CA1287281C - Bifurcated saliva collector - Google Patents
Bifurcated saliva collectorInfo
- Publication number
- CA1287281C CA1287281C CA000562587A CA562587A CA1287281C CA 1287281 C CA1287281 C CA 1287281C CA 000562587 A CA000562587 A CA 000562587A CA 562587 A CA562587 A CA 562587A CA 1287281 C CA1287281 C CA 1287281C
- Authority
- CA
- Canada
- Prior art keywords
- chambers
- vessel
- saliva
- chamber
- constitute
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 210000003296 saliva Anatomy 0.000 title claims abstract description 29
- 239000007788 liquid Substances 0.000 claims abstract description 6
- 206010013781 dry mouth Diseases 0.000 description 8
- 208000005946 Xerostomia Diseases 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000009885 systemic effect Effects 0.000 description 3
- 206010039424 Salivary hypersecretion Diseases 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 208000026451 salivation Diseases 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- -1 antispasmodics Substances 0.000 description 1
- HQTJHTMBKSOUFU-UHFFFAOYSA-N Andelin Natural products CC=C(C)/C(=O)OC1C(OC(=O)C=C(C)C)c2cc3C=CC(=O)Oc3cc2OC1(C)C HQTJHTMBKSOUFU-UHFFFAOYSA-N 0.000 description 1
- 206010002961 Aplasia Diseases 0.000 description 1
- 206010013911 Dysgeusia Diseases 0.000 description 1
- 206010028116 Mucosal inflammation Diseases 0.000 description 1
- 201000010927 Mucositis Diseases 0.000 description 1
- 208000018737 Parkinson disease Diseases 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002921 anti-spasmodic effect Effects 0.000 description 1
- 239000000935 antidepressant agent Substances 0.000 description 1
- 229940005513 antidepressants Drugs 0.000 description 1
- 229940030600 antihypertensive agent Drugs 0.000 description 1
- 239000002220 antihypertensive agent Substances 0.000 description 1
- 239000000164 antipsychotic agent Substances 0.000 description 1
- 229940005529 antipsychotics Drugs 0.000 description 1
- 229940124575 antispasmodic agent Drugs 0.000 description 1
- 239000002830 appetite depressant Substances 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 229940112822 chewing gum Drugs 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- 229940121657 clinical drug Drugs 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 229940030606 diuretics Drugs 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000001339 gustatory effect Effects 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 229940035363 muscle relaxants Drugs 0.000 description 1
- 239000003158 myorelaxant agent Substances 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 210000003079 salivary gland Anatomy 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 239000012780 transparent material Substances 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
- A61B10/0051—Devices for taking samples of body liquids for taking saliva or sputum samples
Abstract
ABSTRACT
This patent relates to a bifurcated vessel for the collection of saliva comprising:
a) a receptacle open at one end and divided into two chambers for holding liquid;
b) an open edge portion angularly disposed integral with one of said chambers to constitute a flared funnel to said chamber; and c) a second open edge portion angularly disposed to and integral with the other of said two chambers to constitute a flared funnel.
This patent relates to a bifurcated vessel for the collection of saliva comprising:
a) a receptacle open at one end and divided into two chambers for holding liquid;
b) an open edge portion angularly disposed integral with one of said chambers to constitute a flared funnel to said chamber; and c) a second open edge portion angularly disposed to and integral with the other of said two chambers to constitute a flared funnel.
Description
; BIFURCATED SALIVA COLLECTOR
Field of the Invention This invention relates to xerostomia, or dry mouth.
Xerostomia has a multitude of structural and/or systemic causes and associations such as severe dental caries, periodontal disease, mucositis, salivary gland aplasia, disturbed oral sensation, and altered taste function. Additionally, xerostomia is a common side effect in the administration of over 400 clinical drugs as well as radiation treatment to the head or neck region. Among the many drugs which can cause xerostomia in certain patients are the major antihypertensives, antidepressants, antispasmodics, diuretics, muscle relaxants, antipsychotics, appetite depressants, and therapeutics for Parkinson's disease. Many patients suffering from rheumatoid ¦ arthritis also exhibit decreased secretion of saliva.
Psychological stress can also lead to symptoms of xerostomia.
For patients whose dry mouth symptoms are secondary, increased consumption of liquids, chewing gum, and sucking flavored lozenges often suffice to maintain salivation between meals. At meal times the presence and eating of food often stimulates secretion of sufficient saliva for comfort and digestion.
Sialometry, measurement of the flow rate of saliva, is a sensitive index of potential or existing oral or systemic l maladies. It is useful in many instances for the dentist or i physician to know both the unstimulated and stimulated rates of i salivation. This invention relates to apparatus for ; 1l unambiguously measuring the flow of saliva under both ¦ unstimulated and seimulated conditions.
. .
1287~81 Back~round of the Invention and Discussion of the Prior Art The general methods for collecting human saliva has been reviewed in the American Journal of Otolaryngology, volume 4 p. 288, 1983 by Nava~esh and Ship.
An apparatus for collecting saliva comprising a container with a threaded open end and a conical closed end, a threaded funnel for sometime use on the open end or a threaded cap to seal such, and a base for holding the closed conical end has been disclosed by Fay in U.S. Patent 4,589,548 issued May 20, 1986.
An apparatus for sequentially collecting saliva in a flavored absorbent, masticated sponge and then pressing the sample out with a piston plunger through a small hole, through which the sponge cannot pass but the sample can, was shown April 8, 1986 by O'Brien et al. in U.S. Patent 4,580,577.
A specimen collection and transport system was disclosed by Schlesinger in V.S. Patent 4,283,498. The system comprises a specimen receptacle having a closed bottom and an open top, a conduit to the receptacle, a base to hold the conical closed end, and a protective covering so that the specimen can be transported.
A collection apparatus for saliva is shown by Andelin et al.
in U.S. Patent 3,518,164. This apparatus also has a receptacle ;
closed at one end and open at the other, a funnel and discharge ' tube leading to the receptacle, a funnel cover, an outer ' protective body also functioning as a support, and a threaded cap.
Objects of the Invention It is an object of the present invention to provide an apparatus for the collection of saliva under unstimulated and stimulated conditions.
lX87~81 It is a further object of this invention to measure and compare unstimulated and stimulated saliva flow as a diagnostic tool.
It is another object of t:he invention to provide samples for analysis and comparison of the chemical and physical properties of unstimulated and stimulated saliva.
It is yet another object of the invention to separate cellular and particulate components from saliva, so that the supernatant fluid may be easily analyzed for various components whose absence or presence may show different pathological disorders.
Other objects of the invention will be apparent to those skilled in the art.
Summary of the Invention The above and other objects are surprisingly fulfilled by a bifurcated vessel for the collection of stimulated and unstimulated amounts of saliva. The bifurcated vessel comprises:
a) a vertical receptacle open at the top and divided into two parallel chambers for holding liquid;
b) an upper edge portion angularly disposed to and integral with one of the parallel chambers to constitute a flared funnel to that chamber;
c) a second upper edge portion angularly disposed to and integral with the second parallel chamber to constitute a flared funnel; and d) a base closing off the bottom of both parallel chambers, whereby saliva may be separately collected at two different times and compared volumetrically and chemically as well as separated into fractions for chemical analysis.
~1 ; lZ87Z8~
Once the volume of saliva has been determined, one can carry out arlalyses on the two salivas while they remain in the chambers.
I Brief Description of the Drawings Figure l is a side elevational view of one embodiment of the present invention.
Figure 2 is a vertical section view through the line 2-2 of Figure 4.
Figure 3 is a cross section view taken through the line 3-3 of Figure 1.
Figure 4 is a top plan view of the embodiment of Figure l.
Description of the Preferred Embodiments The unstimulated, whole mouth saliva production of a healthy adult can range from about 0.08 to about 1.85 ml/min and averages about 0.3 ml/min. For a six-minute test period, the unstimulated normal sample would be about 1.8 to 3 ml. Actually "unstimulated" is a misnomer really meaning "minimally"
stimulated.
Stimulated, whole mouth production is achieved by gustatory (e.g. citric acid) or masticatory (e.g. inert gum, rubber band, paraffin wax) means and increases the rate normally three-to six-fold to about 6-12 ml for a six-minute test period. A "six minute" test period generally means three, two-minute periods by expectoration with swallowing permitted in between.
Therefore, although the size of the chambers in the apparatus of the present invention may vary widely, a preferred embodiment would have an unstimulated collection chamber, preferably calibrated per 0.1 ml. of about 4 ml., and a stimulated collection chamber from about 10 to about 15 ml.,¦
calibrated pref rably per 0.1 ml .
lZ8qZ81 Of course, for patients suffering from xerostomia for primary (organic) or secondary (systemic or psychological) reasons the salivary flow may be reduced to almost or actually nothing. A patient is labeled xerostomic at an unstimulated production of less than about 0.6 ml. in six minutes or a stimulated production less than about 4 ml. in a six-minute test period. This boundary between normal and unhealthy may be indicated by a colored or other differentiating marking on the apparatus of this invention. Also, it is convenient that the dimensions for a single two-minute volume be differentiated.
The collector of the present invention may be constructed of glass, crystal, plastic or any other convenient material. A
transparent material is preferred but is not necessary.
The volume of the larger (stimulated flow) chamber of the collector preferably is about four times that of the smaller (unstimulated flow) chamber, but this ratio is not necessary.
Preferably the cross-sectional area of the larger chamber is also about four times that of the smaller chamber, so that either a normal or abnormal flow will register at about the same height on the calibrated device. It is preferable, but not necessary, that the lower section of the bifurcated device be smaller in cross-section than the middle and upper sections of the device, so that small flows can be measured with high accuracy. It is also convenient, but not necessary, that this lower section of the device be constructed with thicker material to gain higher structural strength.
Preferably, but not necessarily, the upper section of the receptacle is flared to form a funnel. This enables the patient to expectorate into the receptacle easier and guarantees that all the sal ~t be measured. It is preferable that the funnel I
extend all around the upper ]ip and that the angle of the funnel be uniform around the entire circumference. Since the "stimulated" side of the device is preferably larger in cross-section than the "unstimulated" side of the device, the angular portion of the unstimulated side will extend lower down the device if a uniform flare is to be maintained, as shown in Figure Preferably, but not necessarily, the upper end of the divider between the two chambers of the receptacle extends above the preferably flared upper edge of the receptacle. This ensures that all the saliva is collected. Furthermore, so that the patient being tested can come even closer to the flared, divided top of the receptacle, a notch to accommodate the nose is made in the upper section of the divider, as shown in Figure 2.
Figure 1 shows an embodiment of the bifurcated saliva collector of the present invention, generally indicated as 10.
The tubular receptacle is divided by inner wall 11 into a smaller chamber 12, intended for collection of unstimulated saliva, and larger chamber 13, intended for collection of stimulated flow.
The bifurcated collector is closed off and supported by base 14.
Divider 11 is reinforced near the bottom up to a point 18, which is conveniently the point where chambers 12 and 13 are of smaller diameter so that the accuracy of measurements of small volumes is higher. Preferably the entire receptacle is calibrated by markings 19a and 19b into convenient volumes such as milliliters.
Preferably the two sides of the upper edge are uniformly flared at 15 and 16 to create a funnel to help receive all the saliva.l The uniform flare of 15 and 16 at the upper edge requires that¦
the angulation of the small diameter side end lower at 20 than¦
that of the large diameter side at 21.
lZ87Z81 In Figure 2 the top of divider 11 is shown with a notch for the nose 17.
In Figure 3 the cross-section of the receptacle at the line 3-3 in Figure 1 is shown with the relative si~e of small diameter 12 to that of la:rge diameter 13, as separated by divider 11.
In Figure 4 the top plan view shows the uniform flare of upper edges 15 and 16 with the top of tubular chambers 12 and 3.
Many other embodiments will occur to those skilled in the art, but such will be within the scope of Letters Patent based on the following claims:
Field of the Invention This invention relates to xerostomia, or dry mouth.
Xerostomia has a multitude of structural and/or systemic causes and associations such as severe dental caries, periodontal disease, mucositis, salivary gland aplasia, disturbed oral sensation, and altered taste function. Additionally, xerostomia is a common side effect in the administration of over 400 clinical drugs as well as radiation treatment to the head or neck region. Among the many drugs which can cause xerostomia in certain patients are the major antihypertensives, antidepressants, antispasmodics, diuretics, muscle relaxants, antipsychotics, appetite depressants, and therapeutics for Parkinson's disease. Many patients suffering from rheumatoid ¦ arthritis also exhibit decreased secretion of saliva.
Psychological stress can also lead to symptoms of xerostomia.
For patients whose dry mouth symptoms are secondary, increased consumption of liquids, chewing gum, and sucking flavored lozenges often suffice to maintain salivation between meals. At meal times the presence and eating of food often stimulates secretion of sufficient saliva for comfort and digestion.
Sialometry, measurement of the flow rate of saliva, is a sensitive index of potential or existing oral or systemic l maladies. It is useful in many instances for the dentist or i physician to know both the unstimulated and stimulated rates of i salivation. This invention relates to apparatus for ; 1l unambiguously measuring the flow of saliva under both ¦ unstimulated and seimulated conditions.
. .
1287~81 Back~round of the Invention and Discussion of the Prior Art The general methods for collecting human saliva has been reviewed in the American Journal of Otolaryngology, volume 4 p. 288, 1983 by Nava~esh and Ship.
An apparatus for collecting saliva comprising a container with a threaded open end and a conical closed end, a threaded funnel for sometime use on the open end or a threaded cap to seal such, and a base for holding the closed conical end has been disclosed by Fay in U.S. Patent 4,589,548 issued May 20, 1986.
An apparatus for sequentially collecting saliva in a flavored absorbent, masticated sponge and then pressing the sample out with a piston plunger through a small hole, through which the sponge cannot pass but the sample can, was shown April 8, 1986 by O'Brien et al. in U.S. Patent 4,580,577.
A specimen collection and transport system was disclosed by Schlesinger in V.S. Patent 4,283,498. The system comprises a specimen receptacle having a closed bottom and an open top, a conduit to the receptacle, a base to hold the conical closed end, and a protective covering so that the specimen can be transported.
A collection apparatus for saliva is shown by Andelin et al.
in U.S. Patent 3,518,164. This apparatus also has a receptacle ;
closed at one end and open at the other, a funnel and discharge ' tube leading to the receptacle, a funnel cover, an outer ' protective body also functioning as a support, and a threaded cap.
Objects of the Invention It is an object of the present invention to provide an apparatus for the collection of saliva under unstimulated and stimulated conditions.
lX87~81 It is a further object of this invention to measure and compare unstimulated and stimulated saliva flow as a diagnostic tool.
It is another object of t:he invention to provide samples for analysis and comparison of the chemical and physical properties of unstimulated and stimulated saliva.
It is yet another object of the invention to separate cellular and particulate components from saliva, so that the supernatant fluid may be easily analyzed for various components whose absence or presence may show different pathological disorders.
Other objects of the invention will be apparent to those skilled in the art.
Summary of the Invention The above and other objects are surprisingly fulfilled by a bifurcated vessel for the collection of stimulated and unstimulated amounts of saliva. The bifurcated vessel comprises:
a) a vertical receptacle open at the top and divided into two parallel chambers for holding liquid;
b) an upper edge portion angularly disposed to and integral with one of the parallel chambers to constitute a flared funnel to that chamber;
c) a second upper edge portion angularly disposed to and integral with the second parallel chamber to constitute a flared funnel; and d) a base closing off the bottom of both parallel chambers, whereby saliva may be separately collected at two different times and compared volumetrically and chemically as well as separated into fractions for chemical analysis.
~1 ; lZ87Z8~
Once the volume of saliva has been determined, one can carry out arlalyses on the two salivas while they remain in the chambers.
I Brief Description of the Drawings Figure l is a side elevational view of one embodiment of the present invention.
Figure 2 is a vertical section view through the line 2-2 of Figure 4.
Figure 3 is a cross section view taken through the line 3-3 of Figure 1.
Figure 4 is a top plan view of the embodiment of Figure l.
Description of the Preferred Embodiments The unstimulated, whole mouth saliva production of a healthy adult can range from about 0.08 to about 1.85 ml/min and averages about 0.3 ml/min. For a six-minute test period, the unstimulated normal sample would be about 1.8 to 3 ml. Actually "unstimulated" is a misnomer really meaning "minimally"
stimulated.
Stimulated, whole mouth production is achieved by gustatory (e.g. citric acid) or masticatory (e.g. inert gum, rubber band, paraffin wax) means and increases the rate normally three-to six-fold to about 6-12 ml for a six-minute test period. A "six minute" test period generally means three, two-minute periods by expectoration with swallowing permitted in between.
Therefore, although the size of the chambers in the apparatus of the present invention may vary widely, a preferred embodiment would have an unstimulated collection chamber, preferably calibrated per 0.1 ml. of about 4 ml., and a stimulated collection chamber from about 10 to about 15 ml.,¦
calibrated pref rably per 0.1 ml .
lZ8qZ81 Of course, for patients suffering from xerostomia for primary (organic) or secondary (systemic or psychological) reasons the salivary flow may be reduced to almost or actually nothing. A patient is labeled xerostomic at an unstimulated production of less than about 0.6 ml. in six minutes or a stimulated production less than about 4 ml. in a six-minute test period. This boundary between normal and unhealthy may be indicated by a colored or other differentiating marking on the apparatus of this invention. Also, it is convenient that the dimensions for a single two-minute volume be differentiated.
The collector of the present invention may be constructed of glass, crystal, plastic or any other convenient material. A
transparent material is preferred but is not necessary.
The volume of the larger (stimulated flow) chamber of the collector preferably is about four times that of the smaller (unstimulated flow) chamber, but this ratio is not necessary.
Preferably the cross-sectional area of the larger chamber is also about four times that of the smaller chamber, so that either a normal or abnormal flow will register at about the same height on the calibrated device. It is preferable, but not necessary, that the lower section of the bifurcated device be smaller in cross-section than the middle and upper sections of the device, so that small flows can be measured with high accuracy. It is also convenient, but not necessary, that this lower section of the device be constructed with thicker material to gain higher structural strength.
Preferably, but not necessarily, the upper section of the receptacle is flared to form a funnel. This enables the patient to expectorate into the receptacle easier and guarantees that all the sal ~t be measured. It is preferable that the funnel I
extend all around the upper ]ip and that the angle of the funnel be uniform around the entire circumference. Since the "stimulated" side of the device is preferably larger in cross-section than the "unstimulated" side of the device, the angular portion of the unstimulated side will extend lower down the device if a uniform flare is to be maintained, as shown in Figure Preferably, but not necessarily, the upper end of the divider between the two chambers of the receptacle extends above the preferably flared upper edge of the receptacle. This ensures that all the saliva is collected. Furthermore, so that the patient being tested can come even closer to the flared, divided top of the receptacle, a notch to accommodate the nose is made in the upper section of the divider, as shown in Figure 2.
Figure 1 shows an embodiment of the bifurcated saliva collector of the present invention, generally indicated as 10.
The tubular receptacle is divided by inner wall 11 into a smaller chamber 12, intended for collection of unstimulated saliva, and larger chamber 13, intended for collection of stimulated flow.
The bifurcated collector is closed off and supported by base 14.
Divider 11 is reinforced near the bottom up to a point 18, which is conveniently the point where chambers 12 and 13 are of smaller diameter so that the accuracy of measurements of small volumes is higher. Preferably the entire receptacle is calibrated by markings 19a and 19b into convenient volumes such as milliliters.
Preferably the two sides of the upper edge are uniformly flared at 15 and 16 to create a funnel to help receive all the saliva.l The uniform flare of 15 and 16 at the upper edge requires that¦
the angulation of the small diameter side end lower at 20 than¦
that of the large diameter side at 21.
lZ87Z81 In Figure 2 the top of divider 11 is shown with a notch for the nose 17.
In Figure 3 the cross-section of the receptacle at the line 3-3 in Figure 1 is shown with the relative si~e of small diameter 12 to that of la:rge diameter 13, as separated by divider 11.
In Figure 4 the top plan view shows the uniform flare of upper edges 15 and 16 with the top of tubular chambers 12 and 3.
Many other embodiments will occur to those skilled in the art, but such will be within the scope of Letters Patent based on the following claims:
Claims (14)
1. A bifurcated vessel for the collection of saliva comprising:
a) a receptacle open at one end and divided into two chambers for holding liquid;
b) an open edge portion angularly disposed integral with one of said chambers to constitute a flared funnel to said chamber;
c) a second open edge portion angularly disposed to and integral with the other of said two chambers to constitute a flared funnel; and d) a divider between the two chambers, the upper end of said divider extending to or above the upper edge of the receptacle.
a) a receptacle open at one end and divided into two chambers for holding liquid;
b) an open edge portion angularly disposed integral with one of said chambers to constitute a flared funnel to said chamber;
c) a second open edge portion angularly disposed to and integral with the other of said two chambers to constitute a flared funnel; and d) a divider between the two chambers, the upper end of said divider extending to or above the upper edge of the receptacle.
2. The vessel of claim 1, wherein said vessel is vertical and includes base means.
3. The vessel of claim 2, wherein said base is in the form of a flanged circular shape, which closes off the other end of the vessel.
4. The vessel of claim 1, wherein the chambers are parallel.
5. The vessel of claim 1, wherein the chambers are unequal in size.
6. The vessel of claim 1, wherein the divider between the two chambers has a flared end bearing a notch for a nose.
7. The vessel of claim 1, wherein the cross-section of each parallel chamber is in the shape of a half-circle.
8. The vessel of claim 1, wherein the angular disposition of the edge portions for the two chambers is different.
9. The vessel of claim 1, wherein each of the two chambers is individually calibrated for volume.
10. The vessel of claim 1, wherein the closed end portions of the two chambers is smaller in cross-section than the remainder of the two portions.
11. The vessel of claim 5, wherein one chamber is approximately four times larger than the other chamber.
12. The vessel of claim 1, wherein the divider is reinforced near the bottom thereof.
13. A bifurcated vessel for the collection of saliva and used to measure different types of saliva flow comprising:
a) a receptacle open at one end and divided into chambers for holding liquid;
b) an open edge portion angularly disposed integral with one of said chambers to constitute a flared funnel to said chamber;
c) a second open edge portion angularly disposed to and integral with the other of said two chambers to constitute a flared funnel; and d) said vessel being vertical and including base means, wherein said base means is in the form of a flanged circular shape, which closes off the other end of the vessel.
a) a receptacle open at one end and divided into chambers for holding liquid;
b) an open edge portion angularly disposed integral with one of said chambers to constitute a flared funnel to said chamber;
c) a second open edge portion angularly disposed to and integral with the other of said two chambers to constitute a flared funnel; and d) said vessel being vertical and including base means, wherein said base means is in the form of a flanged circular shape, which closes off the other end of the vessel.
14. A bifurcated vessel for the collection of saliva and used to measure different types of saliva flow comprising:
a) a receptacle open at one end and divided into two chambers for holding liquid;
b) an open edge portion angularly disposed integral with one of said chambers to constitute a flared funnel to said chamber;
c) a second open edge portion angularly disposed to and integral with the other of said two chambers to constitute a flared funnel; and d) wherein each of the two chambers is individually calibrated for volume.
a) a receptacle open at one end and divided into two chambers for holding liquid;
b) an open edge portion angularly disposed integral with one of said chambers to constitute a flared funnel to said chamber;
c) a second open edge portion angularly disposed to and integral with the other of said two chambers to constitute a flared funnel; and d) wherein each of the two chambers is individually calibrated for volume.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US046,837 | 1987-05-04 | ||
| US07/046,837 US4768238A (en) | 1987-05-04 | 1987-05-04 | Bifurcated saliva collector |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1287281C true CA1287281C (en) | 1991-08-06 |
Family
ID=21945663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000562587A Expired - Fee Related CA1287281C (en) | 1987-05-04 | 1988-03-25 | Bifurcated saliva collector |
Country Status (2)
| Country | Link |
|---|---|
| US (1) | US4768238A (en) |
| CA (1) | CA1287281C (en) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4834110A (en) * | 1988-02-01 | 1989-05-30 | Richard Patricia A | Suction clamped treatment cup saliva sampler |
| US4906455A (en) * | 1988-04-15 | 1990-03-06 | Wm. Wrigley Jr. Company | Method for treating xerostomia employing chewing gum containing relatively insoluble, hydrophobic, food-grade organic acid |
| US4858250A (en) * | 1988-11-15 | 1989-08-22 | Lee Chin C | Disposable sanitary spittoon |
| US5022409A (en) * | 1989-09-21 | 1991-06-11 | Epitope, Inc. | Oral rinse immunoglobulin collection kit for immunoassay and method thereof |
| EG19721A (en) * | 1991-06-25 | 1995-08-30 | Saliva Diagnostic Systems Inc | Sampling device and sample adequacy system |
| US5980498A (en) * | 1997-02-19 | 1999-11-09 | Innovative Human Services, Inc. | Hygienic saliva compensation device |
| US6652481B1 (en) | 1997-02-19 | 2003-11-25 | Innovative Human Services, Inc. | Hygienic saliva compensation device with improved handheld and intra-oral collection device |
| US20020020008A1 (en) * | 2000-08-10 | 2002-02-21 | Nguyen Nhan S. | Portable spittoon |
| JP4854506B2 (en) * | 2003-04-01 | 2012-01-18 | ユニバーシティ オブ サザン カリフォルニア | Caries risk test to predict and assess disease risk |
| US7114403B2 (en) * | 2003-05-30 | 2006-10-03 | Oakville Hong Kong Co., Ltd | Fluid collection and application device and methods of use of same |
| WO2005008216A2 (en) * | 2003-07-11 | 2005-01-27 | Oakville Hong Kong Co., Limited | Sanitary fluid collection, application and storage device and methods of use of same |
| CN101876657B (en) * | 2003-11-14 | 2013-08-28 | 美艾利尔瑞士公司 | Rapid sample detection and storage devices and methods of use |
| AT500882A3 (en) * | 2004-10-06 | 2009-12-15 | Greiner Bio One Gmbh | IN-VITRO DIAGNOSTICS FOR STORAGE VOLUME DETERMINATION |
| US7915005B2 (en) * | 2005-11-09 | 2011-03-29 | Washington University In St. Louis | Methods for detecting sleepiness |
| WO2007062575A1 (en) | 2005-11-30 | 2007-06-07 | Inverness Medical Switzerland Gmbh | A device for detecting the presence or amount of an analyte in a fluid sample and method thereof |
| AU2007280929B2 (en) | 2006-07-26 | 2012-03-22 | Abbott Rapid Diagnostics International Unlimited Company | Analysis device for biological sample |
| US20110083259A1 (en) * | 2009-10-08 | 2011-04-14 | Wright Victor S | Cough and sneeze arrestor |
| US9113850B2 (en) | 2010-08-20 | 2015-08-25 | Reflex Medical Corp. | Saliva collection device |
| US9075039B2 (en) * | 2011-11-08 | 2015-07-07 | Becton, Dickinson And Company | Container and cap for a biological specimen |
| US8747334B1 (en) | 2011-11-30 | 2014-06-10 | Jack V. Smith | Method for specimen sample collection |
| US9332968B2 (en) | 2013-05-24 | 2016-05-10 | Reflex Medical Corp. | Saliva container with optical volume indicator |
| US10197430B2 (en) * | 2014-01-20 | 2019-02-05 | Falcon Waterfree Technologies, Llc | Visual indicator |
| GB2527516B (en) * | 2014-06-23 | 2020-08-26 | Nepesmo Ltd | Improvements in and relating to sample collection |
| USD783209S1 (en) * | 2016-03-08 | 2017-04-04 | Kerry Morris | Telescopic pet food funnel with handle |
| USD812316S1 (en) * | 2016-07-18 | 2018-03-06 | Ofelia Valdez | Pet food dispenser |
| CN109738237B (en) * | 2019-03-18 | 2024-03-26 | 领因生物科技(上海)有限公司 | Liquid collecting device |
| USD891633S1 (en) * | 2019-04-09 | 2020-07-28 | Cell Projects Limited | Sampling device |
| USD1010851S1 (en) * | 2020-12-23 | 2024-01-09 | Life Technologies Corporation | Saliva collection device |
| CN116650028B (en) * | 2023-07-20 | 2023-10-10 | 山东君泰安德医疗科技股份有限公司 | saliva collector |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2171748A (en) * | 1937-05-22 | 1939-09-05 | Milwaukee Lace Paper Company | Sputum cup |
| US3362315A (en) * | 1964-02-03 | 1968-01-09 | Werner W. Buechner | Photographic treating vessel |
| US3518164A (en) * | 1967-04-11 | 1970-06-30 | B D Lab Inc | Diagnostic sputum collection system |
| US3499327A (en) * | 1968-01-22 | 1970-03-10 | Walter W Lane Jr | Urine collectors |
| US3774455A (en) * | 1971-12-22 | 1973-11-27 | D Seidler | Urine testing apparatus |
| US3831446A (en) * | 1973-05-14 | 1974-08-27 | Kendall & Co | Apparatus for measuring average flow rate |
| US3871230A (en) * | 1973-05-14 | 1975-03-18 | Kendall & Co | Flow measuring apparatus |
| US4042337A (en) * | 1977-02-17 | 1977-08-16 | Griffith Donald P | Urine collection device |
| US4580577A (en) * | 1981-01-12 | 1986-04-08 | Brien Joseph O | Method and apparatus for collecting saliva |
| US4503572A (en) * | 1982-09-17 | 1985-03-12 | Spit Pit, Inc. | Disposable receptacle for spittle |
-
1987
- 1987-05-04 US US07/046,837 patent/US4768238A/en not_active Expired - Fee Related
-
1988
- 1988-03-25 CA CA000562587A patent/CA1287281C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US4768238A (en) | 1988-09-06 |
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