CA1134699A - Prefilled, vented two-compartment syringe - Google Patents
Prefilled, vented two-compartment syringeInfo
- Publication number
- CA1134699A CA1134699A CA000349731A CA349731A CA1134699A CA 1134699 A CA1134699 A CA 1134699A CA 000349731 A CA000349731 A CA 000349731A CA 349731 A CA349731 A CA 349731A CA 1134699 A CA1134699 A CA 1134699A
- Authority
- CA
- Canada
- Prior art keywords
- stopper
- prefilled
- vented
- piercing
- nozzle portion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3123—Details having air entrapping or venting means, e.g. purging channels in pistons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31501—Means for blocking or restricting the movement of the rod or piston
- A61M5/31505—Integral with the syringe barrel, i.e. connected to the barrel so as to make up a single complete piece or unit
- A61M2005/31506—Integral with the syringe barrel, i.e. connected to the barrel so as to make up a single complete piece or unit formed as a single piece, e.g. moulded
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
- A61M5/288—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened by piercing without internal pressure increase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
- A61M5/3134—Syringe barrels characterised by constructional features of the distal end, i.e. end closest to the tip of the needle cannula
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3145—Filters incorporated in syringes
Abstract
NEH:em #3671 PREFILLED, VENTED TWO-COMPARTMENT SYRINGE
Abstract of the Disclosure A prefilled, readily activated syringe assembly wherein a fluid medicament and a diluent therefor can be intermixed in a syringe barrel with a venting thereof.
A medicinal powder is sealed in a barrel by means of an intermediate slidable stopper and the diluent is sealed in the same barrel between the stopper and a plunger stopper. A bypass channel is provided in the syringe barrel which permits intermixing of the diluent and the medicament when the plunger stopper is moved toward the intermediate stopper. Movement of the plunger stopper inwardly in the barrel is afforded by means of a hydro-phobic filter element associated with the nozzle portion.
After intermixing of the diluent and the medicament the filter vent is pierced by means of a piercing tubular member to which is attached a hypodermic needle. Con-tinued movement of the plunger stopper will expel the mixed medicament from the syringe.
Abstract of the Disclosure A prefilled, readily activated syringe assembly wherein a fluid medicament and a diluent therefor can be intermixed in a syringe barrel with a venting thereof.
A medicinal powder is sealed in a barrel by means of an intermediate slidable stopper and the diluent is sealed in the same barrel between the stopper and a plunger stopper. A bypass channel is provided in the syringe barrel which permits intermixing of the diluent and the medicament when the plunger stopper is moved toward the intermediate stopper. Movement of the plunger stopper inwardly in the barrel is afforded by means of a hydro-phobic filter element associated with the nozzle portion.
After intermixing of the diluent and the medicament the filter vent is pierced by means of a piercing tubular member to which is attached a hypodermic needle. Con-tinued movement of the plunger stopper will expel the mixed medicament from the syringe.
Description
~13~919 round of the Invention lhis invention relates to a disposable syringe of the prefilled type. More particularly, it relates to a prefilled, disposable syringe assembly wherein the medicament and diluent are contained in the syringe and separated by an intermediate slidable stopper. When it is desired to mix the components, a plunger stopper is moved toward the intermediate stopper with the intermediate stopper being moved adjacent a bypass channel formed in the syringe barrel. This permits intermixing of the components. Undesired compression of air in the syringe barrel is vented by means of a hydrophobic filter posi-tioned in the nozzle portion. To administer the con-tents of the syringe, the filter is pierced by a piercing tubular member to which is attached a hypodermic needle.
There are currently available many types of disposable syringes wherein a medicament is sealed in the syringe barrel to be later combined with a diluent for the material with the syringe barrel having a bypass channel. Such syringe types are described in U. S.
Patents 2,896,622; 3,330,282; 3,477,431; 3,889,674 as well as Japanese Registration No. 1065744. There are also available wet/dry syringe systems wherein a filter is utilized in the syringe barrel to filter the contents prior to delivery. For example, in U. S. Patent 3,757,779 an intermixing type syringe with a filter is disclosed.
However, the prior art does not afford a wet/dry syringe system wherein intermixing of the wet and dry components can be effected in a single syringe barrel which is vented by means of a hydrophobic filter.
It is an advantage of the present invention to provide a novel preassembled mixing and hypodermic needle assembly which affords a venting of the syringe during the intermixing of the components. Other advantages are a syringe which is completely preassembled, a syringe which utilizes a hydrophobic filter as a vent means and a pointed tubular or cannula member for piercing through the filter for delivery of the mixed materials, and a 113~i99 syringe which affords intermixing of dry and wet materials in a single syringe barrel.
Summary of the Invention __. __ _ The foregoing advantages are accomplished and the shortcomings of the prior art are overcome by the prefilled, readily activated syringe assembly of this in-vention which has a barrel member with the usual nozzle portion. A hydrophobic filter is positioned in or adja-cent the nozzle portion as well as a holder member for a piercing tubular member which holds the piercing member in a slidable manner. A first stopper is positioned in slidable and sealing engagement in the tubular syringe barrel to provide a compartment for a first flowable medicinal material. A plunger stopper is spaced from the first stopper to provide a second chamber for a liquid diluent for the flowable medicinal material in the first chamber. A bypass means is disposed in the barrel wall and the first stopper is spaced from the bypass opposite the nozzle portion. Upon movement of the plunger stopper toward the first stopper, the first stopper will move adjacent the bypass channel to permit intermixing of the two materials with emission of air through the filter element. Upon subsequent movement of the piercing member toward the filter, the filter is pierced. The mixed con-tents of the syringe is delivered by attachment of ahypodermic needle to the piercing tubular member and movement of the plunger stopper toward the first stopper.
In a preferred manner, the piercing member is retained in the holder member by means of a slidable frictional engagement arrangement provided by projections on the tubular member and accommodating grooves in the holder.
A removable second filter element is placed on the end of the holder member opposite the piercing point for sub-sequent placement thereon of a hypodermic needle. A re-movable closure means is positioned over the holder mem-ber and secured to the nozzle portion as is the holder member.
3 ~3~99 Brief Descr1ption of the Drawinq A better understanding of the prefilled, vented, readily activated syringe of this invention will be af-forded by reference to the drawing wherein:
FIGURE 1 is a view in vertical section showing the hypodermic syringe of this invention in a packaged condition.
FIGURES 2 and 3 are views similar to FIGURE 1 showing the unit in the next stages of operation.
FIGURE 4 is a view similar to FIGURE 1 showing the syringe unit with the two components completely mixed and ready for injection.
FIGURES 5 and 6 are partial views in vertical section showing alternative embodiments of the syringe unit.
Description of the Preferred Embodiment The prefilled, vented, readily activated syringe generally 10 is composed of a barrel 11 forming a tubular chamber 12 with internal wall 14. A nozzle portion 16 extends from one end of the syringe barrel and includes a flange 17. Postioned in nozzle portion 16 is a hydro-phobic filter 20 which is retained therein by means of an annular support 21 with a flange section 22 for seating on barrel flange 17. A holder member 23 is in sealing engagement with the nozzle portion 16 and includes a shoulder section 25 for holding the flange section 22 of support 21 against flange 17. The usual ferrule 27 se-cures shoulder 25 to flange 17 with flange 22 therebe-tween. A passage 28 is provided in holder 23 in which is slidably received a piercing tubular member 30 having a piercing point 31. Projection 34 is accommodated by groove 36 to afford a frictional engagement of piercing member 30 in holder 23. A second filter 38 disposed in a cap housing 39 is placed on the end of tubular member 30 opposite point 31. A male luer portion 41 on tubular mem-ber 30 and a female luer portion 42 in the cap housing 39 provides the necessary interfitment. A flange portion 44 extends from piercing member 30 adjacent luer portion 41.
Positioned over piercing member 30 and filter 38 is a re-movable closure cap 45 which is fastened to flange 17 by a second ferrule 46 engaging shoulder 47. A pull-tab 48 provides the usual means of removal.
Referring specifically to FIGURE 1, it will be seen that syringe barrel 11 includes a lateral exten-sion or bypass channel 50 formed as part of the barrel.
A stopper 51 is sealably positioned in barrel 11 and spaced from bypass channel 50 to provide a chamber 53 for a solid medicament 54. A second stopper 55 is also sealably positioned in barrel 11 and spaced from stopper 51 to provide a chamber 12 for a liquid diluent 56. A
plunger rod 57 engages stopper 55 and has an annulus 58 for contact with a stop surface 59. Referring specific-ally to FIGURE 4, it will be noted that prior to delivery of the mixed contents of the syringe 10, filter 38 and cap housing 39 will be replaced with hypodermic needle 60 which through adapter hub 61 is positioned on male luer portion 41.
FIGURES 5 and 6 illustrate various modifica-tions for securing a venting filter to the syringe bar-rel as well as for the frictionally slidable arrange-ment of the tubular piercing member in the holder. Simi-lar numbers are used to indicate similar parts except that they are designated in the "100" and "200" series.
In the FIGURE 5 unit, it will be noted that filter 120 is housed outside the confines of nozzle portion 116 and is attached to support 121 which is sealed to flange 117 by an annular sealing ring 132. It will be further noted that in conjunction with units 110 and 210 that only single grooves I35 and 235 are employed with projections 134 and 234 as the slidable frictional engagement means for tubular members 130 and 230, respectively. Syringe assembly unit 210 differs from units 10 and 110 in that a compartment or chamber 224 is disposed in holder memher 223 for retention of filter 220. A retaining ring 226 provides a secure fitment by forcing filter 220 against abutment 243.
_5_ 113~99 ~E~ation _ A better understanding of the advantages of the readily activated syringe units 10, 110 and 210 will be had by a description of the manner of their operation.
Referring to syringe unit 10, it will be packaged as shown in FIGURE 1. The medicinal material 54 will in this instance be a powdered, flowable material such as a general anesthetic. It will be noted that the medici-nal material will be held in a sterile condition by means of sealing stopper 51 which is positioned in barrel 11 away from bypass channel 50 and opposite nozzle portion 16. A liquid diluent 56 will similarly be held in a sterile condition as it will be sealed between stopper 51 and plunger stopper 55. If desired, the entire syringe unit could be packaged in a sterile overwrap such as composed of sterile paper or aluminum laminate.
When it is desired to utilize unit 10, all that is required is removal of closure cap 45 by a pulling force on tab 48 and a breaking away of ferrule 46. Move-ment of plunger rod 57 inwardly into barrel 11 will beeffected and will force stopper 51 to a position imme-diately adjacent bypass channel 50, as shown in FIGURE 2.
During this movement, air inside barrel 11 will tend to compress. However, such compression will be relieved through hydrophobic filter 20 and passage through tubular piercing member 30 and filter 38. Movement of stopper 55 will be continued until it abuts against stopper 51 as indicated in FIGURE 3. At this stage diluent 56 will have been moved via bypass channel 50 into chamber 53 with medicament 54 to result in a mixed solution 60 of the medicament. No leakage of material from the barrel 11 will be effected because of the hydrophobic nature of the material of filter 20. The syringe will then be shaken to effect mixing of the two components. The next stage is the piercing of filter 20 by movement of piercing member 30 toward the filter until piercing point 31 penetrates therethrough and flange 44 contacts the end of holder 23 as shown in FIGURE 3. At this point, filter 38 and cap gg housing 39 will be removed and replaced with hypodermic needle 60 and hub 61 as indicated in FIGURE 4. Continued movement of plunger 55 into barrel 11 will also effect a corresponding movement of stopper 51 with a subsequent ex-pulsion of the mixed components through hypodermic needle 60.
The functioning of syringe units 110 and 210 will be substantially the same as previously indicated for unit 10. The purpose of illustrating these embodi-ments is to show different methods of fabrication andplacement of the pierceable hydrophobic filters 120 and 220 as well as different designs for the holders 123 and 223.
In conjunctcion with the previously described embodiments, it will be recognized that the needle 60 with adapter 61 could be placed on the holder 23 at the time the unit is packaged as shown in FIG~RE 1. However, closure cap 45 and the additional filter 38 would not be utilized. Some degree of sterility may be compromised and the needle will then have to have a vented sealing cap to cover it. Further, while a bypass channel 50 and double stopper system is utilized as a means of effecting a mixing of the diluent 56 with powder 54, the pierceable hydrophobic vent system of this invention would be oper-able with any wet/dry mixing syringe where internal pres-sure is a problem in resisting stopper movement.
The preferred materials for composing barrels 11, 111 and 211 is gIass. However, they could be formed from other clear or translucent plastic materials such as polypropylene and polymethylpentene polymers. Stoppers such as 51 and 55 are formed from a resilient rubber or plastic material. Hydrophobic filters 10, 38, 120 and 220 are fabricated from a porous acrylic copolymer material.
However, any substance which will repel the diluent to be used with the medicament can be employed if it lends itself to fabrication as a filter material. Tubular piercing members 30, 130 and 230 are preferably formed from a poly-carbonate material whereas holder members 23, 123 and 223 _7_ 113~99 can be conveniently fabricated from a resilient rubber or plastic material.
It will thus be seen that through the present invention there is now provided a prefilled, vented, readily activated, sterile syringe assembly which can be packaged in a ready-to-use manner and involves a mini-mum number of manipulative steps for utilization. A
medicament material and a diluent therefor, which when intermixed result in a unstable product, are retained in a sterile condition in an isolated manner. Positive, sequential operation of the dual component syringe system is afforded by means of a unique filter, venting and de-livery system to effect mixing of the medicament and the diluent as well as delivery thereof. The syringe ~nit can be fabricated without expensive molding operations and can be assembled in a convenient manner and retained in a sterile condition.
The foregoing invention can now be practiced by those skilled in the art. Such skilled persons will know that the invention is not necessarily restricted to the particular embodiments presented herein. The scope of the invention is to be defined by the terms of the following claims as given meaning by the preceding description.
There are currently available many types of disposable syringes wherein a medicament is sealed in the syringe barrel to be later combined with a diluent for the material with the syringe barrel having a bypass channel. Such syringe types are described in U. S.
Patents 2,896,622; 3,330,282; 3,477,431; 3,889,674 as well as Japanese Registration No. 1065744. There are also available wet/dry syringe systems wherein a filter is utilized in the syringe barrel to filter the contents prior to delivery. For example, in U. S. Patent 3,757,779 an intermixing type syringe with a filter is disclosed.
However, the prior art does not afford a wet/dry syringe system wherein intermixing of the wet and dry components can be effected in a single syringe barrel which is vented by means of a hydrophobic filter.
It is an advantage of the present invention to provide a novel preassembled mixing and hypodermic needle assembly which affords a venting of the syringe during the intermixing of the components. Other advantages are a syringe which is completely preassembled, a syringe which utilizes a hydrophobic filter as a vent means and a pointed tubular or cannula member for piercing through the filter for delivery of the mixed materials, and a 113~i99 syringe which affords intermixing of dry and wet materials in a single syringe barrel.
Summary of the Invention __. __ _ The foregoing advantages are accomplished and the shortcomings of the prior art are overcome by the prefilled, readily activated syringe assembly of this in-vention which has a barrel member with the usual nozzle portion. A hydrophobic filter is positioned in or adja-cent the nozzle portion as well as a holder member for a piercing tubular member which holds the piercing member in a slidable manner. A first stopper is positioned in slidable and sealing engagement in the tubular syringe barrel to provide a compartment for a first flowable medicinal material. A plunger stopper is spaced from the first stopper to provide a second chamber for a liquid diluent for the flowable medicinal material in the first chamber. A bypass means is disposed in the barrel wall and the first stopper is spaced from the bypass opposite the nozzle portion. Upon movement of the plunger stopper toward the first stopper, the first stopper will move adjacent the bypass channel to permit intermixing of the two materials with emission of air through the filter element. Upon subsequent movement of the piercing member toward the filter, the filter is pierced. The mixed con-tents of the syringe is delivered by attachment of ahypodermic needle to the piercing tubular member and movement of the plunger stopper toward the first stopper.
In a preferred manner, the piercing member is retained in the holder member by means of a slidable frictional engagement arrangement provided by projections on the tubular member and accommodating grooves in the holder.
A removable second filter element is placed on the end of the holder member opposite the piercing point for sub-sequent placement thereon of a hypodermic needle. A re-movable closure means is positioned over the holder mem-ber and secured to the nozzle portion as is the holder member.
3 ~3~99 Brief Descr1ption of the Drawinq A better understanding of the prefilled, vented, readily activated syringe of this invention will be af-forded by reference to the drawing wherein:
FIGURE 1 is a view in vertical section showing the hypodermic syringe of this invention in a packaged condition.
FIGURES 2 and 3 are views similar to FIGURE 1 showing the unit in the next stages of operation.
FIGURE 4 is a view similar to FIGURE 1 showing the syringe unit with the two components completely mixed and ready for injection.
FIGURES 5 and 6 are partial views in vertical section showing alternative embodiments of the syringe unit.
Description of the Preferred Embodiment The prefilled, vented, readily activated syringe generally 10 is composed of a barrel 11 forming a tubular chamber 12 with internal wall 14. A nozzle portion 16 extends from one end of the syringe barrel and includes a flange 17. Postioned in nozzle portion 16 is a hydro-phobic filter 20 which is retained therein by means of an annular support 21 with a flange section 22 for seating on barrel flange 17. A holder member 23 is in sealing engagement with the nozzle portion 16 and includes a shoulder section 25 for holding the flange section 22 of support 21 against flange 17. The usual ferrule 27 se-cures shoulder 25 to flange 17 with flange 22 therebe-tween. A passage 28 is provided in holder 23 in which is slidably received a piercing tubular member 30 having a piercing point 31. Projection 34 is accommodated by groove 36 to afford a frictional engagement of piercing member 30 in holder 23. A second filter 38 disposed in a cap housing 39 is placed on the end of tubular member 30 opposite point 31. A male luer portion 41 on tubular mem-ber 30 and a female luer portion 42 in the cap housing 39 provides the necessary interfitment. A flange portion 44 extends from piercing member 30 adjacent luer portion 41.
Positioned over piercing member 30 and filter 38 is a re-movable closure cap 45 which is fastened to flange 17 by a second ferrule 46 engaging shoulder 47. A pull-tab 48 provides the usual means of removal.
Referring specifically to FIGURE 1, it will be seen that syringe barrel 11 includes a lateral exten-sion or bypass channel 50 formed as part of the barrel.
A stopper 51 is sealably positioned in barrel 11 and spaced from bypass channel 50 to provide a chamber 53 for a solid medicament 54. A second stopper 55 is also sealably positioned in barrel 11 and spaced from stopper 51 to provide a chamber 12 for a liquid diluent 56. A
plunger rod 57 engages stopper 55 and has an annulus 58 for contact with a stop surface 59. Referring specific-ally to FIGURE 4, it will be noted that prior to delivery of the mixed contents of the syringe 10, filter 38 and cap housing 39 will be replaced with hypodermic needle 60 which through adapter hub 61 is positioned on male luer portion 41.
FIGURES 5 and 6 illustrate various modifica-tions for securing a venting filter to the syringe bar-rel as well as for the frictionally slidable arrange-ment of the tubular piercing member in the holder. Simi-lar numbers are used to indicate similar parts except that they are designated in the "100" and "200" series.
In the FIGURE 5 unit, it will be noted that filter 120 is housed outside the confines of nozzle portion 116 and is attached to support 121 which is sealed to flange 117 by an annular sealing ring 132. It will be further noted that in conjunction with units 110 and 210 that only single grooves I35 and 235 are employed with projections 134 and 234 as the slidable frictional engagement means for tubular members 130 and 230, respectively. Syringe assembly unit 210 differs from units 10 and 110 in that a compartment or chamber 224 is disposed in holder memher 223 for retention of filter 220. A retaining ring 226 provides a secure fitment by forcing filter 220 against abutment 243.
_5_ 113~99 ~E~ation _ A better understanding of the advantages of the readily activated syringe units 10, 110 and 210 will be had by a description of the manner of their operation.
Referring to syringe unit 10, it will be packaged as shown in FIGURE 1. The medicinal material 54 will in this instance be a powdered, flowable material such as a general anesthetic. It will be noted that the medici-nal material will be held in a sterile condition by means of sealing stopper 51 which is positioned in barrel 11 away from bypass channel 50 and opposite nozzle portion 16. A liquid diluent 56 will similarly be held in a sterile condition as it will be sealed between stopper 51 and plunger stopper 55. If desired, the entire syringe unit could be packaged in a sterile overwrap such as composed of sterile paper or aluminum laminate.
When it is desired to utilize unit 10, all that is required is removal of closure cap 45 by a pulling force on tab 48 and a breaking away of ferrule 46. Move-ment of plunger rod 57 inwardly into barrel 11 will beeffected and will force stopper 51 to a position imme-diately adjacent bypass channel 50, as shown in FIGURE 2.
During this movement, air inside barrel 11 will tend to compress. However, such compression will be relieved through hydrophobic filter 20 and passage through tubular piercing member 30 and filter 38. Movement of stopper 55 will be continued until it abuts against stopper 51 as indicated in FIGURE 3. At this stage diluent 56 will have been moved via bypass channel 50 into chamber 53 with medicament 54 to result in a mixed solution 60 of the medicament. No leakage of material from the barrel 11 will be effected because of the hydrophobic nature of the material of filter 20. The syringe will then be shaken to effect mixing of the two components. The next stage is the piercing of filter 20 by movement of piercing member 30 toward the filter until piercing point 31 penetrates therethrough and flange 44 contacts the end of holder 23 as shown in FIGURE 3. At this point, filter 38 and cap gg housing 39 will be removed and replaced with hypodermic needle 60 and hub 61 as indicated in FIGURE 4. Continued movement of plunger 55 into barrel 11 will also effect a corresponding movement of stopper 51 with a subsequent ex-pulsion of the mixed components through hypodermic needle 60.
The functioning of syringe units 110 and 210 will be substantially the same as previously indicated for unit 10. The purpose of illustrating these embodi-ments is to show different methods of fabrication andplacement of the pierceable hydrophobic filters 120 and 220 as well as different designs for the holders 123 and 223.
In conjunctcion with the previously described embodiments, it will be recognized that the needle 60 with adapter 61 could be placed on the holder 23 at the time the unit is packaged as shown in FIG~RE 1. However, closure cap 45 and the additional filter 38 would not be utilized. Some degree of sterility may be compromised and the needle will then have to have a vented sealing cap to cover it. Further, while a bypass channel 50 and double stopper system is utilized as a means of effecting a mixing of the diluent 56 with powder 54, the pierceable hydrophobic vent system of this invention would be oper-able with any wet/dry mixing syringe where internal pres-sure is a problem in resisting stopper movement.
The preferred materials for composing barrels 11, 111 and 211 is gIass. However, they could be formed from other clear or translucent plastic materials such as polypropylene and polymethylpentene polymers. Stoppers such as 51 and 55 are formed from a resilient rubber or plastic material. Hydrophobic filters 10, 38, 120 and 220 are fabricated from a porous acrylic copolymer material.
However, any substance which will repel the diluent to be used with the medicament can be employed if it lends itself to fabrication as a filter material. Tubular piercing members 30, 130 and 230 are preferably formed from a poly-carbonate material whereas holder members 23, 123 and 223 _7_ 113~99 can be conveniently fabricated from a resilient rubber or plastic material.
It will thus be seen that through the present invention there is now provided a prefilled, vented, readily activated, sterile syringe assembly which can be packaged in a ready-to-use manner and involves a mini-mum number of manipulative steps for utilization. A
medicament material and a diluent therefor, which when intermixed result in a unstable product, are retained in a sterile condition in an isolated manner. Positive, sequential operation of the dual component syringe system is afforded by means of a unique filter, venting and de-livery system to effect mixing of the medicament and the diluent as well as delivery thereof. The syringe ~nit can be fabricated without expensive molding operations and can be assembled in a convenient manner and retained in a sterile condition.
The foregoing invention can now be practiced by those skilled in the art. Such skilled persons will know that the invention is not necessarily restricted to the particular embodiments presented herein. The scope of the invention is to be defined by the terms of the following claims as given meaning by the preceding description.
Claims (16)
1. A prefilled, vented, readily activated syringe assembly comprising:
a barrel member defining a substantially tubular chamber having a wall portion;
a nozzle portion communicating with said tubular chamber;
a hydrophobic filter element operatively asso-ciated with said nozzle portion of said barrel member.
a holder member in sealing arrangement with said nozzle portion and positioned outwardly from said filter element;
means to retain said holder member on said nozzle portion;
passage means defined by said holder element;
a piercing tubular member having a piercing point, slidably positioned in said passage means of said holder member and said piercing point spaced from said filter element;
a first stopper in slidable and sealing engage-ment in said tubular chamber to provide a compartment for a first flowable medicinal material;
a second stopper adapted to receive a plunger rod in slidable and sealing engagement in said tubular chamber of said barrel member and spaced from said first stopper to provide a compartment for a second flowable medicinal material;
means constructed and arranged in combination with said first and second stoppers and said barrel mem-ber to provide upon movement of said first stopper toward said second stopper fluid communication between said com-partments for said first and second medicinal materials;
whereby upon movement of said second stopper in the direction of said first stopper, intermixing of said first and second medicinal materials will be effected with emission of air through said filter element; upon subse-quent movement of said piercing tubular member toward said filter with a piercing thereof; attachment of a hypo-dermic needle to said piercing tubular member; and upon further movement of said second stopper toward said first stopper substantially; all of said medicinal materials will be expelled from said syringe.
a barrel member defining a substantially tubular chamber having a wall portion;
a nozzle portion communicating with said tubular chamber;
a hydrophobic filter element operatively asso-ciated with said nozzle portion of said barrel member.
a holder member in sealing arrangement with said nozzle portion and positioned outwardly from said filter element;
means to retain said holder member on said nozzle portion;
passage means defined by said holder element;
a piercing tubular member having a piercing point, slidably positioned in said passage means of said holder member and said piercing point spaced from said filter element;
a first stopper in slidable and sealing engage-ment in said tubular chamber to provide a compartment for a first flowable medicinal material;
a second stopper adapted to receive a plunger rod in slidable and sealing engagement in said tubular chamber of said barrel member and spaced from said first stopper to provide a compartment for a second flowable medicinal material;
means constructed and arranged in combination with said first and second stoppers and said barrel mem-ber to provide upon movement of said first stopper toward said second stopper fluid communication between said com-partments for said first and second medicinal materials;
whereby upon movement of said second stopper in the direction of said first stopper, intermixing of said first and second medicinal materials will be effected with emission of air through said filter element; upon subse-quent movement of said piercing tubular member toward said filter with a piercing thereof; attachment of a hypo-dermic needle to said piercing tubular member; and upon further movement of said second stopper toward said first stopper substantially; all of said medicinal materials will be expelled from said syringe.
2. The prefilled, vented, readily activated syringe assembly as defined in Claim 1 further including a second filter element secured to said piercing tubular member at an end opposite said piercing point.
3. The prefilled, vented, readily activated syringe assembly as defined in Claim 2 wherein said pierc-ing tubular member defines a male luer adapter portion for attachment to said second filter element and said hypoder-mic needle.
4. The prefilled, vented, readily activated syringe assembly as defined in Claim 2 wherein said holder member is composed of a resilient material and said pass-age means and said piercing tubular member defines a slid-able frictional engagement means for said piercing tubular member.
5. The prefilled, vented, readily activated syringe assembly as defined in Claim 4 wherein said slid-able frictional engagement is defined by at least one pro-jection extending from said piercing tubular member and an accommodating groove in said holder member.
6. The prefilled, vented, readily activated syringe assembly as defined in Claim 1 wherein said pierc-ing tubular member includes a flange for contact with said holder member after said piercing point pierces said hy-drophobic filter element.
7. The prefilled, vented, readily activated syringe assembly as defined in Claim 5 wherein said nozzle portion defines a flange portion, said syringe assembly includes an annular support with a flange section seated on said flange portion of said nozzle portion, said hy-drophobic filter element is secured to said annular sup-port and said holder member includes a shoulder section for holding said flange section of said annular support against said flange portion of said nozzle portion.
8. The prefilled, vented, readily activated syringe assembly defined in Claim 7 wherein said annular support is dimensioned to position said filter element within the confines of said nozzle portion.
9. The prefilled, vented, readily activated syringe system as defined in Claim 7 further including an annular sealing element positioned between said flange section of said annular support and said flange portion of said nozzle portion and said filter element is posi-tioned outside the confines of said nozzle portion.
10. The prefilled, vented, readily activated syringe assembly as defined in Claim 5 wherein said nozzle portion defines a flange portion, said holder member in-cludes a shoulder for seating on said flange portion and a compartment for housing said filter element and said syringe assembly includes a filter retaining member for seating in said compartment and retaining said filter therein.
11. The prefilled, vented, readily activated syringe assembly as defined in Claims 7 or 10 further including removable closure means for surrounding said holder member for securing said closure means to said flange portion of said nozzle portion.
12. a prefilled, vented, readily activated syringe assembly comprising:
a barrel member defining a substantially tubu-lar chamber having a wall portion with a bypass channel formed in said wall portion;
a nozzle portion communicating with said tubu-lar chamber;
a hydrophobic filter element in sealing engage-ment with said nozzle portion of said barrel member;
a holder member in sealing engagement with said nozzle portion and positioned outwardly from said filter element;
passage means defined by said holder element;
a piercing tubular member having a piercing point, slidably positioned in said passage means of said holder member and said piercing point spaced from said filter element;
a first stopper in slidable and sealing en-gagement in said tubular chamber and spaced from said bypass channel opposite said nozzle portion to provide a compartment for a first flowable medicinal material;
a second stopper adapted to receive a plunger rod in slidable and sealing engagement in said tubular chamber of said barrel member and spaced from said stop-per to provide a compartment for a second flowable medicinal material;
whereby upon movement of said second stopper in the direction of said first stopper, said first stopper will move adjacent said bypass channel to there-by permit intermixing of said first and second medicinal materials with emission of air through said filter ele-ment; upon subsequent movement of said piercing tubular member toward said filter with a piercing thereof;
attachment of a hypodermic needle to said piercing tubu-lar member; and upon further movement of said second stop-per toward said first stopper substantially all of said medicinal materials will be expelled from said syringe.
a barrel member defining a substantially tubu-lar chamber having a wall portion with a bypass channel formed in said wall portion;
a nozzle portion communicating with said tubu-lar chamber;
a hydrophobic filter element in sealing engage-ment with said nozzle portion of said barrel member;
a holder member in sealing engagement with said nozzle portion and positioned outwardly from said filter element;
passage means defined by said holder element;
a piercing tubular member having a piercing point, slidably positioned in said passage means of said holder member and said piercing point spaced from said filter element;
a first stopper in slidable and sealing en-gagement in said tubular chamber and spaced from said bypass channel opposite said nozzle portion to provide a compartment for a first flowable medicinal material;
a second stopper adapted to receive a plunger rod in slidable and sealing engagement in said tubular chamber of said barrel member and spaced from said stop-per to provide a compartment for a second flowable medicinal material;
whereby upon movement of said second stopper in the direction of said first stopper, said first stopper will move adjacent said bypass channel to there-by permit intermixing of said first and second medicinal materials with emission of air through said filter ele-ment; upon subsequent movement of said piercing tubular member toward said filter with a piercing thereof;
attachment of a hypodermic needle to said piercing tubu-lar member; and upon further movement of said second stop-per toward said first stopper substantially all of said medicinal materials will be expelled from said syringe.
13. The prefilled, vented, readily activated syringe assembly as defined in Claim 12 further including a second hydrophobic filter element secured to said pierc-ing tubular member at an end opposite said piercing point.
14. The prefilled, vented, readily activated syringe assembly as defined in Claim 13 wherein said first flowable medicinal material is solid material in powder form and said second material is a liquid.
15. The prefilled, vented, readily activated syringe assembly as defined in Claim 14 further including a removable closure means positioned over said holder mem-ber and secured to said nozzle portion.
16. The prefilled, vented, readily activated syringe assembly as defined in Claim 15 wherein said sy-ringe barrel is formed from glass and all of said other components are formed from materials other than glass.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/036,927 US4226236A (en) | 1979-05-07 | 1979-05-07 | Prefilled, vented two-compartment syringe |
| US36,927 | 1979-05-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1134699A true CA1134699A (en) | 1982-11-02 |
Family
ID=21891454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000349731A Expired CA1134699A (en) | 1979-05-07 | 1980-04-11 | Prefilled, vented two-compartment syringe |
Country Status (2)
| Country | Link |
|---|---|
| US (1) | US4226236A (en) |
| CA (1) | CA1134699A (en) |
Families Citing this family (102)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4340056A (en) * | 1981-02-02 | 1982-07-20 | The Franklin Institute | Non-air-entraining mixer/dispenser |
| US4599082A (en) * | 1984-08-13 | 1986-07-08 | Becton, Dickinson And Company | Two-component syringe assembly |
| US4689042A (en) * | 1985-05-20 | 1987-08-25 | Survival Technology, Inc. | Automatic medicament ingredient mixing and injecting apparatus |
| LU85916A1 (en) * | 1985-05-29 | 1986-12-05 | Vecta Glass Company | SYRINGE FOR PROMPT EMPLOYMENT |
| DE3674483D1 (en) * | 1985-06-27 | 1990-10-31 | Duphar Int Res | MULTI-CHAMBER SYRINGE. |
| US4685910A (en) * | 1986-01-21 | 1987-08-11 | Abbott Laboratories | Apparatus and method for delivering secondary fluids to a patient using an intravenous administration set feeding a primary fluid |
| EP0245895B1 (en) * | 1986-05-15 | 1991-09-18 | Duphar International Research B.V | Automatic injector |
| US4769026A (en) * | 1986-08-19 | 1988-09-06 | Erbamont, Inc. | Method and apparatus for purging a syringe |
| US4781683A (en) * | 1987-04-22 | 1988-11-01 | The Johns Hopkins University | Single-use, self-annulling injection syringe |
| DE3775054D1 (en) * | 1987-06-16 | 1992-01-16 | Akzo Nv | TWO-CHAMBER SYRINGE AND MANUFACTURING METHOD. |
| IL86799A (en) * | 1987-07-02 | 1993-03-15 | Kabi Pharmacia Ab | Method and device for injection |
| ES2024564B3 (en) * | 1988-02-16 | 1992-03-01 | Arzneimittel Gmbh Apotheker Vetter & Co Ravensburg | SYRINGE FOR MEDICINAL PURPOSES |
| DE3916101A1 (en) * | 1989-05-17 | 1990-11-22 | Vetter & Co Apotheker | SYRINGE FOR MEDICAL PURPOSES |
| DK0440846T3 (en) * | 1990-02-07 | 1993-07-12 | Vetter & Co Apotheker | Double chamber syringe and application method |
| US5238927A (en) * | 1990-11-30 | 1993-08-24 | Brown Nesbitt D | Hydrolytic stabilizer for unstable organic ions |
| HUT67228A (en) * | 1990-12-14 | 1995-03-28 | Univ Johns Hopkins | Viscoelastic memory flow control valve for single-use syringe |
| US6540154B1 (en) | 1991-04-24 | 2003-04-01 | Aerogen, Inc. | Systems and methods for controlling fluid feed to an aerosol generator |
| US7628339B2 (en) | 1991-04-24 | 2009-12-08 | Novartis Pharma Ag | Systems and methods for controlling fluid feed to an aerosol generator |
| JPH0614756Y2 (en) * | 1991-06-26 | 1994-04-20 | 株式会社アルテ | Assembled dual chamber syringe |
| DE4127650C1 (en) * | 1991-08-21 | 1993-02-25 | Arzneimittel Gmbh Apotheker Vetter & Co Ravensburg, 7980 Ravensburg, De | |
| US5226883A (en) * | 1992-03-31 | 1993-07-13 | Sherwood Medical Company | Flashback ventilation cap |
| US5383858B1 (en) | 1992-08-17 | 1996-10-29 | Medrad Inc | Front-loading medical injector and syringe for use therewith |
| US6402718B1 (en) | 1992-08-17 | 2002-06-11 | Medrad, Inc. | Front-loading medical injector and syringe for use therewith |
| TW404844B (en) * | 1993-04-08 | 2000-09-11 | Oxford Biosciences Ltd | Needleless syringe |
| US6085740A (en) | 1996-02-21 | 2000-07-11 | Aerogen, Inc. | Liquid dispensing apparatus and methods |
| US5758637A (en) * | 1995-08-31 | 1998-06-02 | Aerogen, Inc. | Liquid dispensing apparatus and methods |
| US6782886B2 (en) | 1995-04-05 | 2004-08-31 | Aerogen, Inc. | Metering pumps for an aerosolizer |
| US6205999B1 (en) * | 1995-04-05 | 2001-03-27 | Aerogen, Inc. | Methods and apparatus for storing chemical compounds in a portable inhaler |
| US5704921A (en) * | 1995-05-17 | 1998-01-06 | Carilli; Brian D. | Prefilled hypodermic syringe system |
| GB9521287D0 (en) * | 1995-10-18 | 1995-12-20 | Smith & Nephew | Fluid delivery device |
| DE29605790U1 (en) * | 1996-03-28 | 1996-08-08 | Thomae Gmbh Dr K | Syringe for medical purposes |
| US5865804A (en) * | 1997-07-16 | 1999-02-02 | Bachynsky; Nicholas | Rotary cam syringe |
| US6149626A (en) * | 1997-10-03 | 2000-11-21 | Bachynsky; Nicholas | Automatic injecting syringe apparatus |
| US5971953A (en) * | 1998-01-09 | 1999-10-26 | Bachynsky; Nicholas | Dual chamber syringe apparatus |
| US6681475B2 (en) | 1998-04-20 | 2004-01-27 | Becton Dickinson And Company | Method of sealing a medical container with a plastic closure |
| US6378714B1 (en) | 1998-04-20 | 2002-04-30 | Becton Dickinson And Company | Transferset for vials and other medical containers |
| FR2784034B1 (en) * | 1998-10-01 | 2000-12-15 | Marc Brunel | SINGLE USE INJECTION DEVICE FOR PRE-FILLED |
| WO2000047115A1 (en) * | 1999-02-10 | 2000-08-17 | Sub-Q, Inc. | Device and method for facilitating hemostasis of a biopsy tract |
| US6235177B1 (en) | 1999-09-09 | 2001-05-22 | Aerogen, Inc. | Method for the construction of an aperture plate for dispensing liquid droplets |
| US6958053B1 (en) | 1999-11-24 | 2005-10-25 | Medrad, Inc. | Injector providing drive member advancement and engagement with syringe plunger, and method of connecting a syringe to an injector |
| US20030176838A1 (en) * | 1999-12-06 | 2003-09-18 | Medrad, Inc. | Syringes, syringe tubing and fluid transfer systems |
| CN1174780C (en) * | 1999-12-07 | 2004-11-10 | 梅德拉股份有限公司 | Syringes, syringe tubing and fluid transfer systems |
| US6652489B2 (en) | 2000-02-07 | 2003-11-25 | Medrad, Inc. | Front-loading medical injector and syringes, syringe interfaces, syringe adapters and syringe plungers for use therewith |
| MXPA02010884A (en) | 2000-05-05 | 2003-03-27 | Aerogen Ireland Ltd | Apparatus and methods for the delivery of medicaments to the respiratory system. |
| US8336545B2 (en) | 2000-05-05 | 2012-12-25 | Novartis Pharma Ag | Methods and systems for operating an aerosol generator |
| US7971588B2 (en) | 2000-05-05 | 2011-07-05 | Novartis Ag | Methods and systems for operating an aerosol generator |
| US6948491B2 (en) | 2001-03-20 | 2005-09-27 | Aerogen, Inc. | Convertible fluid feed system with comformable reservoir and methods |
| US7600511B2 (en) | 2001-11-01 | 2009-10-13 | Novartis Pharma Ag | Apparatus and methods for delivery of medicament to a respiratory system |
| US7100600B2 (en) | 2001-03-20 | 2006-09-05 | Aerogen, Inc. | Fluid filled ampoules and methods for their use in aerosolizers |
| AUPQ867900A0 (en) | 2000-07-10 | 2000-08-03 | Medrad, Inc. | Medical injector system |
| US6543443B1 (en) | 2000-07-12 | 2003-04-08 | Aerogen, Inc. | Methods and devices for nebulizing fluids |
| US6546927B2 (en) | 2001-03-13 | 2003-04-15 | Aerogen, Inc. | Methods and apparatus for controlling piezoelectric vibration |
| US6550472B2 (en) | 2001-03-16 | 2003-04-22 | Aerogen, Inc. | Devices and methods for nebulizing fluids using flow directors |
| US6554201B2 (en) | 2001-05-02 | 2003-04-29 | Aerogen, Inc. | Insert molded aerosol generator and methods |
| US6732944B2 (en) | 2001-05-02 | 2004-05-11 | Aerogen, Inc. | Base isolated nebulizing device and methods |
| US8061006B2 (en) * | 2001-07-26 | 2011-11-22 | Powderject Research Limited | Particle cassette, method and kit therefor |
| MXPA04006629A (en) | 2002-01-07 | 2004-11-10 | Aerogen Inc | Devices and methods for nebulizing fluids for inhalation. |
| US7677467B2 (en) | 2002-01-07 | 2010-03-16 | Novartis Pharma Ag | Methods and devices for aerosolizing medicament |
| ES2603067T3 (en) | 2002-01-15 | 2017-02-23 | Novartis Ag | Methods and systems for operating an aerosol generator |
| ES2572770T3 (en) | 2002-05-20 | 2016-06-02 | Novartis Ag | Apparatus for providing spray for medical treatment and methods |
| US7553294B2 (en) * | 2002-05-30 | 2009-06-30 | Medrad, Inc. | Syringe plunger sensing mechanism for a medical injector |
| US7419478B1 (en) | 2003-06-25 | 2008-09-02 | Medrad, Inc. | Front-loading syringe for medical injector having a flexible syringe retaining ring |
| US8616195B2 (en) | 2003-07-18 | 2013-12-31 | Novartis Ag | Nebuliser for the production of aerosolized medication |
| US7666169B2 (en) | 2003-11-25 | 2010-02-23 | Medrad, Inc. | Syringe and syringe plungers for use with medical injectors |
| US8147426B2 (en) * | 2003-12-31 | 2012-04-03 | Nipro Diagnostics, Inc. | Integrated diagnostic test system |
| US7267121B2 (en) | 2004-04-20 | 2007-09-11 | Aerogen, Inc. | Aerosol delivery apparatus and method for pressure-assisted breathing systems |
| US7946291B2 (en) | 2004-04-20 | 2011-05-24 | Novartis Ag | Ventilation systems and methods employing aerosol generators |
| US7290541B2 (en) | 2004-04-20 | 2007-11-06 | Aerogen, Inc. | Aerosol delivery apparatus and method for pressure-assisted breathing systems |
| US20060178638A1 (en) * | 2004-12-03 | 2006-08-10 | Reynolds David L | Device and method for pharmaceutical mixing and delivery |
| US8348887B2 (en) * | 2004-12-23 | 2013-01-08 | Harvest Technologies Corporation | Hydrating anhydrous graft materials |
| BRPI0611198B1 (en) | 2005-05-25 | 2018-02-06 | Aerogen, Inc. | VIBRATION SYSTEMS AND METHODS |
| US7503905B2 (en) * | 2005-10-03 | 2009-03-17 | Ultradent Products, Inc. | Venting syringe plunger |
| WO2007048016A2 (en) * | 2005-10-20 | 2007-04-26 | Synthes (U.S.A.) | Perfusion device and method |
| US8926569B2 (en) | 2006-03-15 | 2015-01-06 | Bayer Medical Care Inc. | Plunger covers and plungers for use in syringes and methods of fabricating plunger covers and plungers for use in syringes |
| CA2574746A1 (en) * | 2007-01-22 | 2008-07-22 | Duoject Medical Systems Inc. | Syringe having venting structure and method for mixing two substances in a syringe |
| USD1002840S1 (en) | 2007-03-14 | 2023-10-24 | Bayer Healthcare Llc | Syringe plunger |
| USD847985S1 (en) | 2007-03-14 | 2019-05-07 | Bayer Healthcare Llc | Syringe plunger cover |
| USD942005S1 (en) | 2007-03-14 | 2022-01-25 | Bayer Healthcare Llc | Orange syringe plunger cover |
| JP2010528789A (en) * | 2007-06-13 | 2010-08-26 | デュオジェクト・メディカル・システムズ・インコーポレイテッド | Device for transferring liquid from cartridge to container |
| CN101678175A (en) * | 2007-06-14 | 2010-03-24 | 塞诺菲-安万特德国有限公司 | dual-chamber carpule with attachment |
| WO2008151737A1 (en) * | 2007-06-14 | 2008-12-18 | Sanofi-Aventis Deutschland Gmbh | Dual-chamber carpule |
| EP2237819B1 (en) * | 2007-09-27 | 2013-09-18 | Becton, Dickinson and Company | Cartridge for powder and liquid drug |
| SI2224982T1 (en) * | 2007-12-19 | 2013-11-29 | Sanofi-Aventis Deutschland Gmbh | Dual-chamber injection device having gas-permeable membrane |
| ES2905719T3 (en) | 2008-05-14 | 2022-04-11 | Biolyph Llc | Reagent mixture preparation and dispensing device and associated methods |
| US20090308895A1 (en) * | 2008-06-13 | 2009-12-17 | Reynolds David L | Rack and pinon drive for by-pass cartridge |
| CA2735289A1 (en) * | 2008-08-30 | 2010-03-04 | Sanofi-Aventis Deutschland Gmbh | Cartridge and needle system therefor |
| US9061107B2 (en) | 2008-09-18 | 2015-06-23 | Becton, Dickinson and Comapany | Needle mounting feature for ensuring proper reconstitution sequence |
| WO2011076852A2 (en) | 2009-12-22 | 2011-06-30 | Novo Nordisk A/S | Medical device with bypass arrangement |
| AU2011261296C1 (en) | 2010-06-04 | 2016-08-18 | Bayer Healthcare, Llc. | System and method for planning and monitoring multi-dose radiopharmaceutical usage on radiopharmaceutical injectors |
| ES2669185T3 (en) | 2010-06-29 | 2018-05-24 | Biolyph, Llc | Reagent Preparation Set |
| WO2012067619A1 (en) * | 2010-11-18 | 2012-05-24 | Biolyph, Llc | Reagent preparation and dispensing device |
| WO2012136570A1 (en) | 2011-04-04 | 2012-10-11 | Novo Nordisk Health Care Ag | Piston rod release mechanism |
| GB201210082D0 (en) * | 2012-06-07 | 2012-07-25 | Consort Medical Plc | Improved syringe |
| US9731076B2 (en) * | 2012-06-29 | 2017-08-15 | Ethicon, Inc. | Multi-compartment pre-filled mixing syringes with bypass |
| US9174003B2 (en) | 2012-09-28 | 2015-11-03 | Bayer Medical Care Inc. | Quick release plunger |
| CA2942754C (en) | 2014-03-19 | 2019-10-15 | Bayer Healthcare Llc | System for syringe engagement to an injector |
| US9700680B2 (en) * | 2015-03-31 | 2017-07-11 | Medtrick Inc. | Medical devices and methods for creating bubbles |
| US20170056916A1 (en) * | 2015-08-29 | 2017-03-02 | Malic Bedford | Silicon ball in a glass tube advanced by threaded rod dispensing micro amounts of oils or other materials |
| US9480797B1 (en) | 2015-10-28 | 2016-11-01 | Bayer Healthcare Llc | System and method for syringe plunger engagement with an injector |
| CN109310815B (en) * | 2016-09-12 | 2022-06-10 | 魏民 | Drug delivery device |
| DE102016121607B4 (en) * | 2016-11-11 | 2019-05-16 | Heraeus Medical Gmbh | Apparatus and method for storing and mixing a bone cement |
| WO2019168776A1 (en) | 2018-02-27 | 2019-09-06 | Bayer Healthcare Llc | Syringe plunger engagement mechanism |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2591046A (en) * | 1948-10-18 | 1952-04-01 | Frederick M Turnbull | Hypodermic syringe assembly |
| DE1057737B (en) * | 1955-05-03 | 1959-05-21 | Gruenenthal Chemie | Injection ampoule for multiple media and single use |
| US3330282A (en) * | 1964-08-21 | 1967-07-11 | Upjohn Co | Combination syringe and vial mixing container |
| US3477431A (en) * | 1967-02-03 | 1969-11-11 | Abbott Lab | Combined mixing syringe and container |
| US3757779A (en) * | 1971-05-24 | 1973-09-11 | Century Labor Inc | Filter syringe |
| JPS4910657A (en) * | 1972-05-24 | 1974-01-30 | ||
| US3889674A (en) * | 1973-11-30 | 1975-06-17 | Constabile A Cilento | Mixing syringe |
-
1979
- 1979-05-07 US US06/036,927 patent/US4226236A/en not_active Expired - Lifetime
-
1980
- 1980-04-11 CA CA000349731A patent/CA1134699A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| US4226236A (en) | 1980-10-07 |
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