CA2007064C - Catheter for uniform distribution of therapeutic fluids - Google Patents
Catheter for uniform distribution of therapeutic fluids Download PDFInfo
- Publication number
- CA2007064C CA2007064C CA002007064A CA2007064A CA2007064C CA 2007064 C CA2007064 C CA 2007064C CA 002007064 A CA002007064 A CA 002007064A CA 2007064 A CA2007064 A CA 2007064A CA 2007064 C CA2007064 C CA 2007064C
- Authority
- CA
- Canada
- Prior art keywords
- catheter
- lumens
- tubular body
- fluid
- vascular catheter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
- A61M25/007—Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked
Abstract
A vascular catheter for delivering a uniform flow of therapeutic fluid over a length of the catheter. The catheter is particularly suitable for delivering thrombolytic agents to a thrombus or clot in a patient's arterial system. In a preferred embodiment, the catheter has a relatively thick-walled tubular body with a central lumen for advancement over a guidewire and a plurality of fluid delivering lumens disposed within the relatively thick wall. Each of the smaller lumens has a single flow passageway to discharge therapeutic fluid to the exterior of the catheter.
Description
CATHETER FOR UNIFORM DISTRIBUTION OF
THERAPEUTIC FLUIDS
BACKGROUND OF THE INVENTION
This invention generally relates to a vascular catheter for the delivery of therapeutic fluids and particularly for the uniform delivery of thrombolytic fluids to a vascular location of a patient having a thrombus or clot.
The utilization of therapeutic fluids containing tissue plasminogen activator (TPA), urokinase and streptokiase have shown promise in the treatment of thrombus or clots in a patient's arterial system. The systemic use of such therapeutic fluids have been limited by the fact that the patient's total body is medicated in order to effect sites in the patient's arterial vasculature. Direct delivery of thrombolytic fluids to the target tissue would allow for a much more effective treatment procedure. However, there have been no effective delivery systems available. More particularly, there has not been available a delivery system which can deliver a uniform flow of such therapeutic fluids along the length of a thrombus in a patient's artery. The present invention satisfies that need.
SUMMARY OF THE INVENTION
The present invention is directed to a multilumen vascular catheter which provides a more uniform and thus more effective delivery of fluids containing drugs or therapeutic agents to a desired vasculature location.
More specifically, the invention provides a multilumen vascular catheter for the uniform delivery of fluid containing drugs and therapeutic agents comprising an elongated tubular body having a first lumen for receiving a guidewire to facilitate the advancement of the catheter through a patient's la second lumens having in fluid communication therewith a single flow passageway extending through the wall of the tubular body to the exterior thereof with the flow passageways being longitudinally spaced from each other so that a uniform flow of fluid is discharged over a length of the catheter.
The invention also provides a multilumen vascular catheter for the uniform delivery of fluid containing drugs and therapeutic agents and the like comprising an elongated tubular body having a first lumen and a plurality of second lumens formed in the wall of the tubular body, each of said second lumens having in fluid communication therewith a single flow passageway extending through the wall of the tubular body to the exterior thereof with the flow passageways being longitudinally spaced from each other so that a uniform flow of fluid is discharged over a length of the catheter; said first lumen is circular in cross section and is the central bore of said tubular body and is adapted for receiving a guidewire to facilitate the advancement of the catheter through a patient's vasculature and said second lumens are each circular in cross section and each has a relatively small diameter compared with the diameter of said first lumen.
The vascular catheter disclosed herein comprises an elongated tubular body having a relatively large inner lumen, with an axial opening in the distal end thereof, which is adapted to receive a guidewire and a plurality of relatively small outer lumens which direct fluid containing drugs, therapeutic agents and the like to the distal portion of the tubular body. Each of the smaller lumens has a single flow passageway in fluid communication therewith which extends through the wall of the tubular body and is open to the exterior of the catheter to discharge fluid therefrom.
The flow passageways are spaced longitudinally along a length of the tubular body and have essentially equivalent minimum transverse cross-sections to provide a uniform fluid flow over said length. Preferably, the passageways are spirally arranged to ensure uniform flow around the periphery of the catheter.
In a preferred embodiment the tubular body has a relatively thick walled cylindrical shape with the relatively large diameter lumen adapted to receive the guidewire, being centrally disposed. A plurality of small diameter lumens are provided which extend longitudinally through the relatively thick wall of the tubular body.
The proximal end of the catheter is provided with an adapter which directs fluids through one arm thereof to the small diameter lumens and one arm to direct a guidewire through the relatively large diameter. If desired, each of the small diameter lumens can be provided with separate fluid sources in order to more accurately deliver fluid therethrough.
These and other advantages of the invention will become more apparent from the following detailed description thereof when taken in conjunction with the following exemplary drawings.
BRIEF DESCRIPTION OF THE DRAWINGS
FIGURE 1 is an elevational view, partially in section of a vascular catheter which embodies features of the invention;
FIG. 2 is a transverse cross-sectional view taken along the lines 2-2 shown in FIG. l; and FIG. 3 is an enlarged cross-sectional view of the distal portion of the catheter shown in FIG. 1.
p~ETAILED DESCRIPTION OF THE DRAWINGS
Reference is made to FIGS. 1-3 which illustrate a vascular catheter assembly 10 embodying features of the invention. The catheter assembly 10 generally comprises a tubular body 11 which has a central lumen 12 adapted to receive a guidewire 13 and a relatively thick cylindrical wall 14 which has a plurality of relatively small diameter l0 lumens 15 disposed longitudinally therein which are adapted to direct fluid through the flow passageways 16.
Preferably, the small diameter lumens are equally spaced within the wall 14 about the central lumen 12.
An adapter 17 is provided on the proximal end 18 of the tubular body 11. A first arm 20 thereof is adapted to deliver fluid from a source (not shown) to the small diameter lumens 15 and a second arm 21 is adapted to direct the guidewire 13 into the central lumen 15. A
torquing knob 22 is provided on the proximal end of the guidewire 13 to facilitate the guidance thereof through the patient's vasculature. Reference is made to U. S.
Patent 4,554,929; U. S. Patent No. 4,545,390: and U. S.
Patent 4,721,117 for a more detailed description of guidewires.
The distal end of the tubular body 11 generally has a tapered body 23 which is formed of a plastic material softer than the material from which the tubular body 11 is made in order to minimize trauma to the arterial lining during the advancement of the catheter through a patient's 3o artery. The tapered body 23 blocks off the distal ends of the small diameter lumens 15.
The length of the vascular catheter will vary depending upon the use thereof. For example, for peripheral uses, lengths may be from about 70 to about 100 cm, whereas for coronary uses lengths may vary from about 120 to about 175 cm. The outer diameter of the tubular body 11 may vary from about 0.05 inch (1.27 mm) to about 0.10 inch (2.54 mm). Typical diameters of the large diameter inner lumen is about 0.025 inch (0.635 mm) to 0.045 inch (1.143 mm) and for the small diameter lumens 15 are about 0.005 inch (0.127 mm) to about 0.025 inch (0.635 mm). The flow passageways 16 are preferably uniformly spaced along a length of the tubular body 11 from about 0.5 to 5 cm and the total length of the treating section of the catheter extends from about 2 to about 20 cm.
The tubular body 11 can be made of conventional plastic materials such as polyethylene, polyvinylchloride and the like. Preferably, the stiffness of the tubular body decreases in the distal direction. Stiffness in the proximal portion of the tubular body is desirable from the standpoint of pushability but flexibility is more desirable in the distal portion in order to pass through the patient's tortuous vasculature. The proximal portion can be provided with greater stiffness by making this portion with higher density plastics, e.g., polyethylene, than the distal end. The distal tip is preferably formed of a much softer plastic to avoid trauma to the blood vessel lining when advancing the catheter therethrough.
The flow passageways 16 through the wall of the tubular body can be formed by drilling (e. g., mechanical or laser) or by notching the exterior wall to expose the small diameter lumens. The flow passageways are preferably spiralled about the tubular body of the catheter, as shown in the drawings, to provide a more uniform flow surrounding the catheter.
The minimum transverse cross-sectional area of the flow passages ranges from about 0.00005 in2 (0.032 mm2) to about 0.002 in2 (1.3 mm2) for fluid flows of about 0.1 to about 1.5 cc's per minute at lumen pressures of about 2 to about 5 psi. The cross-sectional areas can be varied depending upon the fluid flow rate desired, the viscosity and density of the fluid and the fluid pressure available.
The number of flow passageways can number from 2 to up to 12 or more, but generally only 4-8 are needed. The spacing between the passageways is preferably uniform but may vary from about 0.5 to about 5 cm.
THERAPEUTIC FLUIDS
BACKGROUND OF THE INVENTION
This invention generally relates to a vascular catheter for the delivery of therapeutic fluids and particularly for the uniform delivery of thrombolytic fluids to a vascular location of a patient having a thrombus or clot.
The utilization of therapeutic fluids containing tissue plasminogen activator (TPA), urokinase and streptokiase have shown promise in the treatment of thrombus or clots in a patient's arterial system. The systemic use of such therapeutic fluids have been limited by the fact that the patient's total body is medicated in order to effect sites in the patient's arterial vasculature. Direct delivery of thrombolytic fluids to the target tissue would allow for a much more effective treatment procedure. However, there have been no effective delivery systems available. More particularly, there has not been available a delivery system which can deliver a uniform flow of such therapeutic fluids along the length of a thrombus in a patient's artery. The present invention satisfies that need.
SUMMARY OF THE INVENTION
The present invention is directed to a multilumen vascular catheter which provides a more uniform and thus more effective delivery of fluids containing drugs or therapeutic agents to a desired vasculature location.
More specifically, the invention provides a multilumen vascular catheter for the uniform delivery of fluid containing drugs and therapeutic agents comprising an elongated tubular body having a first lumen for receiving a guidewire to facilitate the advancement of the catheter through a patient's la second lumens having in fluid communication therewith a single flow passageway extending through the wall of the tubular body to the exterior thereof with the flow passageways being longitudinally spaced from each other so that a uniform flow of fluid is discharged over a length of the catheter.
The invention also provides a multilumen vascular catheter for the uniform delivery of fluid containing drugs and therapeutic agents and the like comprising an elongated tubular body having a first lumen and a plurality of second lumens formed in the wall of the tubular body, each of said second lumens having in fluid communication therewith a single flow passageway extending through the wall of the tubular body to the exterior thereof with the flow passageways being longitudinally spaced from each other so that a uniform flow of fluid is discharged over a length of the catheter; said first lumen is circular in cross section and is the central bore of said tubular body and is adapted for receiving a guidewire to facilitate the advancement of the catheter through a patient's vasculature and said second lumens are each circular in cross section and each has a relatively small diameter compared with the diameter of said first lumen.
The vascular catheter disclosed herein comprises an elongated tubular body having a relatively large inner lumen, with an axial opening in the distal end thereof, which is adapted to receive a guidewire and a plurality of relatively small outer lumens which direct fluid containing drugs, therapeutic agents and the like to the distal portion of the tubular body. Each of the smaller lumens has a single flow passageway in fluid communication therewith which extends through the wall of the tubular body and is open to the exterior of the catheter to discharge fluid therefrom.
The flow passageways are spaced longitudinally along a length of the tubular body and have essentially equivalent minimum transverse cross-sections to provide a uniform fluid flow over said length. Preferably, the passageways are spirally arranged to ensure uniform flow around the periphery of the catheter.
In a preferred embodiment the tubular body has a relatively thick walled cylindrical shape with the relatively large diameter lumen adapted to receive the guidewire, being centrally disposed. A plurality of small diameter lumens are provided which extend longitudinally through the relatively thick wall of the tubular body.
The proximal end of the catheter is provided with an adapter which directs fluids through one arm thereof to the small diameter lumens and one arm to direct a guidewire through the relatively large diameter. If desired, each of the small diameter lumens can be provided with separate fluid sources in order to more accurately deliver fluid therethrough.
These and other advantages of the invention will become more apparent from the following detailed description thereof when taken in conjunction with the following exemplary drawings.
BRIEF DESCRIPTION OF THE DRAWINGS
FIGURE 1 is an elevational view, partially in section of a vascular catheter which embodies features of the invention;
FIG. 2 is a transverse cross-sectional view taken along the lines 2-2 shown in FIG. l; and FIG. 3 is an enlarged cross-sectional view of the distal portion of the catheter shown in FIG. 1.
p~ETAILED DESCRIPTION OF THE DRAWINGS
Reference is made to FIGS. 1-3 which illustrate a vascular catheter assembly 10 embodying features of the invention. The catheter assembly 10 generally comprises a tubular body 11 which has a central lumen 12 adapted to receive a guidewire 13 and a relatively thick cylindrical wall 14 which has a plurality of relatively small diameter l0 lumens 15 disposed longitudinally therein which are adapted to direct fluid through the flow passageways 16.
Preferably, the small diameter lumens are equally spaced within the wall 14 about the central lumen 12.
An adapter 17 is provided on the proximal end 18 of the tubular body 11. A first arm 20 thereof is adapted to deliver fluid from a source (not shown) to the small diameter lumens 15 and a second arm 21 is adapted to direct the guidewire 13 into the central lumen 15. A
torquing knob 22 is provided on the proximal end of the guidewire 13 to facilitate the guidance thereof through the patient's vasculature. Reference is made to U. S.
Patent 4,554,929; U. S. Patent No. 4,545,390: and U. S.
Patent 4,721,117 for a more detailed description of guidewires.
The distal end of the tubular body 11 generally has a tapered body 23 which is formed of a plastic material softer than the material from which the tubular body 11 is made in order to minimize trauma to the arterial lining during the advancement of the catheter through a patient's 3o artery. The tapered body 23 blocks off the distal ends of the small diameter lumens 15.
The length of the vascular catheter will vary depending upon the use thereof. For example, for peripheral uses, lengths may be from about 70 to about 100 cm, whereas for coronary uses lengths may vary from about 120 to about 175 cm. The outer diameter of the tubular body 11 may vary from about 0.05 inch (1.27 mm) to about 0.10 inch (2.54 mm). Typical diameters of the large diameter inner lumen is about 0.025 inch (0.635 mm) to 0.045 inch (1.143 mm) and for the small diameter lumens 15 are about 0.005 inch (0.127 mm) to about 0.025 inch (0.635 mm). The flow passageways 16 are preferably uniformly spaced along a length of the tubular body 11 from about 0.5 to 5 cm and the total length of the treating section of the catheter extends from about 2 to about 20 cm.
The tubular body 11 can be made of conventional plastic materials such as polyethylene, polyvinylchloride and the like. Preferably, the stiffness of the tubular body decreases in the distal direction. Stiffness in the proximal portion of the tubular body is desirable from the standpoint of pushability but flexibility is more desirable in the distal portion in order to pass through the patient's tortuous vasculature. The proximal portion can be provided with greater stiffness by making this portion with higher density plastics, e.g., polyethylene, than the distal end. The distal tip is preferably formed of a much softer plastic to avoid trauma to the blood vessel lining when advancing the catheter therethrough.
The flow passageways 16 through the wall of the tubular body can be formed by drilling (e. g., mechanical or laser) or by notching the exterior wall to expose the small diameter lumens. The flow passageways are preferably spiralled about the tubular body of the catheter, as shown in the drawings, to provide a more uniform flow surrounding the catheter.
The minimum transverse cross-sectional area of the flow passages ranges from about 0.00005 in2 (0.032 mm2) to about 0.002 in2 (1.3 mm2) for fluid flows of about 0.1 to about 1.5 cc's per minute at lumen pressures of about 2 to about 5 psi. The cross-sectional areas can be varied depending upon the fluid flow rate desired, the viscosity and density of the fluid and the fluid pressure available.
The number of flow passageways can number from 2 to up to 12 or more, but generally only 4-8 are needed. The spacing between the passageways is preferably uniform but may vary from about 0.5 to about 5 cm.
5 Typically a guidewire is directed through a patient's arterial system to a location therein having a thrombus or clot which occludes or partially occludes the artery. The distal portion of the guidewire is advanced through the clot, then the vascular catheter of the invention is mounted onto the guidewire and advanced thereover until the distal portion of the catheter having the flow passageways in the wall thereof is in position within the thrombus. Fluid containing thrombolytic agents such as urokinase, streptokinase, tissue plasminogen activator (TPA) and the like is then directed through the small diameter lumens and the flow passageway associated with each of such lumens to the exterior of the catheter into the thrombus. The fluid flow rate is relatively low as is the pressure to allow the fluid to penetrate through and dissolve the clot. The flow out of the passageways is uniform over the length of the catheter containing such passageways. In this manner, a uniform thrombolysis is effected. After this treatment, the stenotic region can be treated by balloon dilatation, atherectomy and the like to provide increased blood flow through the region.
While the description of the invention herein has been directed to a catheter for the delivery of thrombolytic fluids, it should be obvious that other fluids can be delivered and that other treatments can be performed. Additionally, while only one source for treatment fluid is shown for the small diameter lumens, each of said lumens can be provided with its own source of such fluid and the flow therethrough regulated independently. Other modifications and improvements can be made to the invention without departing from the scope thereof.
While the description of the invention herein has been directed to a catheter for the delivery of thrombolytic fluids, it should be obvious that other fluids can be delivered and that other treatments can be performed. Additionally, while only one source for treatment fluid is shown for the small diameter lumens, each of said lumens can be provided with its own source of such fluid and the flow therethrough regulated independently. Other modifications and improvements can be made to the invention without departing from the scope thereof.
Claims (19)
1. A multilumen vascular catheter for the uniform delivery of fluid containing drugs and therapeutic agents comprising an elongated tubular body having a first lumen for receiving a guidewire to facilitate the advancement of the catheter through a patient's vasculature and a plurality of second lumens, each of said second lumens having in fluid communication therewith a single flow passageway extending through the wall of the tubular body to the exterior thereof with the flow passageways being longitudinally spaced from each other so that a uniform flow of fluid is discharged over a length of the catheter.
2. The vascular catheter of claim 1 wherein the first lumen is centrally disposed along the longitudinal axis of the tubular body.
3. The vascular catheter of claim 2 wherein the plurality of second lumens are disposed about the first lumen.
4. The vascular catheter of any one of claims 1 to 3 wherein the minimum cross-sectional area of the flow passageway ranges from about 0.00005 to about 0.0002 in2.
5. The vascular catheter of any one of claims 1 to 3 including means at the proximal end of the catheter for directing fluid into the plurality of second lumens.
6. The vascular catheter of claim 4 wherein the minimum cross-sectional areas of each of the flow passageways through the wall of the catheter are essentially the same.
7 7. The vascular catheter of any one of claims 1 to 6 wherein the flow passageways are spaced longitudinally from one another a distance of about 0.5 to about 5 cm.
8. The vascular catheter of any one of claims 1 to 7 wherein at least four second lumens are provided.
9. The vascular catheter of any one of claims 1 to 8 wherein the elongated tubular body comprises a cylindrical member with an outer wall and a central first lumen for receiving a guidewire, with the plurality of second lumens extending longitudinally through the outer wall.
10. The catheter of any one of claims 1 to 9 wherein the flow passageways are radially spaced about the longitudinal axis of the tubular body about 90° from each other so as to be in a spiral orientation.
11. A multilumen vascular catheter for the uniform delivery of fluid containing drugs and therapeutic agents and the like comprising an elongated tubular body having a first lumen and a plurality of second lumens formed in the wall of the tubular body, each of said second lumens having in fluid communication therewith a single flow passageway extending through the wall of the tubular body to the exterior thereof with the flow passageways being longitudinally spaced from each other so that a uniform flow of fluid is discharged over a length of the catheter; wherein said first lumen is circular in cross section and is the central bore of said tubular body and is adapted for receiving a guidewire to facilitate the advancement of the catheter through a patient's vasculature and said second lumens are each circular in cross section and each has a relatively small diameter compared with the diameter of said first lumen.
12. A vascular catheter according to claim 11 wherein the minimum cross-sectional area of the flow passageway ranges from about 0.00032 cm2 to about 0.013 cm2 (0.00005 in2 to about 0.002 in2).
13. A vascular catheter according to claim 11 012 including means at the proximal end of the catheter for directing fluid into the plurality of second lumens.
14. A vascular catheter according to any one of claims 11 to 13 wherein the cross-sectional areas of each of the flow passageways as it extends through the wall of the catheter are essentially the same.
15. A vascular catheter according to any one of claims 11 to 14 wherein the flow passageways are spaced longitudinally from one another a distance of about 0.5 to about 5 cm.
16. A vascular catheter according to any one of claims 11 to 15 wherein at least four second lumens are provided.
17. A catheter according to any one of claims 11 to 16 wherein the flow passageways are radially spaced about the longitudinal axis of the tubular body about 90° from each other so as to be in a spiral orientation.
18. A catheter according to any one of claims 11 to 17 wherein said second lumens are adapted to be in fluid communication with a single source of fluid.
19. A catheter according to any one of claims 11 to 18 wherein said second lumens are adapted to be in fluid communication with separate sources of fluid.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/295,088 US4927418A (en) | 1989-01-09 | 1989-01-09 | Catheter for uniform distribution of therapeutic fluids |
| US295,088 | 1989-01-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2007064A1 CA2007064A1 (en) | 1990-07-09 |
| CA2007064C true CA2007064C (en) | 2001-07-24 |
Family
ID=23136168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002007064A Expired - Fee Related CA2007064C (en) | 1989-01-09 | 1990-01-03 | Catheter for uniform distribution of therapeutic fluids |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4927418A (en) |
| EP (1) | EP0378178B1 (en) |
| JP (1) | JP3020532B2 (en) |
| CA (1) | CA2007064C (en) |
| DE (1) | DE69030825T2 (en) |
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Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4329994A (en) * | 1980-06-18 | 1982-05-18 | American Hospital Supply Corporation | Multilumen catheter |
| US4596564A (en) * | 1981-01-29 | 1986-06-24 | Pmt, Inc. | Medical appliance |
| US4543089A (en) * | 1981-10-16 | 1985-09-24 | Gerald Moss | Gastrointestinal feeding and aspirating device for use in treating patients |
| CA1176929A (en) * | 1982-07-14 | 1984-10-30 | Urotek Inc. | Urodynamic catheter |
| US4543987A (en) * | 1984-04-27 | 1985-10-01 | Eaton Corporation | Relief valve |
| CA1219785A (en) * | 1984-05-24 | 1987-03-31 | Geoffrey S. Martin | Dual lumen cannula |
| SE442377B (en) * | 1984-06-29 | 1985-12-23 | Mediplast Ab | CATS, HEALTH OR SIMILAR DEVICE |
| US4577637A (en) * | 1984-07-13 | 1986-03-25 | Argon Medical Corp. | Flexible metal radiopaque indicator and plugs for catheters |
| CH668192A5 (en) * | 1985-11-29 | 1988-12-15 | Schneider Medintag Ag | CATHETER FOR TREATING NARROW BODIES, FOR EXAMPLE IN A BLOOD VESSEL. |
| US4795439A (en) * | 1986-06-06 | 1989-01-03 | Edward Weck Incorporated | Spiral multi-lumen catheter |
| US4769005A (en) * | 1987-08-06 | 1988-09-06 | Robert Ginsburg | Selective catheter guide |
| CA1330285C (en) * | 1987-12-22 | 1994-06-21 | Geoffrey S. Martin | Triple lumen catheter |
-
1989
- 1989-01-09 US US07/295,088 patent/US4927418A/en not_active Expired - Lifetime
-
1990
- 1990-01-03 CA CA002007064A patent/CA2007064C/en not_active Expired - Fee Related
- 1990-01-09 JP JP2002406A patent/JP3020532B2/en not_active Expired - Lifetime
- 1990-01-09 DE DE69030825T patent/DE69030825T2/en not_active Expired - Lifetime
- 1990-01-09 EP EP90100385A patent/EP0378178B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0378178B1 (en) | 1997-06-04 |
| EP0378178A2 (en) | 1990-07-18 |
| DE69030825T2 (en) | 1997-11-20 |
| US4927418A (en) | 1990-05-22 |
| JP3020532B2 (en) | 2000-03-15 |
| DE69030825D1 (en) | 1997-07-10 |
| JPH03198869A (en) | 1991-08-30 |
| CA2007064A1 (en) | 1990-07-09 |
| EP0378178A3 (en) | 1990-09-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |