CA1255052A - Prosthetic heart valve - Google Patents

Prosthetic heart valve

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Publication number
CA1255052A
CA1255052A CA000486255A CA486255A CA1255052A CA 1255052 A CA1255052 A CA 1255052A CA 000486255 A CA000486255 A CA 000486255A CA 486255 A CA486255 A CA 486255A CA 1255052 A CA1255052 A CA 1255052A
Authority
CA
Canada
Prior art keywords
prosthetic valve
valve
upper portion
flap
tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000486255A
Other languages
French (fr)
Inventor
Shlomo Gabbay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shelhigh Inc
Original Assignee
Shelhigh Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shelhigh Inc filed Critical Shelhigh Inc
Application granted granted Critical
Publication of CA1255052A publication Critical patent/CA1255052A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/0075—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/90—Stent for heart valve

Abstract

Abstract of the Disclosure An improved prosthetic heart valve comprises a support body or stent covered by a layer of biological tissue having only the smooth surfaces thereof presented outwardly. The stent has a cutaway section and a flexible cusp sewn thereto for opening and closing the valve. The valve cusp is made of pericardial tissue which has been doubled over such that the rough side thereof is folded inwardly. A sewing ring is secured around the base of the stent and is made of pericardial or other biological material, so as to increase the likelihood of the sewing ring becoming covered with epithelium. The smooth-surfaced biological construction of the valve is highly durable and reduces the risk of thrombogenic or infection sites.

Description

Inventor: Shlomo Gabbay PROSTHETIC HEART VALVE

Field of the inv~ntion This invention relates to prosthetic valves for regulating blood flow and more particularly to a prosthetic heart valve.

Description of the Prior art In the field of heart valves, conventional prosthetic valves have problems with turbulence which restricts the flow of blood and may cause blood clots, irritation or scarring of the heart wall, or clicking sounds of the valve which can be uncomfortable or disturbing. In. U.S. Patent No. 4,275,469, I disclosed an improved prosthetic heart valve consisting of an open wire frame or a tubular membrane having a flexible inlet end to be attached to the annulus o~ ~ heart and an outlet end having an extended single flap or cusp adapted to move toward and away from the membrane wall so as to close or open the valve at the outlet end.
I have also disclosed an improved form of two-cusp heart valve maintained by a semiflexible support right which closely simulate a natural heart valve, in my U.S. Patent No. 4,491,986, dated January ~, 1985.

However, these and other known forms of heart valves have the problem that areas made of exposed synkhetic material, tj~

.~ ., .
~25.5~z such as the sewing ring by which the valve is attached to the heart wal.l, remain uncovered and are not endothelialized, i.e , enveloped in biological tissue. One reason for this phenomenon i8 that synthetic material tends to reject coverage by livin~
! tissue, i.e. epithelium, or have collecting surfaces that become thrombogenic sites. I have also found that even biological tissue, such as pericardium, which has a rough surface on one side that is usually facing inwardly of the valve in the blood flow area, has the risk of sites on the rough areas tending to cause formation of blood clots leading I . to.thromboembolisms. A related problem is a relatively high ! incidence of infection (endocarditis) due to bacterial growt~
or accumulation of vegetation at such collecting sites. In 1 particular, I have found that the use of pericardial tissue, I having a rough side oriented in the blood flow area, presents a ~j risk of infection or thrombogenesis due to platelet ! accumulation or vegetation growth on the rough surface.
Accordinglyl it is a principal object of the invention to provide a prosthetic heart valve wbich is constructed and made of materials so as to minimize thrombogenic risk. It is a further object to provide a heart valve which ha~ a reduced risk of infectionJ and is flexible, durable and can function for a.lon~ time without failure.
,'', Summary of the Invention In accordance with my invention, an improved prosthetic heart valve has a supporting frame or stent of flexible and durable construction which is covered by biological tissue, such as pericardial material, and has a flap .30 or cusp formed from pericardial material which is folded over so as to present only the smooth surfaces thereof outwardly in the blood flow area~

~5S~S2 The stent is preferably cylindrical in shape and has a cutaway portion at its outlet end which is shaped to accommodate a flap or cusp of the valve suitably in its open or closed positions. The edge of the cutaway portion is preferably lined with a strip of silicone, one or more layers of pericardium, or other supporting material to reduce the possibility of tearing or fracturing along the edge. The cusp, made from the doubled-over biological tissue, is sewn to the pericardium-covered stent along the edges of the cutaway portion. The cusp and cutaway portion are dimensioned so as to allow complete closure oE the blood flow area in the closed position. A sewing ring is provided at the inlet end of the valve and is made of pericardial or other biological tissue, or of dacron material impregnated with collagen or any other biologically acceptable material.
Accordingly, in one broad aspect the present invention ; relates to a prosthetic valve comprising a support body of generally cylindrical shape having a lower circumferential base portion, and upper portion extending over part of a circumference thereof and a cutaway section de~ined over the remaining circumference thereof, the body having edges extending curvilinearly along the cutaway section from the upper portion of the base portion, a plurality o~ sewing holes formed in the body, a covering of biological tissue secured to the body through the sewing holes which has only smooth surfaces thereof presented outwardly, a flexible flap of biological tissue for opening and closing the valve having a lower portion secured to said curved edges and to said base portion~ and an upper portion oE the Elap extending beyond the upper portion of the body~ said flap and said cutaway section ~sq'~

of the body being dimensioned such that the Elap can be collapsed to a closed position against an inner wall of the body to close the valve.
In another broad aspect, the present invention relates to a prosthestic valve comprising a support body oE generally cylindrical shape having a lower circumferential base portion, an upper portion extending over at least half of a circumference thereof and a cutaway section defined over the remaining circumference thereof, the body having edges extending curvilinearly along the cutaway section from the upper portion to the base porkion, a plurality of sewing holes formed in the body, a covering of biological tissue secured to the body through the sewing holes which has only smooth surfaces thereof presented outwardly, a flexible flap of biological tissue for opening and closing the valve having a lower portion secured to said curved edges and to said base portion, and an upper portion of the flap extending beyond the upper portion of the body, said flap and said cutaway section of the body being dimensioned such that the flap can be ?O collapsed to a closed position against an inner wall of the body to close the valve, said flap being made of pericardial tissue doubled over, such that a rough side thereof is folded inwardly and only a smooth side thereof is presented outwardly.
Description of the drawings ; The above objects and further features and advantages of the invention are described in detail below in conjunction with the drawings, of which Figure 1 is a perspective view of a stent in accordance with one embodiment of the inventionî
Figure 2 is a front view of the stent of Figure l;

~ 3a -~l~SS~5~' Figure 3 is a side view oE the stent oE Figure l;
Figure 4 is a perspective view of the stent covered with pericardial material and having a sew.ing ring, in accordance with the invention;
Figure 5 is a perspective view of a complete assembly of the prosthetic heart valve of the invention;
Figure ~ is a sectional side view of the assembled heart valve in the closed position;
Figure 7 is a schematic drawing showing a preferred geometry of the stent profile;
~7 /
/
/
/

~ .
~ .

- 3b - -f ~`
- ~;25s~5~
Figure 8 is a close-up view of the smooth and rough surfaces of pericardial tissue;
Figure 9 shows the assembled heart valve in the open position;
Figure 10 shows the heart valve in the closed position; and Figure 11 is a perspective view of a wire frame support in accordance with another embodiment of the invention.

Detailed Description of the Invention The following is a description of the preferred I embodiments of the invention, and is intended only to be illustrative of the principles of the invention without limitation. In the drawings, like parts are referenced by the same reference numerals.
' Referring to Fi~ a support body or stent 1 is made ¦ of a flexible material, preferably a plastic such as Delrin or ¦ Teflon material, and has a ~enerally right cylindrical form ! with substantially the same diameter throughout. Lower ànnular por~ion 2 constitutes an inlet end for the valve and forms a ~ase for attachment of the valve to the annulus o~ a heartO
` Upper portion 3 of stent 1 includes a cylindrical portion over approximately half the cîrcumference and a cutaway section over the remainder. The cutaway section is defined by downwardly curving edges 4 ending in horizontal edge 5 coplanar with base
2. A rounded corner i5 formed where curved edges 4 join the edges of upper portion 3, to avoid the possibility of tearing of tissue. Stent 1 has a plurality of sewing holes 6 and slits 7 for attaching a layer of covering tissue to the stent, as will be described further herein. Slits 7 terminate in round ~' ~ 25~S~ S Z ~' holes 7a which spread the stress forces at the ends of the slits so as to prevent fracturing of t'he plastic material after repeated flexinF when the valve is used, A backing strip 4a of silicone, single or double layer strip of pericardium, or any other resilient material may be used to trim curved edge 4, in I order to prevent tearin~ of the tissue which is attached thereto.
¦ In order to minimize the exposure of synthetic ¦ surfaces to the blood flow and the creation of possible '~1 10 thrombogen;c sites, the stent is covered with one or ~ore ; layers of biological tissue such as pericardial tissue 8, which has a rough side 10 and a smooth side 9 as shown in Fi~. 8.
Referring to Figs. 4 and 5, the pericardial tissue 8 is folded over the supportin~ wall of the stent, and sewn to the stent -, along downwardly curving edges 4, around the circumferential ¦ base 2, and through slits 7.
' A cusp or flap 11 for the heart valve is then sewn to ; the cutaway section of the stent by its lower edges lla to the sewing holes extendin~'along downwardly curving edges 4 of the , 20 stent. The flap is ormed from biological tissue such as pericardium which has a rough side and a smooth side. Rou~h " side 10 can form collecting sites for bacteria and other vegetation which increases the risk of infection and can result ultimately in calcification. In the invention, the pericardial tissue is doubled over so that the rough side is folder inward and only the smooth sides 9 are exposed outwardly to the blood flow area and to the heart wall in contact with the exterior of the valve~ The doubled-over pericardiu~ also provides a doubl~
thicTcness, and thus is stronger and increases resistence to fatigue, tearing, or other failure of the valve. A glue, such as fibrin glue, may be applied to bond the inner surfaces for a ~ (,) ~ ~SS(~ 2 ~' more cohesive cusp structure. The upper part llb of flap 11 extends above upper portion 3 of the stent. When the valve functions so as to assume its closed position, the upper part llb collapses against the inner wall of upper portion 3, as shown in Fig. 10, to thereby close the blood flow passa~e through the valve. In the open position, flap 11 returns to its upwardly standing position by the blood flow movement through the valve.
The flap 11 is preferably made from a biological 1 10 material such as bovine pericardium (the membrane surrounding ¦ the heart of a calf or other animals). The pericardium is preferably treated with gluteraldehyde which fixes the tissue so that it is inert and not subject to rejection by immunologic response of the human body. The treatment is applied to the pericardium in a mold in order to set the material to the desired curved shape for use in the valve, as shown in the ¦ closed position of Fig. 10. The material is extremely strongI and flexible and has a high modulus of elasticity 50 that the ¦ valve can be continuously opened and closed with the membrane retaining its original shape. Other biologically acceptable I materials include dura mater w~ich is the membrane surrounding ¦ t~e human brain or that of animals such as pigs, sheep and I calves.
The heart valve 1 also has a cuff or sewin~ ring 12 extending circumferentially around base 2 of the stent, and is fixed in position by sewin~ throu~h sewing holes 6, as shown in Fig. 6. Preferably, sewing ring 12 is made of pericardial tissue or other biological material, or dacron impre~nated with collagen or other biologically acceptable material. The use of the above-described valve construction of pericardium, biolozical tissue, or biologically treated material results effectively in a totally biolog;cal heart valve, with smooth surfaces throughout, which reduces the possibility that the valve, when attached to the heart, will have unendothelialized areas or will develop thrombogenic or infection sites.
Referring to Fig. 7, a preEerred geometric profile for I the curved edges 4 of the stent is shown. In the drawing, the ¦ longitudinal direction of the stent is indicated on the Y-axis, I and the transverse direction on the X-axis. The preferred ¦ 10 curvature for edges 4, indicated by arc A-B, is a substantially elliptical curve having its center at O, which is the uppermost point of the flap 11 attached to stent 1 (shown in phantom lines). R indicates a radius of the ellipse extending between point O and point A. L indicates the linear distance from point A to the upper edge of the stent. O.D. indicates the outer diameter of the stent, and the distance extending from point B to the edge of the stent wall is selected to be generally one half of the outer diameter. A particularly preferred geometric profile ~or the curved edges 4 is given by 20- the following relation:
~y2=1 .

7 , and ., R=L2+O.D.2 With this proile, the flap 11 sewn to the curved edges 4 of stent 1 is properly located for collapsing against the inner ; wall of the stent to close the valve. In Figs. 9 and 10, the assembled valve is shown in the open and closed positions.

f J ~ r, The prosthetic valve of the invention thus ha~ a durable construction with smooth surfaces formed by the double-folded cusp of biological tissue and a sewing ring of biological or biologically treated material. This totally biological and smooth-surfaced valve construction reduces the possibility of infection through bacterial growth or vegetation forming on rough surfaces or areas not covered with epithelium. The specified profile for the cutaway portion of , the stent provides a proper dimensioning for complete closure of the valve by the cusp. Although the prosthetic valve is particularly suitable as a heart valve, it may also be used as an arterial or venous valve.
j This improved prosthetic valve using a single layer ~1 cusp has been tested and found to be even more durable than any i¦ other conventional biological valve. In mechanical stress tests, which are about 10 tîmes more stressful than normal use, 1 the improved valve lasted far in excess of 200 million cycles.
-~ Further, in tests in animals, the improved valve showed a-j mlnimal incidence of infectio~ or thromobogenesis. The valve .
of this invention using a double layer cusp would have an even ~reater durability in addition to further reduction of , thrombogen;c risk.
Another particularly advantageous feature of the invention is the improved method of storing the valve in alcohol, or other antiseptic solution which is not harmful to the human body, prior to its installation in the body. The conventional ~ethod is to store a prosthetic valve in glutaraldehyde, and reguires about 5 hours to wash out the valve prior to installation since the glutaraldehyde can cause calcification of the valve in the body. By storing the valve in alcohol, it can be simply washed with water just prior to installation.

Another embod;ment of the lnvention employ~ an ope~
wire frame for the valve, as shown in U.S. Patent No.
4,275,469, for example, instead of the stent of Fig. 1.
Referring to Fig. 11, a suppo~t body 21 for the valve has a rounded wire frame 22 includin~ curved rails 24, a half circumferential upper rim 23, and side braces 25 which are formed to~ether integrally. I'he frame 22 is attached to lower band 26 which has sewing holes 27. Pericardial material i8 folded over the frame 22, with its smooth side facing outward, ' lO and secured to band 26, and a cuff is sewn circumferentially j around the band, so as to form a valve body construction ,I similar to that shown in and described with respect to Fig. 4 j above. Pericardial material is then doubled over to for~ the i smooth surfaced cusp, which is then secured to the valve body alon~ curved rails 24 and band ~6. The curvature of rails 24 is preferably substantially an ellipse of the dimensions given previously, for an optimal confi~uration of the cusp in closing I the valve body.
1 Although these particular embodiments of the invention have been described, there are many other variations and modifications of the principles of the invention which would occur to one skilled in the art, iocluding the substitution of equivalent materials, parts~ or steps. All such variations and i modifications are intended to be enco~passed within the scope o~ the invention, as defined in the appended claims.

_g_ ,

Claims (31)

THE EMBODIMENTS OF THE INVENTION IN WHICH AN EXCLUSIVE
PROPERTY OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:
1. A prosthetic valve comprising a support body of generally cylindrical shape having a lower circumferential base portion, an upper portion extending over part of a circumference thereof and a cutaway section defined over the remaining circumference thereof, the body having edges extending curvilinearly along the cutaway section from the upper portion to the base portion, a plurality of sewing holes formed in the body, a covering of biological tissue secured to the body through the sewing holes which has only smooth surfaces thereof presented outwardly, a flexible flap of biological tissue for opening and closing the valve having a lower portion secured to said curved edges and to said base portion, and an upper portion of the flap extending beyond the upper portion of the body, said flap and said cutaway section of the body being dimensioned such that the flap can be collapsed to a closed position against an inner wall of the body to close the valve.
2. The prosthetic valve of Claim 1, wherein said flap is made of pericardial tissue doubled over, such that a rough side thereof is folded inwardly and only a smooth side thereof is presented outwardly.
3. The prosthetic valve of Claim 1 further comprising a sewing ring extending circumferentially around the base portion and being made of pericardial tissue, biological tissue, or dacron tissue impregnated with collagen material.
4. The prosthetic valve of Claim 1, wherein said flap is formed from dura mater.
5. The prosthetic valve of Claim 1, wherein said curved edges have an elliptical cross-section defined by an ellipse of the following relation:

wherein R is the length of the flap from its upper portion to its lower portion at the base of the body;
L is the length from the intersection of the base with the curved edge to the upper portion of the body;
O.D. is the outer diameter of the cylindrical body;
X is the coordinate of the ellipse in the transverse direction of the body along the curved edge; and Y is the coordinate of the ellipse in a longitudinal direction of the body along the curved edge.
6. The prosthetic valve of Claim 1, wherein said covering is made of pericardial tissue folded over said upper portion of the body and secured thereto through said sewing holes.
7. The prosthetic valve of Claim 1, wherein said body is a cylindrically shaped stent made of synthetic material.
8. The prosthetic valve of Claim 1, wherein said body comprises an open wire frame constituting said upper portion, cutaway section, and curved edges, and a lower band mounted to the wire frame and having a plurality of sewing holes therein.
9. The prosthetic valve of Claim 1, further comprising a reinforcing strip secured to at least the curved edges of the support body.
10. The prosthetic valve of Claim 10, wherein said reinforcing strip is made of silicone.
11. The prosthetic valve of Claim 10, wherein said reinforcing strip is made of a layer of pericardial tissue.
12. The prosthetic valve of Claim 2 t wherein said doubled-over rough side of pericardial tissue is secured together with glue.
13. The prosthetic valve of Claim 1, wherein said support body has transverse sewing slits formed therein.
14. The prosthetic valve of Claim 13, wherein said slits terminate in circular holes at both ends for reducing mechanical fracture at said ends.
15. The prosthetic valve of Claim 6, wherein said covering comprises plural layers of pericardial tissue.
16. An improved method of preparing a prosthetic valve made of biological material for use comprising the steps of storing the valve in alcohol and of washing the valve just prior to installation.
17. A method as claimed in Claim 16, wherein said biological tissue is selected from the group including paricardium and dura mater.
18. A prosthetic valve comprising a support body of generally cylindrical shape having a lower circumferential base portion, an upper portion extending over at least half of a circumference thereof and a cutaway section defined over the remaining circumference thereof, the body having edges extending curvilinearly along the cutaway section fromthe upper portion to the base portion, a plurality of sewing holes formed in the body, a covering of biological tissue secured to the body through the sewing holes which has only smooth surfaces thereof presented outwardly, a flexible flap of biological tissue for opening and closing the valve having a lower portion secured to said curved edges and to said base portion, and an upper portion of the flap extending beyond the upper portion of the body, said flap and said cutaway section of the body being dimensioned such that the flap can be collapsed to a closed position against an inner wall of the body to close the valve, said flap being made of pericardial tissue doubled over, such that a rough side thereof is folded inwardly and only a smooth side thereof is presented outwardly.
19. The prosthetic valve of Claim 18 further comprising a sewing ring extending circumferentially around the base portion and being made of pericardial tissue, biological tissue, or dacron tissue impregnated with collagen material.
20. The prosthetic valve of Claim 18, wherein said flap is formed from dura mater.
21. The prosthetic valve of Claim 18, wherein said curved edges have an elliptical cross-section defined by an ellipse of the following relation:
wherein R is the length of the flap from its upper portion to its lower portion at the base of the body;

L is the length from the intersection of the base with the curved edge to the upper portion of the body.

O.D. is the outer diameter of the cylindrical body;

X is the coordinate of the ellipse in the transverse direction of the body along the curved edge; and Y is the coordinate of the ellipse in the longitudinal direction of the body along the curved edge.
22. The prosthetic valve of Claim 18, wherein said covering is made of pericardial tissue folded over said upper portion of the body and secured thereto through said sewing holes.
23. The prosthetic valve of Claim 18, wherein said body is a cylindrically shaped steut made of synthetic material.
24. The prosthetic valve of Claim 18, wherein said body comprises an open wire frame constituting said upper portion, cutaway section, and curved edges, and a lower band mounted to the wire frame and having a plurality of sewing holes therein.
25. The prosthetic valve of Claim 18, further comprising a reinforcing strip secured to at least the curved edges of the support body.
26. The prosthetic valve of Claim 25, wherein said reinforcing strip is made of silicone.
27. The prosthetic valve of Claim 25, wherein said reinforcing strip is made of a layer of pericardial tissue.
28. The prosthetic valve of Claim 18, wherein said doubled-over rough side of pericardial tissue is secured together with glue.
29. The prosthetic valve of Claim 18, wherein said support body has transverse sewing slits formed therein.
30. The prosthetic valve of Claim 29, wherein said slits terminate in circular holes at both ends for reducing mechanical fracture at said ends.
31. The prosthetic valve of Claim 22, wherein said covering comprises plural layers of pericardial tissue.
CA000486255A 1984-12-07 1985-07-03 Prosthetic heart valve Expired CA1255052A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/679,261 US4759758A (en) 1984-12-07 1984-12-07 Prosthetic heart valve
US679,261 1984-12-07

Publications (1)

Publication Number Publication Date
CA1255052A true CA1255052A (en) 1989-06-06

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Family Applications (1)

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CA000486255A Expired CA1255052A (en) 1984-12-07 1985-07-03 Prosthetic heart valve

Country Status (13)

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US (1) US4759758A (en)
EP (1) EP0183904B1 (en)
JP (1) JPS61137556A (en)
AT (1) ATE46815T1 (en)
AU (1) AU582360B2 (en)
CA (1) CA1255052A (en)
DE (1) DE3573371D1 (en)
DK (1) DK565985A (en)
ES (1) ES8608308A1 (en)
IL (1) IL75301A (en)
NO (1) NO852272L (en)
PT (1) PT80671B (en)
ZA (1) ZA853590B (en)

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US4275469A (en) * 1979-12-13 1981-06-30 Shelhigh Inc. Prosthetic heart valve
US4364126A (en) * 1981-07-28 1982-12-21 Vascor, Inc. Heart valve with removable cusp protector band
US4535483A (en) * 1983-01-17 1985-08-20 Hemex, Inc. Suture rings for heart valves
US4629459A (en) * 1983-12-28 1986-12-16 Shiley Inc. Alternate stent covering for tissue valves

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AU4246785A (en) 1986-06-12
PT80671B (en) 1987-02-06
AU582360B2 (en) 1989-03-23
DK565985A (en) 1986-06-08
DE3573371D1 (en) 1989-11-09
US4759758A (en) 1988-07-26
ES8608308A1 (en) 1986-07-16
PT80671A (en) 1985-07-01
DK565985D0 (en) 1985-12-06
IL75301A (en) 1991-08-16
EP0183904A3 (en) 1987-01-21
IL75301A0 (en) 1985-09-29
JPS61137556A (en) 1986-06-25
EP0183904A2 (en) 1986-06-11
ZA853590B (en) 1985-12-24
ES544301A0 (en) 1986-07-16
NO852272L (en) 1986-06-09
ATE46815T1 (en) 1989-10-15
EP0183904B1 (en) 1989-10-04

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