CA1089264A - Specimen slide holder - Google Patents
Specimen slide holderInfo
- Publication number
- CA1089264A CA1089264A CA287,338A CA287338A CA1089264A CA 1089264 A CA1089264 A CA 1089264A CA 287338 A CA287338 A CA 287338A CA 1089264 A CA1089264 A CA 1089264A
- Authority
- CA
- Canada
- Prior art keywords
- slide
- frame
- specimen
- holder
- slide holder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/54—Labware with identification means
- B01L3/545—Labware with identification means for laboratory containers
Abstract
Abstract Of The Disclosure A slide holder is disclosed which is suitable for use in an automated differential blood cell classifier.
The molded plastic holder provides a readily identifiable, stackable, and nestable device for protectively handling, positioning, and transporting a specimen such as a film of blood to be analyzed.
The molded plastic holder provides a readily identifiable, stackable, and nestable device for protectively handling, positioning, and transporting a specimen such as a film of blood to be analyzed.
Description
~o~
Back~round Of The Invention The present invention r~lates to a specimen holder. In general, it concerns a device for protectively manipulating a film-like specimen to be analyzed. More particularly, it provides a molded plastic slide holder which can be transported, stacked, ancl nestled with other such holders.
In se~eral different fields of technology, auto-mated analysis of samples or specimens is of continuing interest.
For example, in the medical or health care field various instruments for automated blood cell analysis, e.g., classifi-cation and counting, have been disclosed and marketed. Auto-mated analytical instruments are also of current interest in the field o~ pollution analysis and control. In these, as well as other, technological fields, a variety of different automated instruments analyze a plurality of specimens each of which is generally in the form of a relatively thin film.
For example, in automated differential blood cell analysis it is common practice to employ a specimen comprising a gtained monolayer of blood cells on a glass microscope slide. U. S. Patent 3,8S1,156, ~or example, discloses a method and apparatus particularly suitable for automated differential blood cell analysis, A specimen holder which is suitable for use with an automated analytical instrument must, of course, hold the specimen in proper orientation or position for analysis ~389~69L ^ ` ~ ~ ~
within the particular instrument. In addition, it must permit the specimen to be transported or moved through the instrument, for e~ample, from a sample input storage area through a scanning stage o~ the instrument and into a sample output storage area. During such transpor~ing, as well as during any handling by a laboratory technician, it is usually important that the specimen be protected, for example, from scraping or abrasion from contact with other objects. In . addition, it is desirable that specimen~ be in a form which permits their compact handling and storage. Thus, stackable and nestable forms of specimens offer certain advantages.
It is also preferable that each oE. the various specimens be readily .identi~iable, to distinguish them one Erom another and to permit r~.lating a particular specimen with its source.
The present invention provides a slide holder for accommodating a planar specimen slide which comprises: a molded rame to accommodate the slide; integral cooperating slide holding means Eor retaining the slide defined by the frame; nesting means defined by opposing sides of the frame to communicate with vertically stacked adjacent slide holders constructed in a range to permit movement o:E one slide holder in one and opposing directions but to prevent movement in a direction substantially transverse thereto; and transport means operatively associated with the frame to permit mechanical transfer of the slide holder.
Brief Descrip-tion Of The Drawings .
The present invention will be better understood from the following detailed description of a preferred embodiment and by reference to the accompanying illustrative drawin~s, in which:
FIGURE 1 is a top view showing a glass slide and a slide holder of the present invention;
B ~
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FIGURE 2 is a top view, similar to FIGURE 1, but showing the slide held encompassed by the slide holder;
FIGURE 3 is a bottom view showing a preferred embodiment of a slide holder of the prlesent invention;
5FIGURES 4 and 5 are both enlarged, side sectional views taken along the lines 4-4 and 5-5, respectivel~, in FIGURE 3;
FIGURE 6 is a top view showing another embodiment wherein a sample holder has an integral, transparent planar surface area; and FIGURE 7 is an end view, partially pictorial and partially diagramatic~ showing slide holders o~ the present invention being used with an apparatus for automatically counting and classifying the blood cells in specimens on the slide holders.
Detailed Description O~ The lnvention Referring to FlGURES 1-5, a molded plastic slide holder 10 i9 shown in conjunction with a glass slide 20. The slide holder 10 generally comprises a carrier frame 11 surrounding or encompassing an opening or window 12. The holder 10 is provided with integral slide holding means composed of a pair of projections 14a and 14b, a spring 13a and 13bJ a backing support 16 and a projection or lip 15 which cooperate together to hold glass slide 20 in proper position. As best shown in FIGURE 2, the glass slide 20 is held in position with the backing support 16 abutting the edges of the bottom of the slide 20, while the lip 15 and projections 14a and 14b overlap and abut portions of the top of the slide 20. Integral spring 13a and 13b is biased to urge the slide 20 in the direction of lip 15.
~arrier frame 11 is provided with alignment means, such as notch 28 and teeth 21a, 21b and 21c ~or properly and selectively positioning the holder. Alignment notch 28 permits the holder 10 to be easily and correctly aligned,for example, when stored in a stacked position in hopper 40 having a pro-jection or ear 45 which must mate with the notch 28 in order ~or the holder 10 to enter t~e hopper 40. Teeth 21a, 21b and 21c help permit slide holder lO to be automatically drivan or moved by a transporting mechanism (not shown) such as worm gears, star gears and the like. The holder 10 has a first pair of spacer-s~ops 22a and 22b molded on its front surface. The back sur~ace of slide holder 10 is provided with a second pair of spacer-stops 23a and 23b and a rib 24.
These spacer-stops 22 and 23 and rib 24 help make the slide holder 10 stackable and nestabl~ with other such slide holders.
In a preferred embodiment o~ the present invention, slide holder 10 contains one or more identification or en-coding areas. As shown in FIGURES 1 and 2, slide holder 10 includes an opaque or frosted area 30 upon which, if desired, a laboratory technician can write or place an identifying symbol, such as a patient's name. In addition to providing an area 30 ~or a human readable code or indicia, the holder 1~89qZ~i~
10 also includes a molded bar code area 31 comprising six groups of five rectangular indents 32. In FIGURE 1~ code area 31 is shown prior to having any code applied. In FIGURE 2 a machine readable code has been applied, for example, by techniques known in the art,such as hot stamping. Rectangular indents 32 provide a series of raised areas 33 between indents 32 which facilitate application of a machine readable bar code by providing well defined, or crisp, edges.
As is shown in FIGURE 6, the specimen holder~ in another embodiment of the present invention, can be integral or one piece and thus not employ a separate gla~s slide but rather be a single piece~ molded ~rom pla~tic materlal which exhibits suitable transparency.
Referring to FIGURE 7, a plurality of slide holders 10 of the present invention are shown in use with an apparatus for automatically counting and classifying blood cells. The apparatus includes an input storage container or hopper 40 and an output container or hopper 41, a scanner 42 and a lense ~ystem 43. Ear 45 on an inside wall of hopper 41 mates with notch 28 on holder 10 to properly orient each holder 10. Stacked and nestled slide holders 10 are moved one at a time by a trans-porting device (not shown) from hopper 40 past scanner 42, which optically reads the different codes appearing on each slide holder 10. The slide holder lO then passes between lense system 43 which illuminates and optically views the specImen, for example~ as described in U. S. Patent 3~851,156. Finally~ the slide holder 10 is transported from the lense system 43 and stored in hopper 41.
1089Z6~L
As mentioned above, the specimen holder is preferably constructed from a molded plastic material. Suitable plastics will be apparent to those skilled in the art and will generally provide relatively rigid, transparent molded products. For example, polycarbonates, polyacrylates and polymethacrylates may be employed.
Having described in detail a preferred embodiment of my invention it will be apparent to those skilled in the art that numerous modifications can be made without parting from the scope of the invention.
Back~round Of The Invention The present invention r~lates to a specimen holder. In general, it concerns a device for protectively manipulating a film-like specimen to be analyzed. More particularly, it provides a molded plastic slide holder which can be transported, stacked, ancl nestled with other such holders.
In se~eral different fields of technology, auto-mated analysis of samples or specimens is of continuing interest.
For example, in the medical or health care field various instruments for automated blood cell analysis, e.g., classifi-cation and counting, have been disclosed and marketed. Auto-mated analytical instruments are also of current interest in the field o~ pollution analysis and control. In these, as well as other, technological fields, a variety of different automated instruments analyze a plurality of specimens each of which is generally in the form of a relatively thin film.
For example, in automated differential blood cell analysis it is common practice to employ a specimen comprising a gtained monolayer of blood cells on a glass microscope slide. U. S. Patent 3,8S1,156, ~or example, discloses a method and apparatus particularly suitable for automated differential blood cell analysis, A specimen holder which is suitable for use with an automated analytical instrument must, of course, hold the specimen in proper orientation or position for analysis ~389~69L ^ ` ~ ~ ~
within the particular instrument. In addition, it must permit the specimen to be transported or moved through the instrument, for e~ample, from a sample input storage area through a scanning stage o~ the instrument and into a sample output storage area. During such transpor~ing, as well as during any handling by a laboratory technician, it is usually important that the specimen be protected, for example, from scraping or abrasion from contact with other objects. In . addition, it is desirable that specimen~ be in a form which permits their compact handling and storage. Thus, stackable and nestable forms of specimens offer certain advantages.
It is also preferable that each oE. the various specimens be readily .identi~iable, to distinguish them one Erom another and to permit r~.lating a particular specimen with its source.
The present invention provides a slide holder for accommodating a planar specimen slide which comprises: a molded rame to accommodate the slide; integral cooperating slide holding means Eor retaining the slide defined by the frame; nesting means defined by opposing sides of the frame to communicate with vertically stacked adjacent slide holders constructed in a range to permit movement o:E one slide holder in one and opposing directions but to prevent movement in a direction substantially transverse thereto; and transport means operatively associated with the frame to permit mechanical transfer of the slide holder.
Brief Descrip-tion Of The Drawings .
The present invention will be better understood from the following detailed description of a preferred embodiment and by reference to the accompanying illustrative drawin~s, in which:
FIGURE 1 is a top view showing a glass slide and a slide holder of the present invention;
B ~
~89'~6~
FIGURE 2 is a top view, similar to FIGURE 1, but showing the slide held encompassed by the slide holder;
FIGURE 3 is a bottom view showing a preferred embodiment of a slide holder of the prlesent invention;
5FIGURES 4 and 5 are both enlarged, side sectional views taken along the lines 4-4 and 5-5, respectivel~, in FIGURE 3;
FIGURE 6 is a top view showing another embodiment wherein a sample holder has an integral, transparent planar surface area; and FIGURE 7 is an end view, partially pictorial and partially diagramatic~ showing slide holders o~ the present invention being used with an apparatus for automatically counting and classifying the blood cells in specimens on the slide holders.
Detailed Description O~ The lnvention Referring to FlGURES 1-5, a molded plastic slide holder 10 i9 shown in conjunction with a glass slide 20. The slide holder 10 generally comprises a carrier frame 11 surrounding or encompassing an opening or window 12. The holder 10 is provided with integral slide holding means composed of a pair of projections 14a and 14b, a spring 13a and 13bJ a backing support 16 and a projection or lip 15 which cooperate together to hold glass slide 20 in proper position. As best shown in FIGURE 2, the glass slide 20 is held in position with the backing support 16 abutting the edges of the bottom of the slide 20, while the lip 15 and projections 14a and 14b overlap and abut portions of the top of the slide 20. Integral spring 13a and 13b is biased to urge the slide 20 in the direction of lip 15.
~arrier frame 11 is provided with alignment means, such as notch 28 and teeth 21a, 21b and 21c ~or properly and selectively positioning the holder. Alignment notch 28 permits the holder 10 to be easily and correctly aligned,for example, when stored in a stacked position in hopper 40 having a pro-jection or ear 45 which must mate with the notch 28 in order ~or the holder 10 to enter t~e hopper 40. Teeth 21a, 21b and 21c help permit slide holder lO to be automatically drivan or moved by a transporting mechanism (not shown) such as worm gears, star gears and the like. The holder 10 has a first pair of spacer-s~ops 22a and 22b molded on its front surface. The back sur~ace of slide holder 10 is provided with a second pair of spacer-stops 23a and 23b and a rib 24.
These spacer-stops 22 and 23 and rib 24 help make the slide holder 10 stackable and nestabl~ with other such slide holders.
In a preferred embodiment o~ the present invention, slide holder 10 contains one or more identification or en-coding areas. As shown in FIGURES 1 and 2, slide holder 10 includes an opaque or frosted area 30 upon which, if desired, a laboratory technician can write or place an identifying symbol, such as a patient's name. In addition to providing an area 30 ~or a human readable code or indicia, the holder 1~89qZ~i~
10 also includes a molded bar code area 31 comprising six groups of five rectangular indents 32. In FIGURE 1~ code area 31 is shown prior to having any code applied. In FIGURE 2 a machine readable code has been applied, for example, by techniques known in the art,such as hot stamping. Rectangular indents 32 provide a series of raised areas 33 between indents 32 which facilitate application of a machine readable bar code by providing well defined, or crisp, edges.
As is shown in FIGURE 6, the specimen holder~ in another embodiment of the present invention, can be integral or one piece and thus not employ a separate gla~s slide but rather be a single piece~ molded ~rom pla~tic materlal which exhibits suitable transparency.
Referring to FIGURE 7, a plurality of slide holders 10 of the present invention are shown in use with an apparatus for automatically counting and classifying blood cells. The apparatus includes an input storage container or hopper 40 and an output container or hopper 41, a scanner 42 and a lense ~ystem 43. Ear 45 on an inside wall of hopper 41 mates with notch 28 on holder 10 to properly orient each holder 10. Stacked and nestled slide holders 10 are moved one at a time by a trans-porting device (not shown) from hopper 40 past scanner 42, which optically reads the different codes appearing on each slide holder 10. The slide holder lO then passes between lense system 43 which illuminates and optically views the specImen, for example~ as described in U. S. Patent 3~851,156. Finally~ the slide holder 10 is transported from the lense system 43 and stored in hopper 41.
1089Z6~L
As mentioned above, the specimen holder is preferably constructed from a molded plastic material. Suitable plastics will be apparent to those skilled in the art and will generally provide relatively rigid, transparent molded products. For example, polycarbonates, polyacrylates and polymethacrylates may be employed.
Having described in detail a preferred embodiment of my invention it will be apparent to those skilled in the art that numerous modifications can be made without parting from the scope of the invention.
Claims (9)
OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:
1. A slide holder for accommodating a planar specimen slide which comprises:
(a) a molded frame to accommodate said slide;
(b) integral cooperating slide holding means for retaining said slide defined by said frame;
(c) nesting means defined by opposing sides of said frame to communicate with vertically stacked adjacent slide holders constructed in a range to permit movement of one slide holder in one and opposing directions but to prevent movement in a direction substantially transverse thereto; and (d) transport means operatively associated with said frame to permit mechanical transfer of said slide holder.
(a) a molded frame to accommodate said slide;
(b) integral cooperating slide holding means for retaining said slide defined by said frame;
(c) nesting means defined by opposing sides of said frame to communicate with vertically stacked adjacent slide holders constructed in a range to permit movement of one slide holder in one and opposing directions but to prevent movement in a direction substantially transverse thereto; and (d) transport means operatively associated with said frame to permit mechanical transfer of said slide holder.
2. A slide holder according to Claim 1 wherein said frame includes an encoding area.
3. A slide holder according to Claim 2 wherein said encoding area is machine readable.
4. A slide holder according to Claim 2 wherein said encoding area is human readable.
5. A slide holder according to Claim 1 wherein said frame can accommodate a glass planar specimen slide.
6. A slide holder according to Claim 1 wherein said frame can accommodate a plastic planar specimen slide.
7. A slide holder according to Claim 1 wherein said integral cooperating slide holding means includes a resilient biasing means.
8. A specimen holder which comprises:
(a) a planar specimen slide;
(b) a molded frame to accommodate said slide;
(c) integral cooperating slide holding means for retaining said slide in said frame;
(d) nesting means defined by opposing sides of said frame to communicate with vertically stacked adjacent specimen holders constructed in a range to permit movement of one slide holder in one and opposing directions but to prevent movement in a direction substantially transverse thereto; and, (e) transport means operatively associated with said frame to permit mechanical transfer of said specimen holder.
(a) a planar specimen slide;
(b) a molded frame to accommodate said slide;
(c) integral cooperating slide holding means for retaining said slide in said frame;
(d) nesting means defined by opposing sides of said frame to communicate with vertically stacked adjacent specimen holders constructed in a range to permit movement of one slide holder in one and opposing directions but to prevent movement in a direction substantially transverse thereto; and, (e) transport means operatively associated with said frame to permit mechanical transfer of said specimen holder.
9. A specimen holder which comprises:
(a) an integral planar specimen slide;
(b) a frame encompassing said slide;
(c) nesting means defined by opposing sides of said frame to communicate with vertically stacked adjacent specimen holders constructed in such a range to permit move-ment of one slide holder in one and opposing directions but to prevent movement in a direction substantially transverse thereto; and, (d) transport means operatively associated with said frame to permit mechanical transfer of said specimen holder.
(a) an integral planar specimen slide;
(b) a frame encompassing said slide;
(c) nesting means defined by opposing sides of said frame to communicate with vertically stacked adjacent specimen holders constructed in such a range to permit move-ment of one slide holder in one and opposing directions but to prevent movement in a direction substantially transverse thereto; and, (d) transport means operatively associated with said frame to permit mechanical transfer of said specimen holder.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US734,582 | 1976-10-21 | ||
| US05/734,582 US4159875A (en) | 1976-10-21 | 1976-10-21 | Specimen holder |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1089264A true CA1089264A (en) | 1980-11-11 |
Family
ID=24952268
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA287,338A Expired CA1089264A (en) | 1976-10-21 | 1977-09-23 | Specimen slide holder |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4159875A (en) |
| JP (1) | JPS5353394A (en) |
| BE (1) | BE859947A (en) |
| CA (1) | CA1089264A (en) |
| DE (1) | DE2747200C3 (en) |
| FR (1) | FR2368774A1 (en) |
| GB (1) | GB1561936A (en) |
| NL (1) | NL7711484A (en) |
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| FR2142637A1 (en) * | 1971-06-22 | 1973-02-02 | Hoffmann La Roche | Plastic sample table - for use with automatic analysers |
| US3738730A (en) * | 1971-07-06 | 1973-06-12 | Aerojet General Co | Microscope attachment |
| JPS5354312Y2 (en) * | 1974-04-19 | 1978-12-26 | ||
| US3951512A (en) * | 1974-11-04 | 1976-04-20 | Tolles Walter E | Microscope slide reference apparatus |
| US3957583A (en) * | 1974-12-02 | 1976-05-18 | Mcdonnell Douglas Corporation | Apparatus and process for determining the susceptibility of microorganisms to antibiotics |
| US3961346A (en) * | 1975-01-30 | 1976-06-01 | Miles Laboratories, Inc. | Liquid inspection slide |
| US4038151A (en) * | 1976-07-29 | 1977-07-26 | Mcdonnell Douglas Corporation | Card for use in an automated microbial detection system |
-
1976
- 1976-10-21 US US05/734,582 patent/US4159875A/en not_active Expired - Lifetime
-
1977
- 1977-09-23 CA CA287,338A patent/CA1089264A/en not_active Expired
- 1977-10-13 JP JP12196077A patent/JPS5353394A/en active Granted
- 1977-10-19 NL NL7711484A patent/NL7711484A/en active Search and Examination
- 1977-10-20 BE BE181925A patent/BE859947A/en unknown
- 1977-10-20 DE DE2747200A patent/DE2747200C3/en not_active Expired
- 1977-10-20 FR FR7731636A patent/FR2368774A1/en not_active Withdrawn
- 1977-10-20 GB GB43759/77A patent/GB1561936A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS578410B2 (en) | 1982-02-16 |
| GB1561936A (en) | 1980-03-05 |
| BE859947A (en) | 1978-04-20 |
| NL7711484A (en) | 1978-04-25 |
| FR2368774A1 (en) | 1978-05-19 |
| DE2747200C3 (en) | 1980-12-04 |
| JPS5353394A (en) | 1978-05-15 |
| DE2747200A1 (en) | 1978-05-03 |
| US4159875A (en) | 1979-07-03 |
| DE2747200B2 (en) | 1980-03-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |