Iontophoretic treatment apparatus |
US4543958A (en) * | 1979-04-30 | 1985-10-01 | Ndm Corporation | Medical electrode assembly |
JPS56501274A (en) * | 1979-10-10 | 1981-09-10 | ||
DE3020789A1 (en) * | 1980-05-31 | 1982-01-07 | Rudolf Dr.-Ing. Lugano-Cassarate Steineck | DC therapy instrument - has rechargeable button cells applied directly to skin of patient |
US4416274A (en) * | 1981-02-23 | 1983-11-22 | Motion Control, Inc. | Ion mobility limiting iontophoretic bioelectrode |
EP0060451B1 (en) * | 1981-03-06 | 1986-09-17 | Medtronic, Inc. | Iontophoretic electrode |
US4820263A (en) * | 1981-03-06 | 1989-04-11 | Medtronic, Inc. | Apparatus and method for iontophoretic drug delivery |
US4731926A (en) * | 1985-02-19 | 1988-03-22 | Drug Delivery Systems Inc. | Method of manufacturing disposable and/or replenishable transdermal drug applicators |
US4622031A (en) * | 1983-08-18 | 1986-11-11 | Drug Delivery Systems Inc. | Indicator for electrophoretic transcutaneous drug delivery device |
US4883457A (en) * | 1983-08-18 | 1989-11-28 | Drug Delivery Systems Inc. | Disposable and/or replenishable transdermal drug applicators and methods of manufacturing same |
DE3505900A1 (en) * | 1985-02-21 | 1986-08-21 | Bayer Ag, 5090 Leverkusen | 2,4-DICHLORTHIAZOLE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF |
DE3703321A1 (en) * | 1986-09-01 | 1988-03-10 | Transcutan Gmbh | Therapeutic device for application of electrical current |
US4865582A (en) * | 1987-06-05 | 1989-09-12 | Drug Delivery Systems Inc. | Disposable transdermal drug applicators |
DE68925030T2 (en) * | 1988-01-21 | 1996-07-25 | Massachusetts Inst Technology | MOLECULE TRANSPORT THROUGH FABRICS WITH THE USE OF ELECTROPORATION. |
IL86076A (en) * | 1988-04-14 | 1992-12-01 | Inventor S Funding Corp Ltd | Transdermal drug delivery device |
US5088977A (en) * | 1988-12-21 | 1992-02-18 | Drug Delivery Systems Inc. | Electrical transdermal drug applicator with counteractor and method of drug delivery |
US4950229A (en) * | 1989-09-25 | 1990-08-21 | Becton, Dickinson And Company | Apparatus for an electrode used for iontophoresis |
US5047007A (en) * | 1989-12-22 | 1991-09-10 | Medtronic, Inc. | Method and apparatus for pulsed iontophoretic drug delivery |
-
1989
- 1989-09-25 US US07/412,056 patent/US4950229A/en not_active Expired - Lifetime
-
1990
- 1990-06-28 US US07/545,214 patent/US5284471A/en not_active Expired - Lifetime
- 1990-08-07 IE IE285490A patent/IE902854A1/en unknown
- 1990-08-07 CA CA002022824A patent/CA2022824C/en not_active Expired - Fee Related
- 1990-08-09 AT AT90115288T patent/ATE129416T1/en not_active IP Right Cessation
- 1990-08-09 DK DK90115288.4T patent/DK0419820T3/en active
- 1990-08-09 DE DE69023199T patent/DE69023199T2/en not_active Expired - Fee Related
- 1990-08-09 EP EP90115288A patent/EP0419820B1/en not_active Expired - Lifetime
- 1990-08-09 ES ES90115288T patent/ES2081326T3/en not_active Expired - Lifetime
- 1990-09-25 JP JP2255030A patent/JPH03133464A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
US4950229A (en) | 1990-08-21 |
ATE129416T1 (en) | 1995-11-15 |
EP0419820A3 (en) | 1991-09-11 |
EP0419820B1 (en) | 1995-10-25 |
ES2081326T3 (en) | 1996-03-01 |
DK0419820T3 (en) | 1995-12-04 |
DE69023199D1 (en) | 1995-11-30 |
DE69023199T2 (en) | 1996-05-02 |
IE902854A1 (en) | 1991-04-10 |
JPH03133464A (en) | 1991-06-06 |
CA2022824C (en) | 1995-05-02 |
EP0419820A2 (en) | 1991-04-03 |
JPH0474030B2 (en) | 1992-11-25 |
US5284471A (en) | 1994-02-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2022824A1 (en) | Apparatus for an electrode and method used for iontophoresis | |
DE69416448D1 (en) | Electrical connector assembly with biased shielding plates | |
HK1108402A1 (en) | Electrolytic eluent generator and method of use | |
DE69314809D1 (en) | ELECTRICAL CONNECTOR WITH HIGH PACKING DENSITY | |
EP0879470A4 (en) | Over-voltage protection device and method for making same | |
MY127655A (en) | Process and apparatus for recovering of sealed type battery | |
DE3380616D1 (en) | Process for selectively cutting an electrical conductive layer by irradiation with an energy beam | |
FR2801680B3 (en) | METHOD OF ELECTRICALLY TESTING THE CONFORMITY OF THE INTERCONNECTION OF ELECTRICAL CONDUCTORS ON A SUBSTRATE, WITHOUT CONTACT AND WITHOUT TOOLS | |
DE3568954D1 (en) | A device for induction welding | |
DE29711973U1 (en) | Electrical device, electrical device or lighting device | |
SE8302249D0 (en) | SYMMETRIC CURRENT CONDUCTOR SYSTEM FOR DIRECTIONS | |
DK0744021T3 (en) | Galvanic cell reference electrode with an ion conducting solid state electrolyte | |
IL53957A0 (en) | A method for establishing an electrically conductive path through an insulating | |
AU6654696A (en) | Method and apparatus for testing the insulating ability of an insulation on an electric conductor | |
MY110646A (en) | Mixed-valence complex electrodes for a rechargeable electrical energy storage device | |
JPS5757896A (en) | Electrolyzing device for strip-like metallic plate | |
FR2409609B1 (en) | ELECTRIC TIGHTENING LATCH FOR ESTABLISHING AN ELECTRICALLY CONDUCTIVE TIGHTENING CONNECTION | |
SE8200268L (en) | ELECTRICAL DEVICE FOR BUSINESS THREE PHASE LIGHT BAGS | |
DE3470815D1 (en) | Electric circuit for high uniformity magnetic field | |
JPS5698663A (en) | Cable check circuit | |
FR2619965B1 (en) | DEVICE FOR CONNECTING INSULATED ELECTRICAL CONDUCTORS, IN PARTICULAR PILOT GRID | |
FR2409674A7 (en) | Earthing connection for electric appliance - has two jaws, each with earth lead screw against conductor to be earthed | |
JPS56141981A (en) | Electron beam welding machine | |
HUT37177A (en) | Circuit arrangement with split anode for cathode protection of systems of public utilities | |
ATA231883A (en) | ELECTRICAL CONNECTOR, IN PARTICULAR. FOR SWITCHGEAR |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |