CA1020234A - Diagnoses of disease states by fluorescent measurements utilizing scanning laser beams - Google Patents

Diagnoses of disease states by fluorescent measurements utilizing scanning laser beams

Info

Publication number
CA1020234A
CA1020234A CA198,519A CA198519A CA1020234A CA 1020234 A CA1020234 A CA 1020234A CA 198519 A CA198519 A CA 198519A CA 1020234 A CA1020234 A CA 1020234A
Authority
CA
Canada
Prior art keywords
diagnoses
laser beams
disease states
scanning laser
fluorescent measurements
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA198,519A
Other languages
French (fr)
Other versions
CA198519S (en
Inventor
Dale M. Holm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Energy Research and Development Administration ERDA
Original Assignee
Energy Research and Development Administration ERDA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Energy Research and Development Administration ERDA filed Critical Energy Research and Development Administration ERDA
Application granted granted Critical
Publication of CA1020234A publication Critical patent/CA1020234A/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N2021/1734—Sequential different kinds of measurements; Combining two or more methods
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
CA198,519A 1973-05-07 1974-04-30 Diagnoses of disease states by fluorescent measurements utilizing scanning laser beams Expired CA1020234A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US357758A US3918812A (en) 1973-05-07 1973-05-07 Diagnoses of disease states by fluorescent measurements utilizing scanning laser beams

Publications (1)

Publication Number Publication Date
CA1020234A true CA1020234A (en) 1977-11-01

Family

ID=23406911

Family Applications (1)

Application Number Title Priority Date Filing Date
CA198,519A Expired CA1020234A (en) 1973-05-07 1974-04-30 Diagnoses of disease states by fluorescent measurements utilizing scanning laser beams

Country Status (8)

Country Link
US (1) US3918812A (en)
JP (1) JPS5016597A (en)
BE (1) BE814460A (en)
CA (1) CA1020234A (en)
DE (1) DE2422016A1 (en)
FR (1) FR2229063B1 (en)
GB (1) GB1448789A (en)
IT (1) IT1019580B (en)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4006360A (en) * 1974-08-21 1977-02-01 Block Engineering, Inc. Method of discriminating between dyed particles and background fluorescence of the dye
US3992631A (en) * 1975-02-27 1976-11-16 International Diagnostic Technology, Inc. Fluorometric system, method and test article
US4058732A (en) * 1975-06-30 1977-11-15 Analytical Radiation Corporation Method and apparatus for improved analytical fluorescent spectroscopy
US4341957A (en) * 1975-11-26 1982-07-27 Analytical Radiation Corporation Fluorescent antibody composition for immunofluorometric assay
NL180704C (en) * 1976-06-14 Coulter Electronics DEVICE FOR SIMULTANEOUS OPTICAL MEASUREMENT OF CHARACTERISTICS OF PARTICLES CONTAINING IN SUSPENSION.
FR2374636A1 (en) * 1976-12-14 1978-07-13 Block Engineering Irradiation analysis of fluorescent material - includes measurement of simulated fluorescent radiation and integration over specified decay period
US4100416A (en) * 1977-03-02 1978-07-11 Block Engineering, Inc. Serum fluorescence suppression
JPS53135660A (en) * 1977-04-30 1978-11-27 Olympus Optical Co Ltd Fluorescent photometric microscope using laser light
US4152723A (en) * 1977-12-19 1979-05-01 Sperry Rand Corporation Method of inspecting circuit boards and apparatus therefor
CH622369A5 (en) * 1978-04-18 1981-03-31 Radioelectrique Comp Ind
US4172227A (en) * 1978-07-21 1979-10-23 Becton, Dickinson And Company Flow microfluorometer
US4293221A (en) * 1979-04-17 1981-10-06 Research Corporation Multidimensional slit-scan flow system
JPS55140151A (en) * 1979-04-18 1980-11-01 Agency Of Ind Science & Technol Quantitative measurement of microorganism using fluorescent anti-body-antigen reaction
US4284412A (en) * 1979-07-13 1981-08-18 Ortho Diagnostics, Inc. Method and apparatus for automated identification and enumeration of specified blood cell subclasses
US4320462A (en) * 1980-03-31 1982-03-16 Hughes Aircraft Company High speed laser pulse analyzer
US4393311A (en) * 1980-06-13 1983-07-12 Bell Telephone Laboratories, Incorporated Method and apparatus for surface characterization and process control utilizing radiation from desorbed particles
US4350892A (en) * 1980-07-31 1982-09-21 Research Corporation X'-, Y'-, Z'- axis multidimensional slit-scan flow system
DE3037983C2 (en) * 1980-10-08 1983-03-31 Fa. Carl Zeiss, 7920 Heidenheim Method and device for the light-induced scanning microscopic representation of sample parameters in their spatial distribution
US4390787A (en) * 1980-10-29 1983-06-28 The United States Of America As Represented By The Secretary Of Agriculture Method and apparatus for automatic egg mass counting
FR2502783A1 (en) * 1981-03-25 1982-10-01 Cilas Measurement appts. for oxidation-reduction state of living organism - uses UV and IR radiation to produce fluorescent and reflected beams
JPS57198849A (en) * 1981-05-30 1982-12-06 Japan Spectroscopic Co Measuring device for fluorescence
FR2532756A1 (en) * 1982-09-03 1984-03-09 France Henri De SYSTEM FOR AUTOMATIC OBSERVATION AND QUANTIFICATION OF PHENOMENA THAT CAN BE DETECTED BY FLUORESCENCE
JPS5972049A (en) * 1982-10-19 1984-04-23 Horiba Ltd Measuring apparatus of light emission life of sample
JPS59118151A (en) * 1982-12-27 1984-07-07 株式会社トクヤマ Production of dental prothsesis
US4577110A (en) * 1983-04-11 1986-03-18 Biochem Sensors, Inc. Optical apparatus and method for measuring the characteristics of materials by their fluorescence
US4573796A (en) * 1984-01-06 1986-03-04 The United States Of America As Represented By The United States Department Of Energy Apparatus for eliminating background interference in fluorescence measurements
US4622468A (en) * 1985-07-15 1986-11-11 Sequoia-Turner Corporation Fluorescence intensity compensation method and device
AT387860B (en) * 1985-09-16 1989-03-28 Optical Sensing Technology METHOD AND DEVICE FOR TUMOR DIAGNOSIS BY MEANS OF SERA
US4802768A (en) * 1986-04-11 1989-02-07 Sclavo, Inc. Two light source reference system for a fluorometer
US4745285A (en) * 1986-08-21 1988-05-17 Becton Dickinson And Company Multi-color fluorescence analysis with single wavelength excitation
US4867559A (en) * 1988-01-06 1989-09-19 Amoco Corporation Liquid/liquid fiber-optic fluorescence detector and absorbance analyzer
US5089384A (en) * 1988-11-04 1992-02-18 Amoco Corporation Method and apparatus for selective cell destruction using amplified immunofluorescence
US4920275A (en) * 1988-12-30 1990-04-24 Canon Kabushiki Kaisha Particle measuring device with elliptically-shaped scanning beam
US5072382A (en) * 1989-10-02 1991-12-10 Kamentsky Louis A Methods and apparatus for measuring multiple optical properties of biological specimens
US5107422A (en) * 1989-10-02 1992-04-21 Kamentsky Louis A Method and apparatus for measuring multiple optical properties of biological specimens
GB9015793D0 (en) * 1990-07-18 1990-09-05 Medical Res Council Confocal scanning optical microscope
US5202230A (en) * 1990-09-07 1993-04-13 Kamentsky Louis A Methods of detecting cut cells in a tissue section
US5117466A (en) * 1991-04-30 1992-05-26 The United States Of America As Represented By The United States Department Of Energy Integrated fluorescence analysis system
DK66992D0 (en) * 1992-05-21 1992-05-21 Faxe Kalkbrud Aktieselskabet SENSOR
US5556764A (en) * 1993-02-17 1996-09-17 Biometric Imaging, Inc. Method and apparatus for cell counting and cell classification
US5547849A (en) * 1993-02-17 1996-08-20 Biometric Imaging, Inc. Apparatus and method for volumetric capillary cytometry
US5396075A (en) * 1993-07-27 1995-03-07 The United States Of America As Represented By The United States Department Of Energy Method for in situ characterization of a medium of dispersed matter in a continuous phase
US5686988A (en) * 1994-06-28 1997-11-11 Lockheed Martin Energy Systems, Inc. Gas concentration measurement instrument based on the effects of a wave-mixing interference on stimulated emissions
US5537211A (en) * 1995-01-13 1996-07-16 Triliance Corporation Method and apparatus for selecting a wearable to match an object
US6307629B1 (en) * 1997-08-12 2001-10-23 Lj Laboratories, L.L.C. Apparatus and method for measuring optical characteristics of an object
DE19707226A1 (en) * 1997-02-24 1998-08-27 Bodenseewerk Perkin Elmer Co Light scanner
US6501542B2 (en) 1998-06-30 2002-12-31 Lj Laboratories, Llc Apparatus and method for measuring optical characteristics of an object
US6813017B1 (en) 1999-10-20 2004-11-02 Becton, Dickinson And Company Apparatus and method employing incoherent light emitting semiconductor devices as particle detection light sources in a flow cytometer
CN102282465B (en) * 2008-11-14 2014-04-16 罗伯特·博世有限公司 Apparatus and method for detecting glycol
US9372143B2 (en) 2013-05-15 2016-06-21 Captl Llc Scanning image flow cytometer
US10900885B2 (en) 2014-12-19 2021-01-26 Captl Llc Flow cytometry using hydrodynamically planar flow
US10036698B2 (en) 2015-06-19 2018-07-31 Captl Llc Time-sequential cytometry

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3297873A (en) * 1963-12-30 1967-01-10 Avco Corp Microscope system with means for viewing the entire image and means for measuring radiation from a selected segment of image
US3699336A (en) * 1969-08-15 1972-10-17 Hycel Inc Biological cell analyzing system

Also Published As

Publication number Publication date
BE814460A (en) 1974-09-02
FR2229063A1 (en) 1974-12-06
AU6864274A (en) 1975-11-06
DE2422016A1 (en) 1974-11-28
FR2229063B1 (en) 1978-01-13
IT1019580B (en) 1977-11-30
JPS5016597A (en) 1975-02-21
US3918812A (en) 1975-11-11
GB1448789A (en) 1976-09-08

Similar Documents

Publication Publication Date Title
CA1020234A (en) Diagnoses of disease states by fluorescent measurements utilizing scanning laser beams
CA1019975A (en) Classifying biological cells by fluorescent radiation using split laser beam
IT1026065B (en) PROCEDURE FOR PRODUCING DIAKYL THIOPHOSPHATES
CA1027558A (en) Mycophenolic acid derivatives
CA996769A (en) Visibility meter using multiple light beams
IT1004954B (en) PROCEDURE FOR THE SYNTHESIS OF ALOHIL OPTICALLY ACTIVE CHRYSANTHEMATES
CA999504A (en) Intermediate connector for heddle supporting beam
BE816086A (en) PROCEDURE FOR CONSTITUTING CONSTRUCTION ASSEMBLIES
CA1033751A (en) Lactone acid synthesis
IE39917L (en) D-homosteroids.
IT1014466B (en) PROCEDURE FOR THE PREPARATION OF SODIUM PERCARBONATE
BR7406416D0 (en) QUINOLINE-8-CARBOXYL ACID DERIVATIVES
CA1028699A (en) Prostanoic acid derivatives
AR206610A1 (en) PROCEDURE FOR THE PREPARATION OF 2-METOXY-5-SULFONIL (SUBSTITUTED) -BENZAMIDES - (- SUBSTITUTED
IT1019972B (en) PROCEDURE FOR THE PREPARATION OF MONOMETHYL TIN TRICHLORIDE
AU484256B2 (en) Diagnoses of disease states by fluorescent measurements utilizing scanning laser beams
NL7409951A (en) SCAN MICROSCOPE.
IT1020641B (en) PROCEDURE FOR THE PERMENTATIVE PREPARATION OF L. ISTIDINA
CA1019759A (en) N-triiodobenzyl-carbamic acid derivatives as x-ray contrast agents
CA1006540A (en) Preparation of optically active allethrolone via allethronyl acid phthalate
CS190456B2 (en) Instrument for optical instrument for optical scanning of the information
CA1033104A (en) Levelling auxiliaries for acid dyes
IT1021948B (en) PROCEDURE FOR THE PREPARATION OF SUBSTITUTED ANTHRACHINONES
IT1023275B (en) PROCEDURE FOR THE PRODUCTION OF REPLACED CYAN STYRILE BIS COMBUSTS
IT1008926B (en) PROCEDURE FOR THE PRODUCTION OF L LYSINE