CA2004468A1 - Sustained release, comfort formulation for glaucoma therapy - Google Patents

Sustained release, comfort formulation for glaucoma therapy

Info

Publication number
CA2004468A1
CA2004468A1 CA2004468A CA2004468A CA2004468A1 CA 2004468 A1 CA2004468 A1 CA 2004468A1 CA 2004468 A CA2004468 A CA 2004468A CA 2004468 A CA2004468 A CA 2004468A CA 2004468 A1 CA2004468 A1 CA 2004468A1
Authority
CA
Canada
Prior art keywords
sustained release
comfort
formulation
glaucoma therapy
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2004468A
Other languages
French (fr)
Other versions
CA2004468C (en
Inventor
Rajni Jani
Robert Gregg Harris
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Vision LLC
Original Assignee
Alcon Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27508398&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2004468(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to US07/154,514 priority Critical patent/US4911920A/en
Priority to AU45753/89A priority patent/AU621692B2/en
Application filed by Alcon Laboratories Inc filed Critical Alcon Laboratories Inc
Priority to CA002004468A priority patent/CA2004468C/en
Priority to DE68913979T priority patent/DE68913979T2/en
Priority to EP89312590A priority patent/EP0429732B1/en
Priority to IL9252789A priority patent/IL92527A/en
Priority to JP1321616A priority patent/JPH0725698B2/en
Priority claimed from JP1321616A external-priority patent/JPH0725698B2/en
Publication of CA2004468A1 publication Critical patent/CA2004468A1/en
Priority to US08/334,512 priority patent/US5554367A/en
Priority to US08/396,284 priority patent/US5635172A/en
Priority to HK135695A priority patent/HK135695A/en
Publication of CA2004468C publication Critical patent/CA2004468C/en
Application granted granted Critical
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A61K47/585—Ion exchange resins, e.g. polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears

Abstract

Disclosed are nonstinging, sustained release ophthalmic formulations to control intraocular pressure in antiglaucoma therapy comprising a basic active, a cation exchange resin, and, inter alia, an acidic, mucomimetic polymer. Also disclosed are methods of treatment comprising administering such formulations topically to the eye when indicated for control and lowering for intraocular pressure.
CA002004468A 1984-10-31 1989-12-01 Sustained release, comfort formulation for glaucoma therapy Expired - Lifetime CA2004468C (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
US07/154,514 US4911920A (en) 1986-07-30 1988-02-05 Sustained release, comfort formulation for glaucoma therapy
AU45753/89A AU621692B2 (en) 1986-07-30 1989-11-30 Sustained release, comfort formulation for glaucoma therapy
CA002004468A CA2004468C (en) 1988-02-05 1989-12-01 Sustained release, comfort formulation for glaucoma therapy
DE68913979T DE68913979T2 (en) 1988-02-05 1989-12-01 Medicinal preparations containing delayed release of active substances containing cation exchange resins and carboxyl-containing synthetic resins.
EP89312590A EP0429732B1 (en) 1986-07-30 1989-12-01 Sustained-release compositions containing cation exchange resins and polycarboxylic polymers
IL9252789A IL92527A (en) 1988-02-05 1989-12-01 Opthalmic pharmaceutical composition for glaucoma therapy
JP1321616A JPH0725698B2 (en) 1984-10-31 1989-12-13 Formulation for the treatment of glaucoma with sustained release and comfortable application
US08/334,512 US5554367A (en) 1984-10-31 1994-11-04 Compositions for treatment of glaucoma
US08/396,284 US5635172A (en) 1984-10-31 1995-02-27 Sustained release comfort formulation for glaucoma therapy
HK135695A HK135695A (en) 1986-07-30 1995-08-24 Sustained-release compositions containing cation exchange resins and polycarboxylic polymers

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US07/154,514 US4911920A (en) 1986-07-30 1988-02-05 Sustained release, comfort formulation for glaucoma therapy
CA002004468A CA2004468C (en) 1988-02-05 1989-12-01 Sustained release, comfort formulation for glaucoma therapy
IL9252789A IL92527A (en) 1988-02-05 1989-12-01 Opthalmic pharmaceutical composition for glaucoma therapy
JP1321616A JPH0725698B2 (en) 1984-10-31 1989-12-13 Formulation for the treatment of glaucoma with sustained release and comfortable application
HK135695A HK135695A (en) 1986-07-30 1995-08-24 Sustained-release compositions containing cation exchange resins and polycarboxylic polymers

Publications (2)

Publication Number Publication Date
CA2004468A1 true CA2004468A1 (en) 1991-06-01
CA2004468C CA2004468C (en) 1996-10-01

Family

ID=27508398

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002004468A Expired - Lifetime CA2004468C (en) 1984-10-31 1989-12-01 Sustained release, comfort formulation for glaucoma therapy

Country Status (7)

Country Link
US (2) US4911920A (en)
EP (1) EP0429732B1 (en)
AU (1) AU621692B2 (en)
CA (1) CA2004468C (en)
DE (1) DE68913979T2 (en)
HK (1) HK135695A (en)
IL (1) IL92527A (en)

Families Citing this family (293)

* Cited by examiner, † Cited by third party
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