CA1159621A - Process for the dotting of moulding tools by means of discrete droplets of liquid or suspended lubricants in the manufacture of mouldings in the field pharmaceuticals, foodstuffs or catalysts - Google Patents
Process for the dotting of moulding tools by means of discrete droplets of liquid or suspended lubricants in the manufacture of mouldings in the field pharmaceuticals, foodstuffs or catalystsInfo
- Publication number
- CA1159621A CA1159621A CA000339927A CA339927A CA1159621A CA 1159621 A CA1159621 A CA 1159621A CA 000339927 A CA000339927 A CA 000339927A CA 339927 A CA339927 A CA 339927A CA 1159621 A CA1159621 A CA 1159621A
- Authority
- CA
- Canada
- Prior art keywords
- liquid
- lubricant
- dotting
- piezoelectric
- channel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
- B30B15/0005—Details of, or accessories for, presses; Auxiliary measures in connection with pressing for briquetting presses
- B30B15/0011—Details of, or accessories for, presses; Auxiliary measures in connection with pressing for briquetting presses lubricating means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
- B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
- B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
- B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
- B05B17/0638—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers spray being produced by discharging the liquid or other fluent material through a plate comprising a plurality of orifices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B5/00—Electrostatic spraying apparatus; Spraying apparatus with means for charging the spray electrically; Apparatus for spraying liquids or other fluent materials by other electric means
- B05B5/025—Discharge apparatus, e.g. electrostatic spray guns
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S425/00—Plastic article or earthenware shaping or treating: apparatus
- Y10S425/115—Lubricator
Abstract
ABSTRACT
A method of lubricating moulding apparatus in the manufacture of moulded pharmaceuticals, foodstuffs or catalysts is disclosed, in which liquid or suspended lubricant is dotted in a directed manner before each pressing operation in specific quantities and in the form of discrete droplets of specific volume onto the loaded zones of the pressing tool.
The intermittent dotting of the liquid or suspended lubricant is preferably effected using tube-shaped or plate-shaped piezoelectric transducers.
A method of lubricating moulding apparatus in the manufacture of moulded pharmaceuticals, foodstuffs or catalysts is disclosed, in which liquid or suspended lubricant is dotted in a directed manner before each pressing operation in specific quantities and in the form of discrete droplets of specific volume onto the loaded zones of the pressing tool.
The intermittent dotting of the liquid or suspended lubricant is preferably effected using tube-shaped or plate-shaped piezoelectric transducers.
Description
` --`" l 1~9~
Process for the dotting-of-moulding tools by means of .
discrete droplets of liquid or suspended lubricants in the manufacture of mouldings in the field of pharma-ceuticals, foodstuffs or catalysts The invention is concerned with a process for the intermittent dotting of moulding tools, e.g. of tableting machines, by means of discrete droplets of liquid or suspended lubricants in the manufacture of mouldings in the field of pharmaceuticals, foodstuffs or catalysts.
Canadian Patent Specification No. 1,096,783 describes a process for the coating of press compartments on tableting machines, which is characterised in that dissolved or melted release agents are applied to the inner walls of the press compartment before each pressing operation by means of a no~zle system spraying briefly ("intermittently") at rapid intervals.
It has been shown in the meantime that with the new high-performance tableting machines a hydraulically operated inter-mittent spraying system is still too slow-acting to coat the moulding tools before each pressing operation. Moreover, it is fundamentally , , ,. , ,, ~ , . ~
,~, , ,. ,, ~ ,.
'. , ''', ' '~: ' .
. ., '' ' ~.' ' : `
~ 1~9~1 desirable to keep as small as possible the quantity of lubricant (to achieve an optimal bioavailability, mouldability and a clear and undelayed dissolution of dissolving tablets e.g. for diagnostic purposes or effervescent tablets). It is therefore necessary that the spraying system be especially capable of applying concentratedly the required quantity of lubricant to strongly loaded zones of the moulding tools (e.g. the pressing zone in the cavity) in the shortest possible time, e.g. in a few milliseconds, intermittently and in a directed manner.
It has now been found that these requirements can be met in a superior way due to the fact that liquid or suspended lubricant is dotted in a directed manner onto the loaded zones of the pressing tools before each pressing operation in specific quantities and in the form of discrete droplets of specific volume. The dotting is effected e.g. by means of tube-shaped or plate-shaped piezoelectric transducers inter mittently before each pressing operation. ~owever, a lubricant liquid or suspension can also be broken up after application of a high pressure during passage through a narrow nozzle into discrete droplets of specific volume, whereby the individual droplets are successively charged electrically and are deflected electrostatically to the loaded zones of the pressing tools interMittently for the dotting thereof.
~ system suitable for dotting the liquid or suspended lubricant consists e.g. of an entire row of channels such that a tube-shaped piezoelectric oscillator , .. ., ... .. : ~ :
.. ..
.
.
: , . . . .
1 ~59~21 encases concentrically a section of each channel.
Serving as electrodes to apply the electrical field are conductive layers, e.g. silver layers or gold or nickel layers, on the faces of the tube-shaped pie-zoelectric oscillator.
The outlet openings are aligned so that each individual opening dots a certain region of the passing moulding tools with fîne droplets of lubricant. The individual channels are connected on their feed side e.g. to a common distributor plate which is connected to a supply container and are provided therefrom with lubricant liquid or suspension,~see Figure 1).
The flow back of the liquid or suspension in the nozzle channel is obstructed, for example, due to the fact that the nozzle channel is narrowed towards the outlet opening. As a result of the property of piezoelectric oscillators to undergo an elastic deformation upon the application of a certain electrical field, there arises in the tube-shaped piezoelectric oscillators a shock wave directed to the liquid. The pressure increase associated therewith leads to the ejection of very small quantities of lubricant in lobe form from the outlet openings, these lobes of lubricant assuming a spherical form after leaving the outlet openings. The diameter of a channel is advantageously about lmm in its middle part, the individual channel being narrowed at its outlet opening. The diameter of the outlet opening is e.g. 0.1 mm.
The supply container lies lower than the outlet openings and reference is therefore made to a vacuum :,: . - , , - 4 ~
system. ~ue to the height difference a static vacuum arises in the channels. This static vacuum is overcompensated for a brief moment in the channels upon application of the electrical field in conjunction with the capillary action.
The capillary forces in the channels and in the outlet openings prevent the lubricant liquid or suspension from running back.
Thus, for example 3000 droplets leave the opening with a drop frequency of 3 kHz and a lubricant viscosity of about 20 mPas. The velocity of the droplets is about 4 m/s with a very constant droplet weight of about 0.8 ~g (0.0008 mg). Depending on the electronic control, the drop frequency lies between a few hundred Hertz and 50 kHz, preferably around 3 kHz. The excitation of the piezoelectric oscillators is effected e g. with a voltage pulse of 120 V and a pulse duration of 20 microseconds.
The channel which is surrounded by the piezoelectric oscillator may be curved arbitrarily in front of or behind said oscillator; this form of realisation serves for better adaptation to the spatial conditions e.g.
of the tablet press. However, the channel may also be branched into two or more channels spatially after the piezoelectric oscillator 7 SO that one piezoelectric oscillator supplies several channels with separate outlet openings. The outlet openings may be e.g. holes in a glass or metal plate. If the channel consists of . . .
.
~59~21 a glass capillary tube, then the outlet opening may be formed by drawing out the glass tube at its end.
Another advantageous form of realisation for dotting with liquid or suspended lubricant consists in ~Ising plate-shaped or planar transducers which work on the piezoelectric principle and which are fitted preferably concentrically above the entrance of the channels; again, narrowed outlet openings are situated at the end of the channels. In a preferred form of realisation the piezoelectric plate lies horizontally concentrically to the channel leading away vertically. The piezoelectric plates lie in or on a compartment for receiving the lubricant liquid or suspension. Several chaImels may lead away from a common compartment which is connected, in turn, to a common liquid supply. Thus, e.g also a planar oscillator (piezoelectric plate) can simultaneously generate a pressure wave in several channels connected to the same distributor compartment.
A further advantageous, constructively simplified form of realisation contains a planar oscillator of strong stroke in the compartment and a channel which departs from the compartment and runs preferably vertically to the planar oscillator and at the end of which are situated several nozzles optionally aligned variously in space or an entire nozzle rim. Due to such an arrangement a surface dotting can be obtained with a single stroke generated by the piezoelectric oscillator (see Figures 2a, b and c).
.
, :......... . .
. " ~ . . . . . ..
~ 1~9~21 With high-performance tabletting machines the top force or the bottom force with the cavity runs past the dotting system in a few milliseconds.
Nevertheless, a channel which works with a drop frequency of a few kHz can deliver during this time not only one, but an entire series of lubricant droplets. The control of the dotting system consisting of a larger number of channels with outlet openings may be effected in such a way that all channels spray simultaneously upon the appearance of the mould;ng tools or staggered in time according to their geometric arrangement. Moreover, it is possible to select the droplet frequency of the channels differently depending on which region of the moulding tools is to be dotted.
Thus, more lubricant can be applied in a directed manner to special æones of the moulding tools (e.g. to the pressing zone in the cavity or to the engraving of the top or bottom force) than to less loaded zones.
Finally, there is the possibility of feeding the channels which dot the cavity wall with a different lubricant solution from that of the channels which are provided for dotti,ng the surfaces of the forces.
In order to apply concentratedly to tbe desired surfaces of the moulding tools the droplets generated by pi,ezoelectric transducers, it is advantageous in many cases to charge them after they leave the outlet openings by the application of an electrical voltage in order to control their path subsequently by electrostatic deflection. This control can be effected with convent-ional means, for example on the principle,of cathode-ray deflection in a television tube.
.
. ~ ' " ' : ' ' ~ ~ ' 1 ~9~2~
The piezoceramic bodies may also be used as valves if the lubricant liquid or suspension is supplied with pressure to the oscillator or transducer which opens or closes according to selection. Upon selection, e.g. a slit-shaped opening opens briefly in a channel containing the liquid under pressure and the filling material is delivered through said opening in drop form;
the opening may be fashioned in the oscillator itself which as valve closes the space standing under pressure or in the marginal zone between the oscillator and the material forming the walls of the channel. This operation is possible also in reverse, whereby upon selection the oscillator closes the space standing under pressure.
The drops necessary for dotting may be generated also by the so-called high-pressure process. In the high-pressure process the active substance liquid or suspension is pressed under high pressure through one or more narrow nozzles. The high pressure is generated e.g. by the pump. Immediately after leaving the nozzle the liquid is divided into fine droplets of uniform size which are subsequently charged by a charging electrode; the electrically charged droplets are deflected electrostatically to the desired points of the pressing tools (see Figure 3).
The high-pressure nozzle may also be situated concentrically in the middle of a tube filled with lubricant liquid or suspension. The outlet opening of the high-pressure nozzle is situated just below the level of the lubricant liquid. From the high-pressure nozzle there emerges a carrier or transport liquid : . ~ .
, as a jet which carries with it up to 50% of the lubricant liquid or s~lspension surrounding it. This liquid jet of carrier and lubricant liquid standing under high pressure is decomposed immediately after leaving the nozzle-shaped opening of the tube into uniform droplets which after electrical charging are deflected electrostatically in the direction of the points to be dotted of the pressing tools. Suitable as transport liquid are e.g. water, alcohols such as ethanol or glycol, glycerine. The diameter of the nozzle is e g. 10 mm and the diameter of the surrounding tube is 2 mm. Also coarse lubricant suspensions can be dotted with this arrangement (see Figure 4).
The droplets generated by the above-described high-pressure system have e.g. a diameter of 20 mm.
These droplets can, if desired, be further divided by the application of a strong electrical field of e.g. 500 to 1000 V; these finer charged droplets, also, may be used for the directed dotting of the pressing tools due to electrostatic deflection.
~ owever, with high-performance tabletting machines it may also be of advantage that the discrete droplets of lubricant are accelerated on their way to the moulding tools by a directed and dosed air stream.
This directed air stream can be taken easily eO~ from a ,- contact-controlled nozzle co~nected to a compressed-air system.
: , , .
Process for the dotting-of-moulding tools by means of .
discrete droplets of liquid or suspended lubricants in the manufacture of mouldings in the field of pharma-ceuticals, foodstuffs or catalysts The invention is concerned with a process for the intermittent dotting of moulding tools, e.g. of tableting machines, by means of discrete droplets of liquid or suspended lubricants in the manufacture of mouldings in the field of pharmaceuticals, foodstuffs or catalysts.
Canadian Patent Specification No. 1,096,783 describes a process for the coating of press compartments on tableting machines, which is characterised in that dissolved or melted release agents are applied to the inner walls of the press compartment before each pressing operation by means of a no~zle system spraying briefly ("intermittently") at rapid intervals.
It has been shown in the meantime that with the new high-performance tableting machines a hydraulically operated inter-mittent spraying system is still too slow-acting to coat the moulding tools before each pressing operation. Moreover, it is fundamentally , , ,. , ,, ~ , . ~
,~, , ,. ,, ~ ,.
'. , ''', ' '~: ' .
. ., '' ' ~.' ' : `
~ 1~9~1 desirable to keep as small as possible the quantity of lubricant (to achieve an optimal bioavailability, mouldability and a clear and undelayed dissolution of dissolving tablets e.g. for diagnostic purposes or effervescent tablets). It is therefore necessary that the spraying system be especially capable of applying concentratedly the required quantity of lubricant to strongly loaded zones of the moulding tools (e.g. the pressing zone in the cavity) in the shortest possible time, e.g. in a few milliseconds, intermittently and in a directed manner.
It has now been found that these requirements can be met in a superior way due to the fact that liquid or suspended lubricant is dotted in a directed manner onto the loaded zones of the pressing tools before each pressing operation in specific quantities and in the form of discrete droplets of specific volume. The dotting is effected e.g. by means of tube-shaped or plate-shaped piezoelectric transducers inter mittently before each pressing operation. ~owever, a lubricant liquid or suspension can also be broken up after application of a high pressure during passage through a narrow nozzle into discrete droplets of specific volume, whereby the individual droplets are successively charged electrically and are deflected electrostatically to the loaded zones of the pressing tools interMittently for the dotting thereof.
~ system suitable for dotting the liquid or suspended lubricant consists e.g. of an entire row of channels such that a tube-shaped piezoelectric oscillator , .. ., ... .. : ~ :
.. ..
.
.
: , . . . .
1 ~59~21 encases concentrically a section of each channel.
Serving as electrodes to apply the electrical field are conductive layers, e.g. silver layers or gold or nickel layers, on the faces of the tube-shaped pie-zoelectric oscillator.
The outlet openings are aligned so that each individual opening dots a certain region of the passing moulding tools with fîne droplets of lubricant. The individual channels are connected on their feed side e.g. to a common distributor plate which is connected to a supply container and are provided therefrom with lubricant liquid or suspension,~see Figure 1).
The flow back of the liquid or suspension in the nozzle channel is obstructed, for example, due to the fact that the nozzle channel is narrowed towards the outlet opening. As a result of the property of piezoelectric oscillators to undergo an elastic deformation upon the application of a certain electrical field, there arises in the tube-shaped piezoelectric oscillators a shock wave directed to the liquid. The pressure increase associated therewith leads to the ejection of very small quantities of lubricant in lobe form from the outlet openings, these lobes of lubricant assuming a spherical form after leaving the outlet openings. The diameter of a channel is advantageously about lmm in its middle part, the individual channel being narrowed at its outlet opening. The diameter of the outlet opening is e.g. 0.1 mm.
The supply container lies lower than the outlet openings and reference is therefore made to a vacuum :,: . - , , - 4 ~
system. ~ue to the height difference a static vacuum arises in the channels. This static vacuum is overcompensated for a brief moment in the channels upon application of the electrical field in conjunction with the capillary action.
The capillary forces in the channels and in the outlet openings prevent the lubricant liquid or suspension from running back.
Thus, for example 3000 droplets leave the opening with a drop frequency of 3 kHz and a lubricant viscosity of about 20 mPas. The velocity of the droplets is about 4 m/s with a very constant droplet weight of about 0.8 ~g (0.0008 mg). Depending on the electronic control, the drop frequency lies between a few hundred Hertz and 50 kHz, preferably around 3 kHz. The excitation of the piezoelectric oscillators is effected e g. with a voltage pulse of 120 V and a pulse duration of 20 microseconds.
The channel which is surrounded by the piezoelectric oscillator may be curved arbitrarily in front of or behind said oscillator; this form of realisation serves for better adaptation to the spatial conditions e.g.
of the tablet press. However, the channel may also be branched into two or more channels spatially after the piezoelectric oscillator 7 SO that one piezoelectric oscillator supplies several channels with separate outlet openings. The outlet openings may be e.g. holes in a glass or metal plate. If the channel consists of . . .
.
~59~21 a glass capillary tube, then the outlet opening may be formed by drawing out the glass tube at its end.
Another advantageous form of realisation for dotting with liquid or suspended lubricant consists in ~Ising plate-shaped or planar transducers which work on the piezoelectric principle and which are fitted preferably concentrically above the entrance of the channels; again, narrowed outlet openings are situated at the end of the channels. In a preferred form of realisation the piezoelectric plate lies horizontally concentrically to the channel leading away vertically. The piezoelectric plates lie in or on a compartment for receiving the lubricant liquid or suspension. Several chaImels may lead away from a common compartment which is connected, in turn, to a common liquid supply. Thus, e.g also a planar oscillator (piezoelectric plate) can simultaneously generate a pressure wave in several channels connected to the same distributor compartment.
A further advantageous, constructively simplified form of realisation contains a planar oscillator of strong stroke in the compartment and a channel which departs from the compartment and runs preferably vertically to the planar oscillator and at the end of which are situated several nozzles optionally aligned variously in space or an entire nozzle rim. Due to such an arrangement a surface dotting can be obtained with a single stroke generated by the piezoelectric oscillator (see Figures 2a, b and c).
.
, :......... . .
. " ~ . . . . . ..
~ 1~9~21 With high-performance tabletting machines the top force or the bottom force with the cavity runs past the dotting system in a few milliseconds.
Nevertheless, a channel which works with a drop frequency of a few kHz can deliver during this time not only one, but an entire series of lubricant droplets. The control of the dotting system consisting of a larger number of channels with outlet openings may be effected in such a way that all channels spray simultaneously upon the appearance of the mould;ng tools or staggered in time according to their geometric arrangement. Moreover, it is possible to select the droplet frequency of the channels differently depending on which region of the moulding tools is to be dotted.
Thus, more lubricant can be applied in a directed manner to special æones of the moulding tools (e.g. to the pressing zone in the cavity or to the engraving of the top or bottom force) than to less loaded zones.
Finally, there is the possibility of feeding the channels which dot the cavity wall with a different lubricant solution from that of the channels which are provided for dotti,ng the surfaces of the forces.
In order to apply concentratedly to tbe desired surfaces of the moulding tools the droplets generated by pi,ezoelectric transducers, it is advantageous in many cases to charge them after they leave the outlet openings by the application of an electrical voltage in order to control their path subsequently by electrostatic deflection. This control can be effected with convent-ional means, for example on the principle,of cathode-ray deflection in a television tube.
.
. ~ ' " ' : ' ' ~ ~ ' 1 ~9~2~
The piezoceramic bodies may also be used as valves if the lubricant liquid or suspension is supplied with pressure to the oscillator or transducer which opens or closes according to selection. Upon selection, e.g. a slit-shaped opening opens briefly in a channel containing the liquid under pressure and the filling material is delivered through said opening in drop form;
the opening may be fashioned in the oscillator itself which as valve closes the space standing under pressure or in the marginal zone between the oscillator and the material forming the walls of the channel. This operation is possible also in reverse, whereby upon selection the oscillator closes the space standing under pressure.
The drops necessary for dotting may be generated also by the so-called high-pressure process. In the high-pressure process the active substance liquid or suspension is pressed under high pressure through one or more narrow nozzles. The high pressure is generated e.g. by the pump. Immediately after leaving the nozzle the liquid is divided into fine droplets of uniform size which are subsequently charged by a charging electrode; the electrically charged droplets are deflected electrostatically to the desired points of the pressing tools (see Figure 3).
The high-pressure nozzle may also be situated concentrically in the middle of a tube filled with lubricant liquid or suspension. The outlet opening of the high-pressure nozzle is situated just below the level of the lubricant liquid. From the high-pressure nozzle there emerges a carrier or transport liquid : . ~ .
, as a jet which carries with it up to 50% of the lubricant liquid or s~lspension surrounding it. This liquid jet of carrier and lubricant liquid standing under high pressure is decomposed immediately after leaving the nozzle-shaped opening of the tube into uniform droplets which after electrical charging are deflected electrostatically in the direction of the points to be dotted of the pressing tools. Suitable as transport liquid are e.g. water, alcohols such as ethanol or glycol, glycerine. The diameter of the nozzle is e g. 10 mm and the diameter of the surrounding tube is 2 mm. Also coarse lubricant suspensions can be dotted with this arrangement (see Figure 4).
The droplets generated by the above-described high-pressure system have e.g. a diameter of 20 mm.
These droplets can, if desired, be further divided by the application of a strong electrical field of e.g. 500 to 1000 V; these finer charged droplets, also, may be used for the directed dotting of the pressing tools due to electrostatic deflection.
~ owever, with high-performance tabletting machines it may also be of advantage that the discrete droplets of lubricant are accelerated on their way to the moulding tools by a directed and dosed air stream.
This directed air stream can be taken easily eO~ from a ,- contact-controlled nozzle co~nected to a compressed-air system.
: , , .
2 1 _ 9 _ The dotting system may be fitted anywhere in front of the filling s~oe and behind the ejector device of a tabletting machine. However, it is especially appropriate to arrange the spray opening of the spraying system about l mm above the dial feed in which the cavities are situated, so that it is possible to dot directly from above into the "cup" formed from the cavity bore and the active face of the bottom force~
It is even possible to dot directly into the gap between the cavity and bottom force.
The control signal for releasing the intermittent and precisely directed dotting is obtained e.g. by means of photocells or inductive or capacitive proximity switchesO
.:
~ , `
.
`` l 1~9~21 Besides lubricant solutions and suspensions, even lubricant melts can be used if the distributor head is heated to the appropriate temperature by a built-in heating plate. A heated supply container and hose ensure the conveyance of the lubricant to the spraying head.
All lubricant liquids are conveyed to the channels advantage-ously via a suitable small filter.
Figures 1 to 4 are intended to illustrate schematically and in an exemplary manner a few possible devices for dotting moulding tools with liquid or suspended lubricants.
In accordance with the present invention, there is provided in a method of preparing tablets and cores from agranulate material comprising introducing granulate material into a mold die cavity, compressing the granulate material in the mold die cavity with a cooperating punch to form tablets and cores, and ejecting the tablets and cores from the mold die cavity, the improvement which comprises selectively and intermittently dotting liquid or suspend-ed lubricant in specific quantities and in the form of discrete droplets by piezoelectric means on the ma~ing surfacesof the mold die cavity and cooperating punch to provide complete lubrication of the mating surfaces.
In accordance with the present invention there is further provided apparatus for preparing tablets and cores from a granulate material in a mold die cavity, including means for selectively and intermittently dotting liquid or suspended lubricant in specific quantities and in the form of discrete droplets on mating surfaces of the mold die cavity and a cooperating punch, to provide complete lubrication of the mating surfaces, said means comprising a source `
..; . :".
: :
-` ` l 1~9~2~
of the dotting liquid or suspended lubricant, nozzle means, a fluid channelconnecting the source and the nozzle means, and a piezoelectric transducer in the channel for disch~rging lubricant from the nozzle means.
Figure 1 shows schematically in cross section a dotting system with piezoelectric transducers (1) which each encase a nozzle channel (8); the nozzle channel terminates in a narrowing (7); the individual narrowings (7) are present at corresponding openings of an outlet nozzle plate (6), whereby the nozzles formed by the narrowings (7) and the openings of the oulet plate (6) deliver droplets of liquid (5) when the device is actuated. The nozzle channel (8) is connected via a narrowed liquid channel (9) to a liquid compartment (2)~ The distributor compartment (2) has a vent channel (10); the distributor compartment is connected via a filter plate (4) to a liquid supply container (3). The electrical control of the piezoelectric transducers is effected via contacts (11).
Figures 2a, 2b and 2c show cross section through variously con~.tructed dotting heads with planar transducers working on the piezoelectric principle.
- lOa -, ~;
' ';
' ` l 15~2~
Here, ~1) designates a planar piezoelectric transducer with contacts ~11) for electrical control. The planar piezoelectric transducer lies in a liquid compartment ~12) which is connected via the liquid line ~13) to a supply container. There depart ~rom the compartment ~12) one or more nozzle channels ~18) whose narrowings ~17) terminate at an outlet nozzle plate ~6); ~5) designates the liquid droplets released.
Figure 3 describes schematically a cross section through a so-called high-pressure dotting system. From a liquid supply container ~21) liquid is pressed by means of a pump ~22) through a filter ~23) into the nozzle ~24).
The liquid jet ~27) released at the nozzle ~24) is decomposed into drops ~28) which are charged electrically by a drop charging ring ~25) and are deflected by means of a deflector plate ~26) in an electrical field. The deflected liquid drop ~29) dots the moulding tools. The remaining drops ~29)are drawn up by a suction electrode ~100) and collected and are returned to the container ~21) via the line ~110).
Figure 4 shows a cross section through a hig~-pressure dotting system in which the lubricant is conveyed by a trans-port liquid. The liquid supply container ~31) contains the transport liquid which is pressed by the pump ~32) through a filter ~33) into the nozzle ~34). The tube ~30) contains the lubricant liquid or suspension which is carried along at the nozzle (34a) by the jet ~37~ o~ transport liquid released at - : . ... .
.. . .
, .. . .
? 15~2~ -_ 12 the nozzle (30); the combined jet (37) decomposes into drops (38) which are charged electrically by the drop charging ring (35). The drops (38) are deflected upon passing the deflector plates (36) electrostatically into the desired direction, the deflected drops (39) dotting the pressing tools at specific points. The undeflected drops are removed by a suction electrode (100) .
Altogether, the following advantages of this dotting system are to emphasised:
The system works without any mechanism with the use of piezoelectric oscillators and therefore undergoes practically no wear. Even the supply of the dotting liquid is effected independently due to the caplllary forces of the channels.
The droplet formation is stable and of the highest precision, irrespective oE whether a few hundred or 15,000 droplets per second are delivered by the channel.
The dotting head is sized so that it can be attached even to the smallest tablet press or capsule machine.
The head can be aligned so that it delivers the droplets in all the desired directions.
The head delivers only droplets of the same weight in contrast to a single-substance or double-substance nozzle with droplet distributions between a mist and coarse drops.
With the dotting systems described the rapid and exact mode of operation is to be emphasised; they are suitable for all hitherto known high-speed tablet ., , ~ . .. .
, ~ ' , . . .
1~9~23 presses. The delivery of lubricating liquid or suspension can be effected in less than one millisecond.
The quantities delivered are constant~ The lubricant is applied exactly at the points of the tools where the lubricant must necessarily be used. The hitherto known systems, e.g. spraying of lubricant liquids from a nozzle, produce droplet distributions between a mist and coarse drops, whereby the coarse drops prevent a homogeneous distribution of the lubricant and the mist leads to contamination of the press plate or tablet machine. With the hitherto known systems it was not possible to apply concentratedly to the especially stressed æones of the press tools in a consistent way more lubricant than to less stressed places.
, ,~ , ~ .
.. . .
.
. , 5~23 _ 14 _ Example 1 40 kg of indomethacine, 159 kg of lactose, 200 kg of corn starch, 14 kg of colloidal silicic acid and 6 kg of polyvinyl pyrrolidone are granulated in the conventional way after intensive mixing; for this purpose, an aqueous solution of 10 kg of soluble starch is used.
The granulate is pressed in a double rotary press with an output of 220,000 tablets per hour, the cavity wall and the active force surfaces being dotted by means of a dotting system working piezoceramically and filled with a semi-saturated solution of glycerine monostearate in ethanol. In so doing, the 24 tubes work at a frequency of 10 droplets per millisecond and the pressing tools can be dotted for about 5 milli-seconds during their passage. ~The droplet weight lies around 0.0006 mg. The maximum breaking strength at the specified tabletting speed is 35% higher in comparison with tablets having 1.0% magnesium stearate in the granulate.
Example 2 A powder mixture for hard gelatin capsules is prepared from an active substance A, lactose, corn starch and colloidal silicic acid. A dotting device is attached about 1 mm underneath the passing filling tube of a capsule-filling machine. A planar piezoelec~ric oscillator is situated above the liquid channel of this apparatus; the end of the channel is closed by a nozzle .. , . :
., `` ~ 159~Xl plate with 42 bores 0.06 mm in diameter. During one millisecond 0.1 mg of a 5% alcoholic magnesium stearate suspension is delivered to the inside of the passing filling tube. The tested in vitro release of the active substance from this capsule was substantially quicker (90% release of active substance in 10 minutes instead of 35) in comparison with a capsule prepared according to conventional technology (~ith 2% magnesium stearate in the granulate).
. , ~ , : ; .
. , -: ' ~ '`' ' '' ., :
.~- : , ' :~ ' ,
It is even possible to dot directly into the gap between the cavity and bottom force.
The control signal for releasing the intermittent and precisely directed dotting is obtained e.g. by means of photocells or inductive or capacitive proximity switchesO
.:
~ , `
.
`` l 1~9~21 Besides lubricant solutions and suspensions, even lubricant melts can be used if the distributor head is heated to the appropriate temperature by a built-in heating plate. A heated supply container and hose ensure the conveyance of the lubricant to the spraying head.
All lubricant liquids are conveyed to the channels advantage-ously via a suitable small filter.
Figures 1 to 4 are intended to illustrate schematically and in an exemplary manner a few possible devices for dotting moulding tools with liquid or suspended lubricants.
In accordance with the present invention, there is provided in a method of preparing tablets and cores from agranulate material comprising introducing granulate material into a mold die cavity, compressing the granulate material in the mold die cavity with a cooperating punch to form tablets and cores, and ejecting the tablets and cores from the mold die cavity, the improvement which comprises selectively and intermittently dotting liquid or suspend-ed lubricant in specific quantities and in the form of discrete droplets by piezoelectric means on the ma~ing surfacesof the mold die cavity and cooperating punch to provide complete lubrication of the mating surfaces.
In accordance with the present invention there is further provided apparatus for preparing tablets and cores from a granulate material in a mold die cavity, including means for selectively and intermittently dotting liquid or suspended lubricant in specific quantities and in the form of discrete droplets on mating surfaces of the mold die cavity and a cooperating punch, to provide complete lubrication of the mating surfaces, said means comprising a source `
..; . :".
: :
-` ` l 1~9~2~
of the dotting liquid or suspended lubricant, nozzle means, a fluid channelconnecting the source and the nozzle means, and a piezoelectric transducer in the channel for disch~rging lubricant from the nozzle means.
Figure 1 shows schematically in cross section a dotting system with piezoelectric transducers (1) which each encase a nozzle channel (8); the nozzle channel terminates in a narrowing (7); the individual narrowings (7) are present at corresponding openings of an outlet nozzle plate (6), whereby the nozzles formed by the narrowings (7) and the openings of the oulet plate (6) deliver droplets of liquid (5) when the device is actuated. The nozzle channel (8) is connected via a narrowed liquid channel (9) to a liquid compartment (2)~ The distributor compartment (2) has a vent channel (10); the distributor compartment is connected via a filter plate (4) to a liquid supply container (3). The electrical control of the piezoelectric transducers is effected via contacts (11).
Figures 2a, 2b and 2c show cross section through variously con~.tructed dotting heads with planar transducers working on the piezoelectric principle.
- lOa -, ~;
' ';
' ` l 15~2~
Here, ~1) designates a planar piezoelectric transducer with contacts ~11) for electrical control. The planar piezoelectric transducer lies in a liquid compartment ~12) which is connected via the liquid line ~13) to a supply container. There depart ~rom the compartment ~12) one or more nozzle channels ~18) whose narrowings ~17) terminate at an outlet nozzle plate ~6); ~5) designates the liquid droplets released.
Figure 3 describes schematically a cross section through a so-called high-pressure dotting system. From a liquid supply container ~21) liquid is pressed by means of a pump ~22) through a filter ~23) into the nozzle ~24).
The liquid jet ~27) released at the nozzle ~24) is decomposed into drops ~28) which are charged electrically by a drop charging ring ~25) and are deflected by means of a deflector plate ~26) in an electrical field. The deflected liquid drop ~29) dots the moulding tools. The remaining drops ~29)are drawn up by a suction electrode ~100) and collected and are returned to the container ~21) via the line ~110).
Figure 4 shows a cross section through a hig~-pressure dotting system in which the lubricant is conveyed by a trans-port liquid. The liquid supply container ~31) contains the transport liquid which is pressed by the pump ~32) through a filter ~33) into the nozzle ~34). The tube ~30) contains the lubricant liquid or suspension which is carried along at the nozzle (34a) by the jet ~37~ o~ transport liquid released at - : . ... .
.. . .
, .. . .
? 15~2~ -_ 12 the nozzle (30); the combined jet (37) decomposes into drops (38) which are charged electrically by the drop charging ring (35). The drops (38) are deflected upon passing the deflector plates (36) electrostatically into the desired direction, the deflected drops (39) dotting the pressing tools at specific points. The undeflected drops are removed by a suction electrode (100) .
Altogether, the following advantages of this dotting system are to emphasised:
The system works without any mechanism with the use of piezoelectric oscillators and therefore undergoes practically no wear. Even the supply of the dotting liquid is effected independently due to the caplllary forces of the channels.
The droplet formation is stable and of the highest precision, irrespective oE whether a few hundred or 15,000 droplets per second are delivered by the channel.
The dotting head is sized so that it can be attached even to the smallest tablet press or capsule machine.
The head can be aligned so that it delivers the droplets in all the desired directions.
The head delivers only droplets of the same weight in contrast to a single-substance or double-substance nozzle with droplet distributions between a mist and coarse drops.
With the dotting systems described the rapid and exact mode of operation is to be emphasised; they are suitable for all hitherto known high-speed tablet ., , ~ . .. .
, ~ ' , . . .
1~9~23 presses. The delivery of lubricating liquid or suspension can be effected in less than one millisecond.
The quantities delivered are constant~ The lubricant is applied exactly at the points of the tools where the lubricant must necessarily be used. The hitherto known systems, e.g. spraying of lubricant liquids from a nozzle, produce droplet distributions between a mist and coarse drops, whereby the coarse drops prevent a homogeneous distribution of the lubricant and the mist leads to contamination of the press plate or tablet machine. With the hitherto known systems it was not possible to apply concentratedly to the especially stressed æones of the press tools in a consistent way more lubricant than to less stressed places.
, ,~ , ~ .
.. . .
.
. , 5~23 _ 14 _ Example 1 40 kg of indomethacine, 159 kg of lactose, 200 kg of corn starch, 14 kg of colloidal silicic acid and 6 kg of polyvinyl pyrrolidone are granulated in the conventional way after intensive mixing; for this purpose, an aqueous solution of 10 kg of soluble starch is used.
The granulate is pressed in a double rotary press with an output of 220,000 tablets per hour, the cavity wall and the active force surfaces being dotted by means of a dotting system working piezoceramically and filled with a semi-saturated solution of glycerine monostearate in ethanol. In so doing, the 24 tubes work at a frequency of 10 droplets per millisecond and the pressing tools can be dotted for about 5 milli-seconds during their passage. ~The droplet weight lies around 0.0006 mg. The maximum breaking strength at the specified tabletting speed is 35% higher in comparison with tablets having 1.0% magnesium stearate in the granulate.
Example 2 A powder mixture for hard gelatin capsules is prepared from an active substance A, lactose, corn starch and colloidal silicic acid. A dotting device is attached about 1 mm underneath the passing filling tube of a capsule-filling machine. A planar piezoelec~ric oscillator is situated above the liquid channel of this apparatus; the end of the channel is closed by a nozzle .. , . :
., `` ~ 159~Xl plate with 42 bores 0.06 mm in diameter. During one millisecond 0.1 mg of a 5% alcoholic magnesium stearate suspension is delivered to the inside of the passing filling tube. The tested in vitro release of the active substance from this capsule was substantially quicker (90% release of active substance in 10 minutes instead of 35) in comparison with a capsule prepared according to conventional technology (~ith 2% magnesium stearate in the granulate).
. , ~ , : ; .
. , -: ' ~ '`' ' '' ., :
.~- : , ' :~ ' ,
Claims (12)
PROPERTY OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:
1. In a method of preparing tablets and cores from a granulate material comprising introducing granulate material into a mold die cavity, compressing the granulate material in the mold die cavity with a cooperating punch to form tablets and cores, and ejecting the tablets and cores from the mold die cavity, the improvement which comprises selectively and intermittently dotting liquid or suspended lubricant in specific quantities and in the form of discrete droplets by piezoelectric means on the mating surfaces of the mold die cavity and cooperating punch to provide complete lubrication of the mating surfaces.
2. A method according to claim 1, in which the intermittent dotting of the liquid or suspended lubricant is effected using tube-shaped or plate-shaped piezoelectric transducers.
3. A method according to claim 2, in which the dotting with a piezoelec-tric transducer is effected in such a way that the release of droplets from a liquid standing under pressure is effected by a controlled outlet opening being part of the piezoelectric transducer.
4. A method according to claim 1, 2 or 3 in which certain regions of the moulding tool are dotted independently of one another with lubricant droplets of various types.
5. A method according to claim 1, 2 or 3 in which certain regions of the moulding tool are dotted independently of one another with lubricant droplets of various types.
6. A method according to claim 1, 2 or 3 in which the path of the drop-lets is controlled by electrostatic or electromagnetic deflection.
7, Apparatus for preparing tablets and cores from a granulate material in a mold die cavity, including means for selectively and intermittently dotting liquid or suspended lubricant in specific quantities and in the form of discrete droplets on mating surfaces of the mold die cavity and a cooperating punch, to provide complete lubrication of the mating surfaces, said means comprising a source of the dotting liquid or suspended lubricant, nozzle means, a fluid channel connecting the source and the nozzle means, and a piezoelectric trans-ducer in the channel for discharging lubricant from the nozzle means.
8. Apparatus according to claim 7 comprising one or more piezoelectric transducers which each enclose wholly or partly one or more of said channels, the nozzles comprising point-shaped or slit-shaped outlet openings.
9. Apparatus according to claim 8, in which the piezoelectric trans-ducers themselves contain one or more point-shaped or slit-shaped outlet open-ings as integrated constituents of the liquid channel.
10. Apparatus according to claim 8, in which the or each channel is curved upstream or downstream of the piezoelectric transducer or is branched into two or more channels downstream of the or each piezoelectric transducer, the or each piezoelectric transducer being assisted by at least one further piezoelectric transducer.
11. Apparatus according to claim 7 comprising a plate-shaped or planar piezoelectric transducer fitted horizontally above the entrance of one or more channels which lead away vertically from the entrance and which have nozzles at the other end.
12. Apparatus according to claim 7 comprising a planar oscillator or transducer of strong stroke disposed in a liquid compartment, a channel attached to the compartment and extending therefrom transversely to the planar oscillator, and a plurality of nozzles aligned in space attached at the end of the channel.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP2849496.4 | 1978-11-15 | ||
| DE19782849496 DE2849496A1 (en) | 1977-04-20 | 1978-11-15 | Treating moulding tools with lubricant droplets - generated e.g. in a piezoelectric oscillator, for use in pharmaceutical, food and catalyst prod. |
| DE19792932069 DE2932069A1 (en) | 1979-08-08 | 1979-08-08 | Treating moulding tools with lubricant droplets - generated e.g. in a piezoelectric oscillator, for use in pharmaceutical, food and catalyst prod. |
| DEP2932069.2 | 1979-08-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1159621A true CA1159621A (en) | 1984-01-03 |
Family
ID=25776482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000339927A Expired CA1159621A (en) | 1978-11-15 | 1979-11-15 | Process for the dotting of moulding tools by means of discrete droplets of liquid or suspended lubricants in the manufacture of mouldings in the field pharmaceuticals, foodstuffs or catalysts |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4388343A (en) |
| EP (1) | EP0011269B1 (en) |
| AU (1) | AU536460B2 (en) |
| BR (1) | BR7907431A (en) |
| CA (1) | CA1159621A (en) |
| DD (1) | DD146890A5 (en) |
| DE (1) | DE2965223D1 (en) |
| ES (1) | ES485764A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4707309A (en) * | 1983-04-08 | 1987-11-17 | Dr. Karl Thomae Gmbh | Dotting of molding tools with droplets |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4541564A (en) * | 1983-01-05 | 1985-09-17 | Sono-Tek Corporation | Ultrasonic liquid atomizer, particularly for high volume flow rates |
| US4655393A (en) * | 1983-01-05 | 1987-04-07 | Sonotek Corporation | High volume ultrasonic liquid atomizer |
| US4558598A (en) * | 1984-06-07 | 1985-12-17 | The Boeing Company | Ultrasonic linear array water nozzle and method |
| DE3524701A1 (en) * | 1985-07-11 | 1987-01-15 | Bosch Gmbh Robert | ULTRASONIC SPRAYER NOZZLE |
| GB8530365D0 (en) * | 1985-12-10 | 1986-01-22 | Univ Bath | Manufacture of moulded products |
| DE3713253A1 (en) * | 1986-07-23 | 1988-02-04 | Bosch Gmbh Robert | ULTRASONIC SPRAYER |
| US5763262A (en) * | 1986-09-18 | 1998-06-09 | Quidel Corporation | Immunodiagnostic device |
| US20010023075A1 (en) * | 1992-04-03 | 2001-09-20 | Siu-Yin Wong | A immunodiagnositc device having a dessicant incorporated therein |
| DE3811260A1 (en) * | 1988-04-02 | 1989-10-26 | Thomae Gmbh Dr K | TARGETED DELIVERY OF DOSED AMOUNTS OF FINE DISTRIBUTED SOLIDS WITH VENTURI NOZZLE AND CONTROLLED CONTROL |
| DE3823497A1 (en) * | 1988-07-11 | 1990-01-18 | Siemens Ag | PIEZOELECTRIC LUBRICATION DEVICE FOR A BEARING |
| DE3902293A1 (en) * | 1989-01-26 | 1990-08-02 | Gunther M Voss | NEW METHOD FOR PRESS CHAMBER COATING BY LUBRICANT RING FORMING ON THE TABLET WALL OF TABLET PRESSES |
| FR2665849B1 (en) * | 1990-08-20 | 1995-03-24 | Dynamad | ULTRASONIC DEVICE FOR THE CONTINUOUS PRODUCTION OF PARTICLES. |
| DE4103413C1 (en) * | 1991-02-05 | 1992-11-12 | Gunter M. 8918 Diessen De Voss | |
| DE59208075D1 (en) * | 1992-09-22 | 1997-04-03 | Schablonentechnik Kufstein Ag | Electrostatic nozzle, in particular for spraying out highly viscous liquids |
| DE4400112A1 (en) * | 1994-01-04 | 1995-07-06 | Gunter M Voss | Process for making tablets |
| GB9405952D0 (en) * | 1994-03-25 | 1994-05-11 | Zeneca Ltd | Aqueous ophthalmic sprays |
| US5672364A (en) * | 1994-07-07 | 1997-09-30 | Sankyo Seisakusho Co. & Eisai Co., Ltd. | Apparatus for manufacturing tablets |
| US6620358B2 (en) | 1996-07-03 | 2003-09-16 | Gunter Voss | Process for manufacturing tablets |
| DE19647089A1 (en) * | 1996-11-14 | 1998-05-28 | Bayer Ag | Device for the controlled spraying of powdered lubricants onto punches and dies of tablet presses |
| US7468139B2 (en) | 1997-07-15 | 2008-12-23 | Silverbrook Research Pty Ltd | Method of depositing heater material over a photoresist scaffold |
| US6188415B1 (en) | 1997-07-15 | 2001-02-13 | Silverbrook Research Pty Ltd | Ink jet printer having a thermal actuator comprising an external coil spring |
| US7195339B2 (en) | 1997-07-15 | 2007-03-27 | Silverbrook Research Pty Ltd | Ink jet nozzle assembly with a thermal bend actuator |
| US7337532B2 (en) | 1997-07-15 | 2008-03-04 | Silverbrook Research Pty Ltd | Method of manufacturing micro-electromechanical device having motion-transmitting structure |
| US6935724B2 (en) | 1997-07-15 | 2005-08-30 | Silverbrook Research Pty Ltd | Ink jet nozzle having actuator with anchor positioned between nozzle chamber and actuator connection point |
| US6682174B2 (en) | 1998-03-25 | 2004-01-27 | Silverbrook Research Pty Ltd | Ink jet nozzle arrangement configuration |
| US6648453B2 (en) | 1997-07-15 | 2003-11-18 | Silverbrook Research Pty Ltd | Ink jet printhead chip with predetermined micro-electromechanical systems height |
| US6712453B2 (en) | 1997-07-15 | 2004-03-30 | Silverbrook Research Pty Ltd. | Ink jet nozzle rim |
| US7465030B2 (en) | 1997-07-15 | 2008-12-16 | Silverbrook Research Pty Ltd | Nozzle arrangement with a magnetic field generator |
| US7556356B1 (en) | 1997-07-15 | 2009-07-07 | Silverbrook Research Pty Ltd | Inkjet printhead integrated circuit with ink spread prevention |
| DE29804955U1 (en) * | 1998-03-19 | 1998-12-24 | Steinhauser Lothar | Metering device for powdered piston lubricant |
| US6959981B2 (en) * | 1998-06-09 | 2005-11-01 | Silverbrook Research Pty Ltd | Inkjet printhead nozzle having wall actuator |
| WO2000060238A1 (en) * | 1999-03-31 | 2000-10-12 | Ngk Insulators, Ltd. | Droplet spay device driving method and drive circuit |
| US6702196B2 (en) | 1999-03-31 | 2004-03-09 | Ngk Insulators, Ltd. | Circuit for driving liquid drop spraying apparatus |
| WO2000063006A1 (en) * | 1999-04-19 | 2000-10-26 | Kikusui Seisakusyo Ltd. | Rotary type powder compression molding machine |
| WO2005110726A1 (en) * | 2004-05-18 | 2005-11-24 | Shionogi & Co., Ltd. | Rotary powder compression molding equipment |
| CA2602392A1 (en) | 2005-03-22 | 2006-09-28 | Losan Pharma Gmbh | Solubilized ibuprofen |
| US8235692B2 (en) * | 2006-12-22 | 2012-08-07 | Kikusui Seisakusho Ltd. | Nozzle structure |
| CN101959506A (en) * | 2008-02-28 | 2011-01-26 | 雅培制药有限公司 | Tablets and preparation thereof |
| JP5448501B2 (en) | 2008-06-10 | 2014-03-19 | 株式会社菊水製作所 | Powder compression molding machine |
| KR101545413B1 (en) | 2010-07-15 | 2015-08-18 | 아이노비아 인코포레이티드 | Drop generating device |
| MX2013000604A (en) | 2010-07-15 | 2013-07-05 | Corinthian Ophthalmic Inc | Ophthalmic drug delivery. |
| US10154923B2 (en) | 2010-07-15 | 2018-12-18 | Eyenovia, Inc. | Drop generating device |
| US8733935B2 (en) | 2010-07-15 | 2014-05-27 | Corinthian Ophthalmic, Inc. | Method and system for performing remote treatment and monitoring |
| US10973238B2 (en) | 2011-03-11 | 2021-04-13 | Intercontinental Great Brands Llc | System and method of forming multilayer confectionery |
| US20130150812A1 (en) | 2011-12-12 | 2013-06-13 | Corinthian Ophthalmic, Inc. | High modulus polymeric ejector mechanism, ejector device, and methods of use |
| WO2015134326A1 (en) * | 2014-03-03 | 2015-09-11 | Intercontinental Great Brands Llc | Method for manufacturing a comestible |
| DE102016123279B4 (en) * | 2016-12-01 | 2019-02-21 | Fette Compacting Gmbh | Method and system for feeding a lubricant or release agent to press tools of a tablet press |
| US11938056B2 (en) | 2017-06-10 | 2024-03-26 | Eyenovia, Inc. | Methods and devices for handling a fluid and delivering the fluid to the eye |
| CN112519300B (en) * | 2020-11-12 | 2022-09-13 | 一重集团天津重工有限公司 | Extruder nozzle measuring and matching method |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2512743A (en) * | 1946-04-01 | 1950-06-27 | Rca Corp | Jet sprayer actuated by supersonic waves |
| US3011213A (en) * | 1958-02-19 | 1961-12-05 | Magnetics Inc | Apparatus for lubricating mold cavities |
| US3158111A (en) * | 1962-06-06 | 1964-11-24 | Smith Kline French Lab | Method and apparatus for forming tablets |
| US3281860A (en) * | 1964-11-09 | 1966-10-25 | Dick Co Ab | Ink jet nozzle |
| CH506352A (en) * | 1969-04-18 | 1971-04-30 | Buehler Ag Geb | Method and device for applying release agents or lubricants to metal molds |
| CA976599A (en) * | 1971-04-08 | 1975-10-21 | Senichi Masuda | Electrified particles generating apparatus |
| US3717875A (en) * | 1971-05-04 | 1973-02-20 | Little Inc A | Method and apparatus for directing the flow of liquid droplets in a stream and instruments incorporating the same |
| IT999894B (en) * | 1973-12-05 | 1976-03-10 | Olivetti & Co Spa | DEVICE FOR THE LUBRICATION OF DIES FOR COMPACTION OF POWDER MATERIALS FOR SINTERED PIECES |
| US3960324A (en) * | 1974-01-10 | 1976-06-01 | International Business Machines Corporation | Method for generation of multiple uniform fluid filaments |
| GB1500908A (en) * | 1974-06-05 | 1978-02-15 | Ici Ltd | Process for production of drop streams |
| US4153467A (en) * | 1974-09-03 | 1979-05-08 | Dai Nippon Toryo Co., Ltd. | Method of ink jet printing |
| US4047866A (en) * | 1976-11-22 | 1977-09-13 | The Dow Chemical Company | Automatic self-lubricating rotary tablet press |
| DE2812677A1 (en) * | 1978-03-23 | 1979-10-04 | Gunter M Voss | Moulding tool coating system - sprays lubricant onto working surfaces intermittently and briefly before each compression operation |
| US4138687A (en) * | 1977-07-18 | 1979-02-06 | The Mead Corporation | Apparatus for producing multiple uniform fluid filaments and drops |
| US4188635A (en) * | 1977-10-03 | 1980-02-12 | International Business Machines Corporation | Ink jet printing head |
-
1979
- 1979-11-07 ES ES485764A patent/ES485764A1/en not_active Expired
- 1979-11-12 EP EP79104448A patent/EP0011269B1/en not_active Expired
- 1979-11-12 DD DD79216831A patent/DD146890A5/en not_active IP Right Cessation
- 1979-11-12 DE DE7979104448T patent/DE2965223D1/en not_active Expired
- 1979-11-14 BR BR7907431A patent/BR7907431A/en not_active IP Right Cessation
- 1979-11-15 CA CA000339927A patent/CA1159621A/en not_active Expired
- 1979-11-15 AU AU52856/79A patent/AU536460B2/en not_active Ceased
-
1981
- 1981-11-30 US US06/326,168 patent/US4388343A/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4707309A (en) * | 1983-04-08 | 1987-11-17 | Dr. Karl Thomae Gmbh | Dotting of molding tools with droplets |
| US4758142A (en) * | 1983-04-08 | 1988-07-19 | Dr. Karl Thomae Gmbh | Dotting of molding tools with droplets |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0011269B1 (en) | 1983-04-13 |
| ES485764A1 (en) | 1980-10-01 |
| DE2965223D1 (en) | 1983-05-19 |
| BR7907431A (en) | 1980-08-05 |
| AU5285679A (en) | 1980-05-22 |
| EP0011269A1 (en) | 1980-05-28 |
| DD146890A5 (en) | 1981-03-11 |
| AU536460B2 (en) | 1984-05-10 |
| US4388343A (en) | 1983-06-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA1159621A (en) | Process for the dotting of moulding tools by means of discrete droplets of liquid or suspended lubricants in the manufacture of mouldings in the field pharmaceuticals, foodstuffs or catalysts | |
| USRE31764E (en) | Pharmaceuticals having dotted active ingredients and a method and apparatus for the preparation thereof | |
| US4707309A (en) | Dotting of molding tools with droplets | |
| US4548825A (en) | Method for ink-jet printing on uncoated tablets or uncoated tablet cores | |
| US4323530A (en) | Method of lubricating compression tools of molding machines | |
| CN101107111B (en) | Method and device for feeding molten resin, and method of manufacturing molded part by using the fed molten resin | |
| JP2005532906A (en) | INJECTION DEVICE AND INJECTION DEVICE METHOD | |
| WO2000051746A1 (en) | Apparatus and method for generating droplets | |
| JPS6447467A (en) | Spray apparatus and body for dispersing fluid | |
| GB2074947A (en) | Printing on pharmaceutical mouldings, tablets or coated tablets | |
| US5881954A (en) | Method and device for atomising fluids | |
| JPH0127840B2 (en) | ||
| DE2932069A1 (en) | Treating moulding tools with lubricant droplets - generated e.g. in a piezoelectric oscillator, for use in pharmaceutical, food and catalyst prod. | |
| CA2008554A1 (en) | Process for coating moulding tools in tablets making machinery | |
| CN100427216C (en) | Spray head for fluid product | |
| CA2499509A1 (en) | Dispensing apparatus and method for liquid products, particularly medicinal products | |
| JP2003503174A (en) | Pellet manufacturing method and apparatus | |
| CS231153B2 (en) | Method of molten metal spraying in making metal powder and device to perform the method | |
| PL123534B1 (en) | Process for the preparation of drug with active substance on carrier | |
| US20150217489A1 (en) | Compression Molding Machine and Method of Producing Molded Product | |
| JP2019507009A (en) | Fluid ejector | |
| JPH039757A (en) | Preparation of tablet | |
| DE8310263U1 (en) | DEVICES FOR POINTING MOLDING TOOLS WITH DROPLETS OF LIQUID OR SUSPENDED LUBRICANTS IN THE PRODUCTION OF FORMS IN THE PHARMACEUTICAL, FOOD OR CATALYST AREA | |
| JPH08206546A (en) | Dispenser for high viscosity liquid | |
| JPH02298334A (en) | Method and apparatus for production of particles |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |