CA2011840A1 - Desiccant tablet - Google Patents
Desiccant tabletInfo
- Publication number
- CA2011840A1 CA2011840A1 CA002011840A CA2011840A CA2011840A1 CA 2011840 A1 CA2011840 A1 CA 2011840A1 CA 002011840 A CA002011840 A CA 002011840A CA 2011840 A CA2011840 A CA 2011840A CA 2011840 A1 CA2011840 A1 CA 2011840A1
- Authority
- CA
- Canada
- Prior art keywords
- coating
- water
- desiccant tablet
- tablet
- coated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3291—Characterised by the shape of the carrier, the coating or the obtained coated product
- B01J20/3293—Coatings on a core, the core being particle or fiber shaped, e.g. encapsulated particles, coated fibers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D53/00—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols
- B01D53/26—Drying gases or vapours
- B01D53/28—Selection of materials for use as drying agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
- B01J20/28004—Sorbent size or size distribution, e.g. particle size
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
- B01J20/2803—Sorbents comprising a binder, e.g. for forming aggregated, agglomerated or granulated products
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/3042—Use of binding agents; addition of materials ameliorating the mechanical properties of the produced sorbent
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
- B01J20/3204—Inorganic carriers, supports or substrates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3268—Macromolecular compounds
- B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2220/00—Aspects relating to sorbent materials
- B01J2220/40—Aspects relating to the composition of sorbent or filter aid materials
- B01J2220/49—Materials comprising an indicator, e.g. colour indicator, pH-indicator
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Drying Of Gases (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Abstract
Abstract The invention relates to a coated desiccant tablet, the coating containing as the essential con-stituent a water-soluble film former, in particular a cellulose derivative.
Description
o ~
Merck Patent Gesellschaft mit beschrankter Haftung 6100 D a r m s t a d t Desiccant tablet The invention relates to a coated desiccant tablet (DT), this coating containing as the essential cons~ituen~ a water-soluble film-former.
It is known to employ DTs when pac~aging pharma-ceuticals which are sensitive to moisture. For example, tablets which are sensitive to moisture can be incor-porated into packaging Lmpe~meable to w~ter vapor, the packaging containing, besides the pharmaceutical tablets, an additional desiccant unit in the foDm of a tablet.
Known DTs have the di~advantage that they create pulverulent grindings, for example aused by vibrations during transport, which can contaminate the pharma-ceutical. Moreover, the DTs may be mistaken for the pharmaceutical tablets.
~P-61/291,021 describes DT~ which are covered with a thin layer of liquid resin or rubber, for example also silicon~ rubber, where the pul~erulent grindings are reduced. These tablets, in turn, have other disadvan-tages, for example during their manufacture, which must be carried out in a non aqueou~ medi~m.
The invention is based on the ob~ect to provide a DT which does no~, or to a lesser extent~ have the disadvantages of the known DTs. It was an essential part of the object to find a coating process in which no organic solvent is employed.
It has b~en found that ~he D~s can be pro~ided with a coating which as an essential constituent contains a water-soluble film formar. This coating preven~s abrasion during handling, while drying speed and drying capacity are nok substantially reduced.
The invention relates ~o a coated ~T, charac-terized in that the coating contains as the esse~ial constituenk a water-soluble film former.
Merck Patent Gesellschaft mit beschrankter Haftung 6100 D a r m s t a d t Desiccant tablet The invention relates to a coated desiccant tablet (DT), this coating containing as the essential cons~ituen~ a water-soluble film-former.
It is known to employ DTs when pac~aging pharma-ceuticals which are sensitive to moisture. For example, tablets which are sensitive to moisture can be incor-porated into packaging Lmpe~meable to w~ter vapor, the packaging containing, besides the pharmaceutical tablets, an additional desiccant unit in the foDm of a tablet.
Known DTs have the di~advantage that they create pulverulent grindings, for example aused by vibrations during transport, which can contaminate the pharma-ceutical. Moreover, the DTs may be mistaken for the pharmaceutical tablets.
~P-61/291,021 describes DT~ which are covered with a thin layer of liquid resin or rubber, for example also silicon~ rubber, where the pul~erulent grindings are reduced. These tablets, in turn, have other disadvan-tages, for example during their manufacture, which must be carried out in a non aqueou~ medi~m.
The invention is based on the ob~ect to provide a DT which does no~, or to a lesser extent~ have the disadvantages of the known DTs. It was an essential part of the object to find a coating process in which no organic solvent is employed.
It has b~en found that ~he D~s can be pro~ided with a coating which as an essential constituent contains a water-soluble film formar. This coating preven~s abrasion during handling, while drying speed and drying capacity are nok substantially reduced.
The invention relates ~o a coated ~T, charac-terized in that the coating contains as the esse~ial constituenk a water-soluble film former.
2 ~
,.
Suitable desiccants are in particular those which do not change their volume upon uptake of water (which do not swell), above all silica gelst mainly fine-pored silica gels of a particle size in the range of between about 200 and 400 ~m. Molecular sieves, aluminas or dry clays are also suitable.
The desiccant can be compressed in a customary manner to give tablets of about 50-5000 mg, preferably 100-500 mg. The tablet cores can contain conventional binders, for example polyvinylpyrrolidone (PVP), and o~her conventional additives. If PVP is used, a content of 3-10~ by weight is preferred (based on the total weight of ~he tablet cores). Higher amounts of PVP give harder tablets, lower amounts of PVP give softer tablets.
Cellulose derivatives are preferred among the water-~oluble film formers. A particularly highly sui-table derivative is methylhydro~ypropylcellulose, fur-thexmore, for example, methylcellulose, hydroxypropyl-cellulose or sodium carbo~ymethylcellulose. It is also po~sible for the coatings to contain a plurality of various water-soluble cellulo~e derivatives. Other suitable film formers are polyvinyl alcohol and PVP.
The coating of the DT can, according to the invention, additionally contain one or more plasticizers.
Amongst these plasticizers, the water-soluble ones axe likewise preferred, in particular polyalkylene glycols, preferably pol~eth~lene glyools, such as polyethylene glycol 400 or polyethylene glycol 6000. The following may furthermore be mentioned: alkylene glycols, such as propylene glycol ~1,2-propanediol~, esters~ fox example trialkyl citrates, such as triet~yl citrate, or poly-oxyethylene/pulyoxypropylene block polymer~.
The coating of the DT can, according to the invention, additionally contain one or more pigments.
With the aid of these pigments, it is possible to impart a colour to the DTs, preferably in such a w y that, if appropriate, a clear distinction can be made between them and the pharmaceutical tablets in the same ~ackaging.
Suitable pigments are all those which are conventional in - , :
'; ,, ' ' ~ ~
,.
Suitable desiccants are in particular those which do not change their volume upon uptake of water (which do not swell), above all silica gelst mainly fine-pored silica gels of a particle size in the range of between about 200 and 400 ~m. Molecular sieves, aluminas or dry clays are also suitable.
The desiccant can be compressed in a customary manner to give tablets of about 50-5000 mg, preferably 100-500 mg. The tablet cores can contain conventional binders, for example polyvinylpyrrolidone (PVP), and o~her conventional additives. If PVP is used, a content of 3-10~ by weight is preferred (based on the total weight of ~he tablet cores). Higher amounts of PVP give harder tablets, lower amounts of PVP give softer tablets.
Cellulose derivatives are preferred among the water-~oluble film formers. A particularly highly sui-table derivative is methylhydro~ypropylcellulose, fur-thexmore, for example, methylcellulose, hydroxypropyl-cellulose or sodium carbo~ymethylcellulose. It is also po~sible for the coatings to contain a plurality of various water-soluble cellulo~e derivatives. Other suitable film formers are polyvinyl alcohol and PVP.
The coating of the DT can, according to the invention, additionally contain one or more plasticizers.
Amongst these plasticizers, the water-soluble ones axe likewise preferred, in particular polyalkylene glycols, preferably pol~eth~lene glyools, such as polyethylene glycol 400 or polyethylene glycol 6000. The following may furthermore be mentioned: alkylene glycols, such as propylene glycol ~1,2-propanediol~, esters~ fox example trialkyl citrates, such as triet~yl citrate, or poly-oxyethylene/pulyoxypropylene block polymer~.
The coating of the DT can, according to the invention, additionally contain one or more pigments.
With the aid of these pigments, it is possible to impart a colour to the DTs, preferably in such a w y that, if appropriate, a clear distinction can be made between them and the pharmaceutical tablets in the same ~ackaging.
Suitable pigments are all those which are conventional in - , :
'; ,, ' ' ~ ~
pharmacy, for example oxides, such as titanium dioxide or iron oxide; carbonates, such as calcium carbonate; or coloured lacquers, such as Quinoline Yellow lacquer E 104, Amaranth lacquer E 123 or Indigotin lacquer E 132.
These pigments have virtually no influence on the permeability of the coating to water vapor.
The coating can contain further additives, for example lubricants, such as talc or silicone oil, the latter also in the form of an emulsion.
The coating is preferably applied in a thickness of about 0.7 to 2.5 mg/cm2. Its proportion relative to the total weight of the DT is about 1-5~ by weight.
Preferably, the DTs here have total weights between about 100 and 1000 mg.
The coating is applied according to the invention in a conventional manner. Preferably, aqueous solutions or suspensions which contain the desired constituents and which are sprayed onto the tablet cores, preferably at temperatures between 20 and 100, in particular between 50 and 80~ are used. Since the DT is capable of absorbing water, the film coating can be applied in a~out 1/3 of the conv~ntionally required tLme. Once the DT is coated, the water contained therein can be removed through the film coating without essential problems.
Drying is expediently carried ou~ at temperatures bet~een 20 and 120, in particular between 50 and 80, under reduced pr~ssure.
Example 2.0 kg of methylhydroxypropylc~llulose and 0.467 kg of polyethylene glycol 400 are dissolved in 22.0 kg of water. To this solution is added a suspension of 0.333 kg of titanium~IV) oxide and 0.733 kg of Iron Oxide Red in 7.8 kg of water, and the b tch is mixed and sieved (sieve 180, Ph.Eur.).
The resulting suspension is sprayed, while stirring, onto 90 kg of tablet cores preheated to 70, each individual tablet core cons.t~ing of 190 mg of silica gel, type E 0-400~ and 10 mg of PVP.
2 ~
The resulting coated DTs axe dried for 24 hour3 at 70-80 under reduced pressure.
No abrasion can be detected (Friabilator, type "Roche", 10 minutes).
.
These pigments have virtually no influence on the permeability of the coating to water vapor.
The coating can contain further additives, for example lubricants, such as talc or silicone oil, the latter also in the form of an emulsion.
The coating is preferably applied in a thickness of about 0.7 to 2.5 mg/cm2. Its proportion relative to the total weight of the DT is about 1-5~ by weight.
Preferably, the DTs here have total weights between about 100 and 1000 mg.
The coating is applied according to the invention in a conventional manner. Preferably, aqueous solutions or suspensions which contain the desired constituents and which are sprayed onto the tablet cores, preferably at temperatures between 20 and 100, in particular between 50 and 80~ are used. Since the DT is capable of absorbing water, the film coating can be applied in a~out 1/3 of the conv~ntionally required tLme. Once the DT is coated, the water contained therein can be removed through the film coating without essential problems.
Drying is expediently carried ou~ at temperatures bet~een 20 and 120, in particular between 50 and 80, under reduced pr~ssure.
Example 2.0 kg of methylhydroxypropylc~llulose and 0.467 kg of polyethylene glycol 400 are dissolved in 22.0 kg of water. To this solution is added a suspension of 0.333 kg of titanium~IV) oxide and 0.733 kg of Iron Oxide Red in 7.8 kg of water, and the b tch is mixed and sieved (sieve 180, Ph.Eur.).
The resulting suspension is sprayed, while stirring, onto 90 kg of tablet cores preheated to 70, each individual tablet core cons.t~ing of 190 mg of silica gel, type E 0-400~ and 10 mg of PVP.
2 ~
The resulting coated DTs axe dried for 24 hour3 at 70-80 under reduced pressure.
No abrasion can be detected (Friabilator, type "Roche", 10 minutes).
.
Claims (6)
1. Coated desiccant tablet, characterized in that the coating contains as the essential constituent a water-soluble film former.
2. Desiccant tablet according to Claim 1, charac-terized in that the coating additionally contains at least one plasticizer.
3. Desiccant tablet according to at least one of Claims 1 or 2, characterized in that the coating addi-tionally contains at least one pigment.
4. Process for the preparation of a coated desiccant tablet, characterized in that a desiccant tablet is provided with a coating which as the essential consti-tuent contains a water-soluble film former.
5. Process according to Claim 4, characterized in that no organic solvents are used in the preparation.
6. Use of a desiccant tablet coated with a coating containing as the essential constituent a water-soluble film former for the packaging of pharmaceuticals.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3907973A DE3907973A1 (en) | 1989-03-11 | 1989-03-11 | DRYER TABLET |
| DEP3907973.2 | 1989-03-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2011840A1 true CA2011840A1 (en) | 1990-09-11 |
Family
ID=6376140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002011840A Abandoned CA2011840A1 (en) | 1989-03-11 | 1990-03-09 | Desiccant tablet |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0387604B1 (en) |
| JP (1) | JPH0347513A (en) |
| KR (1) | KR900013945A (en) |
| CA (1) | CA2011840A1 (en) |
| DE (2) | DE3907973A1 (en) |
| ES (1) | ES2041458T3 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8580302B2 (en) | 2000-11-20 | 2013-11-12 | Warner Chilcott Company, Llc | Pharmaceutical dosage form with multiple coatings for reduced impact of coating fractures |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6929682B2 (en) * | 2003-09-11 | 2005-08-16 | Multisorb Technologies, Inc. | Sorbent capsule |
| US7501011B2 (en) * | 2004-11-09 | 2009-03-10 | Multisorb Technologies, Inc. | Humidity control device |
| US8057586B2 (en) | 2008-07-28 | 2011-11-15 | Multisorb Technologies, Inc. | Humidity control for product in a refrigerator |
| ES2399307B1 (en) * | 2011-07-25 | 2014-01-29 | José Antonio TORNEL GARCÍA | ANTIHUMEDAD TABLET WRAPPED ON A SPECIAL FABRIC. |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1671498U (en) * | 1953-12-04 | 1954-02-04 | Herrmann Gebr | CONTAINER WITH A DRYING AGENT TO PROTECT PACKAGED, SENSITIVE GOODS AGAINST HUMIDITY. |
| US2819491A (en) * | 1955-03-31 | 1958-01-14 | Grace W R & Co | Method of preparing molded dehydrating agents |
| DE1053401B (en) * | 1957-10-19 | 1959-03-19 | Herrmann Gebr | Bag for holding means for the adsorption of air humidity, especially for holding silica gel |
| US3091550A (en) * | 1958-09-24 | 1963-05-28 | Union Carbide Corp | Adsorbent compositions and method of coating therewith |
| DE1797173U (en) * | 1959-03-14 | 1959-10-01 | Herrmann Gebr | SILICA GEL TABLET. |
| US2994404A (en) * | 1959-04-28 | 1961-08-01 | Richard E Schifferly | Moisture absorbing device |
| DE1839875U (en) * | 1961-04-08 | 1961-10-19 | Herrmann Gebr | DRYING AGENT BAG. |
| FR1398104A (en) * | 1964-03-26 | 1965-05-07 | Participations Et Procedes Ind | desiccant elements and their manufacturing process |
| DE1931398A1 (en) * | 1969-06-20 | 1971-01-07 | Grace W R & Co | Desiccant in block or tablet form and process for its production |
| DE2108451A1 (en) * | 1971-02-22 | 1972-09-07 | Le Ob Elektronnowo Priboro | Moisture absorbent composn - contg zeolite and hardenable polymer esp epoxy resin |
| BE794951A (en) * | 1972-02-03 | 1973-05-29 | Parke Davis & Co | WATER SOLUBLE PACKAGING |
| DE2722806C2 (en) * | 1977-05-20 | 1984-12-13 | Capsugel AG, Basel | Capsule body for a push-fit capsule for drugs or other substances to be packaged in portions, as well as a process for its production |
| NL7808099A (en) * | 1978-06-27 | 1980-01-02 | Aquarius C | METHOD FOR INDIVIDUALLY PACKING CANDIES IN SOLID FORM AND PACKING CANDIES ACCORDING TO THIS METHOD. |
| US4224366A (en) * | 1978-10-19 | 1980-09-23 | Mccabe Jr Edward G | Moisture absorption sectional pack |
-
1989
- 1989-03-11 DE DE3907973A patent/DE3907973A1/en not_active Withdrawn
-
1990
- 1990-02-28 EP EP90103843A patent/EP0387604B1/en not_active Expired - Lifetime
- 1990-02-28 DE DE9090103843T patent/DE59001875D1/en not_active Expired - Fee Related
- 1990-02-28 ES ES199090103843T patent/ES2041458T3/en not_active Expired - Lifetime
- 1990-03-09 JP JP2056786A patent/JPH0347513A/en active Pending
- 1990-03-09 CA CA002011840A patent/CA2011840A1/en not_active Abandoned
- 1990-03-10 KR KR1019900003194A patent/KR900013945A/en not_active Application Discontinuation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8580302B2 (en) | 2000-11-20 | 2013-11-12 | Warner Chilcott Company, Llc | Pharmaceutical dosage form with multiple coatings for reduced impact of coating fractures |
| US9089492B2 (en) | 2000-11-20 | 2015-07-28 | Warner Chilcott Company, Llc | Pharmaceutical dosage form with multiple coatings for reduced impact of coating fractures |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0387604B1 (en) | 1993-06-30 |
| DE3907973A1 (en) | 1990-09-13 |
| JPH0347513A (en) | 1991-02-28 |
| ES2041458T3 (en) | 1993-11-16 |
| KR900013945A (en) | 1990-10-22 |
| DE59001875D1 (en) | 1993-08-05 |
| EP0387604A1 (en) | 1990-09-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR950004886B1 (en) | Process for preparing pharmaceutical formulations of acid labile substances for oral use | |
| EP0049061B1 (en) | Pharmaceutical formulation | |
| KR910004579B1 (en) | Process for preparing oral type of omeprazole preparation | |
| EP0336298B1 (en) | Pharmaceutical compositions having good stability | |
| KR101325901B1 (en) | Use of a partially neutralized, anionic (meth)acrylate copolymer as a coating for the production of a medicament releasing active substance at reduced ph values | |
| CA1105385A (en) | Stabilized amoxycillin-clavulanate compositions | |
| KR20010032351A (en) | Oxygen Scavenging Composition | |
| AU751609B2 (en) | Oral pharmaceutical preparation comprising an antiulcer activity compound, and process for its production | |
| KR100735506B1 (en) | Multilayer pharmaceutical product for release in the colon | |
| US4629620A (en) | Membrane-coated sustained-release tablets and method | |
| JP4980933B2 (en) | Stabilization method of polyvinylpyrrolidone | |
| JP3606581B2 (en) | Drug chamber in inhaler | |
| JP2017536404A (en) | Gastric retention sustained release suspension composition | |
| KR20010075685A (en) | Pharmaceutical Formulation Comprising Omeprazole | |
| CA2011840A1 (en) | Desiccant tablet | |
| JP3052317B2 (en) | Oxygen scavenger | |
| EA007619B1 (en) | Film coating for tablets and caplets | |
| JP2002506891A (en) | Oxygen scavenging composition and method for producing the same | |
| US8282956B2 (en) | Coated tablet | |
| JP4999329B2 (en) | Pre-printing method for solid preparation | |
| KR101483476B1 (en) | Coating agent for pharmaceutical solid preparation, pharmaceutical film formulation, and coated pharmaceutical solid preparation | |
| CA1296634C (en) | Pharmaceutical formulations of ciprofloxacin | |
| KR102265977B1 (en) | Composition for film-coating having improved damp-proof property and tablet coated with the composition | |
| CN102631327A (en) | Enteric coated omeprazole pellet and preparation method thereof | |
| GB2170210A (en) | Coating composition for dosage forms |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Dead |