CA1336732C - Film-forming gels with high concentration of humectants and emollients - Google Patents

Film-forming gels with high concentration of humectants and emollients

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Publication number
CA1336732C
CA1336732C CA000606026A CA606026A CA1336732C CA 1336732 C CA1336732 C CA 1336732C CA 000606026 A CA000606026 A CA 000606026A CA 606026 A CA606026 A CA 606026A CA 1336732 C CA1336732 C CA 1336732C
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Canada
Prior art keywords
water
weight
film
gels
amount
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA000606026A
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French (fr)
Inventor
Mohan Vishnupad
Jose E. Ramirez
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Imaginative Research Associates Inc
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Imaginative Research Associates Inc
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Application granted granted Critical
Publication of CA1336732C publication Critical patent/CA1336732C/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0208—Tissues; Wipes; Patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/85—Polyesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/008—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q3/00—Manicure or pedicure preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S261/00—Gas and liquid contact apparatus
    • Y10S261/88—Aroma dispensers

Abstract

Novel film-forming gel compositions are described comprising from 10-40% by weight of a water dissipatable polymer, from 10 to 40% by weight of humectants and 20-60% by weight of water. The gel compositions may also be in the form of an emulsion comprising from 15-30% by weight of a water dissipatable polymer, from 15 to 35% by weight of humectants, up to 40% by weight of emollients, from 15 to 35% by weight water and a small amount of emulsifier. Additionally the gels of the present invention may contain optional agents such as, for example, coloring agents, pigments, preservatives, medical agents, cosmetic agents or agents to modify the refractive index of the gel.

Description

-This invention relates generally to film-forming gels. More specifically, this invention relates to film-forming gels having high concentrations of humectants and/or emollients. These novel film-forming gels may be in the form of an emulsion.
Many compositions used for skin treatments contain emollients or humectants such as petroleum jelly. Such compositions are used for may dermatological applications such as moisturizing, amelioration of wrinkles, prevention of chaffing, or wound healing. When applied to the skin, these compositions tend to be greasy, and therefore tend to transfer onto and stain clothing or other surfaces which contact the area of application.
Water soluble gels that form protective films of various types are known. For example, U.S. Patent No.
4,393,048 discloses a water soluble hydrogel of alkali metal alginate and glycerine that dries to a non-toxic, pliable protective film. U.S. Patent No. 3,489,690 describes water-and-oil emulsions which can contain waxy film formers like petroleum jelly to form films which are nonpliable, tacky and transferable when rubbed between surfaces. U.S. Patent No.
3,949,742 discloses a transparent medical dressing which performs as a synthetic film over skin wounds comprised of a laminate of a thin layer of non-porous segmented polyurethane secured to foam. U.S. Patent No. 3,734,874 describes water-dissipatable, meltable polyesters that are useful as adhesives, coating materials, films, packaging materials and other products that can be dissolved, dispersed or otherwise dissipated in water or aqueous solutions. Although the polymers described in U.S. Patent No. 3,734,874 may not pose the problem of transferring to surfaces in contact with the area of application, they do not contain humectants or emollients to serve as satisfactory skin treatment compositions.
It is therefore an object of the present invention to provide novel film-forming gels with high humectant and/or emollient content.

z A further object of the present invention is to provide novel gels with humectant or emollient content of up to 40% by weight based on the total composition of the gel and which, upon application to a surface, dry to form films to prevent the transfer of any portion of the composition to other surfaces.
A further object of this invention is to provide gels which can carry pigments and colorants and which upon application to a surface, dry to form films to prevent the transfer of the composition to other surfaces.
A further object of this invention is to provide gels which form a water soluble film.
A further object of this invention is to provide gels which form a film and can carry topical treatments and which when exposed to a high water content environment, will release said treatments.
Another object of this invention is to provide a film which can be applied to a surface to protect, moisturize and/or treat the surface.
Another object of this invention is to provide compositions containing sunscreens which can be applied as a gel or a pre-formed article (tape, pad, etc.) to a surface to protect the surface from sunlight damage.
Another object of this invention is to provide films which can be applied to wounds, cuts and burns as dressings, bandages and patches, in the form of a tape or other precut forms.
It is also an object of this invention to provide gels which can be case or molded into articles of various shapes and sizes.
Another object of this invention is to provide gels which form thick films and casts which may be used or prosthetic implants, inserts and for transdermal drug delivery patches.
Another object of this invention is to provide compositions containing fragrances, insect repellents and similar chemical compositions which are used in gel form or as a pre-formed article.

These and other advantages of the present invention will be apparent to those skilled in the art from the following description of the invention.
It has now been found that the objectives of this invention may be realized by forming a gel composition comprising from 10-40% by weight of a water dissipatable polymer, from 10 to 40% by weight of humectants and 20-60% by weight of water. The gel compositions may also be in the form of an emulsion comprising from 15-30% by weight of a water dissipatable polymer, from 15 to 35% by weight of humectants, up to 40% by weight of emollients, from 15 to 35% by weight water and a small amount of emulsifier. Additionally, the gels of the present invention may contain optional agents such as, for example, coloring agents, pigments, preservatives, medical agents, and cosmetic agents.
The novel gels of the present invention comprise:
a) a water dissipatable polymer in an amount from 10 to 40% by weight based on the total weight of the composition; b) a humectant in an amount from 10 to 40% by weight based on the total weight of the composition; and c) water in an amount from 20 to 60% by weight based on the total weight of the composition.
The novel gels of the present invention may also be in the form of an emulsion. The emulsion-type gels of the present invention comprise: a) a water dissipatable polymer in an amount from 15% to 30% by weight based on the total weight of the composition; b) a humectant in an amount from 15% to 35% by weight based on the total composition; c) an emollient in an amount up to 40% by weight based on the total composition; d) water in an amount from 15% to 35% by weight based on the total composition; and e) an emulsifier in an amount from 0.01% to 5% based on the total weight of the composition.
Polymers useful in the present invention must be capable of plasticizing with the humectant component of the composition to form a water soluble film. Polymers suitable for use in this invention include the water-dissipatable polyesters and polyesteramides described in U.S. Patent No.

3,734,874 to Kibler, et al., U.S. Patent No. 4,233,196 to Sublett and U.S. Patent No. 4,304,901 to O'Neill, et al. A
preferred water dissipatable polyester is commercially available as Eastman AQ 55S polymer.
Examples of humectants useful in this invention include glycerine, sorbitol, polyethylene glycol, propylene glycol, polysaccharides (such as fructose, glucose, maltose, etc.), corn syrup, polyols, urea and derivatives and natural honey. Preferred humectants are propylene glycol and glycerine.
In forming the emulsion-type gels of the present invention any emollient may be used. Emollients useful in this invention include hydrocarbon oils and semi-solid hydrocarbons, lanolin and derivatives, and esters commonly used in the cosmetic field.
Any suitable emulsifier to obtain a stable film forming emulsion may be used. The choice of appropriate emulsifier for use in this invention will depend upon the compositions of the other components selected. The selection of an appropriate emulsifier for a given system is within the purview of one skilled in the art.
Optionally, a wide variety of agents may be incorporated into the compositions of this invention for a variety of purposes. For example, coloring agents, pigments, perfumes or preservatives may be added to create a product having characteristics desirable in a consumer product.
Medical agents may also be incorporated to prevent infection, kill microorganisms, promote healing or soothe itching.
Cosmetic agents may also be incorporated to moisturize, reduce wrinkles, act as a deodorant or cover moles or blemishes.
The gels of this invention may be applied directly to the skin and may have the same general feel and appearance as conventional gels, jellies or emulsions. When allowed to dry, however, the films formed by the gels of this invention provide protection to the skin and render the humectant component, emollient component or any optional agents in the composition non-transferable. Furthermore, the humectant, emollient or optional agents are in occlusive contact with the ~ =
* Trade-mark 5 surface and contact the area of application to protect, moisturize, heal, etc. Since the films formed by the gels of this invention are water soluble, they can be washed off when desired.
The gels of this invention may also contain fragrances, insect repellents and like chemicals. When allowed to dry, the films formed by the gels of this invention provide the benefits inherent in such compounds by the slow release of the fragrances, insect repellents, etc. when the film is exposed to water in the immediate environment, i.e.
humidity in the air or water from a natural or artificial source.
The gels of this invention may also be pre-formed into any shape. For example, the gels of this invention may be applied to a surface or poured into a tray and dried to a film which may be cut into a tape or a pad of any shape.
Methods for forming tapes or pads from the gels of this invention also include extruding the gel in a partially dried state and allowing it to dry to a desirable thickness. The tape or pad so formed from the gels of this invention can then be applied or secured to the skin or a surface to be treated, protected or lubricated. These pre-formed tapes or pads may be applied to wounds, cuts and burns as dressing, bandages and patches. The novel gels may also be cast or molded into any shape or form. When so cast the pre-formed articles may be useful as prosthetic implants, inserts for transdermal drug delivery patches.
The following examples illustrate how the film-forming gels of this invention may be formed.
EXAMPLE I
A film-forming gel was produced having the following composition:
% BY Wt.
Eastman AQ 55S Polymer 30.00 Propylene Glycol 40.00 Water 30.00 The film-forming gel of EXAMPLE I was prepared by placing the appropriate amounts of propylene glycol and water * Trade-mark - 6 -._ into a suitable container and heating the mixture to 80C.
The heated aqueous phase thus produced was transferred to a blender and the appropriate amount of polymer was gradually added with the blender providing high sheer mixing to dissolve the solids. When all the solids were added, high shear mixing was continued until a clear, straw colored, thick gel was produced. The gel was then cooled to room temperature.
EXAMPLE II
An emulsion-type film-forming gel of this invention 0 was prepared having the following composition:
% By Wt.
Eastman* AQ 55S polymer 24.0 Propylene Glycol 32.0 Petroleum Jelly 19.5 Polyglycerol Isostearate 0.5 Water 24.0 The film-forming gel of EXAMPLE II was formed by placing appropriate amounts of water and propyIene glycol in a suitable container and heating the mixture to 80C. The heated aqueous phase thus produced was transferred to a blender and the appropriate amount of polymer was gradually added with the blender providing high shear mixing to dissolve the solids. When all the solids were added, high shear mixing was continued until a clear, straw colored, thick gel was produced. The petroleum jelly was then melted at 70C and the emulsifier (polyglycerol isostearate) was added thereto to form the oil phase. The aqueous phase gel was transferred to a beaker, the oil phase was added at 70C and the aqueous and oil phases were homogenized using an Epinback homomixer until a smooth emulsion was produced. The emulsion was then cooled to room temperature.
EXAMPLES I I I--XV
The following are additional specific examples of film-forming gels of this invention.

* Trade-mark EXAMPLE III
% BY Wt.
Eastman* AQ 55S polymer 29.80 Propylene Glycol 39,75 Irgasan ( 2,4,41-trichlors-2-hydroxy diphenyl ether) O.15 Fragrance 0. 50 Water 29.80 100.00%

EXAMPLE IV
% BY Wt.
Eastman AQ 55S polymer 24.00 Propylene Glycol 32.00 Irgasan 0.15 Petroleum Jelly 19.35 Polyglycerol Isostearate 0. 50 Water 24.00 100 . 00%

EXAMPLE V
% By Wt.
Eastman* AQ 55S polymer 27.00 Propylene Glycol 36.00 Menthol 10.00 Water 27.00 100 . 00%

EXAMPLE VI
% BY Wt.
Eastman* AQ 55S polymer 24.00 Propylene Glycol 32.00 Menthol 9. 50 Petroleum Jelly 10.00 Polyglycerol Isostearate 0. 50 Water 24.00 100 . 00%

* Trade-mark ..
EXAMPLE VII
% By Wt.
Eastman* AQ 55S polymer 24.00 Propylene Glycol 32.00 Methyl Salicylate 10.00 Petroleum Jelly 9.50 Polyglycerol Isostearate 0.50 Water 24.00 100. 00%
EXAMPLE VIII
% By Wt.
Eastman* AQ 55S polymer 20.85 Propylene Glycol 27.80 Menthol Salicylate 10.00 Polyglycerol Isostearate 0.50 Cyclomethicoe (and) Dimethicone Copolyol 20.00 Water 20.85 100.00%

EXAMPLE IX
% By Wt.
Eastman AQ 55S polymer 25.00 Glycerin 30.00 Polyglycerol Isostearate 0.50 Petroleum Jelly 20.00 Water 24.50 100. 00%

* Trade-mark EXAMPLE X
% BY Wt.
Eastman AQ 55S polymer 22.00 Glycerin 15.00 Propylene glycol 15.00 Polyglycenol Isostearate 0.50 Petroleum Jelly 20.00 Water 27.50 100.00%
EXAMPLE XI
% By Wt.
Eastman AQ 55S polymer 20.00 Glycerin 24.00 Polyglycerol Isostearate 0.50 Petroleum Jelly 16.00 Minoxidil 0.10 Fragrance 0.40 Water 39.00 100.00%

EXAMPLE XII
% By Wt.
Eastman AQ 55S polymer 22.00 Petroleum Jelly 49.00 Glycerin 29.00 100 . 00%

EXAMPLE XIII
% By Wt.
Eastman AQ 55S polymer 36.46 Glycerin 48.56 Escalol* 507 (octyl dimethyl p-aminobenzoic acid) 13.64 Polyglycerol Isostearate 1.34 100. 00%

* Trade-mark 10 -EXAMPLE XIV
% BY Wt.
Eastman AQ 55S polymer 25.00 Glycerin 30 00 Polyglycerol Isostearate 0.50 Alpha Hydroxy Acids1.00 Petroleum Jelly 20.00 Water 23.50 100. 00%
EXAMPLE XV
% By Wt.
Eastman AQ 55S polymer 25.00 Glycerin 30.00 Polyglycenol Isostearate 0.50 Cis, Trans. Retinoic Acids 0.01 Petroleum Jelly 20.00 Water 24.49 100.00%
The film-forming gels of this invention were tested for transferability. The gels of EXAMPLES I and II above, were compared to conventional oil-in-water emulsions and creams. The convention oil-in-water products employed were a hand lotion comprising an oil-in-water emulsion, a cleansing Cold Cream and Petroleum Jelly U.S.P., all of which are commercially available. To test transferability, a 0.5 gram sample of each product was spread on the forearm and allowed to dry for 2 minutes and 5 minutes. A dry, pre-weighed facial tissue was then pressed on the area of application. The tissue was re-weighed after the pressing contact with the product and the percentage of product transferred was calculated. The results of these tests are reported in Table A.

* Trade-mark -TABLE A
% of Product Product DrYinq Time Transferred Hand Lotion 2 min 42%
5 (Oil-in-Water Emulsion) 5 min 34%
Petroleum Jelly U.S.P. 2 min 56%
5 min52%
Cleansing Cold Cream 2 min 62%
5 min68%
10 EXAMPLE I 2 min 12%
5 mino%
EXAMPLE II 2 min 22%
5 min0%

The results in TABLE A show that the gels of this invention are significantly less transferable compared to conventional oil-in-water emulsions and creams after 2 minutes of drying and become non-transferable within 5 minutes.
Although particular illustrative embodiments of the present invention have been described herein, the present invention is not limited to these particular embodiments.
Various changes and modifications may be made thereto by those skilled in the art without departing from the spirit or scope of the invention, which is defined by the appended claims.

Claims (3)

1. A film-forming gel composition which forms a non-transferable film upon drying, characterized in that it comprises:
a) water-dissipatable polyester or polyesteramide in an amount of from 10 to 40% by weight of the total composition;
b) humectant in an amount of from 10 to 40%
by weight of the total composition; and c) water in an amount of from 20 to 60% by weight of the total composition.
2. A film-forming gel composition which forms a non-transferable film upon drying, characterized in that it comprises:
a) water-dissipatable polyester or polyesteramide in an amount of from 15 to 30% by weight of the total composition;
b) humectant in an amount of from 15 to 35%
by weight of the total composition;
c) emollient up to 40% by weight of the total composition;
d) water in an amount of from 15 to 35% by weight of the total composition; and e) emulsifier an amount of from 0.01 to 5%
by weight of the total composition.
3. A composition as claimed in claim 1 or claim 2, wherein the humectant is selected from glycerin, sorbitol, polyethylene glycol, propylene glycol, fructose, glucose, maltose, corn syrup, urea and natural honey.
CA000606026A 1988-07-19 1989-07-18 Film-forming gels with high concentration of humectants and emollients Expired - Fee Related CA1336732C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/221,292 US4950475A (en) 1988-07-19 1988-07-19 Novel film-forming gels with high concentrations of humectants and emollients
US07/221,292 1988-07-19

Publications (1)

Publication Number Publication Date
CA1336732C true CA1336732C (en) 1995-08-15

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Family Applications (1)

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Country Status (5)

Country Link
US (1) US4950475A (en)
EP (1) EP0353896B1 (en)
CA (1) CA1336732C (en)
DE (1) DE68912675T2 (en)
ES (1) ES2062004T3 (en)

Cited By (1)

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US9757330B2 (en) 2013-10-18 2017-09-12 Industrial Technology Research Institute Recipe for in-situ gel, and implant, drug delivery system formed thereby

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US4950475A (en) 1990-08-21
EP0353896B1 (en) 1994-01-26
ES2062004T3 (en) 1994-12-16
EP0353896A2 (en) 1990-02-07
EP0353896A3 (en) 1990-11-22
DE68912675D1 (en) 1994-03-10
DE68912675T2 (en) 1994-05-26

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