CA2021767A1 - Method for preparing a pharmaceutical composition in the form of microparticles - Google Patents

Method for preparing a pharmaceutical composition in the form of microparticles

Info

Publication number
CA2021767A1
CA2021767A1 CA2021767A CA2021767A CA2021767A1 CA 2021767 A1 CA2021767 A1 CA 2021767A1 CA 2021767 A CA2021767 A CA 2021767A CA 2021767 A CA2021767 A CA 2021767A CA 2021767 A1 CA2021767 A1 CA 2021767A1
Authority
CA
Canada
Prior art keywords
preparing
microparticles
pharmaceutical composition
composition
injectable suspensions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2021767A
Other languages
French (fr)
Other versions
CA2021767C (en
Inventor
Piero Orsolini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Debio Recherche Pharmaceutique SA
Original Assignee
Debiopharm SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Debiopharm SA filed Critical Debiopharm SA
Publication of CA2021767A1 publication Critical patent/CA2021767A1/en
Application granted granted Critical
Publication of CA2021767C publication Critical patent/CA2021767C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/25—Growth hormone-releasing factor [GH-RF] (Somatoliberin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Abstract

A method for preparing a pharmaceutical composition in the form of microparticles, the composition thus obtained and its use for preparing injectable suspensions.
CA002021767A 1989-07-28 1990-07-23 Method for preparing a pharmaceutical composition in the form of microparticles Expired - Lifetime CA2021767C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH2829/89-2 1989-07-28
CH2829/89A CH679207A5 (en) 1989-07-28 1989-07-28

Publications (2)

Publication Number Publication Date
CA2021767A1 true CA2021767A1 (en) 1991-01-29
CA2021767C CA2021767C (en) 1996-10-22

Family

ID=4242536

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002021767A Expired - Lifetime CA2021767C (en) 1989-07-28 1990-07-23 Method for preparing a pharmaceutical composition in the form of microparticles

Country Status (23)

Country Link
US (1) US5134122A (en)
JP (1) JPH0662427B2 (en)
AT (1) AT397197B (en)
AU (1) AU619996B2 (en)
BE (1) BE1003093A3 (en)
CA (1) CA2021767C (en)
CH (1) CH679207A5 (en)
DE (1) DE4023134C2 (en)
DK (1) DK175495B1 (en)
ES (1) ES2020890A6 (en)
FI (1) FI97688C (en)
FR (1) FR2650182B1 (en)
GB (1) GB2234169B (en)
GR (1) GR1001215B (en)
IE (1) IE65397B1 (en)
IL (1) IL95120A (en)
IT (1) IT1243357B (en)
LU (1) LU87772A1 (en)
NL (1) NL194858C (en)
NO (1) NO300304B1 (en)
PT (1) PT94842B (en)
SE (1) SE504279C2 (en)
ZA (1) ZA905654B (en)

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Also Published As

Publication number Publication date
SE9002522L (en) 1991-01-29
NO903264D0 (en) 1990-07-23
NL194858C (en) 2003-05-06
SE504279C2 (en) 1996-12-23
IT9021019A1 (en) 1992-01-23
AT397197B (en) 1994-02-25
SE9002522D0 (en) 1990-07-27
US5134122A (en) 1992-07-28
CH679207A5 (en) 1992-01-15
PT94842B (en) 1997-04-30
AU5910390A (en) 1991-01-31
GR1001215B (en) 1993-06-21
BE1003093A3 (en) 1991-11-19
GR900100568A (en) 1991-12-10
NL194858B (en) 2003-01-06
FI903643A0 (en) 1990-07-19
CA2021767C (en) 1996-10-22
ES2020890A6 (en) 1991-10-01
GB2234169B (en) 1993-02-10
DK175495B1 (en) 2004-11-08
LU87772A1 (en) 1990-12-11
ZA905654B (en) 1991-05-29
IT1243357B (en) 1994-06-10
FR2650182A1 (en) 1991-02-01
IE902592A1 (en) 1991-02-27
DK180790D0 (en) 1990-07-27
IT9021019A0 (en) 1990-07-23
IL95120A0 (en) 1991-06-10
GB9015722D0 (en) 1990-09-05
JPH0662427B2 (en) 1994-08-17
ATA154590A (en) 1993-07-15
IE65397B1 (en) 1995-10-18
DE4023134C2 (en) 1997-04-17
FR2650182B1 (en) 1992-05-15
NL9001646A (en) 1991-02-18
DE4023134A1 (en) 1991-01-31
NO300304B1 (en) 1997-05-12
NO903264L (en) 1991-01-29
AU619996B2 (en) 1992-02-06
JPH0366625A (en) 1991-03-22
PT94842A (en) 1991-03-20
IL95120A (en) 1994-10-07
FI97688C (en) 1997-02-10
DK180790A (en) 1991-01-29
GB2234169A (en) 1991-01-30
FI97688B (en) 1996-10-31

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