CA1288089C - Lubricant composition, method of coating and a coated lubricant intubation device - Google Patents
Lubricant composition, method of coating and a coated lubricant intubation deviceInfo
- Publication number
- CA1288089C CA1288089C CA000518563A CA518563A CA1288089C CA 1288089 C CA1288089 C CA 1288089C CA 000518563 A CA000518563 A CA 000518563A CA 518563 A CA518563 A CA 518563A CA 1288089 C CA1288089 C CA 1288089C
- Authority
- CA
- Canada
- Prior art keywords
- intubation device
- surfactant
- coating
- less
- average molecular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J15/00—Feeding-tubes for therapeutic purposes
- A61J15/0003—Nasal or oral feeding-tubes, e.g. tube entering body through nose or mouth
- A61J15/0007—Nasal or oral feeding-tubes, e.g. tube entering body through nose or mouth inserted by using a guide-wire
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
- Y10T428/1352—Polymer or resin containing [i.e., natural or synthetic]
- Y10T428/139—Open-ended, self-supporting conduit, cylinder, or tube-type article
- Y10T428/1393—Multilayer [continuous layer]
Abstract
ABSTRACT OF THE DISCLOSURE
The present invention is a lubricant coating composed of hydrophylic polymer and surfactant for intubation devices such as nasogastric tubes. The coating is strong and attains sufficient lubricity upon contact with water in less than about 5 minutes and preferably less than about 5 to 10 seconds to be used in intubation procedures.
The present invention is a lubricant coating composed of hydrophylic polymer and surfactant for intubation devices such as nasogastric tubes. The coating is strong and attains sufficient lubricity upon contact with water in less than about 5 minutes and preferably less than about 5 to 10 seconds to be used in intubation procedures.
Description
` I LUBRICANT COMPOSITION, MET~OD OF
COATING AND A COATED INTUBATION ~E~
ll 3~2~3~0 1 EIELD OF T~E IN~E~TIQN
~ I The present invention relates to a lubricant 3 3 Icomposition, a method of coating and a coated device. More 4 jparticularly, the invention relateg to lubricant coa~inga for ~ Imedical device~, 8uch as intubating devices, method~ for 6 ~coating such devices and the product~ thereof. , 7 BACKGROUND OF T~E INVENTION
8 Lubricant compo~itions are u~ed as coa~ing~ to 9 reduce friction between the surfaces of moving part~ and have a vast number of applications in ~lmost every field of 11 lengineering practice. ~ubricant coatings for medical uses 12 have special requirement~. Not only must thege coa~ing~
13 ~reduce friction but they must al~o be capable of ~terilization 14 and be biocompatible, e.g.,be nontoxic and nonirritating.
l~xamples of conventional lubrlcant coat~ng~ which have been 16 ~used in the ~edical arts for year~ are mineral oil, petrole~m 17 ~elly, and K-Y Jelly~ ~Trademark of Johnson ~ Johnson Co.).
18 ~These lubricants while effectlve have not proved entirely 19 '~ati5factory for every application.
! For example, na80ga~tric and na~o~e~una~ tubes 21 jwidely u~ed for hyperalimentation must be lubricated on their 22 ~exterior surface~ to facilitate their insertion through ~
23 nasal passage, throat, or the like and to avoid damage to soft 2~ Irespiratory or ga~trointestinal tis~ue. Frequently, these ~tubes must alao have lubrlcated ~nterior ~urface~ to 26 !facilitate movement of stylets used with~n the lumen of ~uch 27 !tube~ to provide ~ufflcient rlgidity to properly po~ition a 28 Itube withln ~ patient~8 body.
29 I ~he term ~ntubation device~ 1B used generically hereln to refer to varlou~ tubes or other device~ that are : 1 .
! l ~ ~38~ 9 lubr;icated for insertion into any part of a human or other animal body including blood vessels, urinary and digestive tract pas-sages, ears and the like. Examples of intubation devices are the nasogastric and nasojejunal tubes and stylets which are more fully described in U.S. Patent No. 4,388,076.
Uniformly coating intubation devices with conventional lubricants by a physician or other person during an intubation procedure is a messy, time consuming and inefficient procedure.
Obviously, manually coating the interior surfaces (lumen) of tubes and like articles is extremely difficult. Similar dif-ficulties are experienced with intubation devices pre-coated with conventional lubricants. Such pre-coating also increases packag-ing and sterilization problems experienced in the manufacture and supply of such devices.
One approach to solving the foregoing difficulties and problems has been to provide the intubation devices with hydroph-ilic polymer coatings. These coatings provide a thin uniform coating that is dry and non-slippery until hydrated with water.
While these polymer coatings have proved effective in some situations their major drawback has been that they take too long, sometimes longer than 30 minutes, to absorb enough water to achieve sufficient lubricity for insertion into a patient. Such delays are unacceptable in many medical situations often result-ing in, for example, wasted time and in some emergency cases a threat to the health of the patient.
Various attemps have been made to modify these hydroph-ilic polymer coatings to accelerate their ability to Ij `_ I1 1 2 ~ 8~9 l Itake up water and reach aufficient lubricity for use.
2 iHowever, theQe attempts have generally not met with c~mplete 3 l~uccess. Fo~ ex~mplc, one attempt involved treating a ~ hydrophilic polymer coated intubation device with aulfurlc S llacid This can result in serious manufacturing difficulties jand toxicity problems associated with the chemical properties 7 and high vi~co~ty of sulfuric acid.
8 ~ Certain polymer coatings based on 9 polyvinylpyrrolidone (PVP) appear to hydrate rapidly enough lo !but are plagued with a ~liming problem. ~Sli~ing" means that ll ¦the coating become~ too soft and can be rubbed off An 12 intubatlon dev~ce during ordinary use.
13 ¦ Accordingly, ~t i~ an ob~ect of thi~ invention to l~ 1provide a lubricant compo~ltion for coatlng application~ which lS rapidly hydrates upon contact with water.
16 It l~ another ob~ect to provide a lubricant coating 17 Iwhich haa suff$clent mechanical ~trength ~n a hydrated 18 condition to re~l~t ~liming, abra~ion, and the llke typlcally 19 lexperienced by intubation devices.
! suMMARY OF ~HE INVENTION
21 ~ ~riefly, the invention provlde~ a lubricant 22 jcomposition comprlsing a hydrophilic polymer including a 23 Icompound selected from the group con~i~tlng of non~onic and 24 ~amphoterlc ~urfactant~ where~n the compound 19 pre~ent $n an lamount ~ufflclent to reduce the coefflclent of frictlon of a 26 ,coating of the lubr~cant composltlon to less than about 0.6 27 !upon contact wlth water ln le~s than about 5 mlnute~.
28 ~ The lnventlon also provldes a method for coatlng 29 lntubatlon devlce~ whlch lnvolve~ the ~teps of formlng a Inolutlon of hydrophll~c polymer lnclud~ng a compound ~elccted 380~9 1 from the group consisting of nonionic and amphoteric 2 Isurfactantss applyin~ a coating of the solution to at least a 3 !portion of an intubation device; drying the coating and curlng the hydrophilic polymer of the coating. ~
The inventlon also provides an lntubation device 6 compri~ing a body coated with a hydrophilic polymer ~ncluding 7 a surfactant selected from the group consisting of nonionic 8 and amphoteric ~urfactants where~n the coatinq is 9 jcharacterized by being able to achieve a lubricity of less Ithan about 0.6 upon contact with water for less than about 5 11 .minutes .
12 1 have discovered that the rate at which certain 13 l ¦hydrophl c poly~er- t~ke up water and attain sufficlent I i ~ lubricity for use in intubation procedure~ is accelerated Iwlthout detracting from other deslrable propert~es of the 16 Ipolymers by thc addit~on of nonionic and amphoteric 17 !surfactants to the polymers .
18 ¦ In one of its prlncipal aspects, the present 19 linvention pro~ides a lubricant coating composition comprising ~a hydrophilic polymer and a non~onlc or amphoteric surfactant, 21 pre~ent in an amount effective to reduce the coefficient of 22 !friction of the composition to less than about 0.6 in less 23 !than about 5 minutes upon contact with water. Preferably, the 24 ¦!hydrophylic polymer ~s a polyurethane, the surfactant 18 ~ nonionic and the coeffic~ent of friction 1~ reduced to less 26 ithan about 0.2 ln less than about one minute and more 27 Ipreferably a coeff~cient of fr~ction less than about 0.1 ln 28 lless than about 5 to 10 ~econds.
29 I In another of it~ aspect~ the pre~ent lnvent~on !Proviae~ an intubation device, ~uch a8 the n~sogastric tube, i ' I
~ 8 ~ ~9 1 llcoated with a hydrophLllc polymer Lncluding ~n amount of 2 ;nonlonic or amphoteric aurfactant effective to reduce the 3 Icoeficient of friction of the hydrophylic polymer to les~
~ ,than 0.6 in les~ than S minutes upon contact with water.
S ~ In y~t another aspect the present invention provides 6 la method for coating intubation devices which compr~es the 7 steps of coating the intubation device with a hydrophilic 8 Ipolymer ~olution including an amount of non~onic or amphoteric 9 ¦aurfactant effective to reduce the coefficient of friction of ¦Ithe hydrophylic polymer to less than about 0.S in less than 11 jabout 5 minutes upon contact with water and drying the coating 12 lat ~u f ficlent temperatures to cure the polymer. $n a 13 ~preferred embodiment the intubation device i~ provided with an 1~ jadditional outer coat of hydrophilic polymer that does not llinclude a ~urfactant.
16 ~RIEF DESCRI~ION OF THE DRAWINGS.
17 ¦ Figure 1 i~ a fragmentary crosa-sectional view of a 18 'na~oga~tric tube in~erted ~n a human patient;
19 ¦ Figure 2 i~ an exploded fragmentary view of a ~ection of the nasogastrlc tube ~n Figure lt 21 I Figure 3 i~ an exploded fragmentary view of the 22 !bolus portion of the nasogastric tube of Figure l; and 23 ¦ Figure 4 i~ an exploded view of the eYtreme end 24 Iportion of a nasogastric tube.
D~TAI~ED DESCRIPTION OF THE INVENTION
26 ¦ The term3 "nonlonic and amphoteric ~urfactant~ as 27 used herein mean any ~urface active agent which accelerates 28 Ithe hydration of hydroph~lic polymer coatings of the present 29 l~nvent~ons ~o that the~e coating~ rapidly achieve their ~lubricating properti~ ~low coefficient of fr~ction) when 1, _5_ , 1 ¦contacted with water without detracting from the polymer'~
2 lother desirable properties. While the physical mechanism 3 !Iwhereby such rapid hydration i~ achieved i9 not fully ~ understood it i8 believed that the ~ufactant~ lower~the S ~int~erfacial ten~on between the polymer~ and hydrating water 6 Imolecules thu~ permltting ~he water to more read~ly,acce~s the 7 hydrophillc functional group~ on the polymer.
8 ¦ Surfactants particularly useful in the practice of 9 Ithi~ ~nvent~on include conventional nonionic ~urfactant~ ~uch ~as, linear alkyl 8ulfonate~, alkylphenyl hydroxypolyoxy-11 1ethylene8, polyethylene glycol ethers and octylphenoxy 12 !polyethoxyethanol. These surfactant~ can be ~ade by 13 ¦technigues well known in the art and many are commercially 1~ lava~lable fro~ establ~shed ~uppliers, e.g., TEGRITOL nonionic Isurfactants available from Union Carbide Corporation, of 16 Danbury, Ct., ~.S.A. are alkylphenyl hydroxypolyoxyethylenes 17 land more particularly, nonylphenol polyethylene glycol ethers, 18 Ihavlng average molecular weights in the range of about 350 to 19 ,2000.
Triton X-100 ~octylphenoxypolyethoxyethanol) i~ a 21 l~urfactant commercially available from Rohm and Haas Company 22 lof Ph$1adelphia, Pa., U.~.A., and i~ the pre~ently preferred 23 ! ~urfactant for purpo~es of the present inventlon.
2~ I ~he term ~hydrophilic polymer~ as used herein means !a water ab~orbing polymer that ha~ lubr~catlng propertie~, 26 I~ e ~ a coefflc~ent of fr~ction les~ than about 0.60, 27 Ipreferably les~ than about 0.20 and more preferrably le~ than 28 labout 0.10, when in the hydrated or partlally hydrated 29 Icondlt~on.
8~B9 A particularly useful class of hydrophilic polymers are the polyurethanes derived from polyethylene glycols, polypropyle-ne glycol or polyalkylene amines reacated under conditions known in the art with isocyanates such as toluene diisocyanates, methylen bis(4-cyclohexylisocyanate) or urethane forming iso-cyanate equivalents.
Another useful class of hydrophilic polymers are the lower alkyl, or alkoxy alkyl, esters or amides of acrylic or methacrylic acid. An example of a useful hydrophilic acrylic polymers are the HYDRON (trade mark) polymers of National Patent Development Corp., New York, New York, U.S.A.).
The hydrophilic polyurethanes, such as those more fully described in U.S. Patents Nos. 3,822,238 and 3,975,350, are preferred for many applications due to their high mechanical strength, resistance to chemical attack and low toxicity, e.g.
compatibility with acids and the like found in the human stomach.
The preferred hydrophilic polymer for use in coatings for nasogastic tubes, as herein described, is a hydroxy-ter-minated hydrophilic polyurethane having an average molecular weight of about 7,5000 which is the product of polyethylene glycol having an average molecular weight of 1890-1900 and methylene bis(4-cyclohexylisocyanate) reacted in the presence of a small amount of urethane forming catalyst, such as, stannous octoate.
Figures 1, 2 and 3 illustrate an intubation device in the form of a nasogastic intubation device 10 coated with a lubricant composition for insertion into a stomach 12 of human patient 14. The nasogastric incubation device 10 ~a ~
A 7 _ 1 !comprises a flexible tube 16 made of any material 3 2 I!conventionally used for ~uch tube~ such as polyurethane, 3 ~ lyethylene or polyvinylchloride having an in~ide diameter of 0.08 inch and outeide diameter of 0.108. The ~ize~~of ~uch ~tubes are typically de~ignated in French unit~. Sizes 5-12 . ~rench ~re preferred for nasogastr~c tube~ and 8 Fre,nch ~
7 moRt preferred. The coating~ of thi~ ~nvention may be of any 8 'thickneqs reguired for a particular application. ~owever, 9 coatings for nasogastric tube~ are preferably about 0.5 to 2.5 mil~ thick.
11 ¦ A connector ~uch as a female luer 18 connector 12 Iprovided with closure cap 20 iu affixed to a proximal end 21 ~3 lof the flexible tube 16 and a bolu~ 24 ig provided at the 1~ distal end 22 of the flexible tube 16. The bolu8 24 has a llplural~ty of t~tanlum weights 26 disposed there~n for a~ding 16 lin positioning, and maintaininq the position, of the flexible 17 Itube 16 in the patient. ~he bolus 24 i~ connected to the 18 flexible tube 16 with a connector 28 provided with a plurality 19 ¦lopening~ 30 therein for permitting the pa~8age of fluid into l,or out of the tube.
21 ! Stylet 31 comprise~ a wire body 32, preferably 22 !~tainle~s steel, having a distal end provided with an enlarged 23 !ball (not ~hown). The enlarged ball may comprise a tightly 24 Iwound ball of wire. Proximal end 21 of the wire body 32 i~
aff~xed to ~ plug 34, which ia preferably hollow and provided 26 ,wlth mean such a~ a tubular passage 35 for permittlng fluid 27 ¦Ito flow into and out of the flexiblc tube 16. Mean~ for 28 laccurately po~itioning and ~ecuring the ~tylet 32 ~n the 29 Iflex~ble tube 16, such ~ a male luer fitting 33 that Icooperate5 with ~emale luer 18 is also provided. The ~ -8- ~I c ~ !
~ 9 1 Iconnector~ 18 and 28, plug 34, cap 20, and like parts may be 2 formed from any ~uitable material such a~ polyethylene, 3 pol~ypropylene or polyvinylchloride.
The flexible tube 10, bolus 24 and connector 28 are 5~ Iprovided with ~ lubricant coating 29 (Figure 3) compris~ng a 6 jhydrophilic polymer ~ncluding a compound selected from the 7 Igroup consisting of nonionic and amphoteric surfactant~- The 8 !~urfactant i~ provided in an amount effective to cause the 9 lubricant coatir.g to rapidly hydrate upon contact with water lo !~o that it has ~ufficient lubricity for intubation procedures 11 ~in les~ than about S m~nute~. It will be appreciated that 12 almo~t any number of auch lubricant coatings may be provided 13 as necessary or desired.
1~ ¦ Figure 4 ~hows an alternatlve embodiment wherein the Inasogastric tube 10 i~ coated with a flr~t layer 40 of 16 Ihydrophillc polymer which ~nclude8 a compound ~elected from 17 jthe group con~i~ting of nonionic and amphoteric surfactants 18 ~that accelerate hydration of the polymer. A aecond layer 42 19 of hydrophilic polymer th~t doe~ not include one of the !~Pec~fied ~urfactant5 capable of accelerating hydration of the 21 !polymer i~ applied over the flr~t layer 40. An advantage of 22 ¦~his two layer ~ystem i~ prolonged lubricity which facil~tate~
23 !removal and reinsertion of the tube.
24 11 An embodiment of the pre8ent ~nventlon is descr~bed jin the following Example for purpose~ o ~llustration and 26 ,further de8crlption and as ~uch the Example~ ~hould not be 27 Iconstrued to limit the invention in any way.
2i8 I~XAMP~S ~
29 ~ A hydroxy-terminated hydrophilic polyurethane having I n ~ve age ~olecular ~elgbt o~ about 7500, Wa9 prep~r~d by g ~1 1 ~ 8 0~9 ~ ¦
1 llreacting about B7.68 grams ~gm) of polyethylene glycol having 2 lan average molecular welght of 1890-19Q0 with about 12.31 gm 3 Imethylene bls~-cyelohexyllsocyanate) ln the presence of about 0.12 gm etannous oetoate eataly~t.
5' A first eoating eomposltion wae prepared by 6 dl~solvlng about 6 gm of a polymer prepared as deecrlbed above 7 ¦ln about 200 gm of a 75 parte methy$ene bichlorlde~25 parte 8 jethyl alcohol solution and add~ng about 40 gm of TRITON-X-100 9 I(octylphenoxy-polyethoxyethanol) ~urfactant. It will be ~appreciated by those skilled ~n the art that solvent eystems 11 lother than methylene bichlorlde and alcohol are u~eful ln the 12 Ipraetlee of thl~ invent~on and that preferred ay~tema will 13 ¦lnclude a component for preparing a ~urfaee to be coated for 1~ ¦forming a strong adhe~ve bond wlth the polymer eoatlng and ,for solubllzlng the polymer, e.g., 75 parts tetrahydrofuran 16 !and 25 part~ aleohol.
17 ¦ A ~econd eoatlng eompo~itlon without a nonionic or 18 lamphoterie eurfactant eapable of accelerating hydratlon of the 19 jpolymer was then prepared by di~solving about 2 gme of a ,polymer prepared as de~cribed above in 100 gm of 75 part~
21 Imethylene bichlor~de/25 parts ethyl aleohol eolvent.
22 ~EXAMPLE 2 23 ~ A firet eoatlng of the first eoating compo~itlon 24 jwl~h ~urfaetant, deserlbed ~n Example 1, wae appl~ed to a plastie tube ~u~table for an intubatlon devlee by submerglng 26 Ithe tube ln the f~r~t eoatlng eompo~ltlon for about 15 27 ;~eeonds; withdraw~ng the tube at a rate of about 15 ~nches per 28 Im~nute and then ~lr dry~ng the eoated tublng for about 5 29 Iminute~ followed by oven drylng at 100C for about 10 mlnute~
Ito eure the ~r~t eoatlng.
!, -lo-I ~
I; The tube having the cured firct coating was cooled Z Ito room temperature, submerged in the second coating 3 Icompo~ition containinq no ~urfactant, described in Example 1, ~ jfor about 15 seconds, and then 310wly withdrawn ~t a rate of labout 15 inches per minute to produce a second coating~ The . Isecond coating was air dried for about 5 minute~, cured ln a 7 Icirculating oven for about 10 minutes at 100C and cooled to 8 ~room temperature. The fin~shed tubing had a multi-layer (~wo 9 .layer) coating, the first (inside) layer beinq hydrophilic Ipolymer containing ~urfactant and the second ~out~ide) layer 11 !being hydrophilic polymer only.
12 I Upon contact with water, the multi-layer coated 13 Itubing very rapidly became lubricated and ab~orbed water as 1~ indicated by the very slippery feel of the tubing ~urfaces and ¦Iwithin a few minutes the coefficient of fr~ct~on of the tubing 16 Illsurface was reduced to le~s than about 0.1. Notably, the 17 ~:interior or lumen of the tube also became lubricated a~
18 ¦indicated by the ea~y movement of a ~tylet within the tube 19 'even when the tube wa~ twisted into complex shape~.
20 ll An important advantage of the multi-coating 21 jlprocedure i~ an observed reduction of the rate at which 22 ¦l3urfactant 19 relea~ed from the coatings into the patient 80 23 Ithat ~uch tubes retain their ability to hydrate rapidly over 2~ ~longer in-use per~ods and thu~ are often reusable.
ll The polymer compos~tion~ prepared in accordance with 26 ¦the present invent~on may be applied ~ thin, e.g. less than 27 labout 2.5 mil, coating~ whlch when contacted with exce~s water 28 become ~ufficiently lubricated for use in intubation 29 proceaures in less than about 5 minutes and more preferably le98 than about 5 to 10 ~econds. Similar coatings which do 1, 1 !! -11- ' Il ~
~ 0 ~9 1 not ~nclude surfactants ~g described herein have been ob~erved 2 ~ o t~ke 10 to 30 mlnutes to achl~ve adegyate lubrlc ~y.
llo ll 13 1' I
ll 11 28 1, Il -12- '
COATING AND A COATED INTUBATION ~E~
ll 3~2~3~0 1 EIELD OF T~E IN~E~TIQN
~ I The present invention relates to a lubricant 3 3 Icomposition, a method of coating and a coated device. More 4 jparticularly, the invention relateg to lubricant coa~inga for ~ Imedical device~, 8uch as intubating devices, method~ for 6 ~coating such devices and the product~ thereof. , 7 BACKGROUND OF T~E INVENTION
8 Lubricant compo~itions are u~ed as coa~ing~ to 9 reduce friction between the surfaces of moving part~ and have a vast number of applications in ~lmost every field of 11 lengineering practice. ~ubricant coatings for medical uses 12 have special requirement~. Not only must thege coa~ing~
13 ~reduce friction but they must al~o be capable of ~terilization 14 and be biocompatible, e.g.,be nontoxic and nonirritating.
l~xamples of conventional lubrlcant coat~ng~ which have been 16 ~used in the ~edical arts for year~ are mineral oil, petrole~m 17 ~elly, and K-Y Jelly~ ~Trademark of Johnson ~ Johnson Co.).
18 ~These lubricants while effectlve have not proved entirely 19 '~ati5factory for every application.
! For example, na80ga~tric and na~o~e~una~ tubes 21 jwidely u~ed for hyperalimentation must be lubricated on their 22 ~exterior surface~ to facilitate their insertion through ~
23 nasal passage, throat, or the like and to avoid damage to soft 2~ Irespiratory or ga~trointestinal tis~ue. Frequently, these ~tubes must alao have lubrlcated ~nterior ~urface~ to 26 !facilitate movement of stylets used with~n the lumen of ~uch 27 !tube~ to provide ~ufflcient rlgidity to properly po~ition a 28 Itube withln ~ patient~8 body.
29 I ~he term ~ntubation device~ 1B used generically hereln to refer to varlou~ tubes or other device~ that are : 1 .
! l ~ ~38~ 9 lubr;icated for insertion into any part of a human or other animal body including blood vessels, urinary and digestive tract pas-sages, ears and the like. Examples of intubation devices are the nasogastric and nasojejunal tubes and stylets which are more fully described in U.S. Patent No. 4,388,076.
Uniformly coating intubation devices with conventional lubricants by a physician or other person during an intubation procedure is a messy, time consuming and inefficient procedure.
Obviously, manually coating the interior surfaces (lumen) of tubes and like articles is extremely difficult. Similar dif-ficulties are experienced with intubation devices pre-coated with conventional lubricants. Such pre-coating also increases packag-ing and sterilization problems experienced in the manufacture and supply of such devices.
One approach to solving the foregoing difficulties and problems has been to provide the intubation devices with hydroph-ilic polymer coatings. These coatings provide a thin uniform coating that is dry and non-slippery until hydrated with water.
While these polymer coatings have proved effective in some situations their major drawback has been that they take too long, sometimes longer than 30 minutes, to absorb enough water to achieve sufficient lubricity for insertion into a patient. Such delays are unacceptable in many medical situations often result-ing in, for example, wasted time and in some emergency cases a threat to the health of the patient.
Various attemps have been made to modify these hydroph-ilic polymer coatings to accelerate their ability to Ij `_ I1 1 2 ~ 8~9 l Itake up water and reach aufficient lubricity for use.
2 iHowever, theQe attempts have generally not met with c~mplete 3 l~uccess. Fo~ ex~mplc, one attempt involved treating a ~ hydrophilic polymer coated intubation device with aulfurlc S llacid This can result in serious manufacturing difficulties jand toxicity problems associated with the chemical properties 7 and high vi~co~ty of sulfuric acid.
8 ~ Certain polymer coatings based on 9 polyvinylpyrrolidone (PVP) appear to hydrate rapidly enough lo !but are plagued with a ~liming problem. ~Sli~ing" means that ll ¦the coating become~ too soft and can be rubbed off An 12 intubatlon dev~ce during ordinary use.
13 ¦ Accordingly, ~t i~ an ob~ect of thi~ invention to l~ 1provide a lubricant compo~ltion for coatlng application~ which lS rapidly hydrates upon contact with water.
16 It l~ another ob~ect to provide a lubricant coating 17 Iwhich haa suff$clent mechanical ~trength ~n a hydrated 18 condition to re~l~t ~liming, abra~ion, and the llke typlcally 19 lexperienced by intubation devices.
! suMMARY OF ~HE INVENTION
21 ~ ~riefly, the invention provlde~ a lubricant 22 jcomposition comprlsing a hydrophilic polymer including a 23 Icompound selected from the group con~i~tlng of non~onic and 24 ~amphoterlc ~urfactant~ where~n the compound 19 pre~ent $n an lamount ~ufflclent to reduce the coefflclent of frictlon of a 26 ,coating of the lubr~cant composltlon to less than about 0.6 27 !upon contact wlth water ln le~s than about 5 mlnute~.
28 ~ The lnventlon also provldes a method for coatlng 29 lntubatlon devlce~ whlch lnvolve~ the ~teps of formlng a Inolutlon of hydrophll~c polymer lnclud~ng a compound ~elccted 380~9 1 from the group consisting of nonionic and amphoteric 2 Isurfactantss applyin~ a coating of the solution to at least a 3 !portion of an intubation device; drying the coating and curlng the hydrophilic polymer of the coating. ~
The inventlon also provides an lntubation device 6 compri~ing a body coated with a hydrophilic polymer ~ncluding 7 a surfactant selected from the group consisting of nonionic 8 and amphoteric ~urfactants where~n the coatinq is 9 jcharacterized by being able to achieve a lubricity of less Ithan about 0.6 upon contact with water for less than about 5 11 .minutes .
12 1 have discovered that the rate at which certain 13 l ¦hydrophl c poly~er- t~ke up water and attain sufficlent I i ~ lubricity for use in intubation procedure~ is accelerated Iwlthout detracting from other deslrable propert~es of the 16 Ipolymers by thc addit~on of nonionic and amphoteric 17 !surfactants to the polymers .
18 ¦ In one of its prlncipal aspects, the present 19 linvention pro~ides a lubricant coating composition comprising ~a hydrophilic polymer and a non~onlc or amphoteric surfactant, 21 pre~ent in an amount effective to reduce the coefficient of 22 !friction of the composition to less than about 0.6 in less 23 !than about 5 minutes upon contact with water. Preferably, the 24 ¦!hydrophylic polymer ~s a polyurethane, the surfactant 18 ~ nonionic and the coeffic~ent of friction 1~ reduced to less 26 ithan about 0.2 ln less than about one minute and more 27 Ipreferably a coeff~cient of fr~ction less than about 0.1 ln 28 lless than about 5 to 10 ~econds.
29 I In another of it~ aspect~ the pre~ent lnvent~on !Proviae~ an intubation device, ~uch a8 the n~sogastric tube, i ' I
~ 8 ~ ~9 1 llcoated with a hydrophLllc polymer Lncluding ~n amount of 2 ;nonlonic or amphoteric aurfactant effective to reduce the 3 Icoeficient of friction of the hydrophylic polymer to les~
~ ,than 0.6 in les~ than S minutes upon contact with water.
S ~ In y~t another aspect the present invention provides 6 la method for coating intubation devices which compr~es the 7 steps of coating the intubation device with a hydrophilic 8 Ipolymer ~olution including an amount of non~onic or amphoteric 9 ¦aurfactant effective to reduce the coefficient of friction of ¦Ithe hydrophylic polymer to less than about 0.S in less than 11 jabout 5 minutes upon contact with water and drying the coating 12 lat ~u f ficlent temperatures to cure the polymer. $n a 13 ~preferred embodiment the intubation device i~ provided with an 1~ jadditional outer coat of hydrophilic polymer that does not llinclude a ~urfactant.
16 ~RIEF DESCRI~ION OF THE DRAWINGS.
17 ¦ Figure 1 i~ a fragmentary crosa-sectional view of a 18 'na~oga~tric tube in~erted ~n a human patient;
19 ¦ Figure 2 i~ an exploded fragmentary view of a ~ection of the nasogastrlc tube ~n Figure lt 21 I Figure 3 i~ an exploded fragmentary view of the 22 !bolus portion of the nasogastric tube of Figure l; and 23 ¦ Figure 4 i~ an exploded view of the eYtreme end 24 Iportion of a nasogastric tube.
D~TAI~ED DESCRIPTION OF THE INVENTION
26 ¦ The term3 "nonlonic and amphoteric ~urfactant~ as 27 used herein mean any ~urface active agent which accelerates 28 Ithe hydration of hydroph~lic polymer coatings of the present 29 l~nvent~ons ~o that the~e coating~ rapidly achieve their ~lubricating properti~ ~low coefficient of fr~ction) when 1, _5_ , 1 ¦contacted with water without detracting from the polymer'~
2 lother desirable properties. While the physical mechanism 3 !Iwhereby such rapid hydration i~ achieved i9 not fully ~ understood it i8 believed that the ~ufactant~ lower~the S ~int~erfacial ten~on between the polymer~ and hydrating water 6 Imolecules thu~ permltting ~he water to more read~ly,acce~s the 7 hydrophillc functional group~ on the polymer.
8 ¦ Surfactants particularly useful in the practice of 9 Ithi~ ~nvent~on include conventional nonionic ~urfactant~ ~uch ~as, linear alkyl 8ulfonate~, alkylphenyl hydroxypolyoxy-11 1ethylene8, polyethylene glycol ethers and octylphenoxy 12 !polyethoxyethanol. These surfactant~ can be ~ade by 13 ¦technigues well known in the art and many are commercially 1~ lava~lable fro~ establ~shed ~uppliers, e.g., TEGRITOL nonionic Isurfactants available from Union Carbide Corporation, of 16 Danbury, Ct., ~.S.A. are alkylphenyl hydroxypolyoxyethylenes 17 land more particularly, nonylphenol polyethylene glycol ethers, 18 Ihavlng average molecular weights in the range of about 350 to 19 ,2000.
Triton X-100 ~octylphenoxypolyethoxyethanol) i~ a 21 l~urfactant commercially available from Rohm and Haas Company 22 lof Ph$1adelphia, Pa., U.~.A., and i~ the pre~ently preferred 23 ! ~urfactant for purpo~es of the present inventlon.
2~ I ~he term ~hydrophilic polymer~ as used herein means !a water ab~orbing polymer that ha~ lubr~catlng propertie~, 26 I~ e ~ a coefflc~ent of fr~ction les~ than about 0.60, 27 Ipreferably les~ than about 0.20 and more preferrably le~ than 28 labout 0.10, when in the hydrated or partlally hydrated 29 Icondlt~on.
8~B9 A particularly useful class of hydrophilic polymers are the polyurethanes derived from polyethylene glycols, polypropyle-ne glycol or polyalkylene amines reacated under conditions known in the art with isocyanates such as toluene diisocyanates, methylen bis(4-cyclohexylisocyanate) or urethane forming iso-cyanate equivalents.
Another useful class of hydrophilic polymers are the lower alkyl, or alkoxy alkyl, esters or amides of acrylic or methacrylic acid. An example of a useful hydrophilic acrylic polymers are the HYDRON (trade mark) polymers of National Patent Development Corp., New York, New York, U.S.A.).
The hydrophilic polyurethanes, such as those more fully described in U.S. Patents Nos. 3,822,238 and 3,975,350, are preferred for many applications due to their high mechanical strength, resistance to chemical attack and low toxicity, e.g.
compatibility with acids and the like found in the human stomach.
The preferred hydrophilic polymer for use in coatings for nasogastic tubes, as herein described, is a hydroxy-ter-minated hydrophilic polyurethane having an average molecular weight of about 7,5000 which is the product of polyethylene glycol having an average molecular weight of 1890-1900 and methylene bis(4-cyclohexylisocyanate) reacted in the presence of a small amount of urethane forming catalyst, such as, stannous octoate.
Figures 1, 2 and 3 illustrate an intubation device in the form of a nasogastic intubation device 10 coated with a lubricant composition for insertion into a stomach 12 of human patient 14. The nasogastric incubation device 10 ~a ~
A 7 _ 1 !comprises a flexible tube 16 made of any material 3 2 I!conventionally used for ~uch tube~ such as polyurethane, 3 ~ lyethylene or polyvinylchloride having an in~ide diameter of 0.08 inch and outeide diameter of 0.108. The ~ize~~of ~uch ~tubes are typically de~ignated in French unit~. Sizes 5-12 . ~rench ~re preferred for nasogastr~c tube~ and 8 Fre,nch ~
7 moRt preferred. The coating~ of thi~ ~nvention may be of any 8 'thickneqs reguired for a particular application. ~owever, 9 coatings for nasogastric tube~ are preferably about 0.5 to 2.5 mil~ thick.
11 ¦ A connector ~uch as a female luer 18 connector 12 Iprovided with closure cap 20 iu affixed to a proximal end 21 ~3 lof the flexible tube 16 and a bolu~ 24 ig provided at the 1~ distal end 22 of the flexible tube 16. The bolu8 24 has a llplural~ty of t~tanlum weights 26 disposed there~n for a~ding 16 lin positioning, and maintaininq the position, of the flexible 17 Itube 16 in the patient. ~he bolus 24 i~ connected to the 18 flexible tube 16 with a connector 28 provided with a plurality 19 ¦lopening~ 30 therein for permitting the pa~8age of fluid into l,or out of the tube.
21 ! Stylet 31 comprise~ a wire body 32, preferably 22 !~tainle~s steel, having a distal end provided with an enlarged 23 !ball (not ~hown). The enlarged ball may comprise a tightly 24 Iwound ball of wire. Proximal end 21 of the wire body 32 i~
aff~xed to ~ plug 34, which ia preferably hollow and provided 26 ,wlth mean such a~ a tubular passage 35 for permittlng fluid 27 ¦Ito flow into and out of the flexiblc tube 16. Mean~ for 28 laccurately po~itioning and ~ecuring the ~tylet 32 ~n the 29 Iflex~ble tube 16, such ~ a male luer fitting 33 that Icooperate5 with ~emale luer 18 is also provided. The ~ -8- ~I c ~ !
~ 9 1 Iconnector~ 18 and 28, plug 34, cap 20, and like parts may be 2 formed from any ~uitable material such a~ polyethylene, 3 pol~ypropylene or polyvinylchloride.
The flexible tube 10, bolus 24 and connector 28 are 5~ Iprovided with ~ lubricant coating 29 (Figure 3) compris~ng a 6 jhydrophilic polymer ~ncluding a compound selected from the 7 Igroup consisting of nonionic and amphoteric surfactant~- The 8 !~urfactant i~ provided in an amount effective to cause the 9 lubricant coatir.g to rapidly hydrate upon contact with water lo !~o that it has ~ufficient lubricity for intubation procedures 11 ~in les~ than about S m~nute~. It will be appreciated that 12 almo~t any number of auch lubricant coatings may be provided 13 as necessary or desired.
1~ ¦ Figure 4 ~hows an alternatlve embodiment wherein the Inasogastric tube 10 i~ coated with a flr~t layer 40 of 16 Ihydrophillc polymer which ~nclude8 a compound ~elected from 17 jthe group con~i~ting of nonionic and amphoteric surfactants 18 ~that accelerate hydration of the polymer. A aecond layer 42 19 of hydrophilic polymer th~t doe~ not include one of the !~Pec~fied ~urfactant5 capable of accelerating hydration of the 21 !polymer i~ applied over the flr~t layer 40. An advantage of 22 ¦~his two layer ~ystem i~ prolonged lubricity which facil~tate~
23 !removal and reinsertion of the tube.
24 11 An embodiment of the pre8ent ~nventlon is descr~bed jin the following Example for purpose~ o ~llustration and 26 ,further de8crlption and as ~uch the Example~ ~hould not be 27 Iconstrued to limit the invention in any way.
2i8 I~XAMP~S ~
29 ~ A hydroxy-terminated hydrophilic polyurethane having I n ~ve age ~olecular ~elgbt o~ about 7500, Wa9 prep~r~d by g ~1 1 ~ 8 0~9 ~ ¦
1 llreacting about B7.68 grams ~gm) of polyethylene glycol having 2 lan average molecular welght of 1890-19Q0 with about 12.31 gm 3 Imethylene bls~-cyelohexyllsocyanate) ln the presence of about 0.12 gm etannous oetoate eataly~t.
5' A first eoating eomposltion wae prepared by 6 dl~solvlng about 6 gm of a polymer prepared as deecrlbed above 7 ¦ln about 200 gm of a 75 parte methy$ene bichlorlde~25 parte 8 jethyl alcohol solution and add~ng about 40 gm of TRITON-X-100 9 I(octylphenoxy-polyethoxyethanol) ~urfactant. It will be ~appreciated by those skilled ~n the art that solvent eystems 11 lother than methylene bichlorlde and alcohol are u~eful ln the 12 Ipraetlee of thl~ invent~on and that preferred ay~tema will 13 ¦lnclude a component for preparing a ~urfaee to be coated for 1~ ¦forming a strong adhe~ve bond wlth the polymer eoatlng and ,for solubllzlng the polymer, e.g., 75 parts tetrahydrofuran 16 !and 25 part~ aleohol.
17 ¦ A ~econd eoatlng eompo~itlon without a nonionic or 18 lamphoterie eurfactant eapable of accelerating hydratlon of the 19 jpolymer was then prepared by di~solving about 2 gme of a ,polymer prepared as de~cribed above in 100 gm of 75 part~
21 Imethylene bichlor~de/25 parts ethyl aleohol eolvent.
22 ~EXAMPLE 2 23 ~ A firet eoatlng of the first eoating compo~itlon 24 jwl~h ~urfaetant, deserlbed ~n Example 1, wae appl~ed to a plastie tube ~u~table for an intubatlon devlee by submerglng 26 Ithe tube ln the f~r~t eoatlng eompo~ltlon for about 15 27 ;~eeonds; withdraw~ng the tube at a rate of about 15 ~nches per 28 Im~nute and then ~lr dry~ng the eoated tublng for about 5 29 Iminute~ followed by oven drylng at 100C for about 10 mlnute~
Ito eure the ~r~t eoatlng.
!, -lo-I ~
I; The tube having the cured firct coating was cooled Z Ito room temperature, submerged in the second coating 3 Icompo~ition containinq no ~urfactant, described in Example 1, ~ jfor about 15 seconds, and then 310wly withdrawn ~t a rate of labout 15 inches per minute to produce a second coating~ The . Isecond coating was air dried for about 5 minute~, cured ln a 7 Icirculating oven for about 10 minutes at 100C and cooled to 8 ~room temperature. The fin~shed tubing had a multi-layer (~wo 9 .layer) coating, the first (inside) layer beinq hydrophilic Ipolymer containing ~urfactant and the second ~out~ide) layer 11 !being hydrophilic polymer only.
12 I Upon contact with water, the multi-layer coated 13 Itubing very rapidly became lubricated and ab~orbed water as 1~ indicated by the very slippery feel of the tubing ~urfaces and ¦Iwithin a few minutes the coefficient of fr~ct~on of the tubing 16 Illsurface was reduced to le~s than about 0.1. Notably, the 17 ~:interior or lumen of the tube also became lubricated a~
18 ¦indicated by the ea~y movement of a ~tylet within the tube 19 'even when the tube wa~ twisted into complex shape~.
20 ll An important advantage of the multi-coating 21 jlprocedure i~ an observed reduction of the rate at which 22 ¦l3urfactant 19 relea~ed from the coatings into the patient 80 23 Ithat ~uch tubes retain their ability to hydrate rapidly over 2~ ~longer in-use per~ods and thu~ are often reusable.
ll The polymer compos~tion~ prepared in accordance with 26 ¦the present invent~on may be applied ~ thin, e.g. less than 27 labout 2.5 mil, coating~ whlch when contacted with exce~s water 28 become ~ufficiently lubricated for use in intubation 29 proceaures in less than about 5 minutes and more preferably le98 than about 5 to 10 ~econds. Similar coatings which do 1, 1 !! -11- ' Il ~
~ 0 ~9 1 not ~nclude surfactants ~g described herein have been ob~erved 2 ~ o t~ke 10 to 30 mlnutes to achl~ve adegyate lubrlc ~y.
llo ll 13 1' I
ll 11 28 1, Il -12- '
Claims (31)
1. A lubricant composition comprising:
a hydrophilic polymer including a compound selected from the group consisting of nonionic and amphoteric surfactants wherein said compound is present in an amount effective to reduce the coefficient of friction of a coating of said lubricant composition to less than about 0.6 upon contact with water in less than about 5 minutes.
a hydrophilic polymer including a compound selected from the group consisting of nonionic and amphoteric surfactants wherein said compound is present in an amount effective to reduce the coefficient of friction of a coating of said lubricant composition to less than about 0.6 upon contact with water in less than about 5 minutes.
2. The lubricant composition of claim 1 wherein:
the coefficient of friction is reduced to less than about 0.2 in less than about 5 to 10 seconds.
the coefficient of friction is reduced to less than about 0.2 in less than about 5 to 10 seconds.
3. The lubricant composition of claim 2 wherein:
said polymer is a polyurethane.
said polymer is a polyurethane.
4. The lubricant composition of claim 3 wherein:
said polyurethane is hydroxy-terminated and comprises the reaction product of:
(A) polyethylene glycol, and (B) methylene bis(4-cyclohexylisocyanate); and said compound is a nonionic surfactant.
said polyurethane is hydroxy-terminated and comprises the reaction product of:
(A) polyethylene glycol, and (B) methylene bis(4-cyclohexylisocyanate); and said compound is a nonionic surfactant.
5. The lubricant composition of claim 4 wherein said polyurethane has an average molecular weight of about 7500 and said polyethylene glycol has an average molecular weight of about 1890 to 1900.
6. The lubricant composition of claim 5 wherein said surfactant is octylphenoxy polyethoxyethanol.
7. The lubricant composition of claim 5 wherein said surfactant is a linear alkyl sulfonate.
8. The lubricant composition of claim 5 wherein said surfactant is an alkylphenylhydroxypolyoxyethylene.
9. The coating composition of claim 5 wherein said surfactant is a nonylphenol polyethylene glycol ether having an average molecular weight of about 350 to 2000.
10. An intubation device having a body and a coating on at least a portion of said body, said coating including a hydrophilic polymer and a compound selected from the group consisting of nonionic and amphoteric surfactants, said compound being present in an amount effective to reduce the coefficient of friction of said coating to less than about 0.6 upon contact with water in less than about 5 minutes.
11. The intubation device of claim 10 wherein the coefficient of friction is reduced to less than about 0.2 in less than about 5 to 10 seconds.
12. The intubation device of claim 11 wherein said polymer is a hydrophilic polyurethane.
13. The intubation device of claim 12 wherein said polyurethane is hydroxy-terminated and comprises the reaction product of:
(A) polyethylene glycol, and (B) methylene bis (4-cyclohexylisocyanate); and said compound is a nonionic surfactant.
(A) polyethylene glycol, and (B) methylene bis (4-cyclohexylisocyanate); and said compound is a nonionic surfactant.
14. The intubation device recited in claim 13 wherein said polyurethane has an average molecular weight of about 7500 and said polyethylene glycol has an average molecular weight of about 1890 to 1900.
15. The intubation device of claim 14 wherein said surfactant is octylphenoxy polyethoxyethanol.
16. The intubation device in claim 14 wherein said surfactant is a linear alkyl sulfonate.
17. The intubation device of claim 14 wherein said surfactant is an alkylphenylhydroxypolyoxyethylene.
18. The intubation device of claim 14 wherein said surfactant is a nonylphenol polyethylene glycol ether having an average molecular weight of about 350 to 2000.
19. The intubation device recited in claim 10 wherein said body comprises a nasogastric tube.
20. The intubation device recited in claim 15 wherein said body comprises a nasogastric tube.
21. The intubation device recited in claim 16 wherein said body comprises a nasogastric tube.
22. The intubation device recited in claim 17 wherein said body comprises a nasogastric tube.
23. The intubation device recited in claim 18 wherein said body comprises a nasogastric tube.
24. A method for coating an intubation device with a lubricating composition comprising the steps of:
forming a hydrophilic polymer solution including a compound selected from the group consisting of nonionic acid amphoteric surfactants wherein said compound is present in an amount effective to reduce the coefficient of friction of a dry surface of the composition to less than about 0.6 in less than about 5 minutes upon contact with water; and applying the solution to at least a portion of an intubation device to form a first coating; and subsequently drying and curing the coating.
forming a hydrophilic polymer solution including a compound selected from the group consisting of nonionic acid amphoteric surfactants wherein said compound is present in an amount effective to reduce the coefficient of friction of a dry surface of the composition to less than about 0.6 in less than about 5 minutes upon contact with water; and applying the solution to at least a portion of an intubation device to form a first coating; and subsequently drying and curing the coating.
25. The method of claim 24 further comprising the step of applying a coating of hydrophilic polymer on said portion of the intubation device prior to applying said first coating thereover.
26. The method of claim 24 wherein said polyurethane is hydroxy-terminated and comprises the reaction product of:
(A) polyethylene glycol, and (B) methylene bis (4-cyclohexylisocyanate); and said compound is a nonionic surfactant.
(A) polyethylene glycol, and (B) methylene bis (4-cyclohexylisocyanate); and said compound is a nonionic surfactant.
27. The method of claim 26 wherein said polyurethane has an average molecular weight of about 7500 and said polyethylene glycol has an average molecular weight of about 1890 to 1900.
28. The method of claim 26 wherein said surfactant is octylphenoxy polyethoxyethanol.
29. The method of claim 26 wherein said surfactant is a linear alkyl sulfonate.
30. The method of claim 26 wherein said surfactant is an alkylphenylhydroxypolyoxyethylene.
31. The method of claim 26 wherein said surfactant is a nonylphenol polyethylene glycol ether having an average molecular weight of about 350 to 2000.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US781,218 | 1985-09-25 | ||
| US06/781,218 US4705709A (en) | 1985-09-25 | 1985-09-25 | Lubricant composition, method of coating and a coated intubation device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1288089C true CA1288089C (en) | 1991-08-27 |
Family
ID=25122054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000518563A Expired - Lifetime CA1288089C (en) | 1985-09-25 | 1986-09-18 | Lubricant composition, method of coating and a coated lubricant intubation device |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4705709A (en) |
| EP (1) | EP0228762B1 (en) |
| AU (1) | AU584742B2 (en) |
| CA (1) | CA1288089C (en) |
| DE (1) | DE3667024D1 (en) |
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| DE2912852A1 (en) * | 1979-03-30 | 1980-10-16 | Erich Prof Dr Med D Matouschek | Lubricating film for catheter - comprises non-conducting polymer with pH 5 6.8 |
| US4388076A (en) * | 1981-02-11 | 1983-06-14 | Biosearch Medical Products Inc. | Intubating device |
| US4557724A (en) * | 1981-02-17 | 1985-12-10 | University Of Utah Research Foundation | Apparatus and methods for minimizing cellular adhesion on peritoneal injection catheters |
| US4499154A (en) * | 1982-09-03 | 1985-02-12 | Howard L. Podell | Dipped rubber article |
| US4536179A (en) * | 1982-09-24 | 1985-08-20 | University Of Minnesota | Implantable catheters with non-adherent contacting polymer surfaces |
| US4548206A (en) * | 1983-07-21 | 1985-10-22 | Cook, Incorporated | Catheter wire guide with movable mandril |
| US4525374A (en) * | 1984-02-27 | 1985-06-25 | Manresa, Inc. | Treating hydrophobic filters to render them hydrophilic |
| US4581390A (en) * | 1984-06-29 | 1986-04-08 | Flynn Vincent J | Catheters comprising radiopaque polyurethane-silicone network resin compositions |
-
1985
- 1985-09-25 US US06/781,218 patent/US4705709A/en not_active Expired - Lifetime
-
1986
- 1986-09-08 AU AU62497/86A patent/AU584742B2/en not_active Ceased
- 1986-09-18 CA CA000518563A patent/CA1288089C/en not_active Expired - Lifetime
- 1986-09-24 DE DE8686307341T patent/DE3667024D1/en not_active Expired
- 1986-09-24 EP EP86307341A patent/EP0228762B1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| US4705709A (en) | 1987-11-10 |
| AU6249786A (en) | 1987-03-26 |
| AU584742B2 (en) | 1989-06-01 |
| DE3667024D1 (en) | 1989-12-28 |
| EP0228762B1 (en) | 1989-11-23 |
| EP0228762A1 (en) | 1987-07-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKLA | Lapsed |