CA1182704A - Elastomeric bladder assembly - Google Patents
Elastomeric bladder assemblyInfo
- Publication number
- CA1182704A CA1182704A CA000419871A CA419871A CA1182704A CA 1182704 A CA1182704 A CA 1182704A CA 000419871 A CA000419871 A CA 000419871A CA 419871 A CA419871 A CA 419871A CA 1182704 A CA1182704 A CA 1182704A
- Authority
- CA
- Canada
- Prior art keywords
- bladder
- bolus
- assembly
- pressure
- diameter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/0055—Containers or packages provided with a flexible bag or a deformable membrane or diaphragm for expelling the contents
- B65D83/0061—Containers or packages provided with a flexible bag or a deformable membrane or diaphragm for expelling the contents the contents of a flexible bag being expelled by the contracting forces inherent in the bag or a sleeve fitting snugly around the bag
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/148—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags
- A61M5/152—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags pressurised by contraction of elastic reservoirs
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D2231/00—Means for facilitating the complete expelling of the contents
- B65D2231/001—Means for facilitating the complete expelling of the contents the container being a bag
- B65D2231/004—Means for facilitating the complete expelling of the contents the container being a bag comprising rods or tubes provided with radial openings, ribs or the like, e.g. dip-tubes, spiral rods
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S128/00—Surgery
- Y10S128/12—Pressure infusion
Abstract
ABSTRACT OF THE DISCLOSURE
Elastomeric bladder assemblies designed for operation at constant pressure to maintain a constant dispensing rate for the contents exhibit a pressure spike shortly before the end of the duty cycle. This pressure spike may be prevented by including within the lumen of the bladder a bolus forming means which prevents the bladder from collapsing to a cylindrical configuration.
Elastomeric bladder assemblies designed for operation at constant pressure to maintain a constant dispensing rate for the contents exhibit a pressure spike shortly before the end of the duty cycle. This pressure spike may be prevented by including within the lumen of the bladder a bolus forming means which prevents the bladder from collapsing to a cylindrical configuration.
Description
7~
This invention relates to an elastomeric bla~der assernbly which is intended to dispense its contents at a subs-tan-tially constant rate over a substantial period of time~
This invention is an improvemen-t in the elastomeric bladder assemblies disclosed in our co-pe,ndiny, Canadian pa-tent application ~o. 368,327 filed January 12th, 19~1 fox Medical Infuser by J.R~ Peery, P.F. Carpenter and W.K. Griesinger and in United States Patent 4~201,207 which in turn were improvements over the devices disclosed in United S-tates Patents 3,895,631 and 4,140,117 all patents being commonly owned. These devices all employed elastomeric collapsing bladders in medical infusers which were adapted to administer a pre-determined amount of pharmaceutic-ally active material to a subject over a prolonged period of time.
Since the flow rate of the pharmaceutical agent from these devices is dependent upon the pressure generated within the elastomeric bladder, it is important the pressure generated by the elastomeric bladder remain relatively constant throughout a substantial portion o~ the operating lifetime of the device. The above-described devices are generally satisfactory for their intended purposes and all represent significant advances over the art. Nevertheless, it has been observed that in the terminal portion of the dispensing cycle, a pressure increase or "spike" occurs just prior to the emptying of the contents of the bladder which causes an increase in the flow rate from the device immediately prior to the final tail off the fluid flow at the end of the duty cycle. ~hile this increase in flow rate is acceptable in most applications~ it could present a problem in those particular instances in which an extreme-ly potent drug is heing administered. Presently, the only way this increase in flow rate can be eliminated is to re:move or change the bladder prior to complete emptying, with a conco~litant loss of unused drug.
~ ccordiny to this invention, however, I have provided a means whereby the terminal pressure spike may be eliminated while still permitting total utilization of the drug within thP bladder.
The i~vention provides a positive expul.sion bladder assembly comprising an elastomeric bladder having a predetermined, unexpanded, internal diameter and core means within said bladder forming a bolus with a diameter greater than said predetermined internal diameter. The elastomeric bladder assembly exerts a substantially constant pressure on its contents throughout its duty cycle. The bolus portion maintains the pressure generated within the bladder at a substantially constant rate throughout its entire collapse.
The invention will be readily apparent from the following description with reference to the accompanying drawings whexein:
~ Figure 1 is a cross-section view through a preferred 20\~ embodiment of the devices of the prior art;
Figure 2 is a pressure time trace produced by the device of Figure 1, illustrating the configuration of the collapsing elastomeric bladder at various stages of operation;
Figure 3 is a view of a preferred embodiment of this invention;
Figure 4 is a view of another embodiment of this inven~
tion.
Referring now to Fiyure ]., the structure of the prior ax-t device disclosed in Canadian Patent Application Serial No. 368,327 noted above, is shown. ThiS device consists of a tubular housing 1 containing an elastomeric bladder 2. The bladder 2 is connec-ted at its discharye end to plug/flow con-trol assernbly 3 mounted in one end of the housing 1 and at its other end to piston/filling assem-bly 4 which is slidably received within housing 1. The end of housing 1 may be sealed with plug 5 which may be provided with means, not shown, for venting the -2a~
~pace between the plug 5 and assembly 4 to the atmosphere. A
delivery conduit 6 is mounted in plug/flow control assembly 3 by means of plug 7 and is adapted to deliver the contents of the bladder to a subject by a standard infusion needle or other conventional apparatus. Bladder 2 is mounted to assembly 3 by l~ any suitable means such as spring clip 9 engaging hollow post 8 extending from the interior surface of assembly 3O The other end of bladder 2 is similarly affixed to a hollow post 10 extending from the interior surface of assembly 4. Assembly 4 is provided with a filling port 11 which communicates with the interior of bladder 2 through the port 12 in post 10 through a puncturable, resealable septum 13 made from rubber or other suitable materials known to the art. Septum 13 is adapted to be punctured by a filling needle and to be capakle of resisting, without leaking or rupturing9 the pressure generated within the inflated bladder. Transverse ports 14 may also be provided in post 10 to facilitate filling. Post 8 is similarly provided with a central port 14 and contains a filter elernent 15 and a capillary flow control element 16 which in combination with the predetermined pressure produced by bladder 2 provides for a constant delivery rate of ~luid from the bladder to delivery conduit 6. 0-ring seals 17 are provided as necessary at the transition points between the various elements within the assembly 3. Figure 1 ~hows the device in its fully filled condition ready for dispensing of fluid. It should be understood that in the uninflated condition, assembly 4 will have slid into housing 1 until the opposing ends Oe posts 10 and 8 are in abutment with their internal ports 12 and 14 in alignment and bladder 2 will be collapsed around the posts 10 and 8. In the deflated condition, posts 10 and 8 act as a core substantially filling the lumen of the empty bladder 2.
This permits the substantially complete expulsion of the contents of the bladder while also acting as a shield for the ?~ ARC 747 ~4--bladder against puncture when the filling needle is introduced through septum 13.
Referring now to Figure 2, a pressure-time trace of a device of Figure 1 is shown together with the observed configuration of the bladder at various points in its operatirg cycle. As can be seen9 the pressure within the bladder remains substantially constant, (within approximately ~ 10~ of mean operation pressure) until shortly before the end of the duty cycle at which point a relatively rapid increase in pressure outside the desired operating range is observed.
lS As can be seen from Figure 2, as the contents of the bladder are expelled, the shape of the aneurism in bladder 2 changes from a roughly sausage shaped configuration at the beginning of the duty cycle (A and B) to an aneurism having bulbar and cylindrical portions (C, D E and F) to a substantially cylindrical aneurism (G and H). As is also seen from Figure
This invention relates to an elastomeric bla~der assernbly which is intended to dispense its contents at a subs-tan-tially constant rate over a substantial period of time~
This invention is an improvemen-t in the elastomeric bladder assemblies disclosed in our co-pe,ndiny, Canadian pa-tent application ~o. 368,327 filed January 12th, 19~1 fox Medical Infuser by J.R~ Peery, P.F. Carpenter and W.K. Griesinger and in United States Patent 4~201,207 which in turn were improvements over the devices disclosed in United S-tates Patents 3,895,631 and 4,140,117 all patents being commonly owned. These devices all employed elastomeric collapsing bladders in medical infusers which were adapted to administer a pre-determined amount of pharmaceutic-ally active material to a subject over a prolonged period of time.
Since the flow rate of the pharmaceutical agent from these devices is dependent upon the pressure generated within the elastomeric bladder, it is important the pressure generated by the elastomeric bladder remain relatively constant throughout a substantial portion o~ the operating lifetime of the device. The above-described devices are generally satisfactory for their intended purposes and all represent significant advances over the art. Nevertheless, it has been observed that in the terminal portion of the dispensing cycle, a pressure increase or "spike" occurs just prior to the emptying of the contents of the bladder which causes an increase in the flow rate from the device immediately prior to the final tail off the fluid flow at the end of the duty cycle. ~hile this increase in flow rate is acceptable in most applications~ it could present a problem in those particular instances in which an extreme-ly potent drug is heing administered. Presently, the only way this increase in flow rate can be eliminated is to re:move or change the bladder prior to complete emptying, with a conco~litant loss of unused drug.
~ ccordiny to this invention, however, I have provided a means whereby the terminal pressure spike may be eliminated while still permitting total utilization of the drug within thP bladder.
The i~vention provides a positive expul.sion bladder assembly comprising an elastomeric bladder having a predetermined, unexpanded, internal diameter and core means within said bladder forming a bolus with a diameter greater than said predetermined internal diameter. The elastomeric bladder assembly exerts a substantially constant pressure on its contents throughout its duty cycle. The bolus portion maintains the pressure generated within the bladder at a substantially constant rate throughout its entire collapse.
The invention will be readily apparent from the following description with reference to the accompanying drawings whexein:
~ Figure 1 is a cross-section view through a preferred 20\~ embodiment of the devices of the prior art;
Figure 2 is a pressure time trace produced by the device of Figure 1, illustrating the configuration of the collapsing elastomeric bladder at various stages of operation;
Figure 3 is a view of a preferred embodiment of this invention;
Figure 4 is a view of another embodiment of this inven~
tion.
Referring now to Fiyure ]., the structure of the prior ax-t device disclosed in Canadian Patent Application Serial No. 368,327 noted above, is shown. ThiS device consists of a tubular housing 1 containing an elastomeric bladder 2. The bladder 2 is connec-ted at its discharye end to plug/flow con-trol assernbly 3 mounted in one end of the housing 1 and at its other end to piston/filling assem-bly 4 which is slidably received within housing 1. The end of housing 1 may be sealed with plug 5 which may be provided with means, not shown, for venting the -2a~
~pace between the plug 5 and assembly 4 to the atmosphere. A
delivery conduit 6 is mounted in plug/flow control assembly 3 by means of plug 7 and is adapted to deliver the contents of the bladder to a subject by a standard infusion needle or other conventional apparatus. Bladder 2 is mounted to assembly 3 by l~ any suitable means such as spring clip 9 engaging hollow post 8 extending from the interior surface of assembly 3O The other end of bladder 2 is similarly affixed to a hollow post 10 extending from the interior surface of assembly 4. Assembly 4 is provided with a filling port 11 which communicates with the interior of bladder 2 through the port 12 in post 10 through a puncturable, resealable septum 13 made from rubber or other suitable materials known to the art. Septum 13 is adapted to be punctured by a filling needle and to be capakle of resisting, without leaking or rupturing9 the pressure generated within the inflated bladder. Transverse ports 14 may also be provided in post 10 to facilitate filling. Post 8 is similarly provided with a central port 14 and contains a filter elernent 15 and a capillary flow control element 16 which in combination with the predetermined pressure produced by bladder 2 provides for a constant delivery rate of ~luid from the bladder to delivery conduit 6. 0-ring seals 17 are provided as necessary at the transition points between the various elements within the assembly 3. Figure 1 ~hows the device in its fully filled condition ready for dispensing of fluid. It should be understood that in the uninflated condition, assembly 4 will have slid into housing 1 until the opposing ends Oe posts 10 and 8 are in abutment with their internal ports 12 and 14 in alignment and bladder 2 will be collapsed around the posts 10 and 8. In the deflated condition, posts 10 and 8 act as a core substantially filling the lumen of the empty bladder 2.
This permits the substantially complete expulsion of the contents of the bladder while also acting as a shield for the ?~ ARC 747 ~4--bladder against puncture when the filling needle is introduced through septum 13.
Referring now to Figure 2, a pressure-time trace of a device of Figure 1 is shown together with the observed configuration of the bladder at various points in its operatirg cycle. As can be seen9 the pressure within the bladder remains substantially constant, (within approximately ~ 10~ of mean operation pressure) until shortly before the end of the duty cycle at which point a relatively rapid increase in pressure outside the desired operating range is observed.
lS As can be seen from Figure 2, as the contents of the bladder are expelled, the shape of the aneurism in bladder 2 changes from a roughly sausage shaped configuration at the beginning of the duty cycle (A and B) to an aneurism having bulbar and cylindrical portions (C, D E and F) to a substantially cylindrical aneurism (G and H). As is also seen from Figure
2, the pressure spike occurs at the point at which the configura-tion of the aneurism changes from partially bulbar and partially cylindrical to substantially cylindrical (between F and G).
According to this invention, the pressure spike is eliminated by the inclusion within bladder 2 of mears to maintain the aneurism in its ~lightly bulbar configuration.
Referring now to Figure 3, a preferred embodiment of this invention is shown with common elements corresponding to those shown in Figure 1. In Yigure 3, the device is shown in its fully deflated condition as it would appear both prior to the time that it is filled with fluid and at the end of its duty cycle after it has expelled its contents. Lumen filling core means 10 and 8 have been configured such that the internal con~iguration of collapsed bladder 2 mimics the internal configuration of a bladder at the point just prior to the disappearance of the bulbar aneurismO The preferred configur-.
~ 7~ ARC 747 ation of the core means for any particular bladder can therefore be readily determined by visual observation of the per~ormance of the bladder during its duty cycle such as is shown in ~igure 2. In general, however, it is preferred that the external diameter of the cylindrical portion 10 of the lumen filling core means be slightly larger than the internal diameter of the bladder in its fully collapsed, relaxed condition, and the bulbar, bolus ~orming portion 80 of lumen filling ~ore means 8 should be sufficient to provide a clearly observable bolus having an dia~eter greater than that of the cylindrical portion.
It should be noted that although the location of the bulbar aneurism in the prior art device is somewhat random occurence the provison of the bulbar portion 80 on the core means predetermines the location of the bulbar aneurism.
Although the preferred embodiment employes core means which fill the entire lumen of the deflated bladder to obtain the desired end configuration for the interior o~ the bladder, this invention can also be utilized in bladder assemblies which do not have the entire lumen of the bladder filled with a core at the end of the duty cycle. Thus in the bladders which are shown, for example, in U S. Patent 3~8959631, a bulbar post with a fluid passage through the interior could be mounted in one end of the bladder assembly. This would result in the cylindrical portion of the aneurism being left with a residue o~ usable drug and would result in the eliminatio~ of the other advantages associated with the lumen filling core means. In the case where just a bolus forming means 80 is included within the bladder, its diameter should be sufficiently greater than the internal diameter of the ~ully collapsed bladder to produce a pronounced bolus in the bladder while the cylindrical portion is still capable of undergoing radial contraction.
Referring now to Figure 4, another embodiment of the invention i3 shown. In Figure ll~ unitary core 20 having a generally cyl'indrical portion 21 and bulbar bolus portion 22 is inserted within elastomeric bladder 2. Core 20 is provided with a port 23 sized to receive a needle or other tube for introduction and withdrawal of ~luid into and out of the device through resealable septum Z4 and ports 25 extending through the wall o~ bolus 22. In this embodiment9 core 20 has an axial length substantially equal to the axial length of bladder 2 in its inflated condition (~hown in dotted lines). In this embodiment as a result of the prestressing of the bladder to its inflated length by core 20, inflation and contraction occurs only in the radial direction. Since there is no axial component of contraction, design ~or constant pressure is simplified.
` EXAMPLE
A pre~erred embodiment of this invention i~ constructed according to Figure 3, using a 7.2 cm long polyisoprene rubber bladder having a wall thickness of 1.00 mm and an internal diameter of 4.30 mm in the unstressed condition. The external diameter o~ the cylindrical portion of the lumen ~illing means is 6.15 mm and the bolus is spherical having an external diameter of 10.5 mm. In operation this bladder ~enerates a pressure of 455 mm i 10% and without a terminal pressure spike~
While this invention has been described with respect to specific embodiments thereo~, it should not be construed as being limited thereto. Various modi~ications may be made by workers skilled in the art without departing from the scope o~
this invention which is limited only by the following claims;
wherei n :
According to this invention, the pressure spike is eliminated by the inclusion within bladder 2 of mears to maintain the aneurism in its ~lightly bulbar configuration.
Referring now to Figure 3, a preferred embodiment of this invention is shown with common elements corresponding to those shown in Figure 1. In Yigure 3, the device is shown in its fully deflated condition as it would appear both prior to the time that it is filled with fluid and at the end of its duty cycle after it has expelled its contents. Lumen filling core means 10 and 8 have been configured such that the internal con~iguration of collapsed bladder 2 mimics the internal configuration of a bladder at the point just prior to the disappearance of the bulbar aneurismO The preferred configur-.
~ 7~ ARC 747 ation of the core means for any particular bladder can therefore be readily determined by visual observation of the per~ormance of the bladder during its duty cycle such as is shown in ~igure 2. In general, however, it is preferred that the external diameter of the cylindrical portion 10 of the lumen filling core means be slightly larger than the internal diameter of the bladder in its fully collapsed, relaxed condition, and the bulbar, bolus ~orming portion 80 of lumen filling ~ore means 8 should be sufficient to provide a clearly observable bolus having an dia~eter greater than that of the cylindrical portion.
It should be noted that although the location of the bulbar aneurism in the prior art device is somewhat random occurence the provison of the bulbar portion 80 on the core means predetermines the location of the bulbar aneurism.
Although the preferred embodiment employes core means which fill the entire lumen of the deflated bladder to obtain the desired end configuration for the interior o~ the bladder, this invention can also be utilized in bladder assemblies which do not have the entire lumen of the bladder filled with a core at the end of the duty cycle. Thus in the bladders which are shown, for example, in U S. Patent 3~8959631, a bulbar post with a fluid passage through the interior could be mounted in one end of the bladder assembly. This would result in the cylindrical portion of the aneurism being left with a residue o~ usable drug and would result in the eliminatio~ of the other advantages associated with the lumen filling core means. In the case where just a bolus forming means 80 is included within the bladder, its diameter should be sufficiently greater than the internal diameter of the ~ully collapsed bladder to produce a pronounced bolus in the bladder while the cylindrical portion is still capable of undergoing radial contraction.
Referring now to Figure 4, another embodiment of the invention i3 shown. In Figure ll~ unitary core 20 having a generally cyl'indrical portion 21 and bulbar bolus portion 22 is inserted within elastomeric bladder 2. Core 20 is provided with a port 23 sized to receive a needle or other tube for introduction and withdrawal of ~luid into and out of the device through resealable septum Z4 and ports 25 extending through the wall o~ bolus 22. In this embodiment9 core 20 has an axial length substantially equal to the axial length of bladder 2 in its inflated condition (~hown in dotted lines). In this embodiment as a result of the prestressing of the bladder to its inflated length by core 20, inflation and contraction occurs only in the radial direction. Since there is no axial component of contraction, design ~or constant pressure is simplified.
` EXAMPLE
A pre~erred embodiment of this invention i~ constructed according to Figure 3, using a 7.2 cm long polyisoprene rubber bladder having a wall thickness of 1.00 mm and an internal diameter of 4.30 mm in the unstressed condition. The external diameter o~ the cylindrical portion of the lumen ~illing means is 6.15 mm and the bolus is spherical having an external diameter of 10.5 mm. In operation this bladder ~enerates a pressure of 455 mm i 10% and without a terminal pressure spike~
While this invention has been described with respect to specific embodiments thereo~, it should not be construed as being limited thereto. Various modi~ications may be made by workers skilled in the art without departing from the scope o~
this invention which is limited only by the following claims;
wherei n :
Claims (6)
PROPERTY OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:
1. A positive expulsion bladder assembly comprising an elastomeric bladder having a predetermined, unexpanded, internal diameter and core means within said bladder forming a bolus with a diameter greater than said predetermined internal diameter.
2. The assembly of Claim 1 wherein said core means comprises a cylindrical portion adjacent to said bolus portion, the external diameter of said cylindrical portion being less than the diameter of the bolus portion and larger than said predetermined internal diameter of said bladder.
3. The apparatus of Claim 2 wherein the combined length of said bolus and cylindrical portions is substantially equal to the inflated length of said bladder.
4. The apparatus of Claim 2 wherein the combined length of said bolus and cylindrical portion is less than the inflated length of said bladder.
5. The apparatus of Claim 1, 2 or 3 further comprising fluid communicating means extending through said core means providing communication between the interior of said bladder and the exterior of the device.
6. The apparatus of Claim 4 further comprising fluid com-municating means extending through said core means providing com-munication between the interior of said bladder and the exterior of the device.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/350,585 US4419096A (en) | 1982-02-22 | 1982-02-22 | Elastomeric bladder assembly |
| US350,585 | 1982-02-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1182704A true CA1182704A (en) | 1985-02-19 |
Family
ID=23377361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000419871A Expired CA1182704A (en) | 1982-02-22 | 1983-01-20 | Elastomeric bladder assembly |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4419096A (en) |
| JP (1) | JPS58149280A (en) |
| CA (1) | CA1182704A (en) |
| CH (1) | CH661664A5 (en) |
| DE (1) | DE3305031A1 (en) |
| FR (1) | FR2521859B1 (en) |
| GB (1) | GB2115494B (en) |
| IT (1) | IT1191247B (en) |
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| WO1986003978A1 (en) * | 1985-01-07 | 1986-07-17 | Baxter Travenol Laboratories, Inc. | Infusor having a distal flow regulator |
| US4904239A (en) * | 1985-01-07 | 1990-02-27 | Baxter International Inc. | Infusor having a distal flow regulator |
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| WO1993011059A1 (en) * | 1991-11-27 | 1993-06-10 | James Owen Camm | Dispenser |
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| US6090071A (en) * | 1992-04-17 | 2000-07-18 | Science Incorporated | Fluid dispenser with fill adapter |
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| US5433709A (en) * | 1992-04-17 | 1995-07-18 | Science Incorporated | Fluid dispensing apparatus including mounting base for a plurality of fluid dispensing devices |
| US5346476A (en) * | 1992-04-29 | 1994-09-13 | Edward E. Elson | Fluid delivery system |
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| US20040206771A1 (en) * | 2003-04-18 | 2004-10-21 | Eric Junkel | Water toy with two port elastic fluid bladder |
| US20050177136A1 (en) * | 2003-12-19 | 2005-08-11 | Miller Landon C. | Externally disposed pump for use with an internally mounted and compliant catheter |
| EP2432523B1 (en) * | 2009-05-20 | 2020-01-15 | Sanofi-Aventis Deutschland GmbH | Assembly for use in a drug delivery device |
| US9498570B2 (en) | 2010-10-25 | 2016-11-22 | Bayer Healthcare Llc | Bladder syringe fluid delivery system |
| US10046106B2 (en) | 2010-10-25 | 2018-08-14 | Bayer Healthcare Llc | Bladder syringe fluid delivery system |
| US9180252B2 (en) | 2012-04-20 | 2015-11-10 | Bayer Medical Care Inc. | Bellows syringe fluid delivery system |
| WO2014046950A1 (en) | 2012-09-24 | 2014-03-27 | Enable Injections, Llc | Medication vial and injector assemblies and methods of use |
| US9814871B2 (en) | 2013-03-15 | 2017-11-14 | Bayer Healthcare Llc | Connector assembly for syringe system |
| WO2014204894A2 (en) | 2013-06-18 | 2014-12-24 | Enable Injections, Llc | Vial transfer and injection apparatus and method |
| JP6593671B2 (en) | 2014-11-10 | 2019-10-23 | 株式会社塚田メディカル・リサーチ | Liquid supply device |
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| RU2731402C2 (en) | 2015-11-25 | 2020-09-02 | БАЙЕР ХелсКер ЛЛСи | Syringe and connector system |
| AU2021224642A1 (en) | 2020-02-21 | 2022-09-15 | Bayer Healthcare Llc | Fluid path connectors for medical fluid delivery |
| BR112022023295A2 (en) | 2020-06-18 | 2023-01-17 | Bayer Healthcare Llc | IN-LINE AIR BUBBLE SUSPENSION APPARATUS FOR INJECTOR FLUID PATHWAY ANGIOGRAPHY |
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|---|---|---|---|---|
| US2201207A (en) * | 1937-10-27 | 1940-05-21 | American Mach & Foundry | End label attachment |
| US3361303A (en) * | 1965-09-17 | 1968-01-02 | Jacuzzi Bros Inc | Liquid and paste dispenser |
| US3469578A (en) * | 1965-10-12 | 1969-09-30 | Howard R Bierman | Infusion device for ambulatory patients with flow control means |
| NL151954C (en) * | 1971-02-11 | |||
| US4201207A (en) * | 1973-03-26 | 1980-05-06 | Alza Corporation | Bladder for liquid dispenser |
| IT1011632B (en) * | 1973-03-26 | 1977-02-10 | Alza Corp | ELASTIC LUG FOR STORAGE AND DISPENSING LIQUIDS UNDER PRESSURE |
| US3993069A (en) * | 1973-03-26 | 1976-11-23 | Alza Corporation | Liquid delivery device bladder |
| US3895631A (en) * | 1974-02-04 | 1975-07-22 | Alza Corp | Liquid infusion unit |
| US4140117A (en) * | 1975-05-12 | 1979-02-20 | Alza Corporation | Cartridge for liquid infusion apparatus |
| AU2492077A (en) * | 1976-05-14 | 1978-11-09 | Plant Ind Inc | Dispenser with expansible bladder |
| CA1077001A (en) * | 1976-10-21 | 1980-05-06 | Winfried J. Werding | Appliance for discharging gaseous liquid or pasty product, and process of its manufacture |
| US4140111A (en) * | 1977-09-06 | 1979-02-20 | Morrill William E | Hand tool for inserting bone fracture pins |
| US4299222A (en) * | 1980-01-08 | 1981-11-10 | Alza Corporation | Self-contained suction pump |
| US4318400A (en) * | 1980-01-18 | 1982-03-09 | Alza Corporation | Medical infusor |
| GB2093473B (en) * | 1981-02-23 | 1984-08-15 | Alza Corp | Elastomeric bladders for medical infusers |
-
1982
- 1982-02-22 US US06/350,585 patent/US4419096A/en not_active Expired - Lifetime
- 1982-10-22 GB GB08230175A patent/GB2115494B/en not_active Expired
- 1982-12-09 JP JP57216262A patent/JPS58149280A/en active Granted
- 1982-12-27 IT IT68522/82A patent/IT1191247B/en active
-
1983
- 1983-01-20 CA CA000419871A patent/CA1182704A/en not_active Expired
- 1983-02-08 CH CH709/83A patent/CH661664A5/en unknown
- 1983-02-14 DE DE19833305031 patent/DE3305031A1/en active Granted
- 1983-02-14 FR FR8302297A patent/FR2521859B1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS58149280A (en) | 1983-09-05 |
| DE3305031C2 (en) | 1992-01-30 |
| US4419096A (en) | 1983-12-06 |
| IT8268522A0 (en) | 1982-12-27 |
| CH661664A5 (en) | 1987-08-14 |
| GB2115494B (en) | 1985-12-11 |
| GB2115494A (en) | 1983-09-07 |
| FR2521859A1 (en) | 1983-08-26 |
| FR2521859B1 (en) | 1985-10-25 |
| IT1191247B (en) | 1988-02-24 |
| DE3305031A1 (en) | 1983-09-01 |
| JPH0242751B2 (en) | 1990-09-25 |
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| MKEC | Expiry (correction) | ||
| MKEX | Expiry |