CA1283827C - Appliance for injection of liquid formulations - Google Patents
Appliance for injection of liquid formulationsInfo
- Publication number
- CA1283827C CA1283827C CA000553554A CA553554A CA1283827C CA 1283827 C CA1283827 C CA 1283827C CA 000553554 A CA000553554 A CA 000553554A CA 553554 A CA553554 A CA 553554A CA 1283827 C CA1283827 C CA 1283827C
- Authority
- CA
- Canada
- Prior art keywords
- appliance
- needle
- pump
- supply vessel
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/14586—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of a flexible diaphragm
- A61M5/14593—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of a flexible diaphragm the diaphragm being actuated by fluid pressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M2005/14204—Pressure infusion, e.g. using pumps with gas-producing electrochemical cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
- A61M2005/14252—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type with needle insertion means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M2005/14264—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body with means for compensating influence from the environment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M2005/14268—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body with a reusable and a disposable component
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/16877—Adjusting flow; Devices for setting a flow rate
- A61M5/16881—Regulating valves
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S128/00—Surgery
- Y10S128/12—Pressure infusion
Abstract
A B S T R A C T
The portable appliance is of use for the subcutaneous or intradermal injection of a liquid formulation of an active principle and it comprises in combination: a supply vessel (3) for the formulation; an injection needle (7) adapted to communicate with the vessel (3): pump means (4, 32, 34, 50) for emptying the vessel (3) through the injection needle (7): securing means (16, 17) for securing the appliance to an appropriate part of the patient's body: and needle-driving means (12, 13) for shooting the injection needle (7) into the patient's skin.
Fig. 1
The portable appliance is of use for the subcutaneous or intradermal injection of a liquid formulation of an active principle and it comprises in combination: a supply vessel (3) for the formulation; an injection needle (7) adapted to communicate with the vessel (3): pump means (4, 32, 34, 50) for emptying the vessel (3) through the injection needle (7): securing means (16, 17) for securing the appliance to an appropriate part of the patient's body: and needle-driving means (12, 13) for shooting the injection needle (7) into the patient's skin.
Fig. 1
Description
R~N 4701/126 The invention relates to a portable appliance for the subcutaneous or intradermal injection o~ a liquid formulation of an active principle.
There has for some time past clearly been a need for small, compact and portable injection appliances which can be worn on a suitable part of the body and which provide a preferably subcutaneous release of accurately defined quantities of active principles into the body over prolonged periods of time. Various devices of this kind having considerable advantages over the conventional subcutaneous syringe are already known. In conventional subcutaneous injection a so-called bolus of an active princi~le is introduced into the body and must be gradually absorbed and distributed therein. Distribution depends to a considerable extent upon the physiological circumstances of the individual being treated and is the'refore uncontrollable.
l'he advantage of appliances which .release an active principle continuously over a prolonged period of time is that administration can be accurately controlled to suit the body's reguirements. Indeed, it is possible for phases of release to alternate with phases of non-release. A
physiologically adapted release of this kind is advantageous more particularly in the case of highly active agents such as insulin, interferon or the like.
Conventionally, known appliances of this kind have a vessel which contains the active principle and with which an injection needle communicate~. Pump means discharge the contents of the vessel into the body over a predetermined period of time. DE-3 121 888 discloses an example of such an ~ ~3~c:7 appliance. Xt has a supply vessel in the form of a hose which a clockwork-driven squeezing roll~r empties through an injection needle connected to the end of the hose.
The needle is introduced into the tissue some distance away from the appliance. The appliance can be worn or carried on the wrist like a wrist watch. An appliance of a different kind disclosed in US P 4 552 561 can be stuck to the skin and carries the injection needle on its underside so that the place where the needle penetrates the skin is covered while the appliance is in use. This appliance also needs the needle to pierce the tissue. It is more particularly the piercing of the tissue with the needle that is problematic in the case of conventional subcutaneous bolus injections and in the case of the more recent subcutaneous injection appliances hereinbefore referred to. People who are not experts in medicine are usually insufficiently practised to place such a needle correctly and they suffer from a completely justified fear of the likely pain.
It is the object of the invention to prepare a portable injection appliance of the kind hereinbefore set out which is free from the disadvantages of the known appliances and which can readily be used more particularly by persons not expert in medicine.
According to the invention, this is achieved by an appliance of the kind hereinbefore referred to which is distinguished by a combination comprising: a supply vessel for the formulation; an injection needle adapted to communicate with the vessel; pump means for emp~ying the vessel through the inject.ion needle; securing means for securing the appliance to an appropriate part of the patient's body; and needle-driving means for shooting the injection needle into the patient's skin.
3~7 _2a -Thus in a broad embodiment the present invention provides a portable appliance for subcutaneous or intradermal injection of a liquid formulation of an active principle into a patient comprising a housing having a patient engaying surface to contact a patient's skin: a supply vessel positioned within said housing for storing the liquid formulation; infusion needle means having an infusion needle and positioned in said housing, said means used for establishing communication between said supply vessel and said infusion needle when said infusion needle is activated to advance into the patient's skin a preselected distance; pump means for emptying the liquid formulation from said supply vessel through said infusion needle means; needle driving means for subcutaneous or intradermal injection of the infusion needle through the patient engaging surface and into the patient's skin through an injection site the preselected distance; and securing means for securing the patient engaging surface of the appliance to a portion of the patient's skin substantially surrounding the injection site through which the infusion needle enters the patient's skin thereby providing a tight adherence of the patient engaging surface to the patient's skin.
The appliance can also comprise flow control means enabling the release of active principle either to be kept 33~
constant or to ~ollow a pred~termined profile.
Accordinq to another feature of the invention, the appliance is in two parts, ~he part containing the more valuable elements being reusable while the other part can be discarded as an expendable item after being used once, The vessel for the active principle or the solution thereof can ~uite simply be, for example, a part of the appliance casing, in which case an appropriate diaphragm which is made of elastomers or metals or the like in single or multilayer form delimits a chamber. Another possibility for a supply vessel is a closed vessel also made of elastomers or metals or the like, for example, in the form f bellows. The supply vessel can als~ take the form o~ a squeezable hose such as referred to by way of example in the introduction hereof. The vessel can also take the form of a elunger syringe whose cylinder is operative as supply vesscl. An absorbent material like a sponge can be used ~o take up the active principle. More than one separa~e supply vessels or chambers can be provided, for example, when two active principles have to be injected or when a lyophilisate of active principle and a reconstituting solvent are used. Various forms of energy can be considered for driving the vessel-emptying pump means. For instance, the pump can be gas- operated, in which event the pressure necessary to empty the vessel can be produced by electrolysis or photolysis or chemical reactions and by propellant vapours such as Freon or the like. Another possibility is to produce the requisite pressure by ordinary osmosis or electro-osmosis. Mechanical drives using, for example, springs or bimetallic elements or memory alloys or clockwork drives are of course another possibility. Electric or magnetic drives such as the known electric ~umps, diaphragm pumps, piezoelectric pumps, electric clock dcives or magnets can also be considered.
An adhesive layer on ~he patient-engaging surface of the appliance, such layer possibly extending as a plaster beyond the appliance, is more particularly suitable for securing the appliance to the appropriate part of the patient's body.
5 A possible alternative is a securing band or tape like the armband shown in the German Offenlegungsschrift hereinbefore mentioned.
The needle-driving device is preferably a metal spring.
~ or constant flow operation the active principle is arranged to be released constantly, for example, by means of capillaries or frits or diaphragms. Also, the flow can be adjusted by adaptation of the viscosity of the liquid formulation of the active principle.
Control of the quantity of active principle released can also be embodied in various ways. For example, a squeezable hose whose diameter is increased or reduced to suit requirements can be disposed between the supply vessel and the needle. Another possibility is to provide a pressure-reducing valve. Another possibility is to select a particular range of the expansion of the deiving spring or to use special cup springs in which the force is constant within limits over a distance. More elaborate flo~ control can be provided by feedback using sensors. ~low control can also be on the basis of a specially programmed pumping mechanism being used for the vessel-emptying operation~
Very thin capillaries - i.e., capillaries having a diameter of preferably < 0.5 mm - are used as injection needles, since pain increases with needle thickness. The depth of penetration and the way in ~hich the needle is ground also have a bearing on pain. Advantageously, therefore, the penetration deeth is at most 5 000 ~m.
Also, the needle is preferably ground at an inclination, for example, like a lancet.
.
Even though needle diameter and penetration depth do not cause pain, the formulation itself may cause pain or irritation. This can be countered by a local anesthetic in the formulation.
Embodiments of the invention will be described hereinafter with reference to the accompanying drawings wherein:
Fig. l is a cross-section through an injection appliance according to the invention;
Fig. 2 is a plan view corresponding to Fig. l:
Fig. 3 is a cross section through another embodiment of the invention;
Fig. ~ is a plan view with partial sectioning of the appliance shown in Fig. 3;
Fig. 5 is a cross-section through another embodiment of the invention;
Fig. 6 is a section on the plane B-B of Fig. 5:
Fig. 7 is a cross-section through another embodiment of the invention;
Fig. 8 is a section on the plane A-A thLough the appliance of Fig. 7, and E'ig. 9 is a section through another embodiment of the invention on a plane perpendicular to the axis.
The appliance shown in Figs. l and 2 comprises a two-part flat cylindrical casing having a bottom part I and a top part 2. The two parts l, 2 are rigidly interconnected, for example, by screwthre~ding (not shown). Annular recesses in the contacting surfaces of the two parts l, 2 together form an annulaL chambèr S. A diaphragm 4 subdivides the same into two separate chambers, both of which communicate with the exterior by way of filling orifices 5, 6 normally closed by plugs.
An injection needle 7 and driving means or shooting the same are disposed at the centre of the discoid casiny. The needle is a steel capillary of 200 ~m diameter.
Alternatively, a ylass capillary could be used, A carrier 8 carries the needle 7. The carrier 8 has a bottom cylindrical part and a top flat discoid part. The cylindrical part is disposed for axial movement in a corresponding bore 9 in the casing bottom part 1 and is formed with a bore 10 which extends perpendicularly io its axis and which communicates with the interior of the needle 7. The cylindrical outside surface of the cylindrical part is formed with three peripheral grooves in which 0-ring seals are introduced.
There is also a shallow peripheral groove at the level of the bore 10.
1~
In its bottom part the bore 9 reduces to a diameter just large enough for the needle to pass through.
The top discoid part of the needle carrier 8 is disposed ~o for axial movement in a corresponding further concentric bore 11 of the casing top part 2. Over substantially two-thirds of the thickness of the part 2 the bore 11 reduces to substantially half its diamete~ so that an abutment is formed. Disposed between the same and the top part of the needle carrier 8 is a driving spring 12 for driving the needle into the patient's skin.
The needle carrier 8 also has resilient retaining fingers 13 which extend upwards from its surface and which have a pawl-like step or shoulder engaging the edge of a widening of the bore 11. When the fingers 13 are in the engaged state the carrier 8 with the needle 7 is in its top position in which the spring 12 is under stress and the needle does not project beyond the casing bottom surface.
Disposed bétween the fingers 13 is a safe~y cover or cap 14 which prevent accidental compression of the fingers 13 likely to trigger the needle drive. The safety cover 14 is formed on its other side with a bore whose diameter is so adapted to appropriate inclined surfaces of the finyers ~3 that the same are pressed together when the cap 1~ is pressed on so that the retaininy mechanism is released.
A communicating bore 15 is disposed in the casing bottom part between the bottom compartment of the chamber 3 and the bore 9. The same widens over some of its length to receive a restrictor element, such as a Teflon~frit. The bore 15 so extends as to join the bore 9 at a height corresponding to the bore 10 in the needle carrier 8 when the same is in its bottom position. In the top end position the opening where - the bore 15 joins the bore 9 is closed by the cylindrical part of the needle carrier 8 and by the bottom two 0-rings.
The appliance has an adhesive layer 16 on its underside.
The appliance is also embedded in a correspondingly shaped securing plastar 17. The layer 16 and the adhesive layer of the plaster are protected before use by a foil 18. The adhesi~e layer 16 on the underside and the adhesive layer of the plaster can contain additional substances such as a local anesthetic.
In production, after the appliance has been assembled the bottom compartment of the chamber 3 is filled with a required active principle by way of the aperture 5, whereafter the same is closed. Also, the top compartment of the chamber 3 is filled with a propellant through the aperture 6. These fillings are usually production operations and in that case are not carried out by the user. However, in the case of some active principles it may be convenient to carry ou~ filling shortly before use. The appliance is then ready for use.
The appliance operates as follows:
The user removes ~he foil 18 and sticks the appliance ~o an appropriate part of his body by means of the plaster 17 and adhesive foil 16. The user then removes the safety cap 14, turns it and presses it onto the inclined surfaces of the fingers 13. The same are therefore compress0d and release the needle drive. The spring 12 expands and presses the needle carrier ~ with the needle 7 downwards through the predetermined distance and through the adhesive foil onto the user's skin. The needle should penetrate something like at least 50 ~m and at most approximately 5000 ~m into the skin. The piercing of the skin by the needle is painless or nearly so because of the reduced depth o~ penetration, the small diameter of the needle and its inclined grinding.
Simultaneously as the needle carrier 8 descends the cross-bore 10 moves to the height of the opening o~ the communicating bore 15 so that the same communicates with the needle 7. The way is then open foe the active principle to flow through the needle, the flow being determined by the pressure of the propellant in the top compartment of the chamber 3 and by the restriction provided by the resteictor 15. The volume of the flow of active principle and, therefore, the duration of injection can be determined by appropriate choice of ~hese factors.
The appliance shown in Figs. 3 and 4 has the same storage vessel and the same needle-shooting device as the embodiment hereinbefore described. An additional feature, operative to compensate for variations in the pressure of the propellant is a pressure-reducing valve. The same is disposed in a segment of the circular casing.
Correspondingly, the chamber 3 extends around only some of the periphery.
The reducing valve has its own casing which is received in a corresponding recess in the appliance casing.
Internally the reducing valve is subdivided by a diaphragm g 20, in a manner conventional in pressure-reducing valves, into a high-pressure chamber 21 and a low~pressure chamber 22. A ram 23 is disposed in the communicating bore bètween the chambers 21 and 22, is secured to the diaphragm Z0 at its centre and can close the communicating orifice by moving axially. A spring 24 is disposed on the other side of the diaphragm between the ram 23 and an adjustable abutment 25.
The spring 24 basically determines the pressure in the low-pressure chamber. The high- pressure chamber 21 communicates by way of a communicating bore 26 with the bottom compartment of the chamber 3 - i.e., the reservoir of active principle. The low-pressure chamber 22 communicates by way of bore 27 with the central bore 9 and, as in the embodiment hereinbefore decribed, opens out at the level of the cross-bore 10 when the needle cacrier is in its bottom end position.
The pressure-reducing ~alve enables a substantially constant release rate of active principle to be maintained irrespective of pressure variations on the high-pressure side. Such~pressure variations may be caused by variations in the vapour pressure of the propellant as a result of temperature variations.
As in the previous example the appliance shown in Figs.
3 and 4 also has an adhesive layer, a securing plaster and a protective foil and operates in virtually the same way as the embodiment previously described.
In ~he embodiment shown in Figs. 5 and 6 an alternative facility for conveying the active principle and a different form of reservoir are provided. The reservoir is in the form of two bags or bubbles or bellows 28 formed on one side with an aperture via which they are secured to a mount 29 formed with a filling aperture 30 and a bore 31 communicating with thè central bore 9. The two mounts 29 are rigidly connected to the central cylindrical part of the casing bottom part 1.
A rotating member 32 is disposed around this stationary part and has two inwardly projecting webs 33 each engaging with the backs of the bags 28.
Between the member 32 and the outside wall of the casing top part 2 is a compartment receiving a spiral spring 34.
The same is sacured at one end in the casing wall and at its other end in the member 32. When the spiral spcing 34 expands, it rotates the member 32, the webs thereo~
compressing the bags 28 so that the active principle therein empties through the orifices 31.
By using just some of the usable number of turns of the spiral spring 34 to produce the rotary movements, a control effect is achieved. Consequently, the driving spring is operative both to convey the active principle and to control flow. In other respects this embodiment operates similarly to the embodiment shown in Figs. l and 2.
In contrast to the embodiments so far described, the appliance shown in Figs. 7 and 8 has two supply vessels or chambers 35, 36 and two separate needle carriers 39, 40 which have needles 37, 38 and which a common activating mechanism 41 drives. This embodiment is of use when it is required to inject two active principles simultaneously and separately.
As an alternative to the version shown, a single needle carrier having two needles could be provided instead of the two needle carriers with two needles, in which event the sealing system would have to be more elaborate.
The embodiment shown in section in Fig. 9 has electrically driven conveyance of the active principle.
Because of the relatively high cost of the electrical elements of this embodiment the appliance is divided into a discardable part 42 and a reusable part 43. The two parts .
42, 43 are interconnected by resilient clips 56 which engage in corresponding recesses.
The disposable part 42 comprises a supply vessel 55 with provision for filling closed by a partition 44~ The system is such that the reservoir can, if required, be filled shortly before use. The disposable par~ 42 also comprises pump means 45 having an intake valve 46 communicating with the supply vessel, a delivery valve 49 controlling a line 47 to an injection needle 48, and a plunger pump 50 disposed between and connected to the two valves. The pump means 45 operate as follows: when the plunger of the pump 50 is drawn back from the position shown a prede~ermined volume is intaken through the intake valve 46 from the supply vessel.
The delivery valve 49 stays closed in this phase. When the piston makes its next advance, the intake valve 46 closes and the delivery valve 49 opens so that the intaken volume is supplied to the injection needle.
The injection needle together with the needle carrier and the piercing mechanism (not shown here) also forms part of the discardable part.
l`he more valuable reusable part 43 contains the electric drive for the pump means, in the form of an electromagnet 51 which draws the plunger of the pump 50 back, the plunger being advanced by a return spring 52. An electronic control facility 53 controls the electromagnet 51. A battery 54 provides power for the electromagnet 51 and the electronic control 53.
An electrically driven pump is particula~ly suitable for combination with electronic control of the release quantity.
36 The release profile can, for example, be pre-programmed and stored in some suitable way. The release rate can be checked by appropriate sensors.
In the embodiments shown the needle-driving means have been combined with the operation of the valve These two operations can readily be separated so that, for example, first the needle is shot, whereafter a valve opens separately. Skin-piercing movements other than simple injection perpendicularly to the skin surface are possible:
for example, the vertical piercing movement can be coupled with rotation of the needle or the needle can be injected into the skin at an inclination to the skin surface.
There has for some time past clearly been a need for small, compact and portable injection appliances which can be worn on a suitable part of the body and which provide a preferably subcutaneous release of accurately defined quantities of active principles into the body over prolonged periods of time. Various devices of this kind having considerable advantages over the conventional subcutaneous syringe are already known. In conventional subcutaneous injection a so-called bolus of an active princi~le is introduced into the body and must be gradually absorbed and distributed therein. Distribution depends to a considerable extent upon the physiological circumstances of the individual being treated and is the'refore uncontrollable.
l'he advantage of appliances which .release an active principle continuously over a prolonged period of time is that administration can be accurately controlled to suit the body's reguirements. Indeed, it is possible for phases of release to alternate with phases of non-release. A
physiologically adapted release of this kind is advantageous more particularly in the case of highly active agents such as insulin, interferon or the like.
Conventionally, known appliances of this kind have a vessel which contains the active principle and with which an injection needle communicate~. Pump means discharge the contents of the vessel into the body over a predetermined period of time. DE-3 121 888 discloses an example of such an ~ ~3~c:7 appliance. Xt has a supply vessel in the form of a hose which a clockwork-driven squeezing roll~r empties through an injection needle connected to the end of the hose.
The needle is introduced into the tissue some distance away from the appliance. The appliance can be worn or carried on the wrist like a wrist watch. An appliance of a different kind disclosed in US P 4 552 561 can be stuck to the skin and carries the injection needle on its underside so that the place where the needle penetrates the skin is covered while the appliance is in use. This appliance also needs the needle to pierce the tissue. It is more particularly the piercing of the tissue with the needle that is problematic in the case of conventional subcutaneous bolus injections and in the case of the more recent subcutaneous injection appliances hereinbefore referred to. People who are not experts in medicine are usually insufficiently practised to place such a needle correctly and they suffer from a completely justified fear of the likely pain.
It is the object of the invention to prepare a portable injection appliance of the kind hereinbefore set out which is free from the disadvantages of the known appliances and which can readily be used more particularly by persons not expert in medicine.
According to the invention, this is achieved by an appliance of the kind hereinbefore referred to which is distinguished by a combination comprising: a supply vessel for the formulation; an injection needle adapted to communicate with the vessel; pump means for emp~ying the vessel through the inject.ion needle; securing means for securing the appliance to an appropriate part of the patient's body; and needle-driving means for shooting the injection needle into the patient's skin.
3~7 _2a -Thus in a broad embodiment the present invention provides a portable appliance for subcutaneous or intradermal injection of a liquid formulation of an active principle into a patient comprising a housing having a patient engaying surface to contact a patient's skin: a supply vessel positioned within said housing for storing the liquid formulation; infusion needle means having an infusion needle and positioned in said housing, said means used for establishing communication between said supply vessel and said infusion needle when said infusion needle is activated to advance into the patient's skin a preselected distance; pump means for emptying the liquid formulation from said supply vessel through said infusion needle means; needle driving means for subcutaneous or intradermal injection of the infusion needle through the patient engaging surface and into the patient's skin through an injection site the preselected distance; and securing means for securing the patient engaging surface of the appliance to a portion of the patient's skin substantially surrounding the injection site through which the infusion needle enters the patient's skin thereby providing a tight adherence of the patient engaging surface to the patient's skin.
The appliance can also comprise flow control means enabling the release of active principle either to be kept 33~
constant or to ~ollow a pred~termined profile.
Accordinq to another feature of the invention, the appliance is in two parts, ~he part containing the more valuable elements being reusable while the other part can be discarded as an expendable item after being used once, The vessel for the active principle or the solution thereof can ~uite simply be, for example, a part of the appliance casing, in which case an appropriate diaphragm which is made of elastomers or metals or the like in single or multilayer form delimits a chamber. Another possibility for a supply vessel is a closed vessel also made of elastomers or metals or the like, for example, in the form f bellows. The supply vessel can als~ take the form o~ a squeezable hose such as referred to by way of example in the introduction hereof. The vessel can also take the form of a elunger syringe whose cylinder is operative as supply vesscl. An absorbent material like a sponge can be used ~o take up the active principle. More than one separa~e supply vessels or chambers can be provided, for example, when two active principles have to be injected or when a lyophilisate of active principle and a reconstituting solvent are used. Various forms of energy can be considered for driving the vessel-emptying pump means. For instance, the pump can be gas- operated, in which event the pressure necessary to empty the vessel can be produced by electrolysis or photolysis or chemical reactions and by propellant vapours such as Freon or the like. Another possibility is to produce the requisite pressure by ordinary osmosis or electro-osmosis. Mechanical drives using, for example, springs or bimetallic elements or memory alloys or clockwork drives are of course another possibility. Electric or magnetic drives such as the known electric ~umps, diaphragm pumps, piezoelectric pumps, electric clock dcives or magnets can also be considered.
An adhesive layer on ~he patient-engaging surface of the appliance, such layer possibly extending as a plaster beyond the appliance, is more particularly suitable for securing the appliance to the appropriate part of the patient's body.
5 A possible alternative is a securing band or tape like the armband shown in the German Offenlegungsschrift hereinbefore mentioned.
The needle-driving device is preferably a metal spring.
~ or constant flow operation the active principle is arranged to be released constantly, for example, by means of capillaries or frits or diaphragms. Also, the flow can be adjusted by adaptation of the viscosity of the liquid formulation of the active principle.
Control of the quantity of active principle released can also be embodied in various ways. For example, a squeezable hose whose diameter is increased or reduced to suit requirements can be disposed between the supply vessel and the needle. Another possibility is to provide a pressure-reducing valve. Another possibility is to select a particular range of the expansion of the deiving spring or to use special cup springs in which the force is constant within limits over a distance. More elaborate flo~ control can be provided by feedback using sensors. ~low control can also be on the basis of a specially programmed pumping mechanism being used for the vessel-emptying operation~
Very thin capillaries - i.e., capillaries having a diameter of preferably < 0.5 mm - are used as injection needles, since pain increases with needle thickness. The depth of penetration and the way in ~hich the needle is ground also have a bearing on pain. Advantageously, therefore, the penetration deeth is at most 5 000 ~m.
Also, the needle is preferably ground at an inclination, for example, like a lancet.
.
Even though needle diameter and penetration depth do not cause pain, the formulation itself may cause pain or irritation. This can be countered by a local anesthetic in the formulation.
Embodiments of the invention will be described hereinafter with reference to the accompanying drawings wherein:
Fig. l is a cross-section through an injection appliance according to the invention;
Fig. 2 is a plan view corresponding to Fig. l:
Fig. 3 is a cross section through another embodiment of the invention;
Fig. ~ is a plan view with partial sectioning of the appliance shown in Fig. 3;
Fig. 5 is a cross-section through another embodiment of the invention;
Fig. 6 is a section on the plane B-B of Fig. 5:
Fig. 7 is a cross-section through another embodiment of the invention;
Fig. 8 is a section on the plane A-A thLough the appliance of Fig. 7, and E'ig. 9 is a section through another embodiment of the invention on a plane perpendicular to the axis.
The appliance shown in Figs. l and 2 comprises a two-part flat cylindrical casing having a bottom part I and a top part 2. The two parts l, 2 are rigidly interconnected, for example, by screwthre~ding (not shown). Annular recesses in the contacting surfaces of the two parts l, 2 together form an annulaL chambèr S. A diaphragm 4 subdivides the same into two separate chambers, both of which communicate with the exterior by way of filling orifices 5, 6 normally closed by plugs.
An injection needle 7 and driving means or shooting the same are disposed at the centre of the discoid casiny. The needle is a steel capillary of 200 ~m diameter.
Alternatively, a ylass capillary could be used, A carrier 8 carries the needle 7. The carrier 8 has a bottom cylindrical part and a top flat discoid part. The cylindrical part is disposed for axial movement in a corresponding bore 9 in the casing bottom part 1 and is formed with a bore 10 which extends perpendicularly io its axis and which communicates with the interior of the needle 7. The cylindrical outside surface of the cylindrical part is formed with three peripheral grooves in which 0-ring seals are introduced.
There is also a shallow peripheral groove at the level of the bore 10.
1~
In its bottom part the bore 9 reduces to a diameter just large enough for the needle to pass through.
The top discoid part of the needle carrier 8 is disposed ~o for axial movement in a corresponding further concentric bore 11 of the casing top part 2. Over substantially two-thirds of the thickness of the part 2 the bore 11 reduces to substantially half its diamete~ so that an abutment is formed. Disposed between the same and the top part of the needle carrier 8 is a driving spring 12 for driving the needle into the patient's skin.
The needle carrier 8 also has resilient retaining fingers 13 which extend upwards from its surface and which have a pawl-like step or shoulder engaging the edge of a widening of the bore 11. When the fingers 13 are in the engaged state the carrier 8 with the needle 7 is in its top position in which the spring 12 is under stress and the needle does not project beyond the casing bottom surface.
Disposed bétween the fingers 13 is a safe~y cover or cap 14 which prevent accidental compression of the fingers 13 likely to trigger the needle drive. The safety cover 14 is formed on its other side with a bore whose diameter is so adapted to appropriate inclined surfaces of the finyers ~3 that the same are pressed together when the cap 1~ is pressed on so that the retaininy mechanism is released.
A communicating bore 15 is disposed in the casing bottom part between the bottom compartment of the chamber 3 and the bore 9. The same widens over some of its length to receive a restrictor element, such as a Teflon~frit. The bore 15 so extends as to join the bore 9 at a height corresponding to the bore 10 in the needle carrier 8 when the same is in its bottom position. In the top end position the opening where - the bore 15 joins the bore 9 is closed by the cylindrical part of the needle carrier 8 and by the bottom two 0-rings.
The appliance has an adhesive layer 16 on its underside.
The appliance is also embedded in a correspondingly shaped securing plastar 17. The layer 16 and the adhesive layer of the plaster are protected before use by a foil 18. The adhesi~e layer 16 on the underside and the adhesive layer of the plaster can contain additional substances such as a local anesthetic.
In production, after the appliance has been assembled the bottom compartment of the chamber 3 is filled with a required active principle by way of the aperture 5, whereafter the same is closed. Also, the top compartment of the chamber 3 is filled with a propellant through the aperture 6. These fillings are usually production operations and in that case are not carried out by the user. However, in the case of some active principles it may be convenient to carry ou~ filling shortly before use. The appliance is then ready for use.
The appliance operates as follows:
The user removes ~he foil 18 and sticks the appliance ~o an appropriate part of his body by means of the plaster 17 and adhesive foil 16. The user then removes the safety cap 14, turns it and presses it onto the inclined surfaces of the fingers 13. The same are therefore compress0d and release the needle drive. The spring 12 expands and presses the needle carrier ~ with the needle 7 downwards through the predetermined distance and through the adhesive foil onto the user's skin. The needle should penetrate something like at least 50 ~m and at most approximately 5000 ~m into the skin. The piercing of the skin by the needle is painless or nearly so because of the reduced depth o~ penetration, the small diameter of the needle and its inclined grinding.
Simultaneously as the needle carrier 8 descends the cross-bore 10 moves to the height of the opening o~ the communicating bore 15 so that the same communicates with the needle 7. The way is then open foe the active principle to flow through the needle, the flow being determined by the pressure of the propellant in the top compartment of the chamber 3 and by the restriction provided by the resteictor 15. The volume of the flow of active principle and, therefore, the duration of injection can be determined by appropriate choice of ~hese factors.
The appliance shown in Figs. 3 and 4 has the same storage vessel and the same needle-shooting device as the embodiment hereinbefore described. An additional feature, operative to compensate for variations in the pressure of the propellant is a pressure-reducing valve. The same is disposed in a segment of the circular casing.
Correspondingly, the chamber 3 extends around only some of the periphery.
The reducing valve has its own casing which is received in a corresponding recess in the appliance casing.
Internally the reducing valve is subdivided by a diaphragm g 20, in a manner conventional in pressure-reducing valves, into a high-pressure chamber 21 and a low~pressure chamber 22. A ram 23 is disposed in the communicating bore bètween the chambers 21 and 22, is secured to the diaphragm Z0 at its centre and can close the communicating orifice by moving axially. A spring 24 is disposed on the other side of the diaphragm between the ram 23 and an adjustable abutment 25.
The spring 24 basically determines the pressure in the low-pressure chamber. The high- pressure chamber 21 communicates by way of a communicating bore 26 with the bottom compartment of the chamber 3 - i.e., the reservoir of active principle. The low-pressure chamber 22 communicates by way of bore 27 with the central bore 9 and, as in the embodiment hereinbefore decribed, opens out at the level of the cross-bore 10 when the needle cacrier is in its bottom end position.
The pressure-reducing ~alve enables a substantially constant release rate of active principle to be maintained irrespective of pressure variations on the high-pressure side. Such~pressure variations may be caused by variations in the vapour pressure of the propellant as a result of temperature variations.
As in the previous example the appliance shown in Figs.
3 and 4 also has an adhesive layer, a securing plaster and a protective foil and operates in virtually the same way as the embodiment previously described.
In ~he embodiment shown in Figs. 5 and 6 an alternative facility for conveying the active principle and a different form of reservoir are provided. The reservoir is in the form of two bags or bubbles or bellows 28 formed on one side with an aperture via which they are secured to a mount 29 formed with a filling aperture 30 and a bore 31 communicating with thè central bore 9. The two mounts 29 are rigidly connected to the central cylindrical part of the casing bottom part 1.
A rotating member 32 is disposed around this stationary part and has two inwardly projecting webs 33 each engaging with the backs of the bags 28.
Between the member 32 and the outside wall of the casing top part 2 is a compartment receiving a spiral spring 34.
The same is sacured at one end in the casing wall and at its other end in the member 32. When the spiral spcing 34 expands, it rotates the member 32, the webs thereo~
compressing the bags 28 so that the active principle therein empties through the orifices 31.
By using just some of the usable number of turns of the spiral spring 34 to produce the rotary movements, a control effect is achieved. Consequently, the driving spring is operative both to convey the active principle and to control flow. In other respects this embodiment operates similarly to the embodiment shown in Figs. l and 2.
In contrast to the embodiments so far described, the appliance shown in Figs. 7 and 8 has two supply vessels or chambers 35, 36 and two separate needle carriers 39, 40 which have needles 37, 38 and which a common activating mechanism 41 drives. This embodiment is of use when it is required to inject two active principles simultaneously and separately.
As an alternative to the version shown, a single needle carrier having two needles could be provided instead of the two needle carriers with two needles, in which event the sealing system would have to be more elaborate.
The embodiment shown in section in Fig. 9 has electrically driven conveyance of the active principle.
Because of the relatively high cost of the electrical elements of this embodiment the appliance is divided into a discardable part 42 and a reusable part 43. The two parts .
42, 43 are interconnected by resilient clips 56 which engage in corresponding recesses.
The disposable part 42 comprises a supply vessel 55 with provision for filling closed by a partition 44~ The system is such that the reservoir can, if required, be filled shortly before use. The disposable par~ 42 also comprises pump means 45 having an intake valve 46 communicating with the supply vessel, a delivery valve 49 controlling a line 47 to an injection needle 48, and a plunger pump 50 disposed between and connected to the two valves. The pump means 45 operate as follows: when the plunger of the pump 50 is drawn back from the position shown a prede~ermined volume is intaken through the intake valve 46 from the supply vessel.
The delivery valve 49 stays closed in this phase. When the piston makes its next advance, the intake valve 46 closes and the delivery valve 49 opens so that the intaken volume is supplied to the injection needle.
The injection needle together with the needle carrier and the piercing mechanism (not shown here) also forms part of the discardable part.
l`he more valuable reusable part 43 contains the electric drive for the pump means, in the form of an electromagnet 51 which draws the plunger of the pump 50 back, the plunger being advanced by a return spring 52. An electronic control facility 53 controls the electromagnet 51. A battery 54 provides power for the electromagnet 51 and the electronic control 53.
An electrically driven pump is particula~ly suitable for combination with electronic control of the release quantity.
36 The release profile can, for example, be pre-programmed and stored in some suitable way. The release rate can be checked by appropriate sensors.
In the embodiments shown the needle-driving means have been combined with the operation of the valve These two operations can readily be separated so that, for example, first the needle is shot, whereafter a valve opens separately. Skin-piercing movements other than simple injection perpendicularly to the skin surface are possible:
for example, the vertical piercing movement can be coupled with rotation of the needle or the needle can be injected into the skin at an inclination to the skin surface.
Claims (37)
1. A portable appliance for subcutaneous or intra-dermal injection of a liquid formulation of an active principle into a patient comprising:
a housing having a patient engaging surface to contact a patient's skin;
a supply vessel positioned within said housing for storing the liquid formulation;
infusion needle means having an infusion needle and positioned in said housing, said means used for establishing communication between said supply vessel and said infusion needle when said infusion needle is activated to advance into the patient's skin a preselected distance, pump means for emptying the liquid formulation from said supply vessel through said infusion needle means;
needle driving means for subcutaneous or intradermal injection of the infusion needle through the patient engaging surface and into the patient's skin through an injection site the preselected distance; and securing means for securing the patient engaging surface of the appliance to a portion of the patient's skin substantially surrounding the injection site through which the infusion needle enters the patient's skin thereby providing a tight adherence of the patient engaging surface to the patient's skin.
a housing having a patient engaging surface to contact a patient's skin;
a supply vessel positioned within said housing for storing the liquid formulation;
infusion needle means having an infusion needle and positioned in said housing, said means used for establishing communication between said supply vessel and said infusion needle when said infusion needle is activated to advance into the patient's skin a preselected distance, pump means for emptying the liquid formulation from said supply vessel through said infusion needle means;
needle driving means for subcutaneous or intradermal injection of the infusion needle through the patient engaging surface and into the patient's skin through an injection site the preselected distance; and securing means for securing the patient engaging surface of the appliance to a portion of the patient's skin substantially surrounding the injection site through which the infusion needle enters the patient's skin thereby providing a tight adherence of the patient engaging surface to the patient's skin.
2. The appliance of claim 1 wherein said injection needle means further comprises: flow control means for controlling the flow of the liquid formulation through the injection needle.
3. The appliance of claim 1, wherein the supply vessel is in the form of a plunger syringe having a cylinder which is operative as supply vessel.
4. The appliance of claim 1, having at least one additional supply vessel.
5. The appliance of claim 1, wherein the pump means comprise a mechanical drive.
6. The appliance of claim 5, wherein the mechanical drive comprises a spring.
7. The appliance of claim 6, wherein only a fraction of a spring deflection of a driving spring is used.
8. The appliance of claim 5 wherein the mechanical drive comprises a memory alloy.
9. The appliance of claim 5 wherein the mechanical drive comprises a clockwork drive.
10. The appliance of claim 1, wherein the securing means is in the form of an adhesive layer.
11. The appliance of claim 10, wherein the adhesive layer contains a local anaesthetic.
12. The appliance of claim 1, wherein the securing means comprises a plaster.
13. The appliance of claim 1, wherein the injection has a diameter of less than about 0.05 mm.
14. The appliance of claim 1, wherein the needle-driving means is combined with a valve controlling communication between the supply vessel and the needle.
15. The appliance of claim 1, wherein electronic control means for controlling the pump means are provided, the control means having a data memory for a programmed release profile.
16. The appliance of claim 1, wherein the pump means is in the form of a squeezable hose pump which is of variable hose cross-section and which enables the release profile to be programmed.
17. The appliance of claim 1, wherein the needle-driving means are designed for a penetration depth of from about 0.5 to about 5 mm.
18. The appliance of claim 1, further comprising sensor means to control or vary the release rate of formulation.
19. The appliance of claim 1 wherein the supply vessel is a supply chamber of the appliance.
20. The appliance of claim 19 wherein the pump means comprises a diaphragm separating the supply chamber into two subchambers.
21. The appliance of claim 1 wherein the pump means further comprises a pump chamber separated from said supply vessel by a resilient diaphragm; and pressure producing means positioned in said pump chamber for producing a preselected pressure to empty said supply vessel of said liquid formulation.
22. The appliance according to claim 21, wherein the pump chamber is filled with a propellant vapour.
23. The appliance according to claim 21 wherein the pressure producing means comprises an electrochemical pressure producing device.
24. The appliance according to claim 23, wherein said electrochemical pressure producing device is an electro-osmotic or osmotic pump.
25. The appliance according to claim 21 wherein said pressure producing means further comprises: a device having photochemical means for producing pressure to empty the liquid formulation from said supply vessel using a photochemical reaction.
26. The appliance according to claim 21 wherein said pressure-producing means further comprises: a device having chemical means for producing pressure to empty the supply vessel using a chemical reaction.
27. The appliance according to claim 1, wherein the supply vessel defines a closable aperture used to fill said vessel; and a partition means for closing said aperture.
28. The appliance according to claim 1 wherein the housing is divided into a reusable part and a discardable part, the reusable part comprising driving means for driving the pump means.
29. The appliance according to claim 28, wherein the discardable part comprises the supply vessel, the infusion needle means, the pump means and the needle driving means.
30. The appliance of claim 1 wherein the supply vessel is a compressible reservoir.
31. The appliance of claim 30 wherein the compressible reservoir is in the form of a bellows.
32. The appliance of claim 31, further comprising an absorbent material which is provided in the supply vessel to take up the active principle.
33. The appliance of claim 1 wherein the pump means comprises an electric drive.
34. The appliance of claim 33 wherein the electric drive is an electric pump.
35. The appliance of claim 34 wherein the electric drive is a piezoelectric pump.
36. The appliance of claim 34 wherein the electric drive is a diaphragm pump.
37. The appliance of claim 1 wherein the pump means `
comprises a magnetic drive.
comprises a magnetic drive.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH5021/86 | 1986-12-18 | ||
CH502186 | 1986-12-18 |
Publications (1)
Publication Number | Publication Date |
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CA1283827C true CA1283827C (en) | 1991-05-07 |
Family
ID=4286578
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA000553554A Expired - Lifetime CA1283827C (en) | 1986-12-18 | 1987-12-04 | Appliance for injection of liquid formulations |
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US (1) | US4886499A (en) |
EP (1) | EP0272530B1 (en) |
JP (1) | JP2648314B2 (en) |
KR (1) | KR960000845B1 (en) |
AT (1) | ATE68358T1 (en) |
AU (1) | AU620536B2 (en) |
CA (1) | CA1283827C (en) |
DE (1) | DE3773867D1 (en) |
DK (1) | DK170660B1 (en) |
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IL (1) | IL84811A (en) |
NZ (1) | NZ222839A (en) |
PH (1) | PH26445A (en) |
ZA (1) | ZA879351B (en) |
Families Citing this family (681)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4894054A (en) * | 1988-06-20 | 1990-01-16 | Miskinyar Shir A | Preloaded automatic disposable syringe |
JPH02307477A (en) * | 1989-05-22 | 1990-12-20 | Kobayashi Shogo | Continuous injector for medical fluid |
US5656032A (en) * | 1989-06-16 | 1997-08-12 | Science Incorporated | Fluid delivery apparatus and method of making same |
US5167633A (en) * | 1990-11-29 | 1992-12-01 | Pacesetter Infusion, Ltd. | Liquid-vapor pressure reservoir for medication infusion pump |
US5527288A (en) * | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
EP0582932A1 (en) * | 1992-08-11 | 1994-02-16 | F. Hoffmann-La Roche Ag | Therapeutic system for the parenteral administration of hematopoietic growth factors |
EP0582933A1 (en) * | 1992-08-11 | 1994-02-16 | F. Hoffmann-La Roche Ag | Therapeutic system for the parenteral administration of hematopoietic growth factors |
CA2132277C (en) * | 1993-10-22 | 2005-05-10 | Giorgio Cirelli | Injection device |
US5997501A (en) * | 1993-11-18 | 1999-12-07 | Elan Corporation, Plc | Intradermal drug delivery device |
US5352201A (en) * | 1994-02-03 | 1994-10-04 | Block Medical, Inc. | Compact uniform pressure infusion apparatus |
US5445616A (en) * | 1994-04-29 | 1995-08-29 | Medtronic, Inc. | Medication delivery device and method of construction |
US5443450A (en) * | 1994-04-29 | 1995-08-22 | Medtronic, Inc. | Medication delivery device and method of construction |
CA2159052C (en) | 1994-10-28 | 2007-03-06 | Rainer Alex | Injection device |
US5575770A (en) * | 1995-04-05 | 1996-11-19 | Therex Corporation | Implantable drug infusion system with safe bolus capability |
US6224572B1 (en) * | 1995-05-04 | 2001-05-01 | Sarcos L.C. | Piston-actuated attachable topical fluid delivery system |
CA2151407A1 (en) * | 1995-06-09 | 1996-12-10 | Duncan Newman | Injection device |
AU7093096A (en) * | 1995-09-05 | 1997-03-27 | Elan Medical Technologies Limited | Chemically driven liquid delivery pumping device |
IE77523B1 (en) * | 1995-09-11 | 1997-12-17 | Elan Med Tech | Medicament delivery device |
US5735818A (en) * | 1995-10-11 | 1998-04-07 | Science Incorporated | Fluid delivery device with conformable ullage |
US5693018A (en) * | 1995-10-11 | 1997-12-02 | Science Incorporated | Subdermal delivery device |
ZA9610374B (en) * | 1995-12-11 | 1997-06-23 | Elan Med Tech | Cartridge-based drug delivery device |
US5785688A (en) * | 1996-05-07 | 1998-07-28 | Ceramatec, Inc. | Fluid delivery apparatus and method |
IE80772B1 (en) * | 1996-06-10 | 1999-02-10 | Elan Corp Plc | Delivery needle |
KR20000016528A (en) | 1996-06-10 | 2000-03-25 | 리안 안네 | Needle for subcutaneous delivery of fluids |
US6558900B2 (en) * | 1996-07-12 | 2003-05-06 | Emory University | Regulation of apoptosis and in vitro model for studies thereof |
US6186982B1 (en) | 1998-05-05 | 2001-02-13 | Elan Corporation, Plc | Subcutaneous drug delivery device with improved filling system |
US6500150B1 (en) | 1997-06-16 | 2002-12-31 | Elan Pharma International Limited | Pre-filled drug-delivery device and method of manufacture and assembly of same |
EP0990151A2 (en) | 1997-06-16 | 2000-04-05 | ELAN CORPORATION, Plc | Methods of calibrating and testing a sensor for (in vivo) measurement of an analyte and devices for use in such methods |
US6200293B1 (en) * | 1997-08-27 | 2001-03-13 | Science Incorporated | Fluid delivery device with temperature controlled energy source |
US6086562A (en) * | 1997-10-27 | 2000-07-11 | Sarcos, Inc. | Disposable automatic injection device |
US6036924A (en) | 1997-12-04 | 2000-03-14 | Hewlett-Packard Company | Cassette of lancet cartridges for sampling blood |
US5957895A (en) * | 1998-02-20 | 1999-09-28 | Becton Dickinson And Company | Low-profile automatic injection device with self-emptying reservoir |
EP1064035B1 (en) * | 1998-03-23 | 2003-11-26 | ELAN CORPORATION, Plc | Drug delivery device |
US6391005B1 (en) | 1998-03-30 | 2002-05-21 | Agilent Technologies, Inc. | Apparatus and method for penetration with shaft having a sensor for sensing penetration depth |
CA2334174A1 (en) * | 1998-06-04 | 1999-12-09 | Izrail Tsals | Gas driven drug delivery device |
US6503231B1 (en) * | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
US7192713B1 (en) | 1999-05-18 | 2007-03-20 | President And Fellows Of Harvard College | Stabilized compounds having secondary structure motifs |
US6458102B1 (en) * | 1999-05-28 | 2002-10-01 | Medtronic Minimed, Inc. | External gas powered programmable infusion device |
US6611707B1 (en) | 1999-06-04 | 2003-08-26 | Georgia Tech Research Corporation | Microneedle drug delivery device |
US20020193740A1 (en) | 1999-10-14 | 2002-12-19 | Alchas Paul G. | Method of intradermally injecting substances |
US6843781B2 (en) * | 1999-10-14 | 2005-01-18 | Becton, Dickinson And Company | Intradermal needle |
US20020198509A1 (en) | 1999-10-14 | 2002-12-26 | Mikszta John A. | Intradermal delivery of vaccines and gene therapeutic agents via microcannula |
US20020095134A1 (en) * | 1999-10-14 | 2002-07-18 | Pettis Ronald J. | Method for altering drug pharmacokinetics based on medical delivery platform |
US20020156453A1 (en) * | 1999-10-14 | 2002-10-24 | Pettis Ronald J. | Method and device for reducing therapeutic dosage |
US8465468B1 (en) * | 2000-06-29 | 2013-06-18 | Becton, Dickinson And Company | Intradermal delivery of substances |
US6494865B1 (en) | 1999-10-14 | 2002-12-17 | Becton Dickinson And Company | Intradermal delivery device including a needle assembly |
US6569123B2 (en) | 1999-10-14 | 2003-05-27 | Becton, Dickinson And Company | Prefillable intradermal injector |
US6776776B2 (en) * | 1999-10-14 | 2004-08-17 | Becton, Dickinson And Company | Prefillable intradermal delivery device |
US6569143B2 (en) | 1999-10-14 | 2003-05-27 | Becton, Dickinson And Company | Method of intradermally injecting substances |
US6677320B2 (en) | 2000-01-20 | 2004-01-13 | Hoffmann-La Roches Inc. | Parenteral bisphosphonate composition with improved local tolerance |
US20010041869A1 (en) * | 2000-03-23 | 2001-11-15 | Causey James D. | Control tabs for infusion devices and methods of using the same |
US6485461B1 (en) | 2000-04-04 | 2002-11-26 | Insulet, Inc. | Disposable infusion device |
US20050008683A1 (en) * | 2000-06-29 | 2005-01-13 | Becton Dickinson And Company | Method for delivering interferons to the intradermal compartment |
US20040175360A1 (en) * | 2000-06-29 | 2004-09-09 | Pettis Ronald J. | Method for altering drug pharmacokinetics based on medical delivery platform |
US6620140B1 (en) * | 2000-06-30 | 2003-09-16 | Ethicon, Inc. | Method and an apparatus for a port access system |
US6589229B1 (en) | 2000-07-31 | 2003-07-08 | Becton, Dickinson And Company | Wearable, self-contained drug infusion device |
JP4532823B2 (en) | 2000-08-18 | 2010-08-25 | ベクトン・ディキンソン・アンド・カンパニー | Constant velocity fluid delivery device with bolus button that allows selection of flow rate and titration |
ES2287156T3 (en) | 2000-09-08 | 2007-12-16 | Insulet Corporation | DEVICES AND SYSTEMS FOR THE INFUSION OF A PATIENT. |
US6669669B2 (en) | 2001-10-12 | 2003-12-30 | Insulet Corporation | Laminated patient infusion device |
EP1702635B1 (en) * | 2000-11-09 | 2008-01-16 | Insulet Corporation | Transcutaneous delivery means |
DE10057832C1 (en) | 2000-11-21 | 2002-02-21 | Hartmann Paul Ag | Blood analysis device has syringe mounted in casing, annular mounting carrying needles mounted behind test strip and being swiveled so that needle can be pushed through strip and aperture in casing to take blood sample |
US8641644B2 (en) | 2000-11-21 | 2014-02-04 | Sanofi-Aventis Deutschland Gmbh | Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means |
EP1345646A2 (en) * | 2000-12-14 | 2003-09-24 | Georgia Tech Research Corporation | Microneedle devices and production thereof |
DE60115707T2 (en) | 2000-12-21 | 2006-08-10 | Insulet Corp., Beverly | REMOTE CONTROL MEDICAL DEVICE |
CA2434731C (en) | 2001-02-22 | 2010-01-26 | Insulet Corporation | Modular infusion device and method |
EP2269639B1 (en) * | 2001-02-23 | 2018-11-28 | GlaxoSmithKline Biologicals s.a. | Influenza vaccine formulations for intradermal delivery |
US20040096463A1 (en) * | 2001-02-23 | 2004-05-20 | Nathalie Garcon | Novel vaccine |
GB0109297D0 (en) | 2001-04-12 | 2001-05-30 | Glaxosmithkline Biolog Sa | Vaccine |
CA2444391A1 (en) * | 2001-04-13 | 2002-10-24 | Becton Dickinson And Company | Methods and devices for administration of substances into the intradermal layer of skin for systemic absorption |
ES2683629T3 (en) * | 2001-04-13 | 2018-09-27 | Becton, Dickinson And Company | Pre-filling intradermal delivery device with hidden needle and passive protection |
GB2386072A (en) * | 2001-04-27 | 2003-09-10 | Becton Dickinson Co | Novel vaccine |
TWI228420B (en) | 2001-05-30 | 2005-03-01 | Smithkline Beecham Pharma Gmbh | Novel vaccine composition |
US20100221284A1 (en) | 2001-05-30 | 2010-09-02 | Saech-Sisches Serumwerk Dresden | Novel vaccine composition |
US7749174B2 (en) | 2001-06-12 | 2010-07-06 | Pelikan Technologies, Inc. | Method and apparatus for lancet launching device intergrated onto a blood-sampling cartridge |
DE60234598D1 (en) | 2001-06-12 | 2010-01-14 | Pelikan Technologies Inc | SELF-OPTIMIZING LANZET DEVICE WITH ADAPTANT FOR TEMPORAL FLUCTUATIONS OF SKIN PROPERTIES |
US8337419B2 (en) | 2002-04-19 | 2012-12-25 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US9795747B2 (en) | 2010-06-02 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
CA2448681C (en) | 2001-06-12 | 2014-09-09 | Pelikan Technologies, Inc. | Integrated blood sampling analysis system with multi-use sampling module |
ATE485766T1 (en) | 2001-06-12 | 2010-11-15 | Pelikan Technologies Inc | ELECTRICAL ACTUATING ELEMENT FOR A LANCET |
US9427532B2 (en) | 2001-06-12 | 2016-08-30 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US9226699B2 (en) | 2002-04-19 | 2016-01-05 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling module with a continuous compression tissue interface surface |
US7682318B2 (en) | 2001-06-12 | 2010-03-23 | Pelikan Technologies, Inc. | Blood sampling apparatus and method |
EP1404234B1 (en) | 2001-06-12 | 2011-02-09 | Pelikan Technologies Inc. | Apparatus for improving success rate of blood yield from a fingerstick |
US7981056B2 (en) | 2002-04-19 | 2011-07-19 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
US7025774B2 (en) | 2001-06-12 | 2006-04-11 | Pelikan Technologies, Inc. | Tissue penetration device |
US20030073609A1 (en) * | 2001-06-29 | 2003-04-17 | Pinkerton Thomas C. | Enhanced pharmacokinetic profile of intradermally delivered substances |
US20050010193A1 (en) * | 2002-05-06 | 2005-01-13 | Laurent Philippe E. | Novel methods for administration of drugs and devices useful thereof |
US20060018877A1 (en) * | 2001-06-29 | 2006-01-26 | Mikszta John A | Intradermal delivery of vacccines and therapeutic agents |
US20030088238A1 (en) * | 2001-09-26 | 2003-05-08 | Poulsen Jens Ulrik | Modular drug delivery system |
US20060122577A1 (en) * | 2001-09-26 | 2006-06-08 | Poulsen Jens U | Modular drug delivery system |
US7344894B2 (en) | 2001-10-16 | 2008-03-18 | Agilent Technologies, Inc. | Thermal regulation of fluidic samples within a diagnostic cartridge |
US6939323B2 (en) * | 2001-10-26 | 2005-09-06 | Massachusetts Institute Of Technology | Needleless injector |
US7429258B2 (en) * | 2001-10-26 | 2008-09-30 | Massachusetts Institute Of Technology | Microneedle transport device |
US20040120964A1 (en) * | 2001-10-29 | 2004-06-24 | Mikszta John A. | Needleless vaccination using chimeric yellow fever vaccine-vectored vaccines against heterologous flaviviruses |
US6971999B2 (en) * | 2001-11-14 | 2005-12-06 | Medical Instill Technologies, Inc. | Intradermal delivery device and method |
US20030109827A1 (en) * | 2001-12-07 | 2003-06-12 | Elan Pharma International Limited | Drug delivery system and method |
ES2329781T3 (en) * | 2002-02-04 | 2009-12-01 | Becton, Dickinson And Company | DEVICE AND METHOD TO SUPPLY OR REMOVE A SUBSTANCE THROUGH THE SKIN. |
EP1476209B1 (en) * | 2002-02-18 | 2008-07-30 | Danfoss A/S | Device for administering of medication in fluid form |
EP1487519B1 (en) * | 2002-02-26 | 2013-06-12 | TecPharma Licensing AG | Insertion device for an insertion set and method of using the same |
US6830558B2 (en) | 2002-03-01 | 2004-12-14 | Insulet Corporation | Flow condition sensor assembly for patient infusion device |
US6692457B2 (en) | 2002-03-01 | 2004-02-17 | Insulet Corporation | Flow condition sensor assembly for patient infusion device |
CA2480072A1 (en) | 2002-03-26 | 2003-10-09 | Becton, Dickinson And Company | Multi-stage fluid delivery device and method |
US7115108B2 (en) * | 2002-04-02 | 2006-10-03 | Becton, Dickinson And Company | Method and device for intradermally delivering a substance |
US9248267B2 (en) | 2002-04-19 | 2016-02-02 | Sanofi-Aventis Deustchland Gmbh | Tissue penetration device |
US7291117B2 (en) | 2002-04-19 | 2007-11-06 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7648468B2 (en) | 2002-04-19 | 2010-01-19 | Pelikon Technologies, Inc. | Method and apparatus for penetrating tissue |
US7232451B2 (en) | 2002-04-19 | 2007-06-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7371247B2 (en) | 2002-04-19 | 2008-05-13 | Pelikan Technologies, Inc | Method and apparatus for penetrating tissue |
US9314194B2 (en) | 2002-04-19 | 2016-04-19 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US7976476B2 (en) | 2002-04-19 | 2011-07-12 | Pelikan Technologies, Inc. | Device and method for variable speed lancet |
US7481776B2 (en) | 2002-04-19 | 2009-01-27 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7226461B2 (en) | 2002-04-19 | 2007-06-05 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device with sterility barrier release |
US8579831B2 (en) | 2002-04-19 | 2013-11-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US8267870B2 (en) | 2002-04-19 | 2012-09-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling with hybrid actuation |
US7892183B2 (en) | 2002-04-19 | 2011-02-22 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
US7901362B2 (en) | 2002-04-19 | 2011-03-08 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8221334B2 (en) | 2002-04-19 | 2012-07-17 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7374544B2 (en) | 2002-04-19 | 2008-05-20 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7582099B2 (en) | 2002-04-19 | 2009-09-01 | Pelikan Technologies, Inc | Method and apparatus for penetrating tissue |
US7491178B2 (en) | 2002-04-19 | 2009-02-17 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7524293B2 (en) | 2002-04-19 | 2009-04-28 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7717863B2 (en) | 2002-04-19 | 2010-05-18 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7297122B2 (en) | 2002-04-19 | 2007-11-20 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7229458B2 (en) | 2002-04-19 | 2007-06-12 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7175642B2 (en) | 2002-04-19 | 2007-02-13 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
US8702624B2 (en) | 2006-09-29 | 2014-04-22 | Sanofi-Aventis Deutschland Gmbh | Analyte measurement device with a single shot actuator |
US7547287B2 (en) | 2002-04-19 | 2009-06-16 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7909778B2 (en) | 2002-04-19 | 2011-03-22 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7331931B2 (en) | 2002-04-19 | 2008-02-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7410468B2 (en) | 2002-04-19 | 2008-08-12 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7563232B2 (en) | 2002-04-19 | 2009-07-21 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7674232B2 (en) | 2002-04-19 | 2010-03-09 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7141058B2 (en) | 2002-04-19 | 2006-11-28 | Pelikan Technologies, Inc. | Method and apparatus for a body fluid sampling device using illumination |
US9795334B2 (en) | 2002-04-19 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US8784335B2 (en) | 2002-04-19 | 2014-07-22 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling device with a capacitive sensor |
US7052251B2 (en) * | 2002-04-22 | 2006-05-30 | Medtronic Minimed, Inc. | Shape memory alloy wire driven positive displacement micropump with pulsatile output |
US6656159B2 (en) | 2002-04-23 | 2003-12-02 | Insulet Corporation | Dispenser for patient infusion device |
US6656158B2 (en) | 2002-04-23 | 2003-12-02 | Insulet Corporation | Dispenser for patient infusion device |
US6960192B1 (en) | 2002-04-23 | 2005-11-01 | Insulet Corporation | Transcutaneous fluid delivery system |
US20060264886A9 (en) * | 2002-05-06 | 2006-11-23 | Pettis Ronald J | Method for altering insulin pharmacokinetics |
CN1655834A (en) * | 2002-05-06 | 2005-08-17 | 贝克顿·迪金森公司 | Method and device for controlling drug pharmacokinetics |
US20050005710A1 (en) * | 2002-05-15 | 2005-01-13 | Therafuse, Inc. | Liquid metering system |
US6932796B2 (en) | 2002-05-15 | 2005-08-23 | Tearafuse, Inc. | Liquid metering system |
US6979316B1 (en) | 2002-05-23 | 2005-12-27 | Seedlings Life Science Ventures Llc | Apparatus and method for rapid auto-injection of medication |
US6723072B2 (en) | 2002-06-06 | 2004-04-20 | Insulet Corporation | Plunger assembly for patient infusion device |
AU2003253859A1 (en) * | 2002-07-08 | 2004-01-23 | Medical Instill Technologies, Inc. | Interadermal delivery device, and method of intradermal delivery |
US7018360B2 (en) | 2002-07-16 | 2006-03-28 | Insulet Corporation | Flow restriction system and method for patient infusion device |
CA2493728C (en) * | 2002-07-22 | 2013-10-29 | Becton, Dickinson And Company | Patch-like infusion device |
EP1539241A2 (en) * | 2002-08-30 | 2005-06-15 | Becton, Dickinson and Company | Method of controlling pharmacokinetics of immunomodulatory compounds |
US20040049129A1 (en) * | 2002-09-05 | 2004-03-11 | Yan Qi | Wafer assembly having a resilient extendable/retractable needle means for healthcare |
JP2005537907A (en) | 2002-09-06 | 2005-12-15 | マサチューセッツ・インスティテュート・オブ・テクノロジー | Biological property measuring apparatus and method |
WO2004024219A1 (en) * | 2002-09-10 | 2004-03-25 | Becton Dickinson And Company | Method and apparatus for epidermal delivery of a substance |
JP2005538773A (en) | 2002-09-12 | 2005-12-22 | チルドレンズ ホスピタル メディカル センター | Method and apparatus for injecting drugs without pain |
US7144384B2 (en) | 2002-09-30 | 2006-12-05 | Insulet Corporation | Dispenser components and methods for patient infusion device |
US7128727B2 (en) | 2002-09-30 | 2006-10-31 | Flaherty J Christopher | Components and methods for patient infusion device |
US20060264926A1 (en) * | 2002-11-08 | 2006-11-23 | Kochamba Gary S | Cutaneous stabilization by vacuum for delivery of micro-needle array |
US6896666B2 (en) * | 2002-11-08 | 2005-05-24 | Kochamba Family Trust | Cutaneous injection delivery under suction |
US8574895B2 (en) | 2002-12-30 | 2013-11-05 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus using optical techniques to measure analyte levels |
US7252651B2 (en) * | 2003-01-07 | 2007-08-07 | Becton, Dickinson And Company | Disposable injection device |
CA2523267C (en) | 2003-04-23 | 2013-09-03 | Biovalve Technologies, Inc. | Hydraulically actuated pump for long duration medicament administration |
WO2004098683A1 (en) * | 2003-05-08 | 2004-11-18 | Novo Nordisk A/S | Internal needle inserter |
EP1475113A1 (en) * | 2003-05-08 | 2004-11-10 | Novo Nordisk A/S | External needle inserter |
JP4509100B2 (en) * | 2003-05-08 | 2010-07-21 | ノボ・ノルデイスク・エー/エス | Infusion device attachable to skin with removable needle insertion actuation |
US6926694B2 (en) * | 2003-05-09 | 2005-08-09 | Medsolve Technologies, Llc | Apparatus and method for delivery of therapeutic and/or diagnostic agents |
AU2004272972A1 (en) | 2003-05-22 | 2005-03-24 | Fraunhofer Usa, Inc. | Recombinant carrier molecule for expression, delivery and purification of target polypeptides |
EP1628567B1 (en) * | 2003-05-30 | 2010-08-04 | Pelikan Technologies Inc. | Method and apparatus for fluid injection |
AU2004251699A1 (en) * | 2003-06-04 | 2005-01-06 | Georgia Tech Research Corporation | Drilling microneedle device |
DK1633235T3 (en) | 2003-06-06 | 2014-08-18 | Sanofi Aventis Deutschland | Apparatus for sampling body fluid and detecting analyte |
WO2006001797A1 (en) | 2004-06-14 | 2006-01-05 | Pelikan Technologies, Inc. | Low pain penetrating |
CA2529048A1 (en) * | 2003-06-13 | 2005-02-24 | Becton, Dickinson And Company | Improved intra-dermal delivery of biologically active agents |
US7604592B2 (en) | 2003-06-13 | 2009-10-20 | Pelikan Technologies, Inc. | Method and apparatus for a point of care device |
DE10327254B4 (en) * | 2003-06-17 | 2010-01-28 | Disetronic Licensing Ag | Modular infusion pump |
EP1502613A1 (en) | 2003-08-01 | 2005-02-02 | Novo Nordisk A/S | Needle device with retraction means |
WO2005018705A2 (en) * | 2003-08-12 | 2005-03-03 | Becton, Dickinson And Company | Patch-like infusion device |
CN1863566B (en) * | 2003-08-12 | 2010-09-01 | 贝克顿·迪金森公司 | Patch-like infusion device |
CA2536669A1 (en) * | 2003-08-26 | 2005-03-17 | Becton, Dickinson And Company | Methods for intradermal delivery of therapeutics agents |
EP1660149B1 (en) | 2003-08-28 | 2018-03-07 | Becton, Dickinson and Company | Intradermal injection device |
WO2005034949A1 (en) * | 2003-09-09 | 2005-04-21 | University Of Florida | Desferrithiocin derivatives and their use as iron chelators |
US7361155B2 (en) * | 2003-09-16 | 2008-04-22 | Therafuse, Inc. | Compensating liquid delivery system and method |
IL157981A (en) | 2003-09-17 | 2014-01-30 | Elcam Medical Agricultural Cooperative Ass Ltd | Auto-injector |
US8282576B2 (en) | 2003-09-29 | 2012-10-09 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for an improved sample capture device |
EP1680014A4 (en) | 2003-10-14 | 2009-01-21 | Pelikan Technologies Inc | Method and apparatus for a variable user interface |
EP1677729B1 (en) * | 2003-10-21 | 2009-07-15 | Novo Nordisk A/S | Reservoir device with integrated mounting means |
ATE446111T1 (en) | 2003-10-21 | 2009-11-15 | Novo Nordisk As | INTERNAL FLUID CONNECTOR FOR PRODUCING A FLUID CONNECTION |
CN100586414C (en) * | 2003-10-21 | 2010-02-03 | 诺沃挪第克公司 | Reservoir device with inclined needle |
DE602004022075D1 (en) * | 2003-10-21 | 2009-08-27 | Novo Nordisk As | RESERVOIR DEVICE WITH INTEGRATED FASTENER |
EP1527792A1 (en) * | 2003-10-27 | 2005-05-04 | Novo Nordisk A/S | Medical injection device mountable to the skin |
KR20060099520A (en) | 2003-10-21 | 2006-09-19 | 노보 노르디스크 에이/에스 | Medical skin mountable device |
PL1682203T3 (en) | 2003-10-23 | 2010-06-30 | Novo Nordisk As | Medical injection device mountable to the skin |
DE602004025025D1 (en) * | 2003-10-27 | 2010-02-25 | Novo Nordisk As | ON THE SKIN FIXABLE MEDICAL INJECTION DEVICE |
EP1706026B1 (en) | 2003-12-31 | 2017-03-01 | Sanofi-Aventis Deutschland GmbH | Method and apparatus for improving fluidic flow and sample capture |
US7822454B1 (en) | 2005-01-03 | 2010-10-26 | Pelikan Technologies, Inc. | Fluid sampling device with improved analyte detecting member configuration |
US7150726B2 (en) * | 2004-01-23 | 2006-12-19 | Norfolk Medical | Device for subcutaneous infusion of fluids |
WO2005079441A2 (en) | 2004-02-17 | 2005-09-01 | Children's Hospital Medical Center | Injection device for administering a vaccine |
WO2005091922A2 (en) * | 2004-03-03 | 2005-10-06 | Becton, Dickinson And Company | Methods and devices for improving delivery of a substance to skin |
US7108679B2 (en) | 2004-03-11 | 2006-09-19 | Becton, Dickinson And Company | Intradermal syringe and needle assembly |
IL160891A0 (en) | 2004-03-16 | 2004-08-31 | Auto-mix needle | |
EP1727577A1 (en) | 2004-03-26 | 2006-12-06 | Unomedical A/S | Injector device for infusion set |
WO2005094920A1 (en) | 2004-03-30 | 2005-10-13 | Novo Nordisk A/S | Actuator system comprising lever mechanism |
JP4432650B2 (en) * | 2004-04-26 | 2010-03-17 | 株式会社日立製作所 | FUEL CELL POWER SUPPLY, ITS OPERATION METHOD AND PORTABLE ELECTRONIC DEVICE USING FUEL CELL POWER SUPPLY |
WO2005115360A2 (en) * | 2004-05-11 | 2005-12-08 | Becton, Dickinson And Company | Formulations of anti-pain agents and methods of using the same |
US8828203B2 (en) | 2004-05-20 | 2014-09-09 | Sanofi-Aventis Deutschland Gmbh | Printable hydrogels for biosensors |
EP1765194A4 (en) | 2004-06-03 | 2010-09-29 | Pelikan Technologies Inc | Method and apparatus for a fluid sampling device |
CN1964689A (en) * | 2004-06-07 | 2007-05-16 | 诺和诺德公司 | Reservoir with liquidly applied seal |
WO2006014425A1 (en) | 2004-07-02 | 2006-02-09 | Biovalve Technologies, Inc. | Methods and devices for delivering glp-1 and uses thereof |
US8062250B2 (en) | 2004-08-10 | 2011-11-22 | Unomedical A/S | Cannula device |
WO2006032689A1 (en) * | 2004-09-22 | 2006-03-30 | Novo Nordisk A/S | Medical device with transcutaneous cannula device |
US9492400B2 (en) | 2004-11-04 | 2016-11-15 | Massachusetts Institute Of Technology | Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals |
US8652831B2 (en) | 2004-12-30 | 2014-02-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte measurement test time |
US20090076451A1 (en) | 2005-01-24 | 2009-03-19 | Nova Nordisk A/S | Medical Device with Protected Transcutaneous Device |
US7833189B2 (en) | 2005-02-11 | 2010-11-16 | Massachusetts Institute Of Technology | Controlled needle-free transport |
US20070060904A1 (en) * | 2005-03-14 | 2007-03-15 | Becton, Dickinson And Company | Filling system and method for syringes with short needles |
US7985199B2 (en) | 2005-03-17 | 2011-07-26 | Unomedical A/S | Gateway system |
AU2006226543B2 (en) | 2005-03-23 | 2011-10-06 | Glaxosmithkline Biologicals S.A. | Use of an influenza virus an oil-in-water emulsion adjuvant to induce CD4 T-cell and/or improved B-memory cell response |
ES2614086T3 (en) | 2005-04-04 | 2017-05-29 | University Of Florida Research Foundation, Inc. | Desferritiocin polyether analogs |
EP1877116A1 (en) * | 2005-04-13 | 2008-01-16 | Novo Nordisk A/S | Medical skin mountable device and system |
US9233203B2 (en) | 2005-05-06 | 2016-01-12 | Medtronic Minimed, Inc. | Medical needles for damping motion |
US20080097291A1 (en) | 2006-08-23 | 2008-04-24 | Hanson Ian B | Infusion pumps and methods and delivery devices and methods with same |
EP1919504B1 (en) * | 2005-08-03 | 2013-10-16 | iBio, Inc. | Antibody to bacillus anthracis protective antigen |
DE602005023458D1 (en) | 2005-09-12 | 2010-10-21 | Unomedical As | A delivery system for an infusion set having first and second spring units |
CN101262897A (en) * | 2005-09-13 | 2008-09-10 | 诺沃-诺迪斯克有限公司 | Reservoir device with inspection aid for detection of drug condition |
WO2007045644A1 (en) * | 2005-10-17 | 2007-04-26 | Novo Nordisk A/S | Vented drug reservoir unit |
SI2926847T1 (en) * | 2005-11-02 | 2022-10-28 | Medicaltree Patents Ltd. | Implantable infusion device with advanceable and retractable needle |
TWI457133B (en) * | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | Novel composition |
WO2007070682A2 (en) | 2005-12-15 | 2007-06-21 | Massachusetts Institute Of Technology | System for screening particles |
RU2419459C2 (en) | 2005-12-23 | 2011-05-27 | Уномедикал А/С | Drug introduction device |
DE602007013723D1 (en) * | 2006-02-09 | 2011-05-19 | Deka Products Lp | SYSTEMS FOR DISPENSING FLUIDS IN PATCH SIZE |
EP1984405A4 (en) * | 2006-02-13 | 2010-06-30 | Fraunhofer Usa Inc | Influenza antigens, vaccine compositions, and related methods |
WO2008048344A2 (en) * | 2006-02-13 | 2008-04-24 | Fraunhofer Usa, Inc. | Bacillus anthracis antigens, vaccine compositions, and related methods |
CA2642056A1 (en) * | 2006-02-13 | 2007-08-23 | Fraunhofer Usa, Inc. | Hpv antigens, vaccine compositions, and related methods |
US20070191780A1 (en) * | 2006-02-16 | 2007-08-16 | Pankaj Modi | Drug delivery device |
KR20080104342A (en) | 2006-02-28 | 2008-12-02 | 우노메디컬 에이/에스 | Inserter for infusion part and infusion part provided with needle protector |
WO2007106415A2 (en) * | 2006-03-10 | 2007-09-20 | Massachusetts Institute Of Technology | Triggered self-assembly conjugates and nanosystems |
CN101401313B (en) | 2006-03-13 | 2014-06-11 | 诺沃—诺迪斯克有限公司 | Secure pairing of electronic devices using dual means of communication |
JP5681362B2 (en) | 2006-03-14 | 2015-03-04 | ユニバーシティー オブ サザン カリフォルニア | MEMS device for delivery of therapeutic agents |
WO2007111806A2 (en) | 2006-03-23 | 2007-10-04 | Massachusetts Eye And Ear Infirmary | Cyclopentane heptanoic acid compounds for reducing body fat |
JP2007252551A (en) * | 2006-03-23 | 2007-10-04 | Shimadzu Corp | Disk-like needleless syringe |
CN103239773B (en) | 2006-03-30 | 2015-08-26 | 瓦莱里塔斯公司 | Multi-cartridge fluid delivery device |
CA2648099C (en) | 2006-03-31 | 2012-05-29 | The Brigham And Women's Hospital, Inc | System for targeted delivery of therapeutic agents |
WO2007120638A2 (en) * | 2006-04-12 | 2007-10-25 | President And Fellows Of Harvard College | Methods and compositions for modulating glycosylation |
WO2007133807A2 (en) | 2006-05-15 | 2007-11-22 | Massachusetts Institute Of Technology | Polymers for functional particles |
EP2492684B1 (en) | 2006-06-02 | 2016-12-28 | President and Fellows of Harvard College | Protein surface remodeling |
CN101460207B (en) | 2006-06-06 | 2012-03-21 | 诺沃-诺迪斯克有限公司 | Assembly comprising skin-mountable device and packaging therefore |
US8439838B2 (en) | 2006-06-07 | 2013-05-14 | Unomedical A/S | Inserter for transcutaneous sensor |
CA2653764A1 (en) | 2006-06-09 | 2007-12-13 | Unomedical A/S | Mounting pad |
WO2007150030A2 (en) | 2006-06-23 | 2007-12-27 | Massachusetts Institute Of Technology | Microfluidic synthesis of organic nanoparticles |
DK2043682T3 (en) | 2006-07-17 | 2014-06-02 | Glaxosmithkline Biolog Sa | INFLUENZA VACCINE |
PT2520168E (en) | 2006-07-21 | 2014-04-29 | California Inst Of Techn | Targeted gene delivery for dendritic cell vaccination |
CN101522234B (en) * | 2006-07-24 | 2012-11-14 | 梅丁格有限公司 | Systems, devices and methods for fluid/drug delivery |
US8435211B2 (en) * | 2006-07-24 | 2013-05-07 | Medingo Ltd. | Systems, devices and methods for fluid/drug delivery |
US9115358B2 (en) * | 2006-08-11 | 2015-08-25 | President And Fellows Of Harvard College | Moenomycin biosynthesis-related compositions and methods of use thereof |
US20100061990A1 (en) * | 2006-08-14 | 2010-03-11 | Massachusetts Institute Of Technology | Hemagglutinin Polypeptides, and Reagents and Methods Relating Thereto |
US20090269342A1 (en) * | 2006-08-14 | 2009-10-29 | Massachusetts Institute Of Technology | Hemagglutinin Polypeptides, and Reagents and Methods Relating Thereto |
WO2008042814A2 (en) | 2006-09-29 | 2008-04-10 | California Institute Of Technology | Mart-1 t cell receptors |
US8202267B2 (en) | 2006-10-10 | 2012-06-19 | Medsolve Technologies, Inc. | Method and apparatus for infusing liquid to a body |
JO3598B1 (en) | 2006-10-10 | 2020-07-05 | Infinity Discovery Inc | Boronic acids and esters as inhibitors of fatty acid amide hydrolase |
EP1917990A1 (en) | 2006-10-31 | 2008-05-07 | Unomedical A/S | Infusion set |
FR2909001B1 (en) * | 2006-11-24 | 2009-12-18 | Bernard Perriere | MINIATURIZED AND AUTOMATIC INJECTION AND SAMPLING DEVICE FOR MEDICAL USE. |
BRPI0719756A2 (en) | 2006-12-01 | 2014-01-21 | Anterios Inc | Amphiphilic Nanoparticles |
US20080213377A1 (en) * | 2006-12-08 | 2008-09-04 | Bhatia Sangeeta N | Delivery of Nanoparticles and/or Agents to Cells |
DK2474525T3 (en) | 2006-12-26 | 2020-07-13 | Lantheus Medical Imaging Inc | Ligands for imaging cardiac innervation |
ES2558928T3 (en) | 2007-01-31 | 2016-02-09 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
WO2008098165A2 (en) | 2007-02-09 | 2008-08-14 | Massachusetts Institute Of Technology | Oscillating cell culture bioreactor |
JP5439193B2 (en) | 2007-03-15 | 2014-03-12 | ユニバーシティー オブ フロリダ リサーチ ファンデーション, インク. | Desferrithiocin polyether analogue |
US7960139B2 (en) | 2007-03-23 | 2011-06-14 | Academia Sinica | Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells |
KR101623985B1 (en) | 2007-03-28 | 2016-05-25 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | Stitched polypeptides |
WO2008124634A1 (en) | 2007-04-04 | 2008-10-16 | Massachusetts Institute Of Technology | Polymer-encapsulated reverse micelles |
WO2008124632A1 (en) | 2007-04-04 | 2008-10-16 | Massachusetts Institute Of Technology | Amphiphilic compound assisted nanoparticles for targeted delivery |
US8679062B2 (en) | 2007-04-10 | 2014-03-25 | Roche Diagnostics Operations Inc. | Apparatus and method for pumping fluid |
KR100876650B1 (en) * | 2007-04-13 | 2009-01-09 | (주) 비에이치케이 | Apparatus for vascular access |
US8778348B2 (en) * | 2007-04-28 | 2014-07-15 | Ibio Inc. | Trypanosoma antigens, vaccine compositions, and related methods |
JP2010529166A (en) * | 2007-06-14 | 2010-08-26 | クルセル スウィツァーランド アーゲー | Intradermal influenza vaccine |
US8524444B2 (en) | 2007-06-15 | 2013-09-03 | President And Fellows Of Harvard College | Methods and compositions for detections and modulating O-glycosylation |
DK2155311T3 (en) | 2007-06-20 | 2013-02-04 | Unomedical As | METHOD AND APPARATUS FOR PREPARING A CATHETIC |
EP2185224A1 (en) | 2007-07-03 | 2010-05-19 | Unomedical A/S | Inserter having bistable equilibrium states |
DE602008005153D1 (en) | 2007-07-10 | 2011-04-07 | Unomedical As | INSERT WITH TWO SPRINGS |
EP2178558B1 (en) | 2007-07-11 | 2014-04-30 | iBio, Inc. | Yersinia pestis antigens, vaccine compositions, and related methods |
EP2022518A1 (en) * | 2007-08-07 | 2009-02-11 | Sensile Pat AG | Modular drug delivery device for administering discrete doses of a medicament |
US20110059130A1 (en) * | 2007-08-20 | 2011-03-10 | Fraunhofer Usa, Inc. | Prophylactic and therapeutic influenza vaccines, antigens, compositions and methods |
US8409145B2 (en) | 2007-09-17 | 2013-04-02 | Tecpharma Licensing Ag | Insertion devices for infusion devices |
US7771391B2 (en) * | 2007-09-28 | 2010-08-10 | Calibra Medical, Inc. | Disposable infusion device with snap action actuation |
US7967795B1 (en) | 2010-01-19 | 2011-06-28 | Lamodel Ltd. | Cartridge interface assembly with driving plunger |
CN101868273B (en) | 2007-10-02 | 2014-10-15 | 莱蒙德尔有限公司 | External drug pump |
US9656019B2 (en) | 2007-10-02 | 2017-05-23 | Medimop Medical Projects Ltd. | Apparatuses for securing components of a drug delivery system during transport and methods of using same |
US10420880B2 (en) | 2007-10-02 | 2019-09-24 | West Pharma. Services IL, Ltd. | Key for securing components of a drug delivery system during assembly and/or transport and methods of using same |
US9345836B2 (en) | 2007-10-02 | 2016-05-24 | Medimop Medical Projects Ltd. | Disengagement resistant telescoping assembly and unidirectional method of assembly for such |
EP2205074A4 (en) * | 2007-10-04 | 2013-07-31 | Harvard College | Moenomycin analogs, methods of synthesis, and uses thereof |
EP3424525A1 (en) | 2007-10-12 | 2019-01-09 | Massachusetts Institute Of Technology | Vaccine nanotechnology |
US8858787B2 (en) * | 2007-10-22 | 2014-10-14 | Baxter International Inc. | Dialysis system having non-invasive fluid velocity sensing |
US8557179B2 (en) | 2007-10-31 | 2013-10-15 | Novo Nordisk A/S | Non-porous material as sterilization barrier |
MX364408B (en) | 2007-12-20 | 2019-04-25 | Univ Southern California | APPARATUS and METHODS FOR DELIVERING THERAPEUTIC AGENTS. |
CN101951927A (en) * | 2008-01-03 | 2011-01-19 | 麻省理工学院 | Decoy influenza therapies |
US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
US8986253B2 (en) | 2008-01-25 | 2015-03-24 | Tandem Diabetes Care, Inc. | Two chamber pumps and related methods |
US8708961B2 (en) | 2008-01-28 | 2014-04-29 | Medsolve Technologies, Inc. | Apparatus for infusing liquid to a body |
CA2713485A1 (en) * | 2008-02-13 | 2009-08-20 | Unomedical A/S | Sealing between a cannula part and a fluid path |
CA2715667A1 (en) | 2008-02-20 | 2009-08-27 | Unomedical A/S | Insertion device with horizontally moving part |
WO2009119787A1 (en) * | 2008-03-28 | 2009-10-01 | テルモ株式会社 | Injector |
TW201000107A (en) | 2008-04-09 | 2010-01-01 | Infinity Pharmaceuticals Inc | Inhibitors of fatty acid amide hydrolase |
WO2009126900A1 (en) | 2008-04-11 | 2009-10-15 | Pelikan Technologies, Inc. | Method and apparatus for analyte detecting device |
JP2011523353A (en) * | 2008-04-28 | 2011-08-11 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | Overcharged protein for cell penetration |
WO2009137785A2 (en) * | 2008-05-08 | 2009-11-12 | Replenish Pumps, Llc | Drug-delivery pumps and methods of manufacture |
WO2009137780A2 (en) | 2008-05-08 | 2009-11-12 | Replenish Pumps, Llc | Implantable pumps and cannulas therefor |
US9849238B2 (en) | 2008-05-08 | 2017-12-26 | Minipumps, Llc | Drug-delivery pump with intelligent control |
US20110212157A1 (en) | 2008-06-26 | 2011-09-01 | Anterios, Inc. | Dermal delivery |
US8680020B2 (en) | 2008-07-15 | 2014-03-25 | Academia Sinica | Glycan arrays on PTFE-like aluminum coated glass slides and related methods |
FR2933872B1 (en) * | 2008-07-18 | 2012-09-28 | Bernard Perriere | MINIATURIZED INJECTION DEVICE FOR MEDICAL USE WITH REMOVABLE CARTRIDGE |
CA2734991A1 (en) * | 2008-07-23 | 2010-01-28 | Massachusetts Institute Of Technology | Activation of histone deacetylase 1 (hdac1) protects against dna damage and increases neuronal survival |
EP2356139A4 (en) | 2008-07-23 | 2013-01-09 | Harvard College | Ligation of stapled polypeptides |
US8986250B2 (en) * | 2008-08-01 | 2015-03-24 | Wisconsin Alumni Research Foundation | Drug delivery platform utilizing hydrogel pumping mechanism |
US8795259B2 (en) * | 2008-08-01 | 2014-08-05 | Wisconsin Alumni Research Foundation | Drug delivery platform incorporating hydrogel pumping mechanism with guided fluid flow |
CA2770931A1 (en) * | 2008-08-18 | 2010-02-25 | Calibra Medical, Inc. | Drug infusion system with reusable and disposable components |
US7959598B2 (en) | 2008-08-20 | 2011-06-14 | Asante Solutions, Inc. | Infusion pump systems and methods |
US9393369B2 (en) | 2008-09-15 | 2016-07-19 | Medimop Medical Projects Ltd. | Stabilized pen injector |
US8734803B2 (en) | 2008-09-28 | 2014-05-27 | Ibio Inc. | Humanized neuraminidase antibody and methods of use thereof |
US8343497B2 (en) | 2008-10-12 | 2013-01-01 | The Brigham And Women's Hospital, Inc. | Targeting of antigen presenting cells with immunonanotherapeutics |
US8343498B2 (en) | 2008-10-12 | 2013-01-01 | Massachusetts Institute Of Technology | Adjuvant incorporation in immunonanotherapeutics |
US8591905B2 (en) | 2008-10-12 | 2013-11-26 | The Brigham And Women's Hospital, Inc. | Nicotine immunonanotherapeutics |
US8277812B2 (en) | 2008-10-12 | 2012-10-02 | Massachusetts Institute Of Technology | Immunonanotherapeutics that provide IgG humoral response without T-cell antigen |
US20100145305A1 (en) * | 2008-11-10 | 2010-06-10 | Ruth Alon | Low volume accurate injector |
US20100130958A1 (en) * | 2008-11-26 | 2010-05-27 | David Kang | Device and Methods for Subcutaneous Delivery of High Viscosity Fluids |
WO2010077806A1 (en) | 2008-12-15 | 2010-07-08 | Greenlight Biosciences, Inc. | Methods for control of flux in metabolic pathways |
MX2011005735A (en) | 2008-12-22 | 2011-06-21 | Unomedical As | Medical device comprising adhesive pad. |
CN105132387A (en) * | 2008-12-22 | 2015-12-09 | 绿光生物科学公司 | Compositions and methods for the production of a compound |
US8152779B2 (en) * | 2008-12-30 | 2012-04-10 | Medimop Medical Projects Ltd. | Needle assembly for drug pump |
US9375169B2 (en) | 2009-01-30 | 2016-06-28 | Sanofi-Aventis Deutschland Gmbh | Cam drive for managing disposable penetrating member actions with a single motor and motor and control system |
US9250106B2 (en) | 2009-02-27 | 2016-02-02 | Tandem Diabetes Care, Inc. | Methods and devices for determination of flow reservoir volume |
WO2010118155A1 (en) | 2009-04-07 | 2010-10-14 | Infinity Pharmaceuticals, Inc. | Inhibitors of fatty acid amide hydrolase |
WO2010118159A1 (en) | 2009-04-07 | 2010-10-14 | Infinity Pharmaceuticals, Inc. | Inhibitors of fatty acid amide hydrolase |
WO2010129023A2 (en) | 2009-04-28 | 2010-11-11 | President And Fellows Of Harvard College | Supercharged proteins for cell penetration |
US9149465B2 (en) * | 2009-05-18 | 2015-10-06 | Infinity Pharmaceuticals, Inc. | Isoxazolines as inhibitors of fatty acid amide hydrolase |
US8927551B2 (en) * | 2009-05-18 | 2015-01-06 | Infinity Pharmaceuticals, Inc. | Isoxazolines as inhibitors of fatty acid amide hydrolase |
US8765735B2 (en) * | 2009-05-18 | 2014-07-01 | Infinity Pharmaceuticals, Inc. | Isoxazolines as inhibitors of fatty acid amide hydrolase |
JP2012528858A (en) | 2009-06-01 | 2012-11-15 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | O-GlcNAc transferase inhibitor and use thereof |
US9163330B2 (en) | 2009-07-13 | 2015-10-20 | President And Fellows Of Harvard College | Bifunctional stapled polypeptides and uses thereof |
TR201819229T4 (en) | 2009-07-24 | 2019-01-21 | Immune Design Corp | Non-integrated lentiviral vectors. |
EP2459252B1 (en) | 2009-07-30 | 2013-08-21 | Unomedical A/S | Inserter device with horizontal moving part |
WO2011014704A2 (en) | 2009-07-30 | 2011-02-03 | Tandem Diabetes Care, Inc. | Infusion pump system with disposable cartridge having pressure venting and pressure feedback |
BR112012002804A2 (en) | 2009-08-07 | 2016-05-31 | Unomedical As | sensor device and one or more cannulas |
EP2467797B1 (en) | 2009-08-18 | 2017-07-19 | MiniPumps, LLC | Electrolytic drug-delivery pump with adaptive control |
US9265461B2 (en) * | 2009-09-01 | 2016-02-23 | Massachusetts Institute Of Technology | Identification techniques and device for testing the efficacy of beauty care products and cosmetics |
WO2011028719A2 (en) | 2009-09-01 | 2011-03-10 | Massachusetts Institute Of Technology | Nonlinear system identification techniques and devices for discovering dynamic and static tissue properties |
US10071198B2 (en) | 2012-11-02 | 2018-09-11 | West Pharma. Servicees IL, Ltd. | Adhesive structure for medical device |
EP2477676B1 (en) | 2009-09-15 | 2019-10-30 | Becton, Dickinson and Company | Self-injection device |
US10071196B2 (en) | 2012-05-15 | 2018-09-11 | West Pharma. Services IL, Ltd. | Method for selectively powering a battery-operated drug-delivery device and device therefor |
US8157769B2 (en) | 2009-09-15 | 2012-04-17 | Medimop Medical Projects Ltd. | Cartridge insertion assembly for drug delivery system |
CA2774973A1 (en) | 2009-09-22 | 2011-03-31 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
WO2011041391A1 (en) | 2009-09-29 | 2011-04-07 | Fraunhofer Usa, Inc. | Influenza hemagglutinin antibodies, compositions, and related methods |
IN2012DN02600A (en) * | 2009-10-13 | 2015-09-04 | Valeritas Inc | |
US10087236B2 (en) | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
US20110143310A1 (en) | 2009-12-15 | 2011-06-16 | Hunter Ian W | Lorentz-Force Actuated Cleaning Device |
EP2512551B1 (en) | 2009-12-16 | 2019-03-20 | Becton, Dickinson and Company | Self-injection device |
DK2512559T3 (en) | 2009-12-16 | 2019-03-25 | Becton Dickinson Co | SELF-INJECTIVE DEVICE |
JP5650242B2 (en) | 2009-12-16 | 2015-01-07 | ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company | Self injection device |
ES2565405T3 (en) | 2009-12-16 | 2016-04-04 | Becton Dickinson And Company | Auto injection device |
JP5894082B2 (en) | 2009-12-16 | 2016-03-23 | ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company | Self-injection device |
ES2617145T3 (en) | 2009-12-16 | 2017-06-15 | Becton, Dickinson And Company | Automatic injection device |
CA2784807C (en) | 2009-12-29 | 2021-12-14 | Dana-Farber Cancer Institute, Inc. | Type ii raf kinase inhibitors |
US8348898B2 (en) | 2010-01-19 | 2013-01-08 | Medimop Medical Projects Ltd. | Automatic needle for drug pump |
AU2011210840B2 (en) | 2010-01-27 | 2014-12-11 | Massachusetts Institute Of Technology | Engineered polypeptide agents for targeted broad spectrum influenza neutralization |
RU2015143910A (en) * | 2010-02-03 | 2018-12-28 | Инфинити Фармасьютикалз, Инк. | FATTY ACID AMID HYDROLASE INHIBITORS |
WO2011112635A1 (en) | 2010-03-08 | 2011-09-15 | Sloan-Kettering Institute For Cancer Research | Cdc7 kinase inhibitors and uses thereof |
CN103025368A (en) * | 2010-03-19 | 2013-04-03 | 海洋酶公司 | Gas-pressured medication delivery device |
US9102697B2 (en) | 2010-03-22 | 2015-08-11 | President And Fellows Of Harvard College | Trioxacarcins and uses thereof |
CA2792138A1 (en) | 2010-03-30 | 2011-10-06 | Unomedical A/S | Medical device |
WO2011130332A1 (en) | 2010-04-12 | 2011-10-20 | Academia Sinica | Glycan arrays for high throughput screening of viruses |
US8965476B2 (en) | 2010-04-16 | 2015-02-24 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
EP2560703A2 (en) | 2010-04-20 | 2013-02-27 | MiniPumps, LLC | Electrolytically driven drug pump devices |
WO2011140296A1 (en) | 2010-05-05 | 2011-11-10 | Infinity Pharmaceuticals | Triazoles as inhibitors of fatty acid synthase |
EP2566853B1 (en) | 2010-05-05 | 2017-01-25 | Infinity Pharmaceuticals, Inc. | Tetrazolones as inhibitors of fatty acid synthase |
EP2566953B1 (en) | 2010-05-07 | 2019-01-02 | Greenlight Biosciences, Inc. | Methods for control of flux in metabolic pathways through enzyme relocation |
WO2011141907A1 (en) | 2010-05-10 | 2011-11-17 | Medimop Medical Projects Ltd. | Low volume accurate injector |
BR122020018186B1 (en) | 2010-05-11 | 2021-07-27 | Lantheus Medical Imaging, Inc | USE OF IMAGING AGENTS TO PREPARE A COMPOSITION FOR DETECTION OF THE NOREPINEPHRIN CONVEYOR (NET) AND METHOD FOR THE DETECTION OF NET |
FI2575935T4 (en) | 2010-06-07 | 2023-11-23 | Amgen Inc | Drug delivery device |
ES2664872T3 (en) | 2010-06-18 | 2018-04-23 | Taiho Pharmaceutical Co., Ltd | PRPK-TPRKB modulators and their uses |
CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
DK2603600T3 (en) | 2010-08-13 | 2019-03-04 | Aileron Therapeutics Inc | PEPTIDOMIMETIC MACROCYCLES |
EP2611922A1 (en) | 2010-08-31 | 2013-07-10 | Greenlight Biosciences, Inc. | Methods for control of flux in metabolic pathways through protease manipulation |
CN103153360B (en) | 2010-09-02 | 2016-04-06 | 贝克顿·迪金森公司 | Have band activate interceptor pin lid from injection device |
US8585677B2 (en) | 2010-09-21 | 2013-11-19 | Brigham Young University | Laminar injection apparatus and method |
US8802110B2 (en) | 2010-09-21 | 2014-08-12 | Massachusetts Institute Of Technology | Influenza treatment and/or characterization, human-adapted HA polypeptides; vaccines |
WO2012040459A2 (en) | 2010-09-22 | 2012-03-29 | President And Fellows Of Harvard College | Beta-catenin targeting peptides and uses thereof |
US8915879B2 (en) | 2010-09-24 | 2014-12-23 | Perqflo, Llc | Infusion pumps |
EP2433663A1 (en) | 2010-09-27 | 2012-03-28 | Unomedical A/S | Insertion system |
EP4108671A1 (en) | 2010-10-01 | 2022-12-28 | ModernaTX, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
EP2436412A1 (en) | 2010-10-04 | 2012-04-04 | Unomedical A/S | A sprinkler cannula |
BR112013007946B1 (en) | 2010-10-04 | 2022-07-12 | Massachusetts Institute Of Technology | PHARMACEUTICAL AND IMMUNOGENIC COMPOSITIONS COMPRISING HEMAGGLUTININ POLYPEPTIDES |
EP2438938A1 (en) * | 2010-10-11 | 2012-04-11 | PharmaSens AG | Syringe type pump |
US9211378B2 (en) | 2010-10-22 | 2015-12-15 | Cequr Sa | Methods and systems for dosing a medicament |
WO2012064973A2 (en) | 2010-11-10 | 2012-05-18 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US8905972B2 (en) | 2010-11-20 | 2014-12-09 | Perqflo, Llc | Infusion pumps |
US8795234B2 (en) * | 2010-11-30 | 2014-08-05 | Becton, Dickinson And Company | Integrated spring-activated ballistic insertion for drug infusion device |
EP2460553A1 (en) | 2010-12-02 | 2012-06-06 | Debiotech S.A. | Device for inserting needles |
UA115767C2 (en) | 2011-01-10 | 2017-12-26 | Інфініті Фармасьютікалз, Інк. | Processes for preparing isoquinolinones and solid forms of isoquinolinones |
US9089579B2 (en) | 2011-01-19 | 2015-07-28 | Topokine Therapeutics, Inc. | Methods and compositions for treating metabolic syndrome |
US20120191074A1 (en) * | 2011-01-21 | 2012-07-26 | Palyon Medical (Bvi) Limited | Reduced sized programmable pump |
DK2667854T3 (en) | 2011-01-24 | 2019-04-23 | Anterios Inc | NANO PARTICLE FORMATIONS |
KR20140005998A (en) | 2011-01-24 | 2014-01-15 | 안테리오스, 인코퍼레이티드 | Nanoparticle compositions, formulations thereof, and uses therefor |
WO2012103037A1 (en) | 2011-01-24 | 2012-08-02 | Anterios, Inc. | Oil compositions |
US8703818B2 (en) | 2011-03-03 | 2014-04-22 | Tersus Pharmaceuticals, LLC | Compositions and methods comprising C16:1n7-palmitoleate |
USD702834S1 (en) | 2011-03-22 | 2014-04-15 | Medimop Medical Projects Ltd. | Cartridge for use in injection device |
US20130281932A1 (en) * | 2011-03-30 | 2013-10-24 | Ziv Harish | Palm-based injector actuation and safety surfaces |
US20120253314A1 (en) * | 2011-03-30 | 2012-10-04 | Ziv Harish | Palm-controlled injectors |
US9193767B2 (en) | 2011-03-30 | 2015-11-24 | Brown University | Enopeptins, uses thereof, and methods of synthesis thereto |
AU2012236099A1 (en) | 2011-03-31 | 2013-10-03 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
WO2012177997A1 (en) | 2011-06-22 | 2012-12-27 | The General Hospital Corporation | Treatment of proteinopathies |
US8969363B2 (en) | 2011-07-19 | 2015-03-03 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
AU2012284091B2 (en) | 2011-07-19 | 2015-11-12 | Infinity Pharmaceuticals Inc. | Heterocyclic compounds and uses thereof |
PT2734510T (en) | 2011-07-22 | 2019-02-13 | Massachusetts Inst Technology | Activators of class i histone deacetlyases (hdacs) and uses thereof |
WO2013032591A1 (en) | 2011-08-29 | 2013-03-07 | Infinity Pharmaceuticals Inc. | Heterocyclic compounds and uses thereof |
WO2013032841A1 (en) | 2011-08-29 | 2013-03-07 | Sid Technologies Llc | Subcutaneous and intradermal patch infusers |
CN104159890B (en) | 2011-09-09 | 2018-04-10 | 蓝瑟斯医学影像公司 | Composition, method and system for synthesizing and using developer |
CA2846893A1 (en) | 2011-09-09 | 2013-03-14 | Greenlight Biosciences, Inc. | Cell-free preparation of carbapenems |
EP2755693A4 (en) | 2011-09-12 | 2015-05-20 | Moderna Therapeutics Inc | Engineered nucleic acids and methods of use thereof |
US9630979B2 (en) | 2011-09-29 | 2017-04-25 | Infinity Pharmaceuticals, Inc. | Inhibitors of monoacylglycerol lipase and methods of their use |
CN103974724B (en) | 2011-10-03 | 2019-08-30 | 现代泰克斯公司 | Nucleosides, nucleotide and nucleic acid of modification and application thereof |
US11197689B2 (en) | 2011-10-05 | 2021-12-14 | Unomedical A/S | Inserter for simultaneous insertion of multiple transcutaneous parts |
US9096684B2 (en) | 2011-10-18 | 2015-08-04 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
EP2583715A1 (en) | 2011-10-19 | 2013-04-24 | Unomedical A/S | Infusion tube system and method for manufacture |
US9440051B2 (en) | 2011-10-27 | 2016-09-13 | Unomedical A/S | Inserter for a multiplicity of subcutaneous parts |
JP6106685B2 (en) | 2011-11-17 | 2017-04-05 | ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド | Inhibitors of C-JUN-N-terminal kinase (JNK) |
GB201119999D0 (en) | 2011-11-20 | 2012-01-04 | Glaxosmithkline Biolog Sa | Vaccine |
GB201120000D0 (en) | 2011-11-20 | 2012-01-04 | Glaxosmithkline Biolog Sa | Vaccine |
CA2859387A1 (en) | 2011-12-16 | 2013-06-20 | Moderna Therapeutics, Inc. | Modified nucleoside, nucleotide, and nucleic acid compositions |
WO2013090750A1 (en) | 2011-12-16 | 2013-06-20 | University Of Florida Research Foundation, Inc. | Uses of 4'-desferrithiocin analogs |
US8426471B1 (en) | 2011-12-19 | 2013-04-23 | Topokine Therapeutics, Inc. | Methods and compositions for reducing body fat and adipocytes |
EP2809375B1 (en) | 2012-01-31 | 2021-08-11 | Medimop Medical Projects Ltd. | Time dependent drug delivery apparatus |
WO2013123267A1 (en) | 2012-02-15 | 2013-08-22 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
AU2013221432B2 (en) | 2012-02-15 | 2018-01-18 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
US9463280B2 (en) | 2012-03-26 | 2016-10-11 | Medimop Medical Projects Ltd. | Motion activated septum puncturing drug delivery device |
US10668213B2 (en) | 2012-03-26 | 2020-06-02 | West Pharma. Services IL, Ltd. | Motion activated mechanisms for a drug delivery device |
US9072827B2 (en) | 2012-03-26 | 2015-07-07 | Medimop Medical Projects Ltd. | Fail safe point protector for needle safety flap |
WO2013149186A1 (en) | 2012-03-30 | 2013-10-03 | Insulet Corporation | Fluid delivery device with transcutaneous access tool, insertion mechansim and blood glucose monitoring for use therewith |
KR102070472B1 (en) | 2012-03-30 | 2020-01-29 | 이뮨 디자인 코포레이션 | Lentiviral vector particles having improved transduction efficiency for cells expressing dc-sign |
EP2850091A1 (en) | 2012-04-06 | 2015-03-25 | President and Fellows of Harvard College | Methods and compounds for identifying glycosyltransferase inhibitors |
WO2013152277A2 (en) | 2012-04-06 | 2013-10-10 | President And Fellows Of Harvard College | Moenomycin analogs, methods of synthesis, and uses thereof |
EP2850090B1 (en) | 2012-04-06 | 2018-10-03 | President and Fellows of Harvard College | Chemoenzymatic methods for synthesizing moenomycin analogs |
US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US10130714B2 (en) | 2012-04-14 | 2018-11-20 | Academia Sinica | Enhanced anti-influenza agents conjugated with anti-inflammatory activity |
EP2841098A4 (en) | 2012-04-23 | 2016-03-02 | Allertein Therapeutics Llc | Nanoparticles for treatment of allergy |
EP2662110A1 (en) | 2012-05-10 | 2013-11-13 | Debiotech S.A. | Device and method for inserting needles |
KR102122618B1 (en) | 2012-05-10 | 2020-06-29 | 메사츄세츠 인스티튜트 어브 테크놀로지 | Agents for influenza neutralization |
US9180242B2 (en) | 2012-05-17 | 2015-11-10 | Tandem Diabetes Care, Inc. | Methods and devices for multiple fluid transfer |
US9555186B2 (en) | 2012-06-05 | 2017-01-31 | Tandem Diabetes Care, Inc. | Infusion pump system with disposable cartridge having pressure venting and pressure feedback |
WO2014024026A1 (en) | 2012-08-06 | 2014-02-13 | Glaxosmithkline Biologicals S.A. | Method for eliciting in infants an immune response against rsv and b. pertussis |
US20140037680A1 (en) | 2012-08-06 | 2014-02-06 | Glaxosmithkline Biologicals, S.A. | Novel method |
AU2013203000B9 (en) | 2012-08-10 | 2017-02-02 | Lantheus Medical Imaging, Inc. | Compositions, methods, and systems for the synthesis and use of imaging agents |
JP6302909B2 (en) | 2012-08-18 | 2018-03-28 | アカデミア シニカAcademia Sinica | Cell-permeable probes for sialidase identification and imaging |
WO2014046950A1 (en) | 2012-09-24 | 2014-03-27 | Enable Injections, Llc | Medication vial and injector assemblies and methods of use |
CA3113959A1 (en) | 2012-09-26 | 2014-04-03 | President And Fellows Of Harvard College | Proline-locked stapled peptides and uses thereof |
US20150225471A1 (en) | 2012-10-01 | 2015-08-13 | President And Fellows Of Harvard College | Stabilized polypeptide insulin receptor modulators |
RS58700B1 (en) | 2012-10-12 | 2019-06-28 | Broad Inst Inc | Gsk3 inhibitors and methods of use thereof |
EP2908881A2 (en) * | 2012-10-16 | 2015-08-26 | SwissInnov Product Sàrl | Fluid delivery system and methods |
WO2014063068A1 (en) | 2012-10-18 | 2014-04-24 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 (cdk7) |
WO2014063061A1 (en) | 2012-10-19 | 2014-04-24 | Dana-Farber Cancer Institute, Inc. | Hydrophobically tagged small molecules as inducers of protein degradation |
US10000483B2 (en) | 2012-10-19 | 2018-06-19 | Dana-Farber Cancer Institute, Inc. | Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof |
CN105102000B (en) | 2012-11-01 | 2021-10-22 | 无限药品公司 | Cancer therapy using PI3 kinase subtype modulators |
MX2015005244A (en) | 2012-11-01 | 2015-07-14 | Aileron Therapeutics Inc | Disubstituted amino acids and methods of preparation and use thereof. |
WO2014071247A1 (en) | 2012-11-02 | 2014-05-08 | Dana-Farber Cancer Institute, Inc. | Pyrrol-1 -yl benzoic acid derivates useful as myc inhibitors |
EP2922542A4 (en) | 2012-11-21 | 2016-10-05 | Topokine Therapeutics Inc | Methods and compositions for locally increasing body fat |
US9775915B2 (en) | 2012-11-26 | 2017-10-03 | President And Fellows Of Harvard College | Trioxacarcins, trioxacarcin-antibody conjugates, and uses thereof |
JP6144355B2 (en) | 2012-11-26 | 2017-06-07 | モデルナティエックス インコーポレイテッドModernaTX,Inc. | Chemically modified mRNA |
US9365555B2 (en) | 2012-12-21 | 2016-06-14 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
US9908887B2 (en) | 2012-12-21 | 2018-03-06 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
EP2935222B1 (en) | 2012-12-21 | 2018-09-05 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
JP2016505002A (en) | 2012-12-21 | 2016-02-18 | エピザイム,インコーポレイティド | PRMT5 inhibitors containing dihydroisoquinoline or tetrahydroisoquinoline and uses thereof |
US9421323B2 (en) | 2013-01-03 | 2016-08-23 | Medimop Medical Projects Ltd. | Door and doorstop for portable one use drug delivery apparatus |
WO2014113089A2 (en) | 2013-01-17 | 2014-07-24 | Moderna Therapeutics, Inc. | Signal-sensor polynucleotides for the alteration of cellular phenotypes |
US20140335504A1 (en) | 2013-02-07 | 2014-11-13 | Massachusetts Institute Of Technology | Human adaptation of h5 influenza |
EP2953638B1 (en) | 2013-02-07 | 2023-07-05 | Children's Medical Center Corporation | Protein antigens that provide protection against pneumococcal colonization and/or disease |
EP2991665A4 (en) | 2013-03-13 | 2016-11-09 | Harvard College | Stapled and stitched polypeptides and uses thereof |
WO2014159813A1 (en) | 2013-03-13 | 2014-10-02 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
US9173998B2 (en) | 2013-03-14 | 2015-11-03 | Tandem Diabetes Care, Inc. | System and method for detecting occlusions in an infusion pump |
US9180243B2 (en) | 2013-03-15 | 2015-11-10 | Tandem Diabetes Care, Inc. | Detection of infusion pump conditions |
WO2014151386A1 (en) | 2013-03-15 | 2014-09-25 | Infinity Pharmaceuticals, Inc. | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
EP3760223A1 (en) | 2013-04-03 | 2021-01-06 | N-Fold Llc | Nanoparticle composition for desensitizing a subject to peanut allergens |
US9982005B2 (en) | 2013-04-04 | 2018-05-29 | President And Fellows Of Harvard College | Macrolides and methods of their preparation and use |
ES2774330T3 (en) | 2013-04-09 | 2020-07-20 | Massachusetts Inst Technology | Drug supply polymer and uses thereof |
US10301359B2 (en) | 2013-04-30 | 2019-05-28 | Massachusetts Institute Of Technology | Human adaptation of H3 influenza |
US9011164B2 (en) | 2013-04-30 | 2015-04-21 | Medimop Medical Projects Ltd. | Clip contact for easy installation of printed circuit board PCB |
WO2014179562A1 (en) | 2013-05-01 | 2014-11-06 | Massachusetts Institute Of Technology | 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof |
US9889256B2 (en) | 2013-05-03 | 2018-02-13 | Medimop Medical Projects Ltd. | Sensing a status of an infuser based on sensing motor control and power input |
NO2753788T3 (en) | 2013-05-10 | 2018-06-16 | ||
EP2803376A1 (en) * | 2013-05-16 | 2014-11-19 | Georg Fischer | Novel active emergency supply valve |
RU2705204C2 (en) | 2013-05-30 | 2019-11-06 | Инфинити Фармасьютикалз, Инк. | Treating malignant tumors using piz-kinase isoform modulators |
US10526375B2 (en) | 2013-06-05 | 2020-01-07 | Massachusetts Institute Of Technology | Human Adaptation of H7 HA |
JP6469661B2 (en) | 2013-06-11 | 2019-02-13 | カラ ファーマシューティカルズ インコーポレイテッド | Urea derivatives and uses thereof |
KR20160019547A (en) | 2013-06-14 | 2016-02-19 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | Stabilized polypeptide insulin receptor modulators |
WO2014204894A2 (en) * | 2013-06-18 | 2014-12-24 | Enable Injections, Llc | Vial transfer and injection apparatus and method |
WO2014210397A1 (en) | 2013-06-26 | 2014-12-31 | Academia Sinica | Rm2 antigens and use thereof |
US9981030B2 (en) | 2013-06-27 | 2018-05-29 | Academia Sinica | Glycan conjugates and use thereof |
BR112016001457A2 (en) | 2013-07-25 | 2017-08-29 | Dana Farber Cancer Inst Inc | TRANSCRIPTION FACTOR INHIBITORS AND THEIR USES |
CN105555304A (en) | 2013-08-05 | 2016-05-04 | 葛兰素史密丝克莱恩生物有限公司 | Combination immunogenic compositions |
WO2015021058A2 (en) | 2013-08-05 | 2015-02-12 | Greenlight Biosciences, Inc. | Engineered proteins with a protease cleavage site |
CN105682666B (en) | 2013-09-06 | 2021-06-01 | 中央研究院 | Activation of human iNKT cells using glycolipids |
US9751888B2 (en) | 2013-10-04 | 2017-09-05 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
TWI657085B (en) | 2013-10-04 | 2019-04-21 | 英菲尼提製藥股份有限公司 | Heterocyclic compounds and uses thereof |
US9982009B2 (en) | 2013-10-15 | 2018-05-29 | Massachusetts Institute Of Technology | Methods for treating polycystic kidney disease and polycystic liver disease |
US9902986B2 (en) | 2013-10-16 | 2018-02-27 | Massachusetts Institute Of Technology | Enterobactin conjugates and uses thereof |
CA2927917C (en) | 2013-10-18 | 2022-08-09 | Syros Pharmaceuticals, Inc. | Heteroaromatic compounds useful for the treatment of proliferative diseases |
WO2015058140A1 (en) | 2013-10-18 | 2015-04-23 | Dana-Farber Cancer Institute, Inc. | Polycyclic inhibitors of cyclin-dependent kinase 7 (cdk7) |
WO2015061204A1 (en) | 2013-10-21 | 2015-04-30 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US9458169B2 (en) | 2013-11-01 | 2016-10-04 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
AU2014369834B2 (en) | 2013-12-24 | 2018-12-20 | President And Fellows Of Harvard College | Cortistatin analogues and syntheses and uses thereof |
EP3094352B1 (en) | 2014-01-16 | 2020-09-23 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
US10150818B2 (en) | 2014-01-16 | 2018-12-11 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
GB2523989B (en) | 2014-01-30 | 2020-07-29 | Insulet Netherlands B V | Therapeutic product delivery system and method of pairing |
WO2015117087A1 (en) | 2014-01-31 | 2015-08-06 | Dana-Farber Cancer Institute, Inc. | Uses of diazepane derivatives |
EP3119415A4 (en) | 2014-03-07 | 2017-11-29 | The Arizona Board of Regents on behalf of the University of Arizona | Non-narcotic crmp2 peptides targeting sodium channels for chronic pain |
JP6701088B2 (en) | 2014-03-19 | 2020-05-27 | インフィニティー ファーマシューティカルズ, インコーポレイテッド | Heterocyclic compounds for use in the treatment of PI3K-gamma mediated disorders |
EP3129767B1 (en) | 2014-03-27 | 2021-09-01 | Academia Sinica | Reactive labelling compounds and uses thereof |
US10293035B2 (en) | 2014-03-28 | 2019-05-21 | University Of Washington Through Its Center For Commercialization | Breast and ovarian cancer vaccines |
US9862688B2 (en) | 2014-04-23 | 2018-01-09 | Dana-Farber Cancer Institute, Inc. | Hydrophobically tagged janus kinase inhibitors and uses thereof |
WO2015164614A1 (en) | 2014-04-23 | 2015-10-29 | Dana-Farber Cancer Institute, Inc. | Janus kinase inhibitors and uses thereof |
WO2015168079A1 (en) | 2014-04-29 | 2015-11-05 | Infinity Pharmaceuticals, Inc. | Pyrimidine or pyridine derivatives useful as pi3k inhibitors |
WO2015168380A1 (en) | 2014-04-30 | 2015-11-05 | Massachusetts Institute Of Technology | Siderophore-based immunization against gram-negative bacteria |
JP6759109B2 (en) | 2014-05-21 | 2020-09-23 | プレジデント アンド フェローズ オブ ハーバード カレッジ | RAS inhibitory peptides and their use |
TWI679020B (en) | 2014-05-27 | 2019-12-11 | 中央研究院 | Anti-her2 glycoantibodies and uses thereof |
US10118969B2 (en) | 2014-05-27 | 2018-11-06 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
TWI717319B (en) | 2014-05-27 | 2021-02-01 | 中央研究院 | Fucosidase from bacteroides and methods using the same |
KR20170003720A (en) | 2014-05-27 | 2017-01-09 | 아카데미아 시니카 | Anti-cd20 glycoantibodies and uses thereof |
KR102494193B1 (en) | 2014-05-28 | 2023-01-31 | 아카데미아 시니카 | Anti-tnf-alpha glycoantibodies and uses thereof |
CA2951430A1 (en) | 2014-06-13 | 2015-12-17 | Glaxosmithkline Biologicals Sa | Immunogenic combinations |
CR20170011A (en) | 2014-06-19 | 2017-04-04 | Ariad Pharma Inc | HETEROARILO COMPOUNDS FOR INHIBITION OF CINASA |
WO2015200425A1 (en) | 2014-06-27 | 2015-12-30 | Topokine Therapeutics, Inc. | Topical dosage regimen |
WO2016004202A1 (en) | 2014-07-02 | 2016-01-07 | Massachusetts Institute Of Technology | Polyamine-fatty acid derived lipidoids and uses thereof |
WO2016011386A1 (en) | 2014-07-18 | 2016-01-21 | University Of Washington | Cancer vaccine compositions and methods of use thereof |
US10736966B2 (en) | 2014-08-12 | 2020-08-11 | Massachusetts Institute Of Technology | Brush-poly (glycoamidoamine)-lipids and uses thereof |
CN107001404B (en) | 2014-09-08 | 2021-06-29 | 中央研究院 | Activation of human iNKT cells using glycolipids |
WO2016049359A1 (en) | 2014-09-24 | 2016-03-31 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
MX2017003819A (en) | 2014-09-24 | 2017-06-15 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and formulations thereof. |
US10159786B2 (en) | 2014-09-30 | 2018-12-25 | Perqflo, Llc | Hybrid ambulatory infusion pumps |
US9708348B2 (en) | 2014-10-03 | 2017-07-18 | Infinity Pharmaceuticals, Inc. | Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof |
EA035145B1 (en) | 2014-10-21 | 2020-05-06 | Ариад Фармасьютикалз, Инк. | Crystalline forms of 5-chloro-n4-[-2-(dimethylphosphoryl)phenyl]-n2-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]pyrimidine-2,4-diamine |
US20180015101A1 (en) | 2014-10-28 | 2018-01-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Compositions and methods for antigen-specific tolerance |
EP3461904A1 (en) | 2014-11-10 | 2019-04-03 | ModernaTX, Inc. | Alternative nucleic acid molecules containing reduced uracil content and uses thereof |
WO2016086026A1 (en) | 2014-11-26 | 2016-06-02 | Kala Pharmaceuticals, Inc. | Crystalline forms of a therapeutic compound and uses thereof |
EP3230272B1 (en) | 2014-12-10 | 2020-08-19 | Kala Pharmaceuticals, Inc. | 1-amino-triazolo(1,5-a)pyridine-substituted urea derivative and uses thereof |
WO2016100949A2 (en) | 2014-12-18 | 2016-06-23 | Windgap Medical, Inc. | Method and compositions for dissolving or solubilizing therapeutic agents |
AU2015369707B2 (en) | 2014-12-23 | 2020-07-23 | Sloan-Kettering Institute For Cancer Research | Polymorph of granaticin B |
AU2015371251B2 (en) | 2014-12-23 | 2020-06-11 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 (CDK7) |
US10495645B2 (en) | 2015-01-16 | 2019-12-03 | Academia Sinica | Cancer markers and methods of use thereof |
US9975965B2 (en) | 2015-01-16 | 2018-05-22 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
JP6779887B2 (en) | 2015-01-24 | 2020-11-04 | アカデミア シニカAcademia Sinica | New glycan conjugate and how to use it |
EP3258989B1 (en) | 2015-02-18 | 2020-01-01 | Medtronic Minimed, Inc. | Ambulatory infusion pump with static and dynamic seals |
US10737024B2 (en) | 2015-02-18 | 2020-08-11 | Insulet Corporation | Fluid delivery and infusion devices, and methods of use thereof |
US9730625B2 (en) * | 2015-03-02 | 2017-08-15 | Verily Life Sciences Llc | Automated blood sampling device |
US10765361B2 (en) * | 2015-03-02 | 2020-09-08 | Verily Life Sciences Llc | Automated sequential injection and blood draw |
US10251813B2 (en) | 2015-03-04 | 2019-04-09 | West Pharma. Services IL, Ltd. | Flexibly mounted cartridge alignment collar for drug delivery device |
US9795534B2 (en) | 2015-03-04 | 2017-10-24 | Medimop Medical Projects Ltd. | Compliant coupling assembly for cartridge coupling of a drug delivery device |
WO2016154058A1 (en) | 2015-03-20 | 2016-09-29 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
WO2016160617A2 (en) | 2015-03-27 | 2016-10-06 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
JP6843065B2 (en) | 2015-03-30 | 2021-03-17 | グリーンライト バイオサイエンシーズ インコーポレーテッドGreenlight Biosciences,Inc. | Cell-free production of ribonucleic acid |
US9744297B2 (en) | 2015-04-10 | 2017-08-29 | Medimop Medical Projects Ltd. | Needle cannula position as an input to operational control of an injection device |
US10293120B2 (en) | 2015-04-10 | 2019-05-21 | West Pharma. Services IL, Ltd. | Redundant injection device status indication |
AU2016255770A1 (en) | 2015-04-27 | 2017-11-16 | University Of Florida Research Foundation, Incorporated | Metabolically programmed metal chelators and uses thereof |
WO2016178591A2 (en) | 2015-05-05 | 2016-11-10 | Gene Predit, Sa | Genetic markers and treatment of male obesity |
US10149943B2 (en) | 2015-05-29 | 2018-12-11 | West Pharma. Services IL, Ltd. | Linear rotation stabilizer for a telescoping syringe stopper driverdriving assembly |
EP3302652B1 (en) | 2015-06-04 | 2023-09-06 | Medimop Medical Projects Ltd. | Cartridge insertion for drug delivery device |
CA2986441A1 (en) | 2015-06-12 | 2016-12-15 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
CA2990172A1 (en) | 2015-06-19 | 2016-12-22 | Massachusetts Institute Of Technology | Alkenyl substituted 2,5-piperazinediones and their use in compositions for delivering an agent to a subject or cell |
US10059741B2 (en) | 2015-07-01 | 2018-08-28 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
JP7028766B2 (en) | 2015-09-09 | 2022-03-02 | ダナ-ファーバー キャンサー インスティテュート, インコーポレイテッド | Inhibitor of cyclin-dependent kinase |
CN108368161A (en) | 2015-09-10 | 2018-08-03 | 艾瑞朗医疗公司 | Peptidomimetic macrocyclic compound as MCL-1 conditioning agents |
DK3350333T3 (en) | 2015-09-17 | 2022-01-31 | Modernatx Inc | POLYNUCLEOTIDES CONTAINING A STABILIZING TAIL REGION |
LT3350157T (en) | 2015-09-17 | 2022-02-25 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of therapeutic agents |
US9987432B2 (en) | 2015-09-22 | 2018-06-05 | West Pharma. Services IL, Ltd. | Rotation resistant friction adapter for plunger driver of drug delivery device |
US10576207B2 (en) | 2015-10-09 | 2020-03-03 | West Pharma. Services IL, Ltd. | Angled syringe patch injector |
WO2017059389A1 (en) | 2015-10-01 | 2017-04-06 | Kythera Biopharmaceuticals, Inc. | Compositions comprising a statin for use in methods of adipolysis |
CN108472438B (en) | 2015-10-09 | 2022-01-28 | 西医药服务以色列分公司 | Tortuous fluid path attachment to pre-filled fluid reservoirs |
BR112018008911A2 (en) | 2015-11-09 | 2018-11-27 | Immune Design Corp | compositions comprising lentiviral vectors expressing il-12 and methods of use thereof |
EP3374373B1 (en) | 2015-11-09 | 2022-12-21 | Immune Design Corp. | A retroviral vector for the administration and expression of replicon rna expressing heterologous nucleic acids |
EP3380061A4 (en) | 2015-11-24 | 2019-07-24 | Insulet Corporation | Wearable automated medication delivery system |
WO2017091584A1 (en) | 2015-11-25 | 2017-06-01 | Insulet Corporation | Wearable medication delivery device |
JP7114465B2 (en) | 2015-12-22 | 2022-08-08 | モデルナティエックス インコーポレイテッド | Compounds and compositions for intracellular delivery of drugs |
WO2017123525A1 (en) | 2016-01-13 | 2017-07-20 | Bigfoot Biomedical, Inc. | User interface for diabetes management system |
EP3453414A1 (en) | 2016-01-14 | 2019-03-13 | Bigfoot Biomedical, Inc. | Adjusting insulin delivery rates |
US10646643B2 (en) | 2016-01-21 | 2020-05-12 | West Pharma. Services IL, Ltd. | Needle insertion and retraction mechanism |
JP6513297B2 (en) | 2016-01-21 | 2019-05-22 | ウェスト ファーマ サービシーズ イスラエル リミテッド | Automatic injector, receiving frame and method of connecting cartridge in automatic injector |
JP6885960B2 (en) | 2016-01-21 | 2021-06-16 | ウェスト ファーマ サービシーズ イスラエル リミテッド | Drug delivery device with visual indicators |
US10363342B2 (en) | 2016-02-04 | 2019-07-30 | Insulet Corporation | Anti-inflammatory cannula |
EP3413954A1 (en) | 2016-02-12 | 2018-12-19 | Perqflo, LLC | Ambulatory infusion pumps and assemblies for use with same |
CN109154005A (en) | 2016-02-23 | 2019-01-04 | 免疫设计股份有限公司 | Polygenes group retroviral vector preparation and for generate and using said preparation method and system |
CA3016170A1 (en) | 2016-03-08 | 2017-09-14 | Academia Sinica | Methods for modular synthesis of n-glycans and arrays thereof |
US9827369B2 (en) * | 2016-03-16 | 2017-11-28 | Baxter International Inc. | Percutaneous administration device and method for injecting medicinal substances |
WO2017161076A1 (en) | 2016-03-16 | 2017-09-21 | Medimop Medical Projects Ltd. | Staged telescopic screw assembly having different visual indicators |
WO2017161116A1 (en) | 2016-03-17 | 2017-09-21 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors |
CR20180525A (en) | 2016-04-06 | 2019-02-14 | Greenlight Biosciences Inc | RIBONUCLEIC ACID PRODUCTION FREE OF CELLS |
CN109310831B (en) | 2016-06-02 | 2021-11-23 | 西医药服务以色列有限公司 | Three position needle retraction |
US11116832B2 (en) | 2016-06-03 | 2021-09-14 | Sanofi Pasteur Inc. | Modification of engineered influenza hemagglutinin polypeptides |
WO2017214337A1 (en) | 2016-06-07 | 2017-12-14 | Massachusetts Institute Of Technology | Drug delivery polymers and uses thereof |
WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
AU2017286606A1 (en) | 2016-06-14 | 2018-12-13 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
EP3490643B1 (en) | 2016-08-01 | 2021-10-27 | West Pharma. Services Il, Ltd. | Anti-rotation cartridge pin |
US11730892B2 (en) | 2016-08-01 | 2023-08-22 | West Pharma. Services IL, Ltd. | Partial door closure prevention spring |
MX2019001341A (en) | 2016-08-05 | 2019-07-04 | Sanofi Pasteur Inc | Multivalent pneumococcal polysaccharide-protein conjugate composition. |
JP7001687B2 (en) | 2016-08-05 | 2022-02-04 | サノフィ パスツール インコーポレイティッド | Polyvalent pneumococcal polysaccharide-protein conjugate composition |
JP7213549B2 (en) | 2016-08-22 | 2023-01-27 | シーエイチオー ファーマ インコーポレイテッド | Antibodies, Binding Fragments, and Methods of Use |
EP3515535A1 (en) | 2016-09-23 | 2019-07-31 | Insulet Corporation | Fluid delivery device with sensor |
US11452820B2 (en) | 2016-09-27 | 2022-09-27 | Sanofi-Aventis Deutschland Gmbh | Medicament delivery device |
US11547791B2 (en) | 2016-09-27 | 2023-01-10 | Sanofi-Aventis Deutschland Gmbh | Medicament delivery device |
CN110035781B (en) * | 2016-09-27 | 2022-07-19 | 赛诺菲-安万特德国有限公司 | Medicament delivery device |
US11583504B2 (en) | 2016-11-08 | 2023-02-21 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
CN117731591A (en) | 2016-11-21 | 2024-03-22 | 艾里奥治疗公司 | Transdermal delivery of large agents |
WO2018106738A1 (en) | 2016-12-05 | 2018-06-14 | Massachusetts Institute Of Technology | Brush-arm star polymers, conjugates and particles, and uses thereof |
CA3046816A1 (en) | 2016-12-15 | 2018-06-21 | Pka Softtouch Corp. | Intradermal drug delivery device having a locked post-dispensing configuration |
US20180207369A1 (en) * | 2017-01-23 | 2018-07-26 | Enable Injections, Inc. | Medical fluid injection device with fill indicator |
WO2018148180A2 (en) | 2017-02-07 | 2018-08-16 | Immune Design Corp. | Materials and methods for identifying and treating cancer patients |
WO2018156548A1 (en) | 2017-02-22 | 2018-08-30 | Insulet Corporation | Needle insertion mechanisms for drug containers |
WO2018170336A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Lipid nanoparticle formulation |
RS63953B1 (en) | 2017-03-15 | 2023-02-28 | Modernatx Inc | Compound and compositions for intracellular delivery of therapeutic agents |
WO2018175324A1 (en) | 2017-03-20 | 2018-09-27 | The Broad Institute, Inc. | Compounds and methods for regulating insulin secretion |
BR112019020810A2 (en) | 2017-04-05 | 2020-04-28 | Biogen Ma Inc | tricyclic compounds as glycogen synthase kinase 3 (gsk3) inhibitors and uses thereof |
CN110869072B (en) | 2017-05-30 | 2021-12-10 | 西部制药服务有限公司(以色列) | Modular drive mechanism for a wearable injector |
WO2018232120A1 (en) | 2017-06-14 | 2018-12-20 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of agents |
US11260171B2 (en) | 2017-07-04 | 2022-03-01 | Medtronic Minimed, Inc. | Ambulatory infusion pumps and assemblies for use with same |
WO2019013789A1 (en) | 2017-07-12 | 2019-01-17 | Curza Global, Llc | Antimicrobial compounds |
WO2019013790A1 (en) | 2017-07-12 | 2019-01-17 | Curza Global, Llc | Antimicrobial compounds and uses thereof |
CA3073211A1 (en) | 2017-08-31 | 2019-03-07 | Modernatx, Inc. | Methods of making lipid nanoparticles |
WO2019067367A1 (en) | 2017-09-26 | 2019-04-04 | Insulet Corporation | Needle mechanism module for drug delivery device |
WO2019075167A1 (en) | 2017-10-11 | 2019-04-18 | Greenlight Biosciences, Inc. | Methods and compositions for nucleoside triphosphate and ribonucleic acid production |
US11147931B2 (en) | 2017-11-17 | 2021-10-19 | Insulet Corporation | Drug delivery device with air and backflow elimination |
WO2019109079A1 (en) | 2017-12-01 | 2019-06-06 | North Carolina State University | Fibrin particles and methods of making the same |
CN114470420A (en) | 2017-12-22 | 2022-05-13 | 西氏医药包装(以色列)有限公司 | Syringe adapted for cartridges of different sizes |
USD928199S1 (en) | 2018-04-02 | 2021-08-17 | Bigfoot Biomedical, Inc. | Medication delivery device with icons |
US11583633B2 (en) | 2018-04-03 | 2023-02-21 | Amgen Inc. | Systems and methods for delayed drug delivery |
CN112236826A (en) | 2018-05-04 | 2021-01-15 | 英赛罗公司 | Safety constraints for drug delivery systems based on control algorithms |
SG11202102478SA (en) | 2018-09-13 | 2021-04-29 | Eirion Therapeutics Inc | Plasminogen activator inhibitor 1 (pai-1) inhibitors and uses therefor |
AU2019339488A1 (en) | 2018-09-13 | 2021-04-08 | Eirion Therapeutics, Inc. | Uses of plasminogen activator inhibitor 1 (PAI-1) inhibitors |
US20220409536A1 (en) | 2018-09-19 | 2022-12-29 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of therapeutic agents |
EP3852728A1 (en) | 2018-09-20 | 2021-07-28 | Modernatx, Inc. | Preparation of lipid nanoparticles and methods of administration thereof |
CA3112209C (en) | 2018-09-28 | 2023-08-29 | Insulet Corporation | Activity mode for artificial pancreas system |
US11565039B2 (en) | 2018-10-11 | 2023-01-31 | Insulet Corporation | Event detection for drug delivery system |
EP3890704A1 (en) | 2018-12-03 | 2021-10-13 | Eirion Therapeutics, Inc. | Improved delivery of large agents |
WO2020150372A1 (en) | 2019-01-16 | 2020-07-23 | Curza Global, Llc | Antimicrobial compounds and methods |
AU2020209170A1 (en) | 2019-01-16 | 2021-08-12 | Curza Global, Llc | Antimicrobial compounds and methods |
CA3128215A1 (en) | 2019-01-31 | 2020-08-06 | Modernatx, Inc. | Methods of preparing lipid nanoparticles |
WO2020168466A1 (en) | 2019-02-19 | 2020-08-27 | Stemirna Therapeutics Co., Ltd. | Modified nucleoside and synthetic methods thereof |
EP3969038A1 (en) | 2019-05-14 | 2022-03-23 | Eirion Therapeutics, Inc. | Delaying peak effect and/or extending duration of response |
US20220280639A1 (en) | 2019-07-31 | 2022-09-08 | Modernatx, Inc. | Compositions and methods for delivery of rna interference agents to immune cells |
CN114728050A (en) | 2019-07-31 | 2022-07-08 | 圣诺菲·帕斯图尔公司 | Multivalent pneumococcal polysaccharide-protein conjugate compositions and methods of use thereof |
WO2021034858A1 (en) * | 2019-08-22 | 2021-02-25 | Verily Life Sciences Llc | Capillary blood collection using varying number of lancets |
US11801344B2 (en) | 2019-09-13 | 2023-10-31 | Insulet Corporation | Blood glucose rate of change modulation of meal and correction insulin bolus quantity |
US11935637B2 (en) | 2019-09-27 | 2024-03-19 | Insulet Corporation | Onboarding and total daily insulin adaptivity |
WO2021097061A1 (en) | 2019-11-13 | 2021-05-20 | Curza Global, Llc | Antimicrobial compounds and methods |
US11833329B2 (en) | 2019-12-20 | 2023-12-05 | Insulet Corporation | Techniques for improved automatic drug delivery performance using delivery tendencies from past delivery history and use patterns |
US20230285297A1 (en) | 2020-01-31 | 2023-09-14 | Modernatx, Inc. | Methods of preparing lipid nanoparticles |
US11551802B2 (en) | 2020-02-11 | 2023-01-10 | Insulet Corporation | Early meal detection and calorie intake detection |
US11547800B2 (en) | 2020-02-12 | 2023-01-10 | Insulet Corporation | User parameter dependent cost function for personalized reduction of hypoglycemia and/or hyperglycemia in a closed loop artificial pancreas system |
US11324889B2 (en) | 2020-02-14 | 2022-05-10 | Insulet Corporation | Compensation for missing readings from a glucose monitor in an automated insulin delivery system |
WO2021173965A1 (en) | 2020-02-28 | 2021-09-02 | Massachusetts Institute Of Technology | Identification of variable influenza residues and uses thereof |
US11607493B2 (en) | 2020-04-06 | 2023-03-21 | Insulet Corporation | Initial total daily insulin setting for user onboarding |
WO2021231729A1 (en) | 2020-05-13 | 2021-11-18 | Sanofi | Adjuvanted stabilized stem hemagglutinin nanoparticles and methods of using the same to induce broadly neutralizing antibodies against influenza |
US11684716B2 (en) | 2020-07-31 | 2023-06-27 | Insulet Corporation | Techniques to reduce risk of occlusions in drug delivery systems |
US20230390296A1 (en) | 2020-10-30 | 2023-12-07 | Keio University | Novel treatment and prevention of sarcopenia-related diseases |
CN116710116A (en) | 2020-10-30 | 2023-09-05 | Xeno-Interface株式会社 | Beta-sheet femoral bridge peptide |
TW202237068A (en) | 2020-12-09 | 2022-10-01 | 美商建南德克公司 | High-throughput methods for preparing lipid nanoparticles and uses thereof |
CN112972821A (en) * | 2021-02-04 | 2021-06-18 | 四川大学华西医院 | Postoperative is with safe continuous automatic electron pressure analgesia infusion device |
WO2022192176A1 (en) | 2021-03-09 | 2022-09-15 | Massachusetts Institute Of Technology | Branched poly(-amino esters) for the delivery of nucleic acids |
US11904140B2 (en) | 2021-03-10 | 2024-02-20 | Insulet Corporation | Adaptable asymmetric medicament cost component in a control system for medicament delivery |
TW202313065A (en) | 2021-05-28 | 2023-04-01 | 美商季卡尼醫療公司 | Compounds for treating genetic diseases |
WO2023018817A1 (en) | 2021-08-11 | 2023-02-16 | Sanofi Pasteur Inc. | Truncated influenza neuraminidase and methods of using the same |
WO2023038778A1 (en) * | 2021-08-19 | 2023-03-16 | Innovative Health Strategies Llc | A smart self-activating wearable device for automatically injecting medicines |
WO2023049900A1 (en) | 2021-09-27 | 2023-03-30 | Insulet Corporation | Techniques enabling adaptation of parameters in aid systems by user input |
WO2023059857A1 (en) | 2021-10-08 | 2023-04-13 | Sanofi Pasteur Inc. | Multivalent influenza vaccines |
WO2023079113A1 (en) | 2021-11-05 | 2023-05-11 | Sanofi | Hybrid multivalent influenza vaccines comprising hemagglutinin and neuraminidase and methods of using the same |
WO2023081798A1 (en) | 2021-11-05 | 2023-05-11 | Sanofi Pasteur Inc. | Multivalent influenza vaccines comprising recombinant hemagglutinin and neuraminidase and methods of using the same |
US11439754B1 (en) | 2021-12-01 | 2022-09-13 | Insulet Corporation | Optimizing embedded formulations for drug delivery |
TW202333654A (en) | 2021-12-16 | 2023-09-01 | 美商現代公司 | Processes for preparing lipid nanoparticles |
WO2023129963A1 (en) | 2021-12-30 | 2023-07-06 | Curza Global, Llc | Antimicrobial compounds and methods |
WO2023144206A1 (en) | 2022-01-27 | 2023-08-03 | Sanofi Pasteur | Modified vero cells and methods of using the same for virus production |
WO2023177579A1 (en) | 2022-03-14 | 2023-09-21 | Sanofi Pasteur Inc. | Machine-learning techniques in protein design for vaccine generation |
CN114632218B (en) * | 2022-03-14 | 2024-03-08 | 重庆倍加医疗器械有限公司 | Pneumatic driving injection device |
WO2023193002A1 (en) | 2022-04-01 | 2023-10-05 | Modernatx, Inc. | Cross mixers for lipid nanoparticle production, and methods of operating the same |
WO2023235380A1 (en) | 2022-06-01 | 2023-12-07 | Zikani Therapeutics, Inc. | Macrolides for treating genetic diseases |
WO2023250513A1 (en) | 2022-06-24 | 2023-12-28 | Zikani Therapeutics, Inc. | 13-membered macrolide compounds for treating diseases mediated by abnormal protein translation |
WO2024026487A1 (en) | 2022-07-29 | 2024-02-01 | Modernatx, Inc. | Lipid nanoparticle compositions comprising phospholipid derivatives and related uses |
WO2024026482A1 (en) | 2022-07-29 | 2024-02-01 | Modernatx, Inc. | Lipid nanoparticle compositions comprising surface lipid derivatives and related uses |
WO2024026475A1 (en) | 2022-07-29 | 2024-02-01 | Modernatx, Inc. | Compositions for delivery to hematopoietic stem and progenitor cells (hspcs) and related uses |
WO2024049994A1 (en) | 2022-09-01 | 2024-03-07 | Zikani Therapeutics, Inc. | Treatment of familial adenomatous polyopsis using a 13-membered macrolide |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB207710A (en) * | 1923-08-29 | 1923-12-06 | George Henry Watts | Improvements in horse and like shoes |
SU787035A1 (en) * | 1978-01-11 | 1980-12-15 | Всесоюзный научно-исследовательский и испытательный институт медицинской техники | Device for injection of medical preparations |
CA1169323A (en) * | 1980-06-03 | 1984-06-19 | Anthony M. Albisser | Insulin infusion device |
US4316463A (en) * | 1981-01-26 | 1982-02-23 | Vac-O-Cast, Inc. | Corrosive protected hypodermic module |
US4340048A (en) * | 1981-03-28 | 1982-07-20 | Alza Corporation | Self-driven hypodermic injector |
US4525164A (en) * | 1981-04-24 | 1985-06-25 | Biotek, Inc. | Wearable medication infusion system with arcuated reservoir |
SE436687B (en) * | 1981-12-14 | 1985-01-21 | Anders Blomberg | INJECTION DEVICE |
AU8704582A (en) * | 1982-03-15 | 1983-09-22 | Ralph Franco | Aid for inserting needle |
DE3227051A1 (en) * | 1982-07-20 | 1984-02-02 | B. Braun Melsungen Ag, 3508 Melsungen | HOSE PUMP, ESPECIALLY FOR MEDICAL APPLICATIONS |
US4552561A (en) * | 1982-12-23 | 1985-11-12 | Alza Corporation | Body mounted pump housing and pump assembly employing the same |
DE3417757C2 (en) * | 1984-05-12 | 1994-11-10 | Lucas Dieter Dr | Hypodermic syringe |
EP0168675B1 (en) * | 1984-06-21 | 1990-04-11 | David R. Fischell | Finger actuated medication infusion system |
JPS61176336A (en) * | 1985-01-31 | 1986-08-08 | オリンパス光学工業株式会社 | Treatment jig for endoscope |
US4626244A (en) * | 1985-02-01 | 1986-12-02 | Consolidated Controls Corporation | Implantable medication infusion device |
EP0195637A3 (en) * | 1985-03-20 | 1987-08-19 | Knight, Robert Leonard Harry | An infusion apparatus |
US4596556A (en) * | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
US4734092A (en) * | 1987-02-18 | 1988-03-29 | Ivac Corporation | Ambulatory drug delivery device |
-
1987
- 1987-12-04 CA CA000553554A patent/CA1283827C/en not_active Expired - Lifetime
- 1987-12-04 US US07/129,018 patent/US4886499A/en not_active Expired - Lifetime
- 1987-12-07 EP EP87118076A patent/EP0272530B1/en not_active Expired - Lifetime
- 1987-12-07 AT AT87118076T patent/ATE68358T1/en not_active IP Right Cessation
- 1987-12-07 DE DE8787118076T patent/DE3773867D1/en not_active Expired - Lifetime
- 1987-12-08 NZ NZ222839A patent/NZ222839A/en unknown
- 1987-12-11 ZA ZA879351A patent/ZA879351B/en unknown
- 1987-12-14 IL IL84811A patent/IL84811A/en not_active IP Right Cessation
- 1987-12-15 KR KR1019870014351A patent/KR960000845B1/en not_active IP Right Cessation
- 1987-12-15 PH PH36231A patent/PH26445A/en unknown
- 1987-12-17 JP JP62320045A patent/JP2648314B2/en not_active Expired - Lifetime
- 1987-12-17 DK DK665887A patent/DK170660B1/en not_active IP Right Cessation
- 1987-12-17 AU AU82663/87A patent/AU620536B2/en not_active Expired
- 1987-12-17 IE IE343087A patent/IE60868B1/en not_active IP Right Cessation
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1994
- 1994-03-24 HK HK274/94A patent/HK27494A/en not_active IP Right Cessation
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IE873430L (en) | 1988-06-18 |
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HK27494A (en) | 1994-03-31 |
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AU620536B2 (en) | 1992-02-20 |
KR880007095A (en) | 1988-08-26 |
US4886499A (en) | 1989-12-12 |
NZ222839A (en) | 1991-03-26 |
DK170660B1 (en) | 1995-11-27 |
EP0272530A3 (en) | 1988-08-31 |
IL84811A (en) | 1993-02-21 |
AU8266387A (en) | 1988-06-23 |
EP0272530B1 (en) | 1991-10-16 |
ATE68358T1 (en) | 1991-11-15 |
DE3773867D1 (en) | 1991-11-21 |
PH26445A (en) | 1992-07-15 |
KR960000845B1 (en) | 1996-01-13 |
JPS63164963A (en) | 1988-07-08 |
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