CA1174976A - Germ-killing materials - Google Patents

Abstract

ABSTRACT OF THE DISCLOSURE
There is disclosed a germ-killing gel, a germ-killing soap, a germ-killing toothpaste and applicators for dispensing germ-killing compositions. These compositions include a first material containing sodium chlorite and a second material con-taining lactic acid in sufficient amount to lower the pH of the aqueous media to less than about seven. The compositions may be used in any manner to kill germs, for example, on the skin such as the skin of animals.

Description

117497~
BACKGROUND OF THE INVENTI'ON
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FIELD OF ~THE:'INVENTION :

This invention relates to germ-killing materials and more particularl~ to materials adapted for use in cleaning, sanitizing, deodorizing, and disinfecting surfaces into or onto which the material is to be applied.

DES'CRIPT'ION OF' THE'P'RIOR ART

Chlorine dioxide (C102) has been tried in the past for skin j disinfection with limited success. One such chlorine dioxide jl preparation was called Cryoclave, produced by International Dioxide. Chlorine dioxide has, however, had more success as an additive to medicine to inhibit microbial growth in the medicine itself, as disclosed in Canadian Patent No. 955,848, than for its antimicrobial activity on the body.
The usual method for using or incorporating chlorine dioxide gas has been to dissolve the gas in a liquid to form a solution.
This method has a number of drawbacks. The chlorine dioxide gas tends to release from the solution so that its shelf-life is relatively short compared to other skin medications. When the product is applied to the skin asva liquid, the lack of adherence of the product to the skin or lesion results in a short contact j time. Since fungus diseases and other types of infected lesions usually require many hours or even days of contact, a strict regimen of reapplication would be necessary to ensure adequate t>erapeutic response.

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These objections to the use of chloxine dioxide on the skin can be overcome or substantially alleviated if the gas is incorporated in a gel base. The high viscosity of these gels and their bioadhesion to the skin prevents escape of the gas and also holds the gas in contact with the skin for long periods, ! particularly in conjunction with the use of a conventional !! occlusive barrier, such as a plastic film bandage for the ! afflicted area.
The process of acidifying sodium chlorite to produce ~chIorine dioxide within the gel is novel. The gelling material must not only be compatible with the strong oxidizing action of chlorine dioxide, so that there is no complexing with this reactive substance, but must also be compatible with the alkaline sodium chlorite and the acid.
~ Many substances are not compatible with chlorine dioxide.
¦IMost flavors and coloring agents, for example, will react with chlorine dioxide. Canadian patent 955,848 discloses adding ,;these kinds of substances, but this addition reduces the germi-I! cidal effectiveness of the chlorine dioxide and thus shortens the Illshelf-life of the product. A further example of incompatibility jjis hydrogen peroxide, which has been successfully gelled with a ,Iglycerin base. Glycerin, however, will react with chlorine dioxide and therefore cannot be used as a "thickener" for a base with chlorine dioxide producing components. The gelling agent must, of course, be non-toxic, non-irritating, and easily removed from the skin.

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1 _3_ ~ 17~976 Thus, the primary object of the present invention is to provide improved cleaning, deodorizing, sanitizing, and disinfecting materials including gels, soap products, toothpaste, and the like, each packaged with one material containing sodium chlorite separate from another material containing lactic acid in sufficient amount to lower the pH of the final product formed upon mixing of the materials to less than about 7.
The invention provides in a germ-killing skin medication adapted for treatment of skin diseases such as acne and burns 10 comprising two gels adapted to be simultaneously applied and mixed in situ and to adhere on the skin or lesion surface to be treated, including the treatment of burns as well as acne, the improvement comprising said first gel being an aqueous gel com-prising sodium chlorite and said second gel being an aqueous gel comprising lactic acid, there being sufficient of said lactic acid to lower the pH of said medication to less than about 7.
Figure 1 is a longitudinal sectional view of a dual syringe used in dispensing the germ-killing product;
Figure 2 is a longitudinal sectional view of a single syringe having dual compartments;
Figure 3 is a schematic diagram illustrating a dual reservoir applicator;
Figure 4 is an exploded perspective view showing a squeezable vial;
Figure 5 is an exploded perspective view of a rigid double dispenser;
Figure 6 is a sectional detail view of a trigger-type dual dispenser;
Figure 7 is a schematic view showing a dual dispenser;
Figure 8 is an elevational view of a dual dispensing plastic pack having a removable separator;

r:~ ~ 4 Figure 9 is a view o~ the dispenser shown in Figure 8 with a separator removed therefrom;
Figure 10 is a sectional detail view of a squeeze bottle with a center separator;

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I f 74976 Fig. 11 is a sectional detail view illustrating means used in a dispenser for preventing unequal dispensing of materials;
Fig. 12 is a sectional detail view illustrating a modified l! form of the means controlling the amounts of fluid flow; and ¦ Fig. 13 is a sectional detail view of yet another dispenser !icontrol means.

DETAILED D~SCRIPTION OF THE INVENTION

The present invention is further illustrated by the following¦
lexamples. All parts and percentages in the examples as well as l~in the specification and claims are by weight unless otherwise specified.

Example I

This Example illustrates the production of a gel mixed in situ This gel is most effective in the treatment of burns ~land is efficacious in killing germs on all surfaces. It is ¦jparticularly useful for the treatment of acne.

GEL
PART A

Thickener METHYL CELLULOSE (High Viscosity, 4,000 CPS) 8.0% W/W
Preservative BENZYL ALCOHOL 5.0% W/W

WATER 85.7~ W/W
, LACTIC ACID 1.3% W/W

l PART B
! I METHYL CELLULOSE (High Viscosity, I

i 4,Q00 CPS~ 8.0% W/W
BENZYL ALCOHOL 5.0~ W/W
i,! -1' .
~l -5- 1 ~ 174976 WATER 86.8% W/W
SODIUM CHLORITE 0.2% W/W

¦~ Procedure for Part A: Heat one-half of the 85.7% water to boiling and add methyl cellulose with constant agitation. Add the balance of the water as "ice water" (i.e., about 5C.) containing the benzyl alcohol and the lactic acid. Stir initially to blend the ingredients, then allow them to cool to room temperature with occasional stirring until the composition I gels.
Procedure for Part B: Same as for Part A, except sub-stitute sodium chlorite for lactic acid.
,j Package parts A and B in separate tubes with directions to mix equal parts before use.
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- Example II
This ~xample illustrates a soap product which employs lactic acid and sodium chlorite.

il I STRIPED SO~P BAR
jl *
Detergent IGEPON AC-78 (83% solids) (1) 58% W/W

Preservative VANCIDE 89*RE (2) 1% W/W

' Thickener VE~GUM F* (2) 1% W/W

Emollient CETYL ALCOHOL 2o W/W

Emulsifier GLYCERYL MONOSTEARATE A.S.6% W/W

Emulsifier STEAI~YL ALCOHOL 7% W/W

Emollient MODULAN (3)* 3% W/W

Humectant POLYETHYLENE GLYCOL 600013% W/W

WATER 9% W/W

(1) Commercially available from GAF Corporation, New York, N.Y.

(2) Commercially available from the R.T. Vanderbilt Co., New , York, N.Y.

(3) Commercially available from the American Cholesterol Products, Inc., Edison, N.J.

* Trade ~ark A

. ~ 174g7~

Procedure: Add the VANCIDE 89RE and the VEEGUM F*to a part of the IGEPON*AC-78, then add the rest of the IGEPON*AC-78 with thorough blending. Heat a mixture of the remaining ingredients , to 75C. Add the IGEPON*mlxture to the remaining ingredients -i, with agitation until uniform. Divide the mixture into two parts, , A and B. 'rO Part A, add 1% W/W sodium chlorite, and to part B
i add 6% W/W lactic acid plus 1% W/W Tartrazine Dye (F. D. & C.).
Allow Parts A and B to cool to room temperature and gently blend jj the two parts to produce swirls of the yellow Part B in the white j Part A. Press the mixture into bars or cakes.

¦¦ EXAMPLE III
, This invention may also be used in producing a toothpaste as described hereinbelow.

STRIPED TOOTHPASTE
Thickener VEEGUM F* 1.25% W/W
! Thickener ~ETHYL CELLULOSE (Med. Viscosity, 1 ~oo CPS) o . 70% ~/w Il WA'I'ER 24.00% W/W
Humectant SORBITOL (70% AQUEOUS SOLUTION)25.00% W/W
Abrasive DICALCIUM PHOSPHATE DIHYDRATE 45.00% W/W
MINT FLAVOR 1.00% W/W
Detergent SODIUM LAURYL SULFATE 1.50% W/W
, Preservative ME'r~lYL PARABEN 0.25% W/W
I,ACTIC ACID 1.30~ W/W
All of the Thickener may be METHYL CELLULOSE.
Procedure: Dry blend the VEEGUM F*and METHYL CELLULOSE.
Add this blend to the water (heated to 70C.) ~lowly, agitating continuously until uniform and cooled to room temperature. Add the SORBITOL solution and DICALCIUM PHOSPHATE DIHYDRATE in alternate portions to the VEEGUM F/METHYL CELLULOSE mixture until * Trade Mark ~ ~174976 smooth. Then add the LACTIC ACID, MINT FLAVOR, M~THYL PARABEN
and SODIUM LAURYL SULFATE in order, blending each thoroughly (use gentle agitation) with the 50DIUN LAURYL SULFATE to avoid incorporation of air.
In a separate operation, prepare the following GEL:

¦l Thickener METHYL CELLULOSE (High Viscosity, 4000 CPS) 8.0% W/W
Preservative BENZYL ALCOHOL 5.0~ W/W
, Color ERYTHROSIN J (F. S. & C.) 1.0% W/W
WATER 85.8~ W/W
SODIUM CHLORITE 0.2~ W/W
Procedure: Heat one-half of the water to boiling and add METHYL CELLULOSE with constant agitation. Add the balance of jl the water as "ice water" (about 5C.), containing BENZYL ALCOHOL, ERYTHROSIN J (cherry-red dye) and SODIUM CHLORITE. Stir ¦initially to blend the ingredients, then allow the blend to cool to room temperature with occasional stirring until gelled.
Package the white toothpaste and the red gel in plastic tubes with separate compartments for each component, but with adjacent extrusion orifices (the toothpaste as a single stream;
¦I for the gel, several small orifices should be arranged around s the periphery of the toothpaste orifice so that a striped effect is produced upon extrusion). Such tubes are commercially available.
¦ The following description refers to the accompanying drawings wherein like reference numerals designate similar parts i throughout the various vieWs.

I! In Fig. 1 there is shown a dual syringe especially adapted for use in dispensing solutions or gels and contains a syringe housing 20 provided with a separator 22 therein. A single actuator 24 controls dual plungers 26 and 28 which expel the "

~174976 contents from the housing 20 simultaneously and in equal amounts as indicated at 30 into a material ready to be evenly spread on the surface to be treated.
In Fig. 2 there is shown a syringe housing 40 having a single actuator 42 controlling a single plunger 44 which, when actuated, causes the material 46 to break through the frangible barrier 48 and mix with the material 50 so that the combination of ingredients can be expelled as composite gel 52 which is ready for use.
In Fig. 3 there is shown two reservoirs 60 and 62 inter-connected by tubing 64 with separate control valves 66 and 68 provided together with a shut-off valve 70 for controlling fluid flow in the direction of arrow 72.
In Fig. 4 there is shown a squeezable vial 80 containing frangible containers 82 and 84 which will break upon application of pressure to the vial permitting the ingredients to admix and be delivered through the cotton dauber 86 in a convenient manner.
In Fig. 5 there is shown a dual applicator including two containers 90 and 92 filled with the two different materials and each having a sponge applicator head 94 and 96 for simul-taneously applying the various materials. The two containers 90 and 92 are bonded or otherwise joined together.
In Fig. 6 there is shown a trigger-actuated dispenser in which a container 100 is provided with a divider 102 for main-taining the solutions 104 and 106 separate. When the trigger 108 of the conventional pump actuator 110 is depressed, material is sucked through each of the tubes 112 and 114 and simultaneous-ly sprayed.
In Fig. 7 there is shown a dual dispenser similar to the foam shaving cream dispenser marketed by The Gilette Company in which the outer container 130 contains a first material while an _g_ It74976 inner container 132 contains the second matexial. Both are under gas pressure and when the actuator 134 is depressed, both materials are simultaneously dispensed as a result of the gaseous pressure.

~ eferring now to Figs. 8 and 9, there is shown a plastic container 200 which is first partially filled with one solution after which a removable separator 202 is applied. Thereafter, the other section is filled through the neck 204 and the cap 206 secured in place. When it is desired to use the contents, the separator is removed and, as shown in Fig. 9, the entire contents are mixed and ready for application.
In Fig. 10 there is shown a tube or container 220 including a separator 22. A tab 224 is provided for which a wind-up key 226 can be used to expeI the contents of the container 220 in equal proportions.
Referring now to Fig. 11, there is shown a container 240 having ~ divider 242 therein. The container 240 is-adapted to contain two different gels 244 and 246 and movement of the gel 244 without corresponding movement of the gel 246 or vice versa through its channel without the other gel moving will actuate a pivotal valve member 250 to prevent passage of the other gel.
For example, if gel 244 was being dispensed and gel 246 was not, the vance 254 would be moved into a valve closed engagement with its valve seat 256 while valve head 258 would contact the neck portion 260 of the container to prevent fluid flow of the gel 246. Even flow of both gels will by-pass the vane and cause equal delivery.
Fig. 12 shows another form of container 280 containing a separator 282 as well as a guide 286 at the neck 288 of the container 280 and is so arranged that the guide 286 will lock on the movement of only one of the gels within the container so " --1 0-- , ~ 17~976 as to cause one of the valve vanes 290 and 292 to prevent further movement until the delivery of both gels has been equal-ized.
In Figure 13 there is shown an additional modified form of the invention in which the container 300 has a divider 302 therein for separating the compartments 304 and 306 containing different gels from each other. Pivoted to the divider 302 is a valve assembly 310 which includes means for preventing unequal flow of the separate gels.
The principles, preferred embodiments, and modes of operation of the present invention have been described in the foregoing specification. The invention which is intended to be protected herein, however, is not to be construed as limited to the particular forms disclosed, since these are to be regarded as illustrative rather than restrictive. Variations and changes may be made by those skilled in this art without departing from the spirit of the invention.

Claims (5)

THE EMBODIMENTS OF THE INVENTION IN WHICH AN EXCLUSIVE
PROPERTY OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:

1. In a germ-killing skin medication adspted for treatment of skin diseases such as acne and burns comprising two gels adapted to be simultaneously applied and mixed in situ and to adhere on the skin or lesion surface to be treated, including the treatment of burns as well as acne, the improvement com-prising said first gel being an aqueous gel comprising sodium chlorite and said second gel being an aqueous gel comprising lactic acid, there being sufficient of said lactic acid to lower the pH of said medication to less than about 7.

2. The medication of claim 1, wherein said first gel includes 0.2% by weight sodium chlorite and said second gel includes 1.3% by weight lactic acid.

3. The medication of claim 2, wherein said first gel and said second gel each include approximately 8% methyl cellulose by weight and approximately 5% benzyl alcohol by weight.

4. The medication of claim 1, wherein said first and second gels each contains a thickener and a preservative.

5. The medication of claim 4, wherein said thickener is methyl cellulose and said preservative is benzyl alcohol.