CA1146868A - Sorbitol and polyvinyl pyrrolidone in toothpaste - Google Patents
Sorbitol and polyvinyl pyrrolidone in toothpasteInfo
- Publication number
- CA1146868A CA1146868A CA000367056A CA367056A CA1146868A CA 1146868 A CA1146868 A CA 1146868A CA 000367056 A CA000367056 A CA 000367056A CA 367056 A CA367056 A CA 367056A CA 1146868 A CA1146868 A CA 1146868A
- Authority
- CA
- Canada
- Prior art keywords
- weight
- toothpaste
- sorbitol
- water
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
- A61K8/8176—Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers
Abstract
ABSTRACT
A toothpaste composition comprises a vehicle containing about 45-80% by weight of liquid phase, comprising up to about 35% by weight of the toothpaste of sorbitol and at least about 25% by weight of the toothpaste of water and a solid phase includ-ing about 3-10% by weight of the toothpaste of gelling agent com-prising at least about 3% by weight of the toothpaste of poly-vinyl pyrrolidone. The composition has an improved ability to prevent drying thereof.
A toothpaste composition comprises a vehicle containing about 45-80% by weight of liquid phase, comprising up to about 35% by weight of the toothpaste of sorbitol and at least about 25% by weight of the toothpaste of water and a solid phase includ-ing about 3-10% by weight of the toothpaste of gelling agent com-prising at least about 3% by weight of the toothpaste of poly-vinyl pyrrolidone. The composition has an improved ability to prevent drying thereof.
Description
1~6868 TOCqHPASTE CoMPOSITIoN
Ihis invention relates to a toothpaste composition having desirable rheological characteristics.
A typical toothpaste vehicle is ccmprised of liquids such as water and humectant and solids such as gelling agents propor-tioned to provide a creamy or gel-like consistency. When the part-iculAr components used are unwisely chosen or their proportion to each other is improper, rheological problems can occur. Such pro-blems include undue hardness or undue liquidity, syneresis or phase separation, drying (especially at the cap end and therefore called "plugging") particularly should the tube be left cpen etc.
Sorbitol solution in water, typically about 50-80% by weight solutian, most oft~n about 70% solution and gly oe rin are the most commanly used toothpaste humectants. They are generally used in amounts ranging up to about 80% by weight of a tookhpaste but most often about 15-40~. Typically water is also present, possibly in amounts of up to 80% by weight of a toothpaste, such as in amounts of about 20-60%.
When sorbitol solution and water (separate from that in which the sorbitol is dissolved) are present in about of up to about 35% by weight and at least about 20% by weight, respectively, after proportianing these liquids with gelling agent drying readily occurs and a hard plug forms at the cap of a toothpaste tube making it very difficult to effectively extrude the paste. Same drying may occur when gly oe rine is used in pla oe of all or part of the sorbitol solu-tion although the plug which might fonm would not be as hard.
``` 11~6868 It is an advantage of this invention that drying of high water content toothpastes containing sorbitol as humectant and gelling agent is reduced or prevented. Other advantages will be apparent upon consideration of the following specification.
In accordance with certain of its aspscts this inven-tion relates to a toothpaste composition comprising a vehicle con-taining about 45-80% by weight of liquid phase comprising up to about 35% by weight (based on the toothpaste) of sorbitol and at least about 25% by weight (based on the toothpaste) of water and a solid phase including about 3-10% by weight (based on the weight of the toothpaste) of gelling agent which comprises at least about 3% by weight (based on the weight o the toothpaste) of polyvinyl pyrrolidone.
In the toothpaste of the present invention up to about 35% by weight of sorbitol is present, typically about 15-35%
preferably about 15-25%. If desired, minor amounts ~e.g. about 10%) of other humectants such as glycerine or polyethylene glycol of average molecular weight of about 380-420 may also be mixed with sorbitol. Glycerine can reduce (although not eliminate) dry-ing in the absence of polyvinyl pyrrolidone.
Sorbitol is generally employed in water solution, typi-cally about 50-80% by weight solution preferably about 70%. At least about 25% by weight typically about 25-50% preferably about 20~ of water is present, such high amounts of water have gen-erally been avoided in the past due to a tendency to dry.
~i46868 The liquid phase OI the toothpaste vehicle, that is humectant and water compr~ses about ~5-80~ by weight of the toothpaste, preferably about 55-70~.
~ he gelling agent may be all or partially pclyvinyl 5. pyrrolidone. In addition to pol~7vin~.~1 pyrrolidone there may be present natural and synthe~ic gumlike material e.g. Irish Moss, gum tragacanth, methyl cellulose, hydroxyethyl cellulose, sodium carboxymethyl cellulose, starch, carboxyvinyl polymers 10. such as those sold under the trade mark CARBOPOL 937 and 940 and synthetic silicates clays such as those sold under trade mark LAPONITE CP or SP. Polyvinyl pyrroli one is present in the toothpaste composition in amount of at least about 3~ and the total gelling 15. agent is about 3-10~ ~y weisht preferably about 5-8%.
In addition to the gelling agent as the solid portion of the toothpaste vehicle, a thickener, such as a thinly divided synthetic colloidalsilica sold under the trade marks CAB-O-SIL, AEROSIL D200 and SYLOID 244 and 266, 20. may be present in amount of about 1-5% by weight.
There is distributed in the toothpaste vehicle a den-tally acceptable water-insoluble polishing material typically in amount of about 15-50% by weight most pre-Lerably about 25-45%. Examples of polishing materials 2S. are water-lnsoluble sodium metaphosphate, potassium metaphosphate, tricalcium phospha~e, dehydrated calcium phosphate, anhydrous dicalcium phosphate, calcium phosphate, magnesium orthophosphate, trimagnesium phos-phate, calcium carbonate, alumina, hydrated alumina, 30. aluminum silicate, zirconium silicate, silica, sodium 11~686~3 4.
aluminosilicate, bentonite, and mixtures thereof. Pre-ferred polishing materials include complex amorphorus sodium aluminosilicate, anhydrous alumina, calcium carbonate and aicalcium phosphate. Th~ polishing materials 5. may be used in admixture.
Organic surface-active a~ents are used in the composi-tions of the present invention to achieve increased proph~lactic ac.ion, assIst in achie~ing thorough and complete dispersion of the Instant compositions through-10. out the oral cavity, and render the instant compositionsmore cosmetically acceptable. The organic surface-active material may ~e anionic, nonionic, ampholytic, or cationic in nature, and it is preferred to employ as the surface-active agent a detersive material which imparts to the 15. composition detersive and foaming properties. Suitable such detergents are water-soluble salts of higher fatty acid monoglyceride monosulphates, such as sodium lauryl sulphate, alkyl aryl sulphonates, such as sodium dodecyl benzene sulphonate, higher alkyl sulphoacetates, higher 20. fatty acid ester of 1,2-dihydroxy propane sulphonates and the substantially saturated higher acyl amides of lower aliphatic amino carboxylic acid compounds, such as those having 12 to 16 carbons in the fatty acid, alkyl or acyl radicals and the like. Examples of the last 25. mentioned amides are N-lauroyl sarcosine, and the sodium, potassium and ethanolamine salts of N-lauroyl, N-myristoyl or N-pa~mitoyl sarcosine which should be su~stantially free from soap or similar higher fatty acid material which tends to substantially reduce the effect 3~, of these compounds. The use of these sarcosinate compounds ~46~6t~
in dentifrice compositions of the present invention is particularly a~antageous since these materials exhibit a prolonged an~ marked effect in the inhibition of acid formation in the oral. cavity due to carbohydrates . breakdown in addition to exerting some reduction in the solubility of tooth enamel in aci~ solutions.
Other particularly suitable surface-active materials include nonionic agents such as condensates of sorbitan monostearate with approximately 6Q moles of ethylene 10. oxide, consensates of ethylene oxi~e with propylene oxide condensates of propylene glycol (~available under the trade mark PLURONICS~ and amphoteric agents such as quaternized imi~azo derivatives which are available under the trade mark MIRANOL such as MIRANOL C2M.
lS. Cationic surface-active germicides and antibacterial compounds such as diisobutylphenoxyethoxyethyl dimethyl benzyl ammonium chloride, benzyl dimethyl stearyl ammo-nium chloride, tertiary amines having one fatty alkyl group (of from 12 to 18 carbon atoms) and two (poly) 20. oxyethylene groups attached to the nitrogen ~.typically containing a total of from about 2 to 50 ethanoxy groups per molecule~. and salts thereof ~ith acids and compounds of the structure (.CH2CH20)zH ~CH2CH20)xH
25. R--N-CH2CH2CH2 N ~(CH2CH20~yH
where R is a fatty alkyl group containing from about 12 to 18 carbon atoms, and x, y and z total 3 or higher, as well as salts thereof with mineral or organic acids, may 30. also be used. It is preferred to use from about 0.05 to 1~46868 6.
to 5~ by weight of the foregoing surface-active materials in the instant oral preparations.
~ luorine-?ro~7idins compounc may be ~resent.
This compound may ~e slightly soluble in water or may be 5. fully water-solu~le. It is characterized by its ability to release fluoride ions in water and by substantial freedom from reaction with other compounds of the oral preparation. Among these materials are inorganic fluoride salts, such as soluble alkali metal, alkaline 10. earth metal and heavy metal salts, for example, sodium fluoride, a copper fluoride such as cuprous fluoride zinc fluoride, a tin fluoride such as stannous flouride or stannous chlorofluoride, barium fluoride, sodium fluorosilicate, ammonium fluorosilicate, sodium fluoro-15. zirconate, sodium monofluorophosphate, aluminium mono-and difluorophosphate. Alkali metal and tin fluorides, such as sodium and stannous fluorides, sodium mono-fluorophosphate and mixtures thereof, are preferred. A
mixture of sodium fluoride and sodium monofluorophosphate is particularly desirable. In the toothpaste an amount of fluorine-providing compound which releases a maximum of about 1% by weight of the toothpaste is satisfactory.
Any suitahle minimum of such compound may be used, but it is preferable to employ sufficient compound to release 25. from about 0.005% to 1%, and preferably about 0.1~ of flouride ion. Typically, in the cases of alkali metal flourides and stannous fluoride, this component is pre-sent in an amount up to 2~ by weight, based on the weight oi the toothpaste, and preferably in the range of from 30. 0.05% to 1%. In the case of sodium monofluorophosphate, 1146~68 the compound may be present in an amount up to 7.6%
by weight, more typically 0.76~. When present in mix-ture the ratio of sodium monofluorophosphate to sodium fluoride is desirably about 1:1 to 3:1 based on fluorine 5. provided by each.
Any suitable flavo~ring or sweetening ~aterial may also be employea. Examples of suitable flavouring con-stituents are flavouring oils e.g. oils of spearmint, peppermint, wintergreen, sassafras, clove, sage, eucalyp-10. tus, marjoram, cinnamon, lemon, orange, and methylsalicylate. Suitable sweetening agents include sucrose, lactose, maltose, sorbitol, sodium cyclamate, perillar-tine and sodium saccharin. Suita~ly, flavouring and sweetening agents may together comprise from 0.01~ to 15. 5% or more of the preparations.
Various other materials may be incorporated in the oral preparations of this invention. Examples thereof are colouring or whitening agents, preservatives, sili-cones, chlorophyll compounds, ammoniated materials such 20. as urea, diammoniumphosphate and mixtures thereof, and other constituents. These adjuvants are incorporated in the instant compositions in amounts which do not substantially adversely affect the properties and characteristics desired and are selected and used in 25. proper amount depending upon the particular type of preparation involved.
The dental cream typically has a pH ~determined di-rectly on the creaml of about 4 to 10.5, preferably about 6-10. If desired, the pH may be adiusted with 30. an acidic material, such as benzoic or citric acid, ~4686t~
8.
or an alkaline material, such as sodium hydroxide, to achieve a particular value. Buffering agents, e.g.
phosphate buffers, may be used.
The dental cream may be prepared by adding humec-5. tant to water and blending therewith the gelling agent and thereafter the polishing material.
In evaluatins toothpastes of the present invention, visccsity may be determined with the ~niversal Testing Instrument ( table model ~ manufactured by Instron 10. Ltd, High Wycombe, England. Viscosity comprising can also be determed within an extension rheometer.
The following specific example is further illustra-tive of the nature of the present invention but it is understood that the invention is not limited thereto.
15. The composition is prepared in the usual manner and all amounts and proportions are by weight unless other-wise specified.
EXAMPLE
20. Sorbitol (~qO~) 16.00 22.00 20.00 Polyvinyl 6.00 3.00 Pyrrolidone Sodium Carboxy- 1.10 1.10. 1.10 methyl Celluose 25. Sodium Saccharin 0.20 0.20 0.18 Titanium Dioxide 0.40 0.40 0.40 Sodium Monofluoro-phosphate 0.80 0.80 0.80 30.
~146~68 Anhydrous lO.OQ 10.00 10.00 Alumina Sodium Alumincsilicate (About 7~ Aluminal20.00 2Q.00 20.00 Sodium Lauryl Sulphate 1.77 1-77 1.50 Flavour 1.10 1.10. 1.00 Water 42.63 39.63 45.00 10. Toothpaste compositions A and B and extrude easily after 7, 16, 24 and 31 hours of being left open, whereas tooth-past C, quickl~ dries and forms into a hard plug within 7 hours of being left opened and is difficult to extrude.
Although this invention has been described with 15. regard to specific example, it will be apparent to one skilled in the art that various modifications may be made thereto wllich fall within its scope.
Ihis invention relates to a toothpaste composition having desirable rheological characteristics.
A typical toothpaste vehicle is ccmprised of liquids such as water and humectant and solids such as gelling agents propor-tioned to provide a creamy or gel-like consistency. When the part-iculAr components used are unwisely chosen or their proportion to each other is improper, rheological problems can occur. Such pro-blems include undue hardness or undue liquidity, syneresis or phase separation, drying (especially at the cap end and therefore called "plugging") particularly should the tube be left cpen etc.
Sorbitol solution in water, typically about 50-80% by weight solutian, most oft~n about 70% solution and gly oe rin are the most commanly used toothpaste humectants. They are generally used in amounts ranging up to about 80% by weight of a tookhpaste but most often about 15-40~. Typically water is also present, possibly in amounts of up to 80% by weight of a toothpaste, such as in amounts of about 20-60%.
When sorbitol solution and water (separate from that in which the sorbitol is dissolved) are present in about of up to about 35% by weight and at least about 20% by weight, respectively, after proportianing these liquids with gelling agent drying readily occurs and a hard plug forms at the cap of a toothpaste tube making it very difficult to effectively extrude the paste. Same drying may occur when gly oe rine is used in pla oe of all or part of the sorbitol solu-tion although the plug which might fonm would not be as hard.
``` 11~6868 It is an advantage of this invention that drying of high water content toothpastes containing sorbitol as humectant and gelling agent is reduced or prevented. Other advantages will be apparent upon consideration of the following specification.
In accordance with certain of its aspscts this inven-tion relates to a toothpaste composition comprising a vehicle con-taining about 45-80% by weight of liquid phase comprising up to about 35% by weight (based on the toothpaste) of sorbitol and at least about 25% by weight (based on the toothpaste) of water and a solid phase including about 3-10% by weight (based on the weight of the toothpaste) of gelling agent which comprises at least about 3% by weight (based on the weight o the toothpaste) of polyvinyl pyrrolidone.
In the toothpaste of the present invention up to about 35% by weight of sorbitol is present, typically about 15-35%
preferably about 15-25%. If desired, minor amounts ~e.g. about 10%) of other humectants such as glycerine or polyethylene glycol of average molecular weight of about 380-420 may also be mixed with sorbitol. Glycerine can reduce (although not eliminate) dry-ing in the absence of polyvinyl pyrrolidone.
Sorbitol is generally employed in water solution, typi-cally about 50-80% by weight solution preferably about 70%. At least about 25% by weight typically about 25-50% preferably about 20~ of water is present, such high amounts of water have gen-erally been avoided in the past due to a tendency to dry.
~i46868 The liquid phase OI the toothpaste vehicle, that is humectant and water compr~ses about ~5-80~ by weight of the toothpaste, preferably about 55-70~.
~ he gelling agent may be all or partially pclyvinyl 5. pyrrolidone. In addition to pol~7vin~.~1 pyrrolidone there may be present natural and synthe~ic gumlike material e.g. Irish Moss, gum tragacanth, methyl cellulose, hydroxyethyl cellulose, sodium carboxymethyl cellulose, starch, carboxyvinyl polymers 10. such as those sold under the trade mark CARBOPOL 937 and 940 and synthetic silicates clays such as those sold under trade mark LAPONITE CP or SP. Polyvinyl pyrroli one is present in the toothpaste composition in amount of at least about 3~ and the total gelling 15. agent is about 3-10~ ~y weisht preferably about 5-8%.
In addition to the gelling agent as the solid portion of the toothpaste vehicle, a thickener, such as a thinly divided synthetic colloidalsilica sold under the trade marks CAB-O-SIL, AEROSIL D200 and SYLOID 244 and 266, 20. may be present in amount of about 1-5% by weight.
There is distributed in the toothpaste vehicle a den-tally acceptable water-insoluble polishing material typically in amount of about 15-50% by weight most pre-Lerably about 25-45%. Examples of polishing materials 2S. are water-lnsoluble sodium metaphosphate, potassium metaphosphate, tricalcium phospha~e, dehydrated calcium phosphate, anhydrous dicalcium phosphate, calcium phosphate, magnesium orthophosphate, trimagnesium phos-phate, calcium carbonate, alumina, hydrated alumina, 30. aluminum silicate, zirconium silicate, silica, sodium 11~686~3 4.
aluminosilicate, bentonite, and mixtures thereof. Pre-ferred polishing materials include complex amorphorus sodium aluminosilicate, anhydrous alumina, calcium carbonate and aicalcium phosphate. Th~ polishing materials 5. may be used in admixture.
Organic surface-active a~ents are used in the composi-tions of the present invention to achieve increased proph~lactic ac.ion, assIst in achie~ing thorough and complete dispersion of the Instant compositions through-10. out the oral cavity, and render the instant compositionsmore cosmetically acceptable. The organic surface-active material may ~e anionic, nonionic, ampholytic, or cationic in nature, and it is preferred to employ as the surface-active agent a detersive material which imparts to the 15. composition detersive and foaming properties. Suitable such detergents are water-soluble salts of higher fatty acid monoglyceride monosulphates, such as sodium lauryl sulphate, alkyl aryl sulphonates, such as sodium dodecyl benzene sulphonate, higher alkyl sulphoacetates, higher 20. fatty acid ester of 1,2-dihydroxy propane sulphonates and the substantially saturated higher acyl amides of lower aliphatic amino carboxylic acid compounds, such as those having 12 to 16 carbons in the fatty acid, alkyl or acyl radicals and the like. Examples of the last 25. mentioned amides are N-lauroyl sarcosine, and the sodium, potassium and ethanolamine salts of N-lauroyl, N-myristoyl or N-pa~mitoyl sarcosine which should be su~stantially free from soap or similar higher fatty acid material which tends to substantially reduce the effect 3~, of these compounds. The use of these sarcosinate compounds ~46~6t~
in dentifrice compositions of the present invention is particularly a~antageous since these materials exhibit a prolonged an~ marked effect in the inhibition of acid formation in the oral. cavity due to carbohydrates . breakdown in addition to exerting some reduction in the solubility of tooth enamel in aci~ solutions.
Other particularly suitable surface-active materials include nonionic agents such as condensates of sorbitan monostearate with approximately 6Q moles of ethylene 10. oxide, consensates of ethylene oxi~e with propylene oxide condensates of propylene glycol (~available under the trade mark PLURONICS~ and amphoteric agents such as quaternized imi~azo derivatives which are available under the trade mark MIRANOL such as MIRANOL C2M.
lS. Cationic surface-active germicides and antibacterial compounds such as diisobutylphenoxyethoxyethyl dimethyl benzyl ammonium chloride, benzyl dimethyl stearyl ammo-nium chloride, tertiary amines having one fatty alkyl group (of from 12 to 18 carbon atoms) and two (poly) 20. oxyethylene groups attached to the nitrogen ~.typically containing a total of from about 2 to 50 ethanoxy groups per molecule~. and salts thereof ~ith acids and compounds of the structure (.CH2CH20)zH ~CH2CH20)xH
25. R--N-CH2CH2CH2 N ~(CH2CH20~yH
where R is a fatty alkyl group containing from about 12 to 18 carbon atoms, and x, y and z total 3 or higher, as well as salts thereof with mineral or organic acids, may 30. also be used. It is preferred to use from about 0.05 to 1~46868 6.
to 5~ by weight of the foregoing surface-active materials in the instant oral preparations.
~ luorine-?ro~7idins compounc may be ~resent.
This compound may ~e slightly soluble in water or may be 5. fully water-solu~le. It is characterized by its ability to release fluoride ions in water and by substantial freedom from reaction with other compounds of the oral preparation. Among these materials are inorganic fluoride salts, such as soluble alkali metal, alkaline 10. earth metal and heavy metal salts, for example, sodium fluoride, a copper fluoride such as cuprous fluoride zinc fluoride, a tin fluoride such as stannous flouride or stannous chlorofluoride, barium fluoride, sodium fluorosilicate, ammonium fluorosilicate, sodium fluoro-15. zirconate, sodium monofluorophosphate, aluminium mono-and difluorophosphate. Alkali metal and tin fluorides, such as sodium and stannous fluorides, sodium mono-fluorophosphate and mixtures thereof, are preferred. A
mixture of sodium fluoride and sodium monofluorophosphate is particularly desirable. In the toothpaste an amount of fluorine-providing compound which releases a maximum of about 1% by weight of the toothpaste is satisfactory.
Any suitahle minimum of such compound may be used, but it is preferable to employ sufficient compound to release 25. from about 0.005% to 1%, and preferably about 0.1~ of flouride ion. Typically, in the cases of alkali metal flourides and stannous fluoride, this component is pre-sent in an amount up to 2~ by weight, based on the weight oi the toothpaste, and preferably in the range of from 30. 0.05% to 1%. In the case of sodium monofluorophosphate, 1146~68 the compound may be present in an amount up to 7.6%
by weight, more typically 0.76~. When present in mix-ture the ratio of sodium monofluorophosphate to sodium fluoride is desirably about 1:1 to 3:1 based on fluorine 5. provided by each.
Any suitable flavo~ring or sweetening ~aterial may also be employea. Examples of suitable flavouring con-stituents are flavouring oils e.g. oils of spearmint, peppermint, wintergreen, sassafras, clove, sage, eucalyp-10. tus, marjoram, cinnamon, lemon, orange, and methylsalicylate. Suitable sweetening agents include sucrose, lactose, maltose, sorbitol, sodium cyclamate, perillar-tine and sodium saccharin. Suita~ly, flavouring and sweetening agents may together comprise from 0.01~ to 15. 5% or more of the preparations.
Various other materials may be incorporated in the oral preparations of this invention. Examples thereof are colouring or whitening agents, preservatives, sili-cones, chlorophyll compounds, ammoniated materials such 20. as urea, diammoniumphosphate and mixtures thereof, and other constituents. These adjuvants are incorporated in the instant compositions in amounts which do not substantially adversely affect the properties and characteristics desired and are selected and used in 25. proper amount depending upon the particular type of preparation involved.
The dental cream typically has a pH ~determined di-rectly on the creaml of about 4 to 10.5, preferably about 6-10. If desired, the pH may be adiusted with 30. an acidic material, such as benzoic or citric acid, ~4686t~
8.
or an alkaline material, such as sodium hydroxide, to achieve a particular value. Buffering agents, e.g.
phosphate buffers, may be used.
The dental cream may be prepared by adding humec-5. tant to water and blending therewith the gelling agent and thereafter the polishing material.
In evaluatins toothpastes of the present invention, visccsity may be determined with the ~niversal Testing Instrument ( table model ~ manufactured by Instron 10. Ltd, High Wycombe, England. Viscosity comprising can also be determed within an extension rheometer.
The following specific example is further illustra-tive of the nature of the present invention but it is understood that the invention is not limited thereto.
15. The composition is prepared in the usual manner and all amounts and proportions are by weight unless other-wise specified.
EXAMPLE
20. Sorbitol (~qO~) 16.00 22.00 20.00 Polyvinyl 6.00 3.00 Pyrrolidone Sodium Carboxy- 1.10 1.10. 1.10 methyl Celluose 25. Sodium Saccharin 0.20 0.20 0.18 Titanium Dioxide 0.40 0.40 0.40 Sodium Monofluoro-phosphate 0.80 0.80 0.80 30.
~146~68 Anhydrous lO.OQ 10.00 10.00 Alumina Sodium Alumincsilicate (About 7~ Aluminal20.00 2Q.00 20.00 Sodium Lauryl Sulphate 1.77 1-77 1.50 Flavour 1.10 1.10. 1.00 Water 42.63 39.63 45.00 10. Toothpaste compositions A and B and extrude easily after 7, 16, 24 and 31 hours of being left open, whereas tooth-past C, quickl~ dries and forms into a hard plug within 7 hours of being left opened and is difficult to extrude.
Although this invention has been described with 15. regard to specific example, it will be apparent to one skilled in the art that various modifications may be made thereto wllich fall within its scope.
Claims (9)
PROPERTY OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:
1. A toothpaste composition comprising a vehicle contain-ing about 45-80% by weight of liquid phase, comprising about 35% by weight of the toothpaste of sorbitol and at least about 25% by weight of the toothpaste of water and a solid phase including about 3-10% by weight of the toothpaste of gelling agent which comprises at least about 3% by weight of the toothpaste of polyvinyl pyrrolidone.
2. A toothpaste composition as claimed in Claim 1 wherein said sorbitol is present in amount of about 15-35% by weight.
3. A toothpaste composition as claimed in Claim 2 wherein said sorbitol is present in amount of about 15-25% by weight.
4. A toothpaste composition as claimed in Claim 1 wherein said water is present in amount of about 25-50% by weight.
5. A toothpaste composition as claimed in Claim 4 where-in said water is present in amount of about 25-45% by weight.
6. A toothpaste composition as claimed in Claim 1 wherein about 15-50% by weight of a dentally acceptable water-insoluble polishing agent is present.
7. A toothpaste composition as claimed in Claim 6 wherein said polishing agent is sodium aluminosilicate.
8. A toothpaste composition as claimed in Claim 1 wherein about 3-6% by weight of polyvinyl pyrrolidone is present.
9. A toothpaste composition as claimed in Claim 1 wherein said gelling agent additionally comprises sodium carboxymethyl cellulose.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7943641A GB2068224B (en) | 1979-12-19 | 1979-12-19 | Toothpaste comprising sorbitol and polyvinyl pyrrolidone |
| GB79/43641 | 1979-12-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1146868A true CA1146868A (en) | 1983-05-24 |
Family
ID=10509928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000367056A Expired CA1146868A (en) | 1979-12-19 | 1980-12-18 | Sorbitol and polyvinyl pyrrolidone in toothpaste |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US4307076A (en) |
| JP (1) | JPS5697216A (en) |
| AR (1) | AR223571A1 (en) |
| AT (1) | AT382778B (en) |
| AU (1) | AU536235B2 (en) |
| BE (1) | BE886709A (en) |
| BR (1) | BR8008287A (en) |
| CA (1) | CA1146868A (en) |
| CH (1) | CH644753A5 (en) |
| DE (1) | DE3046442A1 (en) |
| DK (1) | DK155973C (en) |
| FR (1) | FR2471780B1 (en) |
| GB (1) | GB2068224B (en) |
| GR (1) | GR71917B (en) |
| IT (1) | IT1188974B (en) |
| KE (1) | KE3659A (en) |
| MX (1) | MX153370A (en) |
| NL (1) | NL8006732A (en) |
| NO (1) | NO155475C (en) |
| NZ (1) | NZ195603A (en) |
| PH (1) | PH16983A (en) |
| PT (1) | PT72216B (en) |
| SE (1) | SE8008750L (en) |
| ZA (1) | ZA807333B (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4590065A (en) * | 1985-04-18 | 1986-05-20 | Colgate-Palmolive Company | Stable flavor-containing dentifrice |
| GB9204414D0 (en) * | 1992-02-29 | 1992-04-15 | Smithkline Beecham Plc | Method of treatment |
| GB9204410D0 (en) * | 1992-02-29 | 1992-04-15 | Smithkline Beecham Plc | Method of treatment |
| US6270781B1 (en) | 1999-01-08 | 2001-08-07 | Maxim Pharmaceuticals, Inc. | Method and compositions for topical treatment of damaged tissue using reactive oxygen metabolite production or release inhibitors |
| CN1578650A (en) * | 2001-11-06 | 2005-02-09 | 马克西姆医药公司 | Compositions for the treatment of infectious diseases |
| JP2006232303A (en) * | 2005-02-23 | 2006-09-07 | Daio Paper Corp | Web storing article |
| JP5351379B2 (en) * | 2006-07-21 | 2013-11-27 | 花王株式会社 | Toothpaste composition |
| JP5351421B2 (en) * | 2008-01-23 | 2013-11-27 | 花王株式会社 | Toothpaste composition |
| JP5627190B2 (en) * | 2009-03-31 | 2014-11-19 | 小林製薬株式会社 | Dentifrice composition |
| CL2016002960A1 (en) * | 2016-11-18 | 2017-01-27 | Univ Chile | Hybrid metal / carbon structure formulation with dental applications in the treatment of dentine hypersensitivity, demineralization, and caries |
| US11141364B2 (en) | 2017-11-30 | 2021-10-12 | Colgate-Palmolive Company | Oral care compositions |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1075782A (en) * | 1910-10-19 | 1913-10-14 | Goldschmidt Ag Th | Method of raising the alloying qualification of titanium. |
| FR1030214A (en) | 1950-01-02 | 1953-06-10 | Basf Ag | Toothpastes |
| BE519897A (en) | 1952-05-13 | |||
| US2744049A (en) * | 1952-07-18 | 1956-05-01 | Colgate Palmolive Co | Stabilized dental creams |
| BE526730A (en) | 1953-02-24 | |||
| US3120469A (en) * | 1959-09-24 | 1964-02-04 | Tamas Istvan | Therapeutic dental composition |
| US3431208A (en) * | 1965-11-17 | 1969-03-04 | Schering Corp | Denture spray |
| SE343477C (en) * | 1966-12-05 | 1977-09-15 | Unilever Nv | TOOTH CREAM COMPOSITION CONTAINING A SILICO DIOXIDE |
| IE33101B1 (en) * | 1968-08-05 | 1974-03-20 | Schneider R & Co Kg | Dental preparations |
| DOP1971001860A (en) * | 1970-09-21 | 1979-02-10 | Colgate Palmolive Co | DENTIFRICOS |
| US4069310A (en) * | 1970-11-27 | 1978-01-17 | Colgate Palmolive Company | Method for the manufacture of clear dentifrices |
| BE789477A (en) * | 1971-10-01 | 1973-01-15 | Colgate Palmolive Co | GAS-FREE TOOTHPASTE MANUFACTURING PROCESS |
| GB1400154A (en) * | 1971-10-22 | 1975-07-16 | Unilever Ltd | Toothpaste |
| US3946108A (en) * | 1971-11-26 | 1976-03-23 | Colgate-Palmolive Company | Dentifrice |
| FR2224126A1 (en) * | 1973-04-05 | 1974-10-31 | Chalaust Rene | Hygienic or cosmetic compsns contg polyvinyl pyrrolidone - in appropriate media for use as creams, emulsions or face masks |
| US3970747A (en) * | 1974-03-11 | 1976-07-20 | Colgate-Palmolive Company | Humectant sweetener |
| US3954962A (en) * | 1974-04-01 | 1976-05-04 | Alan R. Tripp | Oral hygiene product |
| FR2341320A1 (en) * | 1976-02-20 | 1977-09-16 | Fabre Sa Pierre | Polyvinyl pyrrolidone complex with phosphate and sodium fluoride - used for teeth protection in dental compositions |
| ZA777063B (en) * | 1976-12-27 | 1979-07-25 | Colgate Palmolive Co | Antibacterial oral composition |
| DE2747092C2 (en) * | 1977-10-20 | 1984-01-05 | Württembergische Parfümerie - Fabrik GmbH, 7332 Eislingen | Dentifrices containing dyes |
-
1979
- 1979-12-19 GB GB7943641A patent/GB2068224B/en not_active Expired
-
1980
- 1980-11-20 NZ NZ195603A patent/NZ195603A/en unknown
- 1980-11-24 ZA ZA00807333A patent/ZA807333B/en unknown
- 1980-11-28 GR GR63490A patent/GR71917B/el unknown
- 1980-12-03 FR FR8025646A patent/FR2471780B1/en not_active Expired
- 1980-12-09 MX MX185098A patent/MX153370A/en unknown
- 1980-12-09 PH PH24963A patent/PH16983A/en unknown
- 1980-12-10 DE DE19803046442 patent/DE3046442A1/en not_active Withdrawn
- 1980-12-11 NL NL8006732A patent/NL8006732A/en not_active Application Discontinuation
- 1980-12-12 SE SE8008750A patent/SE8008750L/en unknown
- 1980-12-15 AU AU65391/80A patent/AU536235B2/en not_active Ceased
- 1980-12-15 IT IT50370/80A patent/IT1188974B/en active
- 1980-12-16 CH CH927880A patent/CH644753A5/en not_active IP Right Cessation
- 1980-12-17 AT AT0614180A patent/AT382778B/en active
- 1980-12-17 PT PT72216A patent/PT72216B/en unknown
- 1980-12-17 BE BE0/203203A patent/BE886709A/en not_active IP Right Cessation
- 1980-12-18 CA CA000367056A patent/CA1146868A/en not_active Expired
- 1980-12-18 BR BR8008287A patent/BR8008287A/en not_active IP Right Cessation
- 1980-12-18 NO NO803870A patent/NO155475C/en unknown
- 1980-12-19 DK DK543980A patent/DK155973C/en not_active IP Right Cessation
- 1980-12-19 AR AR283723A patent/AR223571A1/en active
- 1980-12-19 JP JP18032880A patent/JPS5697216A/en active Granted
- 1980-12-19 US US06/218,594 patent/US4307076A/en not_active Expired - Fee Related
-
1986
- 1986-08-18 KE KE3659A patent/KE3659A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AT382778B (en) | 1987-04-10 |
| BR8008287A (en) | 1981-07-07 |
| IT8050370A1 (en) | 1982-06-15 |
| DK155973B (en) | 1989-06-12 |
| DK543980A (en) | 1981-06-20 |
| NO803870L (en) | 1981-06-22 |
| FR2471780B1 (en) | 1986-02-21 |
| ZA807333B (en) | 1982-07-28 |
| NO155475B (en) | 1986-12-29 |
| BE886709A (en) | 1981-04-16 |
| AU6539180A (en) | 1981-06-25 |
| NO155475C (en) | 1987-04-08 |
| IT8050370A0 (en) | 1980-12-15 |
| AU536235B2 (en) | 1984-05-03 |
| PT72216B (en) | 1981-11-02 |
| NZ195603A (en) | 1983-05-31 |
| PH16983A (en) | 1984-05-04 |
| JPS5697216A (en) | 1981-08-05 |
| PT72216A (en) | 1981-01-01 |
| AR223571A1 (en) | 1981-08-31 |
| DK155973C (en) | 1989-10-30 |
| SE8008750L (en) | 1981-06-20 |
| US4307076A (en) | 1981-12-22 |
| GR71917B (en) | 1983-08-17 |
| FR2471780A1 (en) | 1981-06-26 |
| IT1188974B (en) | 1988-01-28 |
| GB2068224A (en) | 1981-08-12 |
| ATA614180A (en) | 1983-07-15 |
| JPS643844B2 (en) | 1989-01-23 |
| DE3046442A1 (en) | 1981-08-27 |
| GB2068224B (en) | 1983-08-24 |
| KE3659A (en) | 1986-09-12 |
| CH644753A5 (en) | 1984-08-31 |
| MX153370A (en) | 1986-09-30 |
| NL8006732A (en) | 1981-07-16 |
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Legal Events
| Date | Code | Title | Description |
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| MKEX | Expiry |